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Formulas

Estradiol 0.5 mg/g/Estriol 2 mg/g/Testosterone 0.3 mg/gm Topical Cream

The Estradiol 0.5 mg/g, Estriol 2 mg/g, Testosterone 0.3 mg/gm Topical Cream is a compounded medication that combines three hormones in a semisolid dosage form. This cream is specifically designed to be dispensed from a pump mechanism, which allows for convenient and controlled application to the skin. The formulation is intended for localized treatment and is absorbed through the skin to deliver the active ingredients directly to the affected area.

This hormone therapy cream is commonly used in the management of menopausal symptoms, such as hot flashes, vaginal dryness, and osteoporosis prevention. Additionally, it may be prescribed for conditions related to hormone imbalances or deficiencies, such as certain cases of hypoestrogenism, hypogonadism, and to support overall hormonal balance in transgender hormone therapy. The combination of estradiol, estriol, and testosterone in this topical cream aims to provide a synergistic effect, addressing multiple symptoms and disease states associated with hormonal fluctuations or deficiencies.

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Estradiol
Estriol
Testosterone
Topical Cream
655ec3221bd84e1623a2c296
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Formula Information

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The formulation of Estradiol 0.5 mg/g, Estriol 2 mg/g, and Testosterone 0.3 mg/g topical cream is a compounded medication designed to deliver a combination of hormones directly through the skin. This semisolid preparation is dispensed in a pump mechanism, which ensures a convenient, hygienic, and controlled application. The pump is calibrated to dispense a specific dose with each actuation, allowing for consistent dosing and ease of use for the patient.

Estradiol and Estriol are forms of estrogen, a hormone that plays a critical role in female reproductive health and is also important for maintaining skin elasticity, bone density, and cardiovascular health. Testosterone, while typically considered a male hormone, is also present in females and contributes to libido, energy levels, and overall well-being. The combination of these hormones in a topical cream allows for localized treatment, which can be beneficial in managing symptoms associated with menopause, such as hot flashes, vaginal dryness, and mood swings. Additionally, this formulation may be used to address hormone deficiencies or imbalances in both premenopausal and postmenopausal women.

Topical application of hormones can offer advantages over oral administration, such as reduced risk of systemic side effects and first-pass metabolism by the liver. This can result in more consistent hormone levels and improved symptom control. The cream base is designed to facilitate the absorption of the active ingredients through the skin, directly into the bloodstream. This localized approach can also be beneficial for patients who have difficulties with oral medications or those who prefer a non-invasive treatment option.

It is important for both patients and prescribers to understand that this is a compounded medication, which means it is tailored to the specific needs of the patient and is not FDA-approved. The use of this formulation should be based on a thorough evaluation of the patient's medical history, hormone levels, and clinical symptoms. Regular monitoring and follow-up with the healthcare provider are essential to ensure the effectiveness of the treatment and to make any necessary adjustments to the dosage.

For any questions regarding this formulation, its application, or its suitability for a specific patient, please reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is available to provide guidance and support to both patients and prescribers to ensure optimal treatment outcomes.

Drug Interactions

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The topical cream containing estradiol, estriol, and testosterone is a compounded medication used for hormone replacement therapy, primarily in the management of menopausal symptoms, such as hot flashes, vaginal dryness, and osteoporosis prevention. It may also be used for certain conditions that benefit from topical hormone application. The combination of these hormones aims to provide a balanced approach to hormone therapy, leveraging the different effects of each hormone.

When using this topical cream, it is important to consider potential drug interactions. Estradiol and estriol, being estrogens, can interact with a variety of medications. They may reduce the effectiveness of aromatase inhibitors (e.g., anastrozole, letrozole) which are used in the treatment of certain types of breast cancer. Concurrent use of other estrogen products or estrogen-containing therapies should be approached with caution to avoid additive estrogenic effects and increased risk of side effects such as thromboembolism.

