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Formulas

Gabapentin 2.5%/Ketamine HCl 11.5%/Lidocaine HCl 2% Topical Cream

The Gabapentin 2.5%/Ketamine HCl 11.5%/Lidocaine HCl 2% Topical Cream is a specialized semisolid preparation intended for localized application to the skin. This formulation is compounded in a pump mechanism container, which allows for convenient and controlled dispensing of the cream. The combination of active ingredients in this cream is specifically chosen for their synergistic effects in the management of neuropathic pain and complex regional pain syndrome (CRPS). Gabapentin is known for its ability to modulate neuropathic pain signals, while Ketamine HCl, an NMDA receptor antagonist, and Lidocaine HCl, a local anesthetic, work to provide immediate and effective relief from pain and discomfort associated with these disease states. This topical cream is designed to minimize systemic absorption and provide targeted relief at the site of application.

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Topical Cream
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Formula Information

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Gabapentin 2.5%/Ketamine HCl 11.5%/Lidocaine HCl 2% Topical Cream is a compounded medication specifically formulated to provide targeted relief from certain types of pain. This cream is a semisolid preparation that is dispensed in a pump mechanism, which allows for convenient and controlled application directly to the skin. The pump ensures that each dose is consistent, reducing the risk of over- or under-application and facilitating adherence to the prescribed treatment regimen.

The active ingredients in this formulation work synergistically to manage pain. Gabapentin is an anticonvulsant that is also used to treat neuropathic pain. It is believed to work by altering the way nerves send messages to the brain. Ketamine HCl, a medication primarily used for starting and maintaining anesthesia, has been found to have analgesic properties at lower doses. It works by blocking certain pain receptors in the nervous system. Lidocaine HCl is a local anesthetic that provides temporary relief of pain by causing a numbing effect at the site of application.

This combination cream is particularly useful for patients experiencing neuropathic pain, which can be associated with conditions such as postherpetic neuralgia, diabetic neuropathy, and complex regional pain syndrome. The localized effect of the cream can help reduce systemic side effects typically associated with oral medications. It is important for patients and prescribers to note that while this topical formulation can provide significant pain relief, it should be used as part of a comprehensive pain management plan, which may include other medications, physical therapy, and lifestyle modifications.

As with any medication, it is essential to use this cream under the guidance of a healthcare professional. The specific concentration of each ingredient has been chosen to maximize pain relief while minimizing side effects, but individual responses can vary. Patients should inform their healthcare provider of their complete medical history, including any other medications or supplements they are taking, to avoid potential interactions. If you have any questions or require further information about this formulation and its suitability for treating specific disease states, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is dedicated to providing personalized care and support to our patients and prescribers.

Drug Interactions

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The topical cream formulation containing Gabapentin 2.5%, Ketamine HCl 11.5%, and Lidocaine HCl 2% is designed for localized treatment and may be used for conditions such as neuropathic pain, postherpetic neuralgia, or complex regional pain syndrome. While the risk of systemic drug interactions is generally lower with topical administration compared to oral or parenteral routes, there are still potential interactions that should be considered.

Gabapentin, when used topically, is less likely to have systemic effects or interactions; however, caution is advised if the patient is taking other central nervous system (CNS) depressants such as opioids, benzodiazepines, or alcohol, as there may be an additive effect on CNS depression. Additionally, antacids containing aluminum or magnesium may affect the absorption of gabapentin if used systemically, but this is unlikely to be significant with topical application.

Ketamine, a NMDA receptor antagonist, can also cause CNS depression. When used topically, systemic absorption is minimal, but concurrent use with other CNS depressants could potentially enhance sedative, anesthetic, and psychoactive effects. It is important to monitor patients for signs of excessive sedation or CNS depression, especially if they are on multiple medications that affect the CNS.

