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Estradiol 0.8 mg/Estriol 3.2 mg/Testosterone 3 mg/ml Topical Cream

The Estradiol 0.8 mg/Estriol 3.2 mg/Testosterone 3 mg/ml Topical Cream is a compounded medication that combines the estrogen hormones estradiol and estriol with testosterone in a semisolid cream base. This formulation is specifically designed to be dispensed from a pump mechanism, which allows for precise dosing and ease of application to the skin. The cream is intended for localized treatment and is absorbed through the skin to deliver the active ingredients directly to the affected area.

This hormone therapy is commonly used to manage symptoms associated with menopause, such as hot flashes, vaginal dryness, and osteoporosis prevention. Additionally, it may be prescribed for conditions that benefit from topical hormone replacement therapy, including certain hormonal imbalances and deficiencies. The combination of estradiol, estriol, and testosterone in this formulation works synergistically to provide relief from these disease states and improve the overall quality of life for patients undergoing treatment.

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Estradiol
Estriol
Testosterone
Topical Cream
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Formula Information

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The Estradiol 0.8 mg/Estriol 3.2 mg/Testosterone 3 mg/ml Topical Cream is a compounded medication specifically formulated to deliver a combination of estrogen and testosterone hormones directly through the skin. This semisolid preparation is dispensed in a pump mechanism, which ensures a convenient, hygienic, and controlled application. The pump is designed to dispense a consistent dose with each use, which is critical for maintaining the precise dosing required for hormone replacement therapy (HRT).

The combination of estradiol and estriol, both forms of estrogen, is often used in hormone replacement therapy to alleviate symptoms associated with menopause, such as hot flashes, vaginal dryness, and osteoporosis. Estriol is considered a weaker form of estrogen and is often used in combination with estradiol to provide a more balanced estrogenic effect with potentially fewer side effects. The addition of testosterone in this formulation can help address issues such as reduced libido and energy levels, which are sometimes experienced by women during menopause or due to other hormonal imbalances.

Topical application of this cream allows for the hormones to be absorbed through the skin and into the bloodstream, providing a more consistent level of hormones throughout the day compared to oral administration, which can cause peaks and troughs in hormone levels. This method of delivery also bypasses the liver, reducing the risk of certain side effects and metabolic stress that can be associated with oral hormone therapies. The cream base is designed to facilitate the absorption of the active ingredients while also providing a moisturizing effect on the skin.

It is important for patients and prescribers to understand that this is a compounded medication and should be used under the guidance of a healthcare professional with experience in hormone replacement therapy. The specific dose and regimen will be tailored to the individual patient's needs, based on their symptoms, hormone levels, and response to treatment. Regular monitoring and follow-up with the healthcare provider are essential to ensure the effectiveness of the therapy and to make any necessary adjustments to the treatment plan.

For those interested in using this formulation or seeking more information, please reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is available to answer any questions and provide guidance on the appropriate use of this medication.

Drug Interactions

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The estradiol, estriol, and testosterone topical cream is a compounded medication that combines estrogen and testosterone, hormones that play key roles in various physiological processes in the body. This formulation is designed to be applied to the skin, where it can be absorbed into the bloodstream to exert its effects. It is commonly used in hormone replacement therapy for menopausal symptoms, such as hot flashes, vaginal dryness, and osteoporosis prevention, as well as for certain conditions of hormonal imbalance.

When using this topical hormone cream, it is important to consider potential drug interactions. Hormones like estradiol, estriol, and testosterone can interact with a variety of medications, potentially altering their effects or increasing the risk of side effects. For example, concurrent use of this cream with anticoagulants (blood thinners) such as warfarin may increase the risk of bleeding, as estrogen can affect blood clotting. Patients should have their clotting status monitored closely if these medications are used together.

Thyroid hormone levels may also be affected by the use of estrogen-containing products. Estrogens can increase thyroid-binding globulin (TBG) levels, which may alter the amount of thyroid hormone that is free and active in the body. Patients on thyroid replacement therapy may require adjustments to their thyroid medication dosage.

Additionally, certain enzyme inducers, such as some anticonvulsants (e.g., phenytoin, carbamazepine) and antimicrobials (e.g., rifampicin), can increase the metabolism of hormones, potentially reducing the effectiveness of the topical cream. Conversely, enzyme inhibitors, such as some antifungals (e.g., ketoconazole) and protease inhibitors, can decrease hormone metabolism and increase hormone levels, which may necessitate dosage adjustments.

It is also important to note that the use of this hormone cream may influence the metabolism of other medications by affecting liver enzymes. For instance, concurrent use with corticosteroids may result in increased effects of the steroid medication due to alterations in metabolism. Similarly, the metabolism of benzodiazepines, certain antidepressants, and other medications metabolized by CYP450 enzymes may be affected.

Patients should be advised to avoid smoking while using this medication, as smoking can further increase the risk of serious cardiovascular side effects, especially in women over 35 years of age. Additionally, the use of this cream may have additive effects with other medications that can cause fluid retention, such as nonsteroidal anti-inflammatory drugs (NSAIDs), leading to edema.

It is crucial for patients to inform their healthcare provider of all medications, supplements, and herbal products they are currently taking before starting treatment with this topical hormone cream. This will help to identify any potential interactions and allow for proper management. Regular monitoring and follow-up with the healthcare provider are recommended to ensure the safe and effective use of this medication.

If you have any questions or concerns regarding this formulation or its potential interactions with other medications, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to provide you with the information and support you need to safely manage your health.

