Sublingual Semaglutide (generic Ozempic®) now available! Get Started
Dashboard
Formulas

Estriol/Estradiol [50%/50%] 0.05-0.5 mg/Gm/Progesterone 5-50 mg/Gm Topical Gel

Estriol/Estradiol [50%/50%] 0.05-0.5 mg/Gm/Progesterone 5-50 mg/Gm Topical Gel is a specially compounded medication. It is dispensed through a pump mechanism for easy and precise application. This semisolid formulation is designed for targeted treatment or absorption of active ingredients. It is used to treat conditions such as Vulvovaginal Atrophy, Menopausal Symptoms, Uterine Bleeding, Endometriosis, and Dyspareunia.

Want a different strength?
Click the Text Us button below.
To prescribe, you must be a verified prescriber.
To prescribe, you must be in a state where we hold an active out-of-state pharmacy license.
Starting at
Must be E-Prescribed
Get Started
Generate LeafletShow Leaflet
This medication requires a prescription from your doctor
Trusted by 60,357 patients to date.
A group of faces of our past satisfied patients.
A svg symbol of a mortar and pestle with ingredients going in.
Custom made in our compounding labs.
Sliders that show the customization of ingredients.
Personalized treatment for better results.
User with a gear showing the personalization of the formulation.
All strengths and ingredients are tailored to your needs.
This medication is not available at retail pharmacies. It is compounded, and may be more effective at treating you or your patient.
Topical Gel
6427079ea64324876f518ac4
Thank you! Your submission has been received!
Oops! Something went wrong while submitting the form.
Loading icon rotating.
Thank you! Your submission has been received!
Oops! Something went wrong while submitting the form.

Dosing Calculator

Get general dosing information for a patient by using this calculator.
Thank you! Your submission has been received!
Oops! Something went wrong while submitting the form.
Loading icon rotating.
Thank you! Your submission has been received!
Oops! Something went wrong while submitting the form.

Formula Information

A small arrow pointing down

This topical gel formulation is a compounded blend of estriol and estradiol, each constituting 50% of the formulation, with concentrations ranging from 0.05 to 0.5 mg/gm. It also contains progesterone in concentrations ranging from 5 to 50 mg/gm. This unique combination is designed to address a variety of health conditions, including menopausal symptoms, endometriosis, uterine fibroids, and premenstrual syndrome (PMS). It has also been found to potentially reduce the risk of endometrial cancer.

The gel is dispensed through a pump mechanism, which allows for easy and precise application on the skin. The active ingredients are absorbed through the skin and into the bloodstream, providing targeted treatment. The gel-like consistency ensures a smooth application process.

It is crucial to note that this formulation is not suitable for pregnant women or women who are breastfeeding. The active ingredients may cause harm to the fetus or pass into breast milk, potentially causing harm to the infant.

When used as directed, this formulation has been shown to effectively alleviate symptoms such as hot flashes, night sweats, and vaginal dryness. It may also contribute to a reduced risk of developing endometrial cancer and uterine fibroids.

If you have any questions or concerns about this formulation, please do not hesitate to contact us at Bayview Pharmacy. Our team of compounding pharmacists is well-equipped with the knowledge and expertise to assist you.

Drug Interactions

A small arrow pointing down

This compounded formulation of Estriol/Estradiol [50%/50%] 0.05-0.5 mg/Gm/Progesterone 5-50 mg/Gm is a topical gel designed for precise application on the skin. It is primarily used for the treatment of menopausal symptoms such as hot flashes, night sweats, and vaginal dryness. It can also be beneficial in treating vulvovaginal atrophy, a condition common in postmenopausal women due to decreased estrogen levels.

Additionally, this formulation may be used in the treatment of endometriosis, a condition where tissue that normally lines the uterus grows outside of it. Certain types of breast cancer in premenopausal women may also be treated with this formulation.

However, it is important to note that this formulation should not be used by women who are pregnant or breastfeeding. Women with a history of stroke, blood clots, or liver disease should also avoid using this product. If you are currently taking other medications, such as anticoagulants, it is crucial to consult your healthcare provider before starting this treatment.

The gel should be applied to the affected area once daily, or as directed by your healthcare provider. It is recommended to use the lowest effective dose for the shortest duration of time. Exceeding the recommended dose may increase the risk of side effects.

