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Formulas

Fluconazole 150 mg Oral Capsules (Gluten Free)

Fluconazole 150 mg Oral Capsules are a gluten-free solid dosage form, specifically designed for patients with dietary restrictions. Each capsule is composed of two halves, either gelatin-based or made from vegetarian alternatives, that seamlessly encapsulate the medication. This design ensures the capsules are easy to swallow and provide a precise 150 mg dose of fluconazole, the active antifungal ingredient.

Fluconazole is commonly used to treat various fungal infections, including vaginal yeast infections (vulvovaginal candidiasis), oral thrush (oropharyngeal candidiasis), and other systemic candidiasis. It is also employed as a prophylactic agent in patients with compromised immune systems to prevent fungal infections. The gluten-free formulation of these capsules makes them suitable for patients with celiac disease or gluten sensitivity who require antifungal treatment.

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Fluconazole
Capsules
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Formula Information

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Fluconazole 150 mg Oral Capsules are a specialized gluten-free medication designed to treat various fungal infections. These solid dosage forms are meticulously crafted, consisting of either gelatin or vegetarian-based shells that encapsulate the active pharmaceutical ingredient, fluconazole. The capsule format ensures that patients receive a precise 150 mg dose of fluconazole, which is essential for the effective management of fungal diseases. The shells are designed to be easy to swallow, enhancing patient compliance, and are suitable for individuals with dietary restrictions such as a gluten intolerance.

Fluconazole is a potent antifungal agent that belongs to the triazole class of antifungal drugs. It functions by inhibiting the synthesis of ergosterol, a critical component of fungal cell membranes. Without ergosterol, the cell membrane becomes compromised, leading to the leakage of cellular contents and ultimately the death of the fungal cell. This mechanism of action makes fluconazole an effective treatment for a variety of fungal infections, including but not limited to, vaginal yeast infections, oral thrush, systemic candidiasis, and cryptococcal meningitis. It is also used as a prophylactic agent in immunocompromised patients to prevent fungal infections.

For prescribers, it is important to note that fluconazole's efficacy and safety profile have been well-established in clinical trials. However, as with all medications, there are potential side effects and drug interactions that should be considered. Common side effects may include nausea, headache, skin rash, and abdominal pain. More serious adverse effects, although rare, can occur and should be monitored. Fluconazole is metabolized through the liver and can interact with a wide array of medications, potentially increasing the serum levels of certain drugs, which necessitates careful patient monitoring and possible dose adjustments.

Patients prescribed Fluconazole 150 mg Oral Capsules should be advised to take the medication exactly as directed by their healthcare provider. It is crucial to complete the full course of treatment, even if symptoms improve before the medication is finished, to prevent the recurrence of infection. Patients should also be informed about the potential side effects and the importance of reporting any unusual symptoms to their healthcare provider promptly.

At Bayview Pharmacy, we are committed to providing high-quality, patient-specific pharmaceutical care. Our team of compounding pharmacists is available to answer any questions and provide additional information regarding Fluconazole 150 mg Oral Capsules or any other medication needs. If you have any questions or require further assistance, please do not hesitate to reach out to us.

Drug Interactions

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Fluconazole is an antifungal medication that works by inhibiting the fungal cytochrome P450 enzyme 14α-demethylase. This action prevents the conversion of lanosterol to ergosterol, an essential component of the fungal cell membrane, thereby exerting its antifungal effect. Fluconazole 150 mg oral capsules are commonly prescribed for the treatment of various fungal infections, including vaginal yeast infections, oral thrush, and systemic candidiasis, among others. As with any medication, fluconazole can interact with other drugs, which may affect its efficacy or increase the risk of adverse effects.

One significant interaction is with drugs that are metabolized by the cytochrome P450 (CYP) enzyme system, particularly CYP3A4, CYP2C9, and CYP2C19. Fluconazole is a potent inhibitor of CYP2C9 and a moderate inhibitor of CYP3A4. Therefore, it can increase the plasma concentrations of drugs metabolized by these enzymes, potentially leading to toxicity. Examples include warfarin, certain antiepileptic drugs (such as phenytoin), and some benzodiazepines. Patients taking these medications may require dose adjustments and close monitoring for adverse effects when starting or stopping fluconazole.