How Does it Work

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The Estradiol 0.8 mg/Estriol 3.2 mg/Testosterone 3 mg/ml Topical Cream is a compounded medication that combines three hormones, estradiol, estriol, and testosterone, in a cream base for topical application. This formulation is designed to deliver hormones directly through the skin, where they can be absorbed into the bloodstream to exert their effects. The cream is dispensed in a pump mechanism, which allows for precise dosing and ensures that each application delivers a consistent amount of medication.

Estradiol and estriol are forms of estrogen, a hormone that plays a critical role in female reproductive health and is also important for maintaining skin health, bone density, and cardiovascular function. Testosterone, while typically considered a male hormone, is also present in females and contributes to libido, muscle mass, and energy levels. The combination of these hormones in a topical cream can be used to address symptoms associated with menopause, such as hot flashes, vaginal dryness, and osteoporosis, as well as to improve sexual function and overall well-being.

The topical application of this hormone cream allows for the hormones to be absorbed through the skin and into the local tissue, which may reduce systemic side effects compared to oral hormone replacement therapy. This is particularly beneficial for patients who may be at risk for certain side effects or who have difficulty with oral medications. The cream base is formulated to enhance the absorption of the hormones and to provide a moisturizing effect on the skin, which can further alleviate symptoms like dryness and itching.

For patients, it is important to apply the cream as directed by the healthcare provider, typically to clean, dry skin on areas such as the inner arms, thighs, or abdomen. The site of application should be rotated to avoid skin irritation. For prescribers, it is crucial to tailor the hormone dosage to the individual needs of the patient, taking into account their medical history, current symptoms, and hormone levels. Regular monitoring of hormone levels and clinical response is recommended to ensure the effectiveness of the treatment and to adjust the dosage as necessary.

If you have any questions about this formulation or how it can be used to treat specific disease states, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to provide you with the information and support you need to ensure the safe and effective use of this medication.

Other Uses

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Beyond its primary indication for hormone replacement therapy to address symptoms associated with menopause, such as hot flashes, vaginal atrophy, and osteoporosis prevention, this compounded topical cream formulation of estradiol 0.8 mg, estriol 3.2 mg, and testosterone 3 mg/ml may have additional applications. Some prescribers have found utility in using this formulation to address various conditions related to hormonal imbalance. For example, some patients may experience an improvement in general skin health, as estrogens can contribute to skin hydration and elasticity, potentially reducing fine lines and wrinkles associated with aging. Testosterone in the mix may support mood, energy, and sexual health, areas that can be affected in both men and women due to hormonal fluctuations or deficiencies.

Another potential use for this compounded cream is the off-label management of sexual dysfunction in women, such as low libido or dyspareunia (painful intercourse), which may be associated with hormonal changes. Additionally, the combination of estrogens with testosterone has been explored for its effects on bone density and muscle strength in certain patient populations. It's important to note that these uses are not approved by the FDA and the efficacy and safety for these conditions have not been established. Moreover, testosterone use in women for indications other than significant hormone deficiency is contested and requires careful monitoring by a healthcare professional.

It is also crucial to understand that hormone levels must be closely monitored when using this product to avoid potential side effects or hormone imbalances. Patients should follow the dosage and administration prescribed by their healthcare professional and report any adverse reactions or concerns that may arise. It's also imperative that patients using this formulation do so under the guidance of a healthcare practitioner who can personalize treatment and monitor progress through regular follow-ups and lab work.

If you are a patient or prescriber considering this formulation for an alternative use, or if you have questions regarding the potential benefits and risks, we encourage you to reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is committed to providing the information and support necessary to help ensure the safe and effective use of this compounded medication.

Frequently Asked Questions

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What is this topical cream used for?

This compounded formulation is commonly used for hormone replacement therapy. It combines estradiol, estriol, and testosterone, which together may help alleviate symptoms associated with menopause or hormonal imbalances such as hot flashes, vaginal dryness, and reduced libido.

How should I apply the topical cream?

The cream should be applied to clean, dry skin as directed by your healthcare provider. Common areas of application include the inner arms, thighs, or abdomen. Do not apply to the breasts or genital area unless otherwise instructed by a physician.

What is the pump mechanism for?

The pump mechanism is designed to provide a controlled dose of the cream with each pump, ensuring consistent and accurate application of the medication. It also helps prevent contamination of the product.

How often should I use this cream?

The frequency of use will depend on the individual's specific healthcare needs and the guidance of their healthcare provider. Typically, it might be applied once or twice daily. Always follow the prescribed dosing regimen.

Can the dose be adjusted?

Yes, the dose can be adjusted according to the directions of your healthcare provider. Because it's a compounded formulation, the strength and dosage may be tailored to your individual hormone levels and treatment needs.

Is it normal for the skin to feel irritated after application?

Some individuals may experience mild irritation at the application site. If the irritation persists or becomes bothersome, consult with your healthcare provider for advice.

What should I do if I miss a dose?

If you miss a dose, apply the cream as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.

Can I apply sunscreen or lotion over the cream?

You may apply sunscreen or lotion over the area where the cream has been applied, but it is best to wait for the medication to be fully absorbed into the skin before applying other products. This typically takes a few minutes.

How should the cream be stored?

Keep the cream at room temperature, away from heat and direct light, and out of reach of children and pets. Do not freeze. The pump should be closed when not in use to maintain the integrity of the medication.

Will this cream affect my hormone tests?

Yes, using this topical cream can affect hormone levels and subsequently alter hormone test results. Inform your healthcare provider that you are using this cream before undergoing any hormone tests.

Is it safe to use this cream while pregnant or breastfeeding?

This medication is not typically recommended for use during pregnancy or while breastfeeding. If you become pregnant or plan to breastfeed while using this medication, contact your healthcare provider for guidance.

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Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.