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Formulas

Fluoxetine 80 mg Oral Capsules

Fluoxetine 80 mg Oral Capsules are a solid dosage form consisting of two halves of either gelatin or vegetarian-based shells that encapsulate the active medication. This design ensures the capsules are easy to swallow and provide a precise dose of fluoxetine, which is essential for maintaining therapeutic levels in the body. Fluoxetine is a selective serotonin reuptake inhibitor (SSRI) commonly used to treat a variety of disease states, including major depressive disorder, obsessive-compulsive disorder, bulimia nervosa, and panic disorder. By adjusting the balance of serotonin in the brain, fluoxetine helps to improve mood, sleep, appetite, and energy level, while also decreasing fear, anxiety, unwanted thoughts, and the number of panic attacks. It is also used in the treatment of premenstrual dysphoric disorder (PMDD) to relieve symptoms like mood swings, irritability, bloating, and breast tenderness.

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Fluoxetine Hydrochloride
Capsules
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Formula Information

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Fluoxetine 80 mg Oral Capsules are a solid dosage form consisting of two halves of either gelatin or vegetarian-based shells that encapsulate the active pharmaceutical ingredient, fluoxetine. These capsules are designed to be easily swallowed, ensuring patient compliance and convenience. The encapsulation of the medication provides a precise dosage, which is critical for maintaining the therapeutic efficacy of the drug. Fluoxetine is a selective serotonin reuptake inhibitor (SSRI), which is commonly prescribed for the treatment of a variety of psychiatric conditions.

Fluoxetine works by increasing the levels of serotonin in the brain, a neurotransmitter associated with mood regulation. This action helps to alleviate symptoms of depression, one of the primary indications for fluoxetine. It is also effective in treating obsessive-compulsive disorder (OCD), bulimia nervosa, panic disorder, and premenstrual dysphoric disorder (PMDD). By normalizing serotonin levels, fluoxetine can help to reduce anxiety, improve mood, and decrease unwanted thoughts and behaviors.

The 80 mg dosage of fluoxetine in these capsules is typically reserved for patients who require a higher dose, often after initial treatment with a lower dose or for those with severe conditions that have not responded adequately to standard treatments. It is important for prescribers to carefully monitor patients on this high dosage for any potential side effects or adverse reactions. Common side effects may include nausea, headache, insomnia, fatigue, and sexual dysfunction. Patients should be counseled on the importance of adherence to the prescribed regimen and to report any bothersome or persistent side effects to their healthcare provider.

It is essential for patients to understand that it may take several weeks to experience the full benefits of fluoxetine, and they should continue taking the medication as directed, even if they feel well. Abrupt discontinuation should be avoided due to the risk of withdrawal symptoms. Prescribers should provide guidance on how to safely discontinue the medication if necessary. Additionally, fluoxetine may interact with other medications, so a thorough medication history should be obtained to avoid potential drug interactions.

Bayview Pharmacy's team of compounding pharmacists is dedicated to providing high-quality, customized medications to meet the specific needs of each patient. Our expertise in compounding allows us to offer fluoxetine in an 80 mg oral capsule form, ensuring precise dosing and patient-centered care. If you have any questions or require further information about this formulation or its use in treating various disease states, please do not hesitate to reach out to us. We are here to support both patients and prescribers in the effective management of mental health conditions.

Drug Interactions

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Fluoxetine is a selective serotonin reuptake inhibitor (SSRI) commonly used to treat a variety of psychiatric conditions including major depressive disorder, obsessive-compulsive disorder, panic disorder, and certain eating disorders. As with any medication, fluoxetine can interact with a wide range of other drugs, which can alter its effectiveness or increase the risk of adverse effects. It is important for both patients and prescribers to be aware of these potential interactions.

One of the most significant interactions is with monoamine oxidase inhibitors (MAOIs). Combining fluoxetine with MAOIs can lead to a potentially life-threatening condition called serotonin syndrome. This syndrome is characterized by symptoms such as confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea. Due to this risk, fluoxetine should not be used in combination with an MAOI, or within 14 days of discontinuing treatment with an MAOI. Similarly, an MAOI should not be started until at least 5 weeks after stopping fluoxetine, due to its long half-life.

Other medications that can increase serotonin levels, such as other SSRIs, serotonin and norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants (TCAs), triptans used for migraine, fentanyl, lithium, tramadol, tryptophan, buspirone, and St. John's Wort should be used with caution. The combination can lead to serotonin syndrome, and if these medications must be used together, it is recommended to monitor the patient closely for symptoms of serotonin syndrome.

