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Formulas

Estradiol 0.6 mg/Estriol 2.4 mg/Progesterone 50 mg/ml Topical Cream

The Estradiol 0.6 mg/Estriol 2.4 mg/Progesterone 50 mg/ml Topical Cream is a compounded medication that combines the estrogen hormones estradiol and estriol with progesterone in a semisolid cream base. This formulation is specifically designed to be dispensed from a pump mechanism, which allows for easy, consistent, and controlled dosing. The cream is intended for topical application on the skin, where it can be used for localized treatment or systemic absorption of the hormones.

This hormone combination cream is commonly used in the management of menopausal symptoms, such as hot flashes, night sweats, vaginal dryness, and mood swings. Additionally, it may be prescribed for hormone replacement therapy (HRT) in postmenopausal women or for those who have had a hysterectomy. The cream can also be used in the treatment of certain conditions related to hormone imbalances or deficiencies.

Patients are advised to follow their healthcare provider's instructions regarding the use of this medication, including the amount of cream to apply and the frequency of application. The pump mechanism facilitates accurate dosing, which is critical for the effectiveness and safety of hormone therapy.

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Estradiol
Estriol
Progesterone
Topical Cream
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Formula Information

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The Estradiol 0.6 mg/Estriol 2.4 mg/Progesterone 50 mg/ml Topical Cream is a compounded medication specifically formulated to deliver a combination of bioidentical hormones through the skin. This semisolid preparation is dispensed in a pump mechanism, which ensures a convenient, hygienic, and controlled application. The pump is designed to dispense a consistent dose with each use, which is crucial for maintaining the correct hormone levels in the body. The cream base is formulated to enhance the absorption of the active ingredients, providing a localized effect or systemic absorption, depending on the treatment goals.

The combination of estradiol, estriol, and progesterone in this formulation is commonly used in hormone replacement therapy (HRT) for the management of menopausal symptoms. Estradiol, a potent form of estrogen, can alleviate symptoms such as hot flashes, vaginal dryness, and bone loss. Estriol, a weaker estrogen, offers benefits with a potentially reduced risk of estrogen-related side effects. Progesterone is included to counterbalance the effects of estrogen on the endometrium, reducing the risk of endometrial hyperplasia and cancer in women with an intact uterus. This balance of hormones can also support mood regulation, sleep quality, and overall well-being.

Patients and prescribers should be aware that the use of bioidentical hormone therapy should be individualized and based on a thorough evaluation of the patient's hormonal needs, medical history, and risk factors. Regular monitoring of hormone levels and clinical response is recommended to ensure the safety and efficacy of the treatment. Additionally, patients should be educated on the proper application of the cream to maximize absorption and therapeutic outcomes.

For those considering this formulation for treatment, it is important to consult with a healthcare provider to determine if this therapy is appropriate for their specific condition. If you have any questions or require further information about this compounded medication, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is dedicated to providing comprehensive support and guidance to both patients and prescribers.

Drug Interactions

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The formulation containing Estradiol 0.6 mg, Estriol 2.4 mg, and Progesterone 50 mg/ml in a topical cream is designed to deliver hormones directly through the skin into the bloodstream. This combination of hormones is often used in hormone replacement therapy (HRT) for the management of menopausal symptoms such as hot flashes, vaginal dryness, and osteoporosis prevention. It is important to consider potential drug interactions when using this formulation.

Estradiol and estriol are forms of estrogen, and progesterone is a progestin. These hormones can interact with a variety of medications. For instance, they may reduce the effectiveness of enzyme-inducing drugs such as some anticonvulsants (e.g., phenytoin, carbamazepine) and some anti-infectives (e.g., rifampicin, rifabutin). Conversely, these enzyme inducers may decrease the effectiveness of the hormones in this formulation. Patients using these medications should be monitored closely for changes in hormone levels and clinical effects.

Additionally, certain drugs can increase the levels of estrogens and progestins in the body, potentially increasing the risk of side effects. These include some protease inhibitors used for treating HIV, certain antidepressants (e.g., fluoxetine, sertraline), and some antifungals (e.g., ketoconazole, itraconazole). Patients taking these medications should be advised of the potential for increased side effects and may require dosage adjustments.