Testosterone, included in this formulation, can interact with oral anticoagulants like warfarin, potentially requiring dose adjustments due to changes in the metabolism and clearance of the anticoagulant. Additionally, patients using insulin or oral diabetes medications may experience altered blood glucose control when starting testosterone therapy, necessitating close monitoring and possible dose adjustments of their diabetes medication.

Enzyme-inducing drugs such as certain anticonvulsants (e.g., phenytoin, carbamazepine) and antibiotics (e.g., rifampicin) can increase the metabolism of hormones in this cream, potentially reducing their effectiveness. Conversely, enzyme inhibitors like certain antifungals (e.g., ketoconazole) and protease inhibitors may increase hormone levels, leading to an increased risk of side effects.

Thyroid function may also be affected by the use of estrogens, which can increase thyroid-binding globulin (TBG) levels, leading to altered thyroid hormone levels. Patients on thyroid replacement therapy may require monitoring and dose adjustments. Additionally, corticosteroids or corticotropin may have their effects increased by estrogen, necessitating a careful assessment of the need for dose adjustments.

It is also important to note that smoking can increase the risk of serious cardiovascular side effects from estrogen use, especially in women over 35 years of age. Patients should be advised of this risk and encouraged to quit smoking if they are using this topical hormone therapy.

Given the complexity of hormone interactions with other drugs, prescribers should review the patient's entire medication profile for potential interactions before initiating therapy with this cream. Patients should be instructed to inform all healthcare providers about their use of this compounded medication and to report any new medications or changes in their health status. For any questions or concerns regarding this formulation and its interactions with other drugs, please reach out to us at Bayview Pharmacy for professional advice and guidance.

How Does it Work

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The Estradiol 0.5 mg/g, Estriol 2 mg/g, Testosterone 0.3 mg/gm Topical Cream is a compounded medication that combines three naturally occurring hormones, each with distinct roles in the body, into a single topical formulation. This cream is designed to be applied directly to the skin, where it can be absorbed into the bloodstream to exert its effects. The semisolid preparation is dispensed in a pump mechanism, which allows for a convenient, hygienic, and controlled application, ensuring consistent dosing with each use.

Estradiol and estriol are forms of estrogen, a hormone that plays a critical role in the regulation of many processes in the female body, including the menstrual cycle and reproductive system. Estrogen is also important for maintaining skin health, bone density, and cardiovascular function. In this formulation, estradiol and estriol are used to alleviate symptoms associated with menopause, such as hot flashes, vaginal dryness, and osteoporosis. The combination of these two estrogens can provide a balanced effect, with estriol often considered a milder form of estrogen that may carry a lower risk of side effects when used in conjunction with estradiol.

Testosterone, although commonly recognized as a male hormone, is also present in females and plays a vital role in muscle strength, bone density, and sexual function. In women, testosterone levels naturally decline with age, particularly during menopause, which can lead to symptoms such as decreased libido, fatigue, and loss of muscle mass. The inclusion of testosterone in this topical cream aims to address these issues by supplementing the body's natural hormone levels.

The topical route of administration for this hormone combination is advantageous because it allows the hormones to be absorbed directly into the systemic circulation, bypassing the gastrointestinal tract and liver, which can metabolize and inactivate some of the hormones if taken orally. This can result in a more efficient hormone utilization and potentially fewer side effects. Additionally, the topical application can target specific areas of the body, which may be beneficial for localized symptoms such as skin or vaginal issues.

This compounded cream is often prescribed for women who are experiencing symptoms of menopause or hormonal imbalances. It may also be used in certain cases of hormone replacement therapy (HRT) for individuals who have had a hysterectomy or for those who are transitioning genders. As with any medication, it is important to use this cream under the guidance of a healthcare provider, who can tailor the treatment to the individual's specific needs and monitor for any adverse effects.

If you have any questions about this formulation or how it can be used to treat specific disease states, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to provide you with the information and support you need to ensure safe and effective treatment for your patients or yourself.