Another important interaction is with QT-prolonging drugs. Fluconazole can prolong the QT interval on an electrocardiogram, and when used in combination with other QT-prolonging drugs, such as certain antiarrhythmics, antipsychotics, and antibiotics, there is an increased risk of serious cardiac arrhythmias like torsades de pointes. Patients with existing cardiac conditions or those taking medications that affect electrolyte balance may be at higher risk.

Fluconazole also interacts with statins metabolized by CYP3A4, such as atorvastatin and simvastatin, increasing the risk of myopathy and rhabdomyolysis. Patients on these statins may need to be monitored for muscle pain or weakness and may require a statin dose adjustment.

Oral hypoglycemic agents, particularly sulfonylureas, can have their effects potentiated by fluconazole, leading to hypoglycemia. Careful monitoring of blood glucose levels is advised when initiating or discontinuing fluconazole in diabetic patients on sulfonylureas.

Immunosuppressants like cyclosporine, tacrolimus, and sirolimus are also affected by fluconazole, as it can increase their blood levels, potentially leading to increased risk of nephrotoxicity and other adverse effects. Dosage adjustments and monitoring of drug levels may be necessary.

Lastly, fluconazole can reduce the efficacy of hormonal contraceptives. Patients should be advised to use an additional non-hormonal method of birth control to prevent pregnancy during treatment with fluconazole.

This is not an exhaustive list of all potential drug interactions with fluconazole. It is crucial for patients and prescribers to review all current medications, including over-the-counter drugs and herbal supplements, to identify any potential interactions. If you have any questions or concerns regarding the use of Fluconazole 150 mg Oral Capsules or potential drug interactions, please reach out to us at Bayview Pharmacy for further assistance.

How Does it Work

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Fluconazole 150 mg Oral Capsules are a solid dosage form specifically designed to treat fungal infections. These capsules are composed of two halves, either made from gelatin or a vegetarian substitute, which encapsulate the powdered form of fluconazole. This design ensures that the medication is delivered in a precise 150 mg dose, which is critical for the effectiveness of the treatment. The capsules are also gluten-free, catering to patients with gluten sensitivities or celiac disease.

Fluconazole, the active ingredient in these capsules, is a potent antifungal medication that works by inhibiting the synthesis of ergosterol, a vital component of fungal cell membranes. Without ergosterol, the fungal cell membrane becomes weak and porous, ultimately leading to the death of the fungal cell. This mechanism of action makes fluconazole effective against a wide range of fungal infections, including vaginal yeast infections, oral thrush, and systemic candidiasis, among others.

The 150 mg dose of fluconazole is commonly used as a single-dose treatment for vaginal yeast infections, which simplifies the treatment regimen and improves patient compliance. For other infections, the dosing may vary, and a healthcare provider will determine the appropriate regimen based on the type and severity of the infection. It is important for patients to take the medication exactly as prescribed to ensure the best possible outcome.

Patients and prescribers should be aware that while fluconazole is a well-tolerated medication, it can interact with other drugs and may not be suitable for everyone, including those with certain pre-existing health conditions. Therefore, a thorough medical history and medication review are essential before initiating treatment with fluconazole capsules.

For those interested in using Fluconazole 150 mg Oral Capsules (Gluten Free) for the treatment of fungal infections, or if you have any questions regarding this formulation, please reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is here to provide guidance and support to ensure safe and effective treatment for our patients.

Other Uses

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Fluconazole 150 mg oral capsules, provided in gluten-free form, are primarily indicated for the treatment of various fungal infections. These infections can include vaginal yeast infections, thrush (oral candidiasis), and other systemic candida infections such as urinary tract infections, peritonitis, and systemic candidiasis. Due to its antifungal properties, fluconazole has also been found to be effective in managing fungal infections in patients with weakened immune systems, such as those undergoing chemotherapy or those with HIV/AIDS, helping to reduce their risk of developing serious fungal infections.