Lidocaine is a local anesthetic and, when applied topically, has a low risk of systemic interactions. However, caution should be exercised if the patient is on class I antiarrhythmic drugs (such as tocainide and mexiletine) due to the additive cardiac effects. Lidocaine metabolism may be affected by CYP1A2 and CYP3A4 enzyme inhibitors or inducers, potentially altering its efficacy and toxicity profile.

It is also important to consider the potential for local skin reactions or interactions with other topical products. Patients should be advised to inform their healthcare provider of all topical medications they are using to avoid potential interactions. Additionally, the absorption of the active ingredients may be altered by the application of heat or occlusive dressings over the site of application, which could inadvertently increase systemic exposure.

Patients should be instructed to use the cream as directed and to report any adverse effects or concerns to their healthcare provider immediately. Prescribers should review the patient's medication profile for potential interactions and adjust therapy as needed. If you have any questions or require further information regarding this formulation and its use, please do not hesitate to reach out to us at Bayview Pharmacy.

How Does it Work

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The Gabapentin 2.5%/Ketamine HCl 11.5%/Lidocaine HCl 2% Topical Cream is a compounded medication that combines three active ingredients, each with distinct mechanisms of action, to provide relief from certain types of pain. This cream is formulated as a semisolid preparation and is dispensed in a pump mechanism, which allows for convenient, controlled, and localized application on the skin.

Gabapentin, the first active ingredient, is traditionally known as an anticonvulsant but has also been found to be effective in the treatment of neuropathic pain. It works by binding to the alpha-2-delta subunit of voltage-gated calcium channels in the central nervous system, which decreases the release of excitatory neurotransmitters and thus reduces the abnormal excitation of nerves that is associated with pain.

Ketamine HCl, the second active ingredient, is an N-methyl-D-aspartate (NMDA) receptor antagonist. By blocking these receptors, ketamine can prevent the transmission of pain signals in the spinal cord and brain. This action helps to reduce central sensitization, which is a condition where the central nervous system becomes sensitized to pain stimuli, leading to increased pain perception. Ketamine's role in this cream is particularly important for managing chronic pain conditions that may not respond well to other treatments.

Lidocaine HCl, the third active ingredient, is a local anesthetic that works by blocking sodium channels on the neuronal cell membrane. This action inhibits the initiation and conduction of nerve impulses, thereby providing a numbing effect and temporary relief from pain. Lidocaine is effective for providing immediate relief from pain and can help to reduce discomfort during the application of the cream.

When applied topically, this combination of gabapentin, ketamine, and lidocaine works synergistically to provide localized pain relief. This can be particularly beneficial for patients suffering from neuropathic pain, complex regional pain syndrome (CRPS), or certain types of chronic pain conditions where systemic treatments may not be desirable or may cause unwanted side effects.

It is important for both patients and prescribers to understand that this is a specially compounded formulation and should be used under the guidance of a healthcare professional. The specific concentration of each ingredient has been chosen to maximize therapeutic effects while minimizing the potential for systemic absorption and side effects. Patients should follow the application instructions provided by their healthcare provider to ensure safe and effective use of the medication.

If you have any questions about this formulation or how it may benefit your specific condition, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to provide you with the information and support you need to manage your pain effectively.

Other Uses

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While this particular topical cream formulation comprising Gabapentin, Ketamine HCl, and Lidocaine HCl is primarily indicated for the management of neuropathic pain and conditions such as postherpetic neuralgia, it may have other potential uses due to the properties of its individual components. Gabapentin is known to modulate the release of neurotransmitters, Ketamine is a NMDA receptor antagonist which can have analgesic effects, and Lidocaine is a local anesthetic that blocks sodium channels, thereby reducing pain signaling.

Patients with complex regional pain syndrome or other chronic pain disorders might find symptomatic relief with this formulation. Additionally, this cream could potentially be beneficial for those experiencing pain related to fibromyalgia or limited joint and muscle pain conditions, given that each active ingredient contributes to pain relief through different mechanisms. It should be noted that off-label uses of the product should be with the guidance and prescription of a licensed healthcare provider who can monitor efficacy and safety.