Thyroid hormone replacement therapy may need to be adjusted when taking this hormone formulation, as estrogens can increase thyroid-binding globulin (TBG) levels, leading to decreased free thyroid hormone levels. Thyroid function should be monitored to ensure therapeutic levels are maintained.

Patients on anticoagulant therapy, such as warfarin, should be aware that estrogen-containing products can potentiate or weaken the effects of anticoagulants, and close monitoring of coagulation parameters is advised. Similarly, the use of corticosteroids or corticotropin may be affected by estrogen, potentially requiring dosage adjustments.

It is also important to note that smoking can increase the risk of serious cardiovascular side effects from estrogen-containing products, especially in women over 35 years of age. Patients are strongly advised not to smoke while using this formulation.

Lastly, the use of this hormone combination may influence the metabolism of other substances, such as certain lipids and glucose. Patients with diabetes or lipid metabolism disorders should be monitored closely, and adjustments to medications for these conditions may be necessary.

This formulation is intended for topical use only and should not be applied to broken or irritated skin. It should not be used in patients with known hypersensitivity to any of its components or in those with a history of hormone-sensitive cancers or thromboembolic disorders unless specifically directed by a healthcare provider.

As with all medications, it is essential to inform healthcare providers of all prescription, over-the-counter medications, herbal supplements, and vitamins that are being taken to avoid potential interactions. If you have any questions or concerns regarding this formulation or its interactions with other drugs, please reach out to us at Bayview Pharmacy for further assistance.

How Does it Work

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The Estradiol 0.6 mg/Estriol 2.4 mg/Progesterone 50 mg/ml Topical Cream is a compounded medication that combines three hormones commonly used in hormone replacement therapy (HRT). This formulation is designed to alleviate symptoms associated with menopause, perimenopause, and other hormonal imbalances. The cream is applied topically, which allows for the hormones to be absorbed directly through the skin into the bloodstream, providing a more consistent release and avoiding first-pass metabolism by the liver, which can occur with oral medications.

Estradiol is a form of estrogen, a female hormone that regulates many processes in the body. Estriol is another form of estrogen that is considered weaker than estradiol but plays an important role in the health of the urogenital tract. Progesterone is a hormone that prepares the lining of the uterus for a fertilized egg and maintains pregnancy. In this formulation, estradiol and estriol are used to replenish estrogen levels that decrease during menopause, helping to relieve symptoms such as hot flashes, vaginal dryness, and bone loss. Progesterone is added to counterbalance estrogen's effects on the uterus, reducing the risk of endometrial hyperplasia and cancer that can occur with estrogen therapy alone.

The cream is dispensed in a pump mechanism, which ensures that each dose is measured accurately, providing consistent dosing with each application. This is particularly important for hormone therapies, where precise dosing is crucial for effectiveness and safety. The semisolid preparation is designed to be easily absorbed by the skin, facilitating the delivery of the active ingredients to the bloodstream. Patients are typically instructed to apply the cream to areas of thin skin, such as the inner arms or thighs, where absorption can be maximized.

For patients, it is important to understand that this topical cream is a form of bioidentical hormone replacement therapy (BHRT). Bioidentical hormones are chemically identical to those the human body produces naturally. This can potentially lead to better tolerance and fewer side effects compared to synthetic hormones. However, as with any medication, there are risks associated with HRT, and it is essential to use this medication under the guidance of a healthcare provider.

For prescribers, it is crucial to tailor the hormone therapy to the individual needs of the patient, considering factors such as the patient's symptoms, hormone levels, and risk factors for hormone-sensitive conditions. Regular monitoring and follow-up are necessary to adjust the dose and ensure the treatment's efficacy and safety.

If you have any questions or require further information about this formulation and its use in treating hormonal imbalances, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to provide support and guidance to both patients and healthcare providers.