Aside from its primary indications, fluconazole may also be used for off-label purposes as deemed appropriate by a healthcare provider. It may be prescribed for prophylactic use in patients who are at high risk of developing fungal infections, such as those with advanced cancer, bone marrow transplantation, or those in intensive care units. Furthermore, fluconazole has been used in the treatment of fungal infections of the nails (onychomycosis) and ringworm when first-line treatment options are unsuitable or have failed. It is also occasionally employed to treat fungal meningitis in individuals with compromised immune systems.

For conditions such as tinea versicolor, a common fungal skin infection causing white or light brown patches on the skin, fluconazole may be used in cases where topical treatments have not been successful. Temporary relief of the symptoms associated with fungal skin infections can also be achieved through the use of fluconazole in circumstances where other treatments have not been well-tolerated.

It is important to note that while fluconazole can serve various therapeutic roles, it should only be used under the guidance of a licensed healthcare provider who can evaluate the appropriateness of its use for a given condition. The specific gluten-free formulation of our fluconazole 150 mg capsules ensures that patients with celiac disease or gluten sensitivity can safely use this medication without concern for gluten-induced reactions. This is especially relevant as many solid dosage forms may contain excipients with gluten, which can lead to adverse effects in these patient populations.

If there are any questions or if further information is needed regarding the potential other uses of fluconazole 150 mg oral capsules in this formulation, please reach out to us at Bayview Pharmacy. We are committed to providing comprehensive support to both patients and prescribers to optimize therapeutic outcomes and ensure safe medication practices.

Frequently Asked Questions

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What is Fluconazole 150 mg Oral Capsule?

Fluconazole 150 mg Oral Capsule is a prescription medication used to treat fungal infections. It comes as a solid dosage form with two shells, made either from gelatin or a vegetarian alternative, that encases the medication. This form allows for accurate dosing and easy oral administration.

Is this Fluconazole capsule gluten-free?

Yes, this formulation of Fluconazole 150 mg Oral Capsules is gluten-free, making it suitable for individuals with gluten sensitivity or celiac disease.

How should I take Fluconazole 150 mg Oral Capsules?

Fluconazole 150 mg Oral Capsules should be taken as directed by your healthcare provider, usually in a single dose. The capsule should be swallowed whole with water; it should not be crushed or chewed.

What are the potential side effects of taking Fluconazole capsules?

Common side effects may include headache, dizziness, diarrhea, stomach pain, or changes in taste. If you experience severe reactions such as skin rash, swelling, or trouble breathing, seek medical help immediately.

Can Fluconazole 150 mg Oral Capsules be taken with food?

Fluconazole capsules can be taken with or without food. However, if you experience stomach upset, it might be beneficial to take it with food.

Are Fluconazole 150 mg capsules safe for everyone?

Most adults can safely take Fluconazole 150 mg capsules, but they are not suitable for everyone. People with certain conditions, allergies, or those taking specific medications should consult with their healthcare provider before use.

Can pregnant or breastfeeding women take Fluconazole 150 mg capsules?

Pregnant or breastfeeding women should only use Fluconazole if it is clearly needed and prescribed by a healthcare provider due to potential risks to the fetus or infant.

How should I store Fluconazole 150 mg Oral Capsules?

Store the capsules at room temperature away from direct light and moisture. Keep them out of reach of children and pets.

Can I drink alcohol while taking Fluconazole 150 mg capsules?

It is best to avoid alcohol while taking Fluconazole, as combining the two can increase the risk of liver damage and enhance the side effects of the medication.

What should I do if I miss a dose of Fluconazole 150 mg capsule?

If you miss a dose of Fluconazole, take it as soon as you remember. However, if it's almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.

Can I stop taking Fluconazole 150 mg capsules once my symptoms improve?

Even if symptoms begin to improve, it is important to complete the full prescribed course unless instructed otherwise by your healthcare provider to ensure the infection is properly treated and to prevent resistance.

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Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.