Other Uses

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The estradiol/estriol/testosterone topical cream formulation is specifically designed for the management of symptoms associated with hormonal imbalances or deficiencies, such as those experienced during menopause. In addition to its primary indications for treating menopausal symptoms like hot flashes, night sweats, and vaginal dryness, there are other use cases for this cream as well. Our compounding pharmacy formulates this cream to potentially address conditions such as libido disorders, certain forms of incontinence, and even some skin aging concerns.

For instance, the testosterone component of the cream can be beneficial for women suffering from decreased libido or sexual dysfunction, a problem that can arise due to low levels of testosterone which can accompany aging. The estradiol and estriol, both forms of estrogen, may indirectly benefit skin health by improving skin hydration, elasticity, and thickness - factors that could contribute to a more youthful skin appearance and slow down the formation of wrinkles.

Moreover, while this cream is tailored for a local effect, some systemic absorption can occur. As a result, it is essential for patients and prescribers to monitor for potential systemic side effects and adjust dosing accordingly. It is critical to note that these potential 'other uses' are secondary and not the primary purpose of the cream; therefore, it should be used for such issues only with the guidance and prescription of a healthcare provider who can evaluate the risks and benefits for the individual patient.

Our carefully compounded formulation ensures uniformity in dosage and consistency, enabling appropriate absorption through the skin. The pump mechanism is designed to deliver a controlled amount of cream with each actuation, allowing for accurate dosing and ease of use. Patients are advised to apply the cream to clean, dry skin, following their prescriber's instructions on dosage and application sites. As with any medication, adherence to the prescribed regimen is crucial to obtain the maximum therapeutic benefits.

If prescribers or patients have any questions about the potential alternate uses of this topical cream or require more information on its primary indications, we encourage them to reach out to us. Our team is committed to providing support and guidance to ensure safe and effective use of this compounded formulation.

Frequently Asked Questions

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What is the purpose of this compounded formulation of hormones?

This topical cream is designed to deliver a combination of hormones - Estradiol, Estriol, and Testosterone - through the skin to help address specific hormonal imbalances or deficiencies. It is typically prescribed by a healthcare professional based on individual hormonal needs.

How is the cream applied?

The cream is applied to the skin using a pump mechanism, which dispenses a controlled amount of the medication. Follow your healthcare provider's instructions on the exact application site and method.

What areas of the body should I apply the cream to?

Application sites may vary depending on your healthcare provider's recommendations. Common areas include the forearms, thighs, or abdomen. Avoid applying the cream to broken or irritated skin.

How often should I use this hormone cream?

The frequency of application is determined by your healthcare professional and is based on your individual treatment plan. It is important to use the medication exactly as prescribed.

Are there any side effects associated with this cream?

Possible side effects can include skin irritation, redness, or allergic reactions. Systemic side effects may also occur if hormones are absorbed into the bloodstream. Contact your healthcare provider if you notice any adverse effects.

Can this cream affect other medications I'm taking?

It is possible for topical hormones to interact with other medications. Always inform your healthcare provider of all the medications you are taking to ensure safety and avoid interactions.

How should this cream be stored?

Store the cream at room temperature away from light and moisture, and keep it out of reach of children and pets. Do not freeze the cream, and discard any medication that has expired or is no longer needed.

What should I do if I miss a dose?

If you miss a dose, apply it as soon as you remember. If it is almost time for your next dose, skip the missed dose and return to your regular schedule. Do not double doses to make up for a missed one.

How long does it take for the cream to work?

The onset of action can vary depending on individual factors, such as the area of application and skin type. Some patients may notice effects within a few weeks, while for others it may take longer. Discuss with your healthcare provider what to expect.

Is it safe to use this cream during pregnancy or breastfeeding?

This cream contains hormones that may not be safe during pregnancy or breastfeeding. Always consult with your healthcare provider before using any hormonal products if you are pregnant, planning to become pregnant, or breastfeeding.

Can I apply other lotions or products on top of the hormone cream?

It is best to avoid using other topical products on the same area where you've applied the hormone cream unless your healthcare provider advises otherwise. Other products may affect the absorption or efficacy of the hormones.

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Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.