Other Uses

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While this topical cream formulation featuring a combination of estradiol, estriol, and progesterone is primarily indicated for the management of menopause-related symptoms, such as hot flashes, vaginal dryness, and osteoporosis prevention, its applicability may extend to several other conditions warranting hormonal support. For instance, some patients may find relief of premenstrual syndrome (PMS) and premenstrual dysphoric disorder (PMDD) with the use of this cream, as it provides a balance of estrogen and progesterone which can mitigate the hormone fluctuations that contribute to these conditions. Additionally, certain skin disorders that are responsive to hormonal treatment, such as hormonal acne, may also see improvements with the application of this compound although this is considered off-label use and should be approached with caution.

Another potential application, which requires further clinical research and should be considered investigational, is the use of this formulation in enhancing skin elasticity and moisture in patients experiencing age-related skin changes. The estrogen component is understood to play a role in maintaining skin health, and therefore, some patients use hormone replacement therapies to alleviate thinning skin and wrinkles associated with declining hormone levels. However, it is essential to note that such use is not FDA-approved and should be undertaken only under the guidance of a healthcare professional, with careful consideration of the risks and benefits.

Beyond these uses, healthcare providers have also employed hormone replacement therapy for overall quality of life improvements in postmenopausal women, citing benefits such as enhanced mood, better cognitive function, and overall vitality. Nevertheless, the decision to use this formulation for such purposes must be individualized, taking into consideration the patient's medical history, hormone receptor status, and specific health goals, accented by the need for periodic reassessment of therapy efficacy and safety.

It is crucial for both patients and prescribers to recognize that while there is potential for other uses, they have not been extensively studied or approved, and individual responses can vary widely. Any off-label use should be supported by clinical judgment and after a thorough review of available scientific evidence. For inquiries regarding the suitability of this topical cream for conditions outside of its primary indications, or to discuss the formulation in more detail, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is dedicated to providing personalized medication solutions, ensuring safety and efficacy for our patients and offering support to our prescriber partners.

Frequently Asked Questions

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What is the purpose of the compounded formulation containing Estradiol, Estriol, and Progesterone?

This topical cream is designed to provide hormone therapy through the skin, delivering specific doses of Estradiol, Estriol, and Progesterone. It is often prescribed to alleviate symptoms associated with menopause, hormonal imbalances, or other conditions for which hormone supplementation may be indicated.

How do I use this topical cream?

Apply the cream as directed by your healthcare provider. The pump mechanism dispenses a controlled dose, which should be applied to clean, dry skin on areas recommended by your physician, such as the inner forearm or thigh. Avoid applying the cream to the breasts or face unless instructed otherwise.

How often should I apply this cream?

The frequency of application will be determined by your healthcare provider based on your individual needs and the treatment regimen prescribed. Do not alter the frequency of use without consulting your healthcare provider.

What are the advantages of using a pump mechanism for this cream?

The pump mechanism offers a convenient and hygienic way to dispense the medication, reducing the risk of contamination. It also provides a consistent dose with each pump, ensuring accurate delivery of the hormones.

Can I apply other products on the skin where I have used the cream?

It is advisable to wait until the cream is fully absorbed before applying other products to the same area. Consult your healthcare provider for specific guidance on the use of additional topical products in conjunction with this medication.

Are there any side effects associated with this hormone cream?

As with any medication, side effects are possible. Common side effects may include skin irritation at the application site, mood changes, headache, or nausea. If you experience any severe or concerning symptoms, contact your healthcare provider promptly.

Can this cream be used during pregnancy?

This cream contains hormones that may not be recommended during pregnancy. Always inform your healthcare provider if you are pregnant, planning to become pregnant, or if you become pregnant while using this cream.

What should I do if I miss a dose?

If you miss a dose, apply it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.

How should I store this hormonal cream?

Store the cream at room temperature away from direct sunlight and heat. Keep out of reach of children and pets. The pump should be closed when not in use to maintain the potency and effectiveness of the medication.

Is this formulation of hormone cream safe for long-term use?

The safety of long-term use of hormone therapy can vary between individuals. It is essential to have regular check-ups with your healthcare provider to monitor the effectiveness and safety of the treatment over time.

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Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.