Common side effects include skin irritation, itching, and redness. If these occur, it is advised to contact your healthcare provider. Rare but serious side effects such as chest pain, shortness of breath, and leg swelling should be treated as medical emergencies and require immediate attention.

If you have any questions or concerns about this formulation, please do not hesitate to reach out to your healthcare provider or pharmacist for further information and guidance.

How Does it Work

A small arrow pointing down

This topical gel is a compounded formulation of estriol and estradiol, each present in a 50/50 ratio, with concentrations ranging from 0.05-0.5 mg/gm. Additionally, it contains progesterone in concentrations of 5-50 mg/gm. This unique combination is designed to address a variety of health conditions, including menopausal symptoms, endometriosis, and uterine fibroids.

Upon application to the skin, the estriol and estradiol components are absorbed into the bloodstream. These hormones work to alleviate menopausal symptoms such as hot flashes, night sweats, and vaginal dryness. The progesterone component of the gel serves to mitigate the risk of endometrial hyperplasia, a condition that can arise when estrogen levels are excessively high. Furthermore, progesterone aids in reducing the symptoms associated with endometriosis and uterine fibroids.

When utilizing this formulation, adherence to the instructions provided by your healthcare provider is crucial. The gel is typically applied to the skin once or twice daily, depending on the severity of the symptoms. It is essential to apply the gel to clean, dry skin, and to avoid contact with the eyes, nose, and mouth. Washing your hands after applying the gel is also recommended.

If you have any queries regarding this formulation or its application, please do not hesitate to contact us. We are committed to assisting you in finding the most effective treatment for your condition.

Other Uses

A small arrow pointing down

This compounded formulation of Estriol/Estradiol [50%/50%] 0.05-0.5 mg/Gm/Progesterone 5-50 mg/Gm Topical Gel is a versatile treatment option for a range of conditions. It is often used in the management of acne, hirsutism, and polycystic ovary syndrome, providing targeted treatment through its easy-to-apply gel consistency. For postmenopausal women undergoing estrogen therapy, this formulation can help reduce the risk of endometrial hyperplasia. It also serves as a preventive measure against osteoporosis in postmenopausal women.

Furthermore, this formulation can be beneficial in addressing symptoms associated with premenstrual syndrome, such as mood swings, irritability, and bloating. It is also used in the treatment of hypoactive sexual desire disorder in women, providing relief and improving overall quality of life. If you have any questions or need further information about the use of this formulation for any of these conditions, please do not hesitate to contact us.

Frequently Asked Questions

A small arrow pointing down

What is the Estriol/Estradiol [50%/50%] 0.05-0.5 mg/Gm/Progesterone 5-50 mg/Gm Topical Gel?

This is a compounded formulation of Estriol, Estradiol, and Progesterone in a semisolid gel form. It is dispensed through a pump mechanism for easy and precise application on the skin.

How does the pump mechanism work?

The pump mechanism allows for easy and precise dispensing of the gel. It ensures that the correct amount of medication is applied each time, reducing the risk of over or under-dosing.

How should I apply this topical gel?

You should apply this gel directly to your skin as directed by your healthcare provider. The pump mechanism allows for easy and precise application.

What is the purpose of the gel-like consistency?

The gel-like consistency allows for targeted treatment or absorption of the active ingredients. It is designed to adhere to the skin and deliver the medication directly to the affected area.

What are the active ingredients in this formulation?

The active ingredients in this formulation are Estriol, Estradiol, and Progesterone. These are hormones that are commonly used in hormone replacement therapy.

What is the concentration of the active ingredients?

The concentration of Estriol and Estradiol is 50% each, ranging from 0.05 to 0.5 mg per gram. The concentration of Progesterone ranges from 5 to 50 mg per gram.

What are the potential side effects of this medication?

As with any medication, there may be potential side effects. These can include skin irritation at the application site, changes in mood or weight, and others. Always consult your healthcare provider for a complete list of potential side effects.

Can I use this medication if I am pregnant or breastfeeding?

It is important to consult your healthcare provider before using this medication if you are pregnant or breastfeeding. They will be able to provide you with the most accurate and up-to-date information.

How should I store this medication?

This medication should be stored at room temperature, away from heat and direct light. Keep it out of reach of children and pets.

What should I do if I miss a dose?

If you miss a dose, apply it as soon as you remember. However, if it is close to the time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Related Formulas

Related Products
Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.