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Fluconazole 100 mg/5 mL Oral Liquid

Fluconazole 100 mg/5 mL Oral Liquid is a specially compounded medication designed for oral use, offering a precise and accessible means of administering the antifungal agent fluconazole. This liquid formulation is particularly beneficial for patients who experience difficulty swallowing pills, such as children and the elderly. The medication is indicated for the treatment of various fungal infections, including but not limited to candidiasis, cryptococcal meningitis, and other systemic fungal diseases. By providing fluconazole in a liquid form, this formulation ensures accurate dosing and ease of use for effective management of these disease states.

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Fluconazole
Oral Liquid
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Formula Information

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Fluconazole 100 mg/5 mL Oral Liquid is a custom-prepared medication designed to provide an effective treatment for fungal infections in a form that is suitable for patients who may have difficulty swallowing pills or tablets. This oral suspension offers a precise 100 mg dose of fluconazole in every 5 mL, ensuring accurate dosing for each patient. Fluconazole is a potent antifungal agent that works by inhibiting the growth of a wide variety of fungi by disrupting the production of the fungal cell membrane. This action is particularly effective against Candida infections, including thrush (oral candidiasis), esophageal candidiasis, and systemic candidiasis, as well as cryptococcal meningitis.

The liquid formulation is especially beneficial for pediatric and geriatric patients, or those with dysphagia or other conditions that make swallowing solid forms difficult. It also allows for dose adjustments to be made easily, which is crucial for tailoring the treatment to the specific needs of the patient. The suspension is typically flavored to improve palatability, further encouraging adherence to the prescribed treatment regimen. It is important for patients to shake the bottle well before each use to ensure the medication is evenly distributed throughout the suspension.

For prescribers, it is essential to consider the patient's liver function, as fluconazole is metabolized hepatically, and dose adjustments may be necessary for those with hepatic impairment. Additionally, potential interactions with other medications should be reviewed, as fluconazole can affect the metabolism of certain drugs. Monitoring for side effects, such as gastrointestinal disturbances, skin reactions, or changes in liver enzymes, is also recommended during treatment.

Bayview Pharmacy's team of compounding pharmacists is dedicated to providing high-quality, customized medications to meet the unique needs of each patient. If you have any questions about Fluconazole 100 mg/5 mL Oral Liquid or its use in treating fungal infections, please do not hesitate to reach out to us. We are here to support both patients and healthcare providers with expert advice and comprehensive medication solutions.

Drug Interactions

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Fluconazole is an antifungal medication that works by inhibiting the growth of various types of fungi. It is commonly used to treat and prevent a variety of fungal infections, including yeast infections of the mouth, throat, esophagus, abdomen, lungs, blood, and other organs, as well as meningitis caused by fungus. When prescribing fluconazole in an oral liquid formulation, it is crucial to consider potential drug interactions that may affect the efficacy of the treatment or cause adverse effects.

Fluconazole is known to interact with a wide range of medications due to its influence on the cytochrome P450 enzyme system, particularly CYP2C9, CYP2C19, and CYP3A4. This can lead to either increased or decreased plasma levels of concomitant medications. For instance, fluconazole can increase the plasma concentrations of certain drugs such as warfarin, oral sulfonylureas (e.g., glipizide, glyburide), phenytoin, cyclosporine, tacrolimus, zidovudine, and statins, potentially leading to toxicity. Patients taking these medications should be monitored closely for signs of overdose, and dosage adjustments may be necessary.

Conversely, fluconazole's effectiveness may be reduced when taken with drugs such as rifampin or phenobarbital, which can induce the metabolism of fluconazole, leading to lower plasma levels and reduced efficacy. Additionally, fluconazole can prolong the QT interval on an electrocardiogram and should be used with caution in combination with other drugs known to prolong the QT interval, such as certain antiarrhythmics, antipsychotics, and antibiotics, to avoid the risk of serious cardiac events.

Patients should also be advised to avoid alcohol while taking fluconazole, as concurrent use may increase the risk of liver toxicity. Moreover, fluconazole can interact with oral hypoglycemic agents, and patients with diabetes should be monitored for hypoglycemia. It is also important to note that fluconazole can reduce the efficacy of hormonal contraceptives, and alternative or additional contraceptive measures may be necessary.

It is essential for patients to inform their healthcare provider of all medications, supplements, and herbal products they are currently taking before starting treatment with fluconazole. Healthcare providers should review the patient's medication profile for potential drug interactions to ensure safe and effective use of fluconazole oral liquid. If you have any questions or concerns regarding the use of fluconazole or its interactions with other medications, please reach out to us at Bayview Pharmacy for further assistance.

How Does it Work

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Fluconazole is an antifungal medication that works by inhibiting the growth of various types of fungi. It achieves this by disrupting the production of a vital component of fungal cell membranes, ergosterol. Without ergosterol, the cell membrane becomes weak and allows essential cellular contents to leak out, leading to the death of the fungal cell. This mechanism of action makes fluconazole effective in treating a range of fungal infections.

The Fluconazole 100 mg/5 mL Oral Liquid formulation is designed to provide a specific dose of fluconazole in a liquid form, which is particularly beneficial for patients who have difficulty swallowing pills or capsules, such as children and the elderly. The liquid form allows for flexible dosing, which can be easily adjusted according to the patient's weight, age, and severity of the infection. The medication is typically administered using a measuring device to ensure an accurate dose is given each time.