Due to its topical administration, the cream might also be used in scenarios where systemic side effects of these medications are a concern and localized therapy is preferred. Some patients may use this formulation as an adjunct treatment for painful diabetic neuropathy, although its use should be carefully considered in diabetic patients with skin integrity issues. It is important for both patients and prescribers to remember that while these other uses are possible, clinical data supporting these indications may be limited and prescribing should be on a case-by-case basis, evaluating the risks and benefits for the individual patient.

The semi-solid preparation dispensed via a pump mechanism allows for ease of use, consistent dosing, and minimizes the potential for contamination, which could be particularly beneficial in a home setting or for patients with limited dexterity. The main goal of the product design is to target pain at the localized site with minimal systemic involvement. This can be advantageous for patients who are on multiple systemic medications or for those who need to avoid systemic side effects or drug-drug interactions.

Finally, while this topical cream may offer diverse therapeutic benefits, its use should be accompanied by professional medical advice ensuring it is appropriate for the patient’s specific condition. The safety profile and the potential for allergic reactions or skin irritation must also be considered. For any questions regarding this formulation or its potential uses, please reach out to us at Bayview Pharmacy. We are here to ensure that you and your patients receive comprehensive information and guidance on the use of our compounded medications.

Frequently Asked Questions

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What is Gabapentin/Ketamine HCl/Lidocaine HCl Topical Cream?

This is a compounded formulation of three active ingredients: Gabapentin, Ketamine HCl, and Lidocaine HCl, which are combined in a cream base. Gabapentin is used for nerve pain relief, Ketamine HCl has anesthetic properties, and Lidocaine HCl is a local anesthetic. The cream is formulated to treat localized areas of pain and discomfort.

How should this topical cream be used?

This cream should be applied to the affected area as directed by your healthcare provider. The pump mechanism is designed to dispense a controlled amount of the product to ensure consistent dosing. Gently rub in the cream until it is fully absorbed.

How often can I apply this compounded cream?

The frequency of application should be according to the instructions provided by your healthcare provider, who will determine the dosage based on your specific condition and needs.

Can this cream be used with other medications?

While this cream is designed for localized treatment, it is important to inform your healthcare provider of all medications you are currently using to avoid potential interactions. Your provider will advise whether this topical formulation can be used in conjunction with other medications.

What are the potential side effects of this topical cream?

Side effects can include skin irritation, redness, itching, or a burning sensation at the site of application. Systemic side effects are less common but can occur, especially with prolonged use or over-application. Consult your healthcare provider if you experience these or any other unusual symptoms.

Is this cream suitable for all skin types?

Individuals with sensitive skin or with a history of allergic reactions to any of the active ingredients, or other local anesthetics, should not use this cream. A skin patch test may be recommended by your healthcare provider to ensure compatibility.

How should this product be stored?

The cream should be stored at room temperature, away from direct sunlight and heat. Keep the container tightly closed when not in use.

What should I do if I miss a dose of the cream?

If a dose is missed, apply the cream as soon as you remember. However, if it is almost time for your next dose, skip the missed application and resume your regular dosing schedule.

Can I apply the cream to open wounds or damaged skin?

No, do not apply the cream to open wounds, cuts, or any areas of infection or damaged skin. The formulation is intended for use on intact skin only.

How long does it take for the cream to work?

The onset of action can vary based on individual response and the condition being treated. Some people may experience relief shortly after application, while for others, it may take longer. Follow your healthcare provider's instructions and give the medication time to work.

Do I need a prescription to get this topical cream?

Yes, this is a compounded medication that requires a prescription from a licensed healthcare provider.

What should I do in case of over-application or if someone ingests the cream?

In case of over-application, wipe off the excess cream with a tissue and contact your healthcare provider for advice. If the cream is ingested, especially by a child, contact a poison control center or emergency room immediately.

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Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.