Fluoxetine can also interact with drugs that affect the cytochrome P450 2D6 enzyme system in the liver. Fluoxetine is a known inhibitor of this enzyme, which can lead to increased blood levels of drugs metabolized by this pathway. This includes certain antipsychotics like haloperidol and clozapine, beta-blockers such as metoprolol, and Type 1C antiarrhythmics like propafenone and flecainide. When used with fluoxetine, the doses of these medications may need to be reduced, and therapeutic drug monitoring may be necessary.

Warfarin and other anticoagulants may also interact with fluoxetine. Fluoxetine can potentiate the effects of warfarin, which may increase the risk of bleeding. Patients taking both medications should have their prothrombin time or international normalized ratio (INR) monitored closely, especially when starting or stopping fluoxetine.

Additionally, fluoxetine can interact with drugs that cause sedation, such as benzodiazepines, some antihistamines, opioids, and alcohol. The combination can increase the risk of sedation, dizziness, and impaired coordination. Patients should be advised to avoid or limit the use of alcohol and be cautious when taking other central nervous system depressants.

It is also important to note that fluoxetine can affect blood sugar levels, so patients with diabetes should be monitored for hypoglycemia or hyperglycemia when starting or changing doses of fluoxetine. Adjustments to diabetes medication may be necessary.

Lastly, fluoxetine can cause QT prolongation, a change in the heart's electrical activity that can lead to an irregular heartbeat. Caution is advised when using fluoxetine with other medications known to cause QT prolongation or electrolyte imbalances.

This is not an exhaustive list of all potential interactions with fluoxetine. Patients should be encouraged to inform their healthcare provider of all medications, supplements, and herbal products they are taking. Prescribers should consult detailed references and consider a patient's complete medication profile to avoid interactions. If you have any questions or concerns about using this formulation of fluoxetine 80 mg oral capsules, please reach out to us at Bayview Pharmacy for further assistance.

How Does it Work

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Fluoxetine 80 mg Oral Capsules are a solid dosage form that consists of two halves of either gelatin or vegetarian-based shells, which are known as the capsule. The active ingredient, fluoxetine, is contained within these shells in a powder or granule form. When the capsule is ingested, the shells dissolve in the gastric fluids of the stomach, releasing the fluoxetine for absorption into the bloodstream. This delivery method is designed to be easy to swallow and provides a precise dosage of the medication, ensuring consistency and reliability in dosing.

Fluoxetine is a selective serotonin reuptake inhibitor (SSRI), which means it works by increasing the levels of serotonin in the brain. Serotonin is a neurotransmitter that is involved in the regulation of mood, anxiety, and other functions. By preventing the reuptake of serotonin back into the nerve cells, fluoxetine allows for more serotonin to be available in the brain. This helps to improve mood and reduce the symptoms of depression and anxiety disorders.

The 80 mg dosage of fluoxetine in these capsules is typically used for the treatment of various disease states, including major depressive disorder, obsessive-compulsive disorder (OCD), bulimia nervosa, panic disorder, and premenstrual dysphoric disorder (PMDD). It may take several weeks for the full effects of fluoxetine to be felt, and it is important for patients to continue taking the medication as prescribed, even if they feel well, to maintain its benefits.

Patients should be aware that fluoxetine can have side effects, and it may interact with other medications. It is important to discuss all medications, including over-the-counter drugs and supplements, with a healthcare provider before starting fluoxetine. Additionally, abrupt discontinuation of fluoxetine should be avoided due to the risk of withdrawal symptoms; any changes in dosing should be done under the guidance of a healthcare provider.

Prescribers should monitor patients for any signs of adverse reactions, especially during the initial treatment period or when changing doses. Regular follow-up appointments are recommended to assess the effectiveness of the medication and to make any necessary adjustments to the treatment plan.

At Bayview Pharmacy, we are committed to providing high-quality compounded medications tailored to the needs of our patients. If you have any questions about Fluoxetine 80 mg Oral Capsules or any other formulations, please reach out to us. Our knowledgeable team of compounding pharmacists is here to assist you with your medication needs.

Other Uses

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Fluoxetine 80 mg oral capsules are traditionally prescribed for the treatment of major depressive disorder (MDD), obsessive-compulsive disorder (OCD), panic disorder, and bulimia nervosa. Beyond these commonly recognized indications, fluoxetine has a range of other uses which harness its pharmacological profile. It has been utilized in the management of premenstrual dysphoric disorder (PMDD), a severe form of premenstrual syndrome (PMS) with pronounced mood-related symptoms. Clinical evidence also suggests potential benefits when fluoxetine is used off-label for the treatment of various anxiety disorders, including social anxiety disorder and generalized anxiety disorder, though it is not FDA-approved for these specific conditions.