This oral liquid formulation is used to treat various fungal infections, including but not limited to, oropharyngeal candidiasis (thrush), esophageal candidiasis, systemic candidiasis, urinary tract infections, peritonitis, and some cases of cryptococcal meningitis. It is also used as a prophylactic agent in patients with compromised immune systems, such as those undergoing chemotherapy or radiation therapy, to prevent fungal infections.

For patients and prescribers considering the use of Fluconazole 100 mg/5 mL Oral Liquid, it is important to understand that while it is effective against many fungal infections, it should be used with caution in patients with certain pre-existing conditions, such as liver or kidney disease, and may interact with other medications. Therefore, a thorough medical history and medication review are essential before initiating treatment. Additionally, the duration of treatment with fluconazole can vary depending on the type and severity of the infection, and it is crucial to complete the full course of therapy as prescribed to prevent the recurrence of infection.

If you have any questions about the Fluconazole 100 mg/5 mL Oral Liquid formulation or its use in treating fungal infections, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to provide you with the information and support you need to ensure safe and effective treatment.

Other Uses

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The Fluconazole 100 mg/5 mL Oral Liquid, while primarily indicated for the management of various fungal infections such as candidiasis, cryptococcal meningitis, and other systemic fungal infections, may also have off-label uses where the evidence supports its efficacy and safety. For instance, this formulation can be considered for prophylactic use in immunocompromised patients, including those with cancer undergoing chemotherapy or those who have received organ transplants, to prevent fungal infections. It's essential to note that while Fluconazole is widely recognized for its antifungal properties, any decision to use it for conditions outside of its approved indications should only be made by a healthcare professional taking into account patient-specific factors including age, renal function, and potential drug-drug interactions. Furthermore, Fluconazole oral liquid could be used in research settings as part of clinical trials exploring alternative indications or in customized therapy regimens tailored to the specific needs of individuals with unique medical profiles.

Moreover, some practitioners may utilize the oral liquid formulation of Fluconazole for the treatment of severe, refractory yeast infections that require higher systemic doses, or in situations where the absorption of the oral tablet is compromised such as gastrointestinal disorders, including malabsorption syndromes. In paediatric patients or others unable to swallow pills, liquid formulations offer a practical solution. Pediatric doses vary based on weight and the specific condition being treated, hence the liquid formulation allows for precise dosing. Similarly, geriatric patients who might struggle with pill burden due to polypharmacy or those with dysphagia can also benefit from the liquid dosage form. In all cases, continuous monitoring for therapeutic outcomes and potential adverse effects is vital when using fluconazole, whether within or outside its conventional indications.

It's essential to understand that the use of Fluconazole 100 mg/5 mL Oral Liquid for purposes other than its indicated uses should always be approached with caution under the guidance of a healthcare provider. Additionally, healthcare professionals should meticulously adhere to the principles of antifungal stewardship to mitigate the risk of resistance development. If you are a patient or prescriber considering the use of this formulation, or if you have any questions related to the potential other uses of Fluconazole 100 mg/5 mL Oral Liquid, please reach out to us at Bayview Pharmacy. Our knowledgeable team of compounding pharmacists is ready to provide guidance and support to ensure optimal patient care and medication efficacy.

Frequently Asked Questions

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What is Fluconazole 100 mg/5 mL Oral Liquid used for?

Fluconazole 100 mg/5 mL Oral Liquid is used to treat and prevent certain yeast and fungal infections. It works by stopping the growth of certain types of fungus.

How should Fluconazole Oral Liquid be taken?

The medication should be measured with an accurate measuring device and taken as prescribed by your healthcare provider, usually once a day. It can be taken with or without food.

Can children take Fluconazole Oral Liquid?

Yes, this liquid formulation is often given to children, especially when they have trouble swallowing pills. However, the dose for children is based on weight, so it's important to follow the pediatrician's instructions carefully.

Is Fluconazole Oral Liquid suitable for elderly patients?

Yes, the liquid form can be beneficial for elderly patients who may have difficulties with swallowing solid dosage forms. Dosage may need adjusting based on renal function and the specific condition being treated.

How long does it take for Fluconazole Oral Liquid to work?

Some patients may start to feel better within 24 to 48 hours after treatment begins. However, it's important to continue taking the medication for the full prescribed length of time, even if symptoms disappear quickly.

What should I do if I miss a dose of Fluconazole Oral Liquid?

If you miss a dose, take it as soon as you remember. If it is close to the time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.

Are there any side effects of Fluconazole Oral Liquid?

Some common side effects include nausea, vomiting, diarrhea, stomach pain, headache, and dizziness. Contact your healthcare provider if you experience any severe or persistent side effects.

Can I store Fluconazole Oral Liquid in the fridge?

Follow storage instructions on the label or from your pharmacist. Some liquid medications are stored in the refrigerator but others may be stored at room temperature. Do not freeze the medication.

Can Fluconazole Oral Liquid interact with other medications?

Yes, Fluconazole can interact with a variety of medications. It's important to inform your healthcare provider about all the medications you are currently taking, including over-the-counter drugs and supplements.

Is Fluconazole Oral Liquid ever used for conditions other than fungal infections?

While Fluconazole is primarily used to treat fungal infections, it may be prescribed for other conditions as off-label use, but only under the strict supervision of a healthcare provider.

How should I dispose of any unused Fluconazole Oral Liquid?

Dispose of any unused medication after the expiration date or when it is no longer needed according to your local regulations. Your pharmacy or local waste disposal company may have specific instructions on medication disposal.

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Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.