In addition to psychiatric applications, fluoxetine has been explored for its potential impact on pain management, particularly in the context of neuropathic pain and migraine prophylaxis. While not a primary indication, some prescribers may consider it in a multimodal approach to chronic pain management. Furthermore, fluoxetine has been studied for its effects on weight management in patients with obesity due to its influence on serotonin levels, which may affect appetite and satiety, although its use in obesity is not substantiated by large-scale clinical trials.

Fibromyalgia, a chronic condition characterized by widespread pain and fatigue, has also been a subject of investigation regarding fluoxetine's efficacy. Limited trials suggest that it may offer symptomatic relief, potentially improving quality of life for individuals with this condition. Additionally, there is some evidence indicating that fluoxetine might be beneficial in addressing impulsive behavior in certain personality disorders and may play a role in treating dermatological conditions with a psychosomatic component, such as trichotillomania and skin picking disorder.

While fluoxetine is well-known for its antidepressant properties, the potential spectrum of its utilization is broad. It is crucial for prescribers to evaluate the evidence base for these other uses and to consider individual patient profiles. Patients should be thoroughly counseled on the risks and benefits of using fluoxetine for both approved and off-label indications. Dose adjustments may be necessary based on the specific use-case, and close monitoring for efficacy and adverse reactions is imperative. As always, if you have any questions regarding the use of fluoxetine 80 mg oral capsules for indications outside of those traditionally recognized, please reach out to us at Bayview Pharmacy for further information and guidance.

Frequently Asked Questions

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What are Fluoxetine 80 mg Oral Capsules?

Fluoxetine 80 mg Oral Capsules are a solid dosage form of medication, consisting of two halves of either gelatin or vegetarian material that contain a precise dose of the active ingredient, fluoxetine, which is commonly used as an antidepressant. These capsules are designed for easy oral administration and consistent dosing.

How should I take Fluoxetine 80 mg Oral Capsules?

Fluoxetine 80 mg Oral Capsules should be taken exactly as prescribed by your healthcare provider. Usually, they are taken once daily with or without food. Swallow the capsules whole without crushing or chewing them.

Can I open the Fluoxetine capsule and mix it with food?

It is generally not recommended to open the capsules as they are designed to release the medication into your body at a certain rate. If you have difficulty swallowing capsules, discuss alternative forms of the medication with your healthcare provider.

Who should not take Fluoxetine 80 mg Oral Capsules?

Individuals who have had an allergic reaction to fluoxetine or who are taking other medications that can interact dangerously with fluoxetine, such as MAO inhibitors, should not take this medication. Consult your healthcare provider for a full list of contraindications.

What are the possible side effects of Fluoxetine 80 mg Oral Capsules?

Common side effects may include nausea, drowsiness, dizziness, anxiety, insomnia, loss of appetite, and sweating, among others. Contact your healthcare provider if you experience any side effects that persist or worsen.

Can I drink alcohol while taking Fluoxetine 80 mg Oral Capsules?

Alcohol consumption is not recommended while taking fluoxetine, as it can increase the risk of side effects such as dizziness and impair your judgment and motor coordination.

What should I do if I miss a dose of Fluoxetine 80 mg Oral Capsules?

If you miss a dose, take it as soon as you remember. If it’s near the time of your next dose, skip the missed dose and continue on your regular schedule. Do not double up on doses to make up for the one missed.

How long does it take for Fluoxetine 80 mg Oral Capsules to work?

It can take several weeks to feel the full effect of fluoxetine. It’s important to keep taking the medication as prescribed and to keep your healthcare provider informed of your progress.

Can Fluoxetine 80 mg Oral Capsules be used during pregnancy?

Fluoxetine should only be used during pregnancy if the potential benefits outweigh the risks, as there may be potential risks to the fetus. Consult with your healthcare professional to make a well-informed decision.

How should I store Fluoxetine 80 mg Oral Capsules?

Store Fluoxetine 80 mg Oral Capsules at room temperature, away from moisture and heat. Keep the container tightly closed and out of reach of children and pets.

Are there any long-term effects of taking Fluoxetine 80 mg Oral Capsules?

Some individuals may experience long-term effects from taking fluoxetine, including sexual dysfunction or weight changes. Discuss any concerns about long-term effects with your healthcare provider.

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Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.