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Formulas

Estradiol 0.5 mg/Estriol 2 mg/Progesterone 20 mg/ml Topical Cream

The Estradiol 0.5 mg/Estriol 2 mg/Progesterone 20 mg/ml Topical Cream is a compounded medication that combines the estrogen hormones estradiol and estriol with progesterone in a semisolid cream base. This formulation is specifically designed to be dispensed from a pump mechanism, which allows for convenient, controlled, and consistent dosing. The cream is intended for topical application on the skin, where it can be used for localized treatment or systemic absorption of the active ingredients.

This hormone combination cream is commonly used in the management of menopausal symptoms, such as hot flashes, night sweats, vaginal dryness, and mood swings. It may also be prescribed for hormone replacement therapy (HRT) in postmenopausal women or for those who have had a hysterectomy. Additionally, this formulation can be used to address hormonal imbalances and support overall hormonal health.

Patients are advised to follow their healthcare provider's instructions regarding the use of this medication, including the amount of cream to apply and the frequency of application. The cream should be applied to clean, dry skin, and the site of application may vary as directed by a healthcare professional.

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Estradiol
Estriol
Progesterone
Topical Cream
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Formula Information

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The Estradiol 0.5 mg/Estriol 2 mg/Progesterone 20 mg/ml Topical Cream is a compounded medication specifically designed to deliver a combination of hormones directly through the skin. This semisolid preparation is dispensed in a pump mechanism, which ensures a convenient, hygienic, and controlled application. The pump is calibrated to deliver a precise dose with each actuation, minimizing the risk of dosing errors and ensuring consistency in the amount of medication applied.

The formulation combines estradiol and estriol, two forms of estrogen, with progesterone. Estrogens are primarily responsible for the development and maintenance of female reproductive tissues but also have important effects on bone density, cardiovascular health, and skin integrity. Progesterone is another key hormone in the female reproductive system, crucial for regulating the menstrual cycle and maintaining pregnancy. Together, these hormones can be used to address a variety of conditions related to hormonal imbalances or deficiencies, such as menopausal symptoms (including hot flashes, vaginal dryness, and mood swings), certain menstrual disorders, and osteoporosis prevention.

Topical administration of these hormones offers the advantage of localized treatment, which can reduce systemic side effects and improve the targeted delivery of the medication. This is particularly beneficial for patients who may be sensitive to oral hormone therapies or those who prefer a non-invasive route of administration. The cream is designed to be absorbed through the skin, directly into the bloodstream, bypassing the liver and reducing the risk of metabolic byproducts that may occur with oral administration.

It is important for both patients and prescribers to understand that this is a compounded medication, meaning it is tailored to individual patient needs and is not FDA-approved. Patients should be monitored for therapeutic efficacy and potential side effects. Prescribers should consider individual patient hormone levels and symptoms when determining the appropriate dosing regimen. As with any hormone replacement therapy, the risks and benefits should be thoroughly evaluated on a case-by-case basis.

For more detailed information or if you have any questions regarding this formulation, please do not hesitate to reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is committed to providing high-quality, personalized care to meet the unique needs of each patient.

Drug Interactions

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The formulation containing Estradiol 0.5 mg, Estriol 2 mg, and Progesterone 20 mg/ml in a topical cream is designed to deliver hormones directly through the skin. This method of delivery can help in the management of menopausal symptoms, such as hot flashes, vaginal dryness, and osteoporosis prevention. It is also used in hormone replacement therapy (HRT) for conditions that cause low hormone levels, such as hypogonadism or certain types of infertility. However, it is important to consider potential drug interactions when using this formulation.

Patients should be aware that the use of this hormone cream may interact with other medications. For example, drugs that induce liver enzymes, such as carbamazepine, phenytoin, and rifampicin, may increase the metabolism of hormones and reduce their effectiveness. Conversely, substances that inhibit certain liver enzymes, like ketoconazole and erythromycin, may increase hormone levels and the risk of side effects.

Additionally, the use of this formulation with other hormonal therapies, such as oral contraceptives or other forms of HRT, should be approached with caution. The combined effect of multiple hormone sources can lead to an imbalance and increase the risk of adverse effects such as thromboembolic disorders, breast tenderness, or bleeding irregularities. Patients should also be cautious when using this cream with anticoagulants like warfarin, as progesterone can affect blood coagulation parameters, potentially necessitating dose adjustments.

Thyroid function tests may also be affected by the use of estrogen-containing products. Estrogens can increase thyroid-binding globulin (TBG) levels, leading to increased circulating total thyroid hormone, as measured by protein-bound iodine (PBI), T4 levels (by column or by radioimmunoassay), or T3 levels by radioimmunoassay. T3 resin uptake is decreased, reflecting the elevated TBG. Patients on thyroid replacement therapy may require higher doses of thyroid hormone.

Patients with a history of hormone-sensitive cancers or conditions should use this formulation with extreme caution, as it may exacerbate these conditions. It is also important to consider the potential for an increased risk of dementia in women who initiate hormone therapy after the age of 65.

It is crucial for patients to inform their healthcare providers of all medications, supplements, and herbal products they are currently using before starting treatment with this hormone cream. This will help to identify any potential interactions and allow for proper management to ensure safety and efficacy of the treatment. If you have any questions or concerns regarding this formulation or its interactions with other drugs, please reach out to us at Bayview Pharmacy for further assistance.

How Does it Work

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The Estradiol 0.5 mg/Estriol 2 mg/Progesterone 20 mg/ml Topical Cream is a compounded formulation that combines three hormones commonly used in hormone replacement therapy (HRT). Estradiol and estriol are forms of estrogen, a female hormone that regulates many processes in the body. Progesterone is another hormone that plays a vital role in the menstrual cycle and in maintaining the early stages of pregnancy. When applied topically, this cream delivers these hormones directly through the skin into the bloodstream, where they can exert their effects.

The mechanism of action for each hormone in this formulation is distinct. Estradiol, the most potent form of estrogen, can alleviate symptoms of estrogen deficiency such as hot flashes, vaginal dryness, and osteoporosis. It does this by binding to estrogen receptors in various target tissues throughout the body, which then activates gene expression that leads to the desired therapeutic effects. Estriol, a weaker estrogen, offers similar benefits but with a potentially reduced risk of side effects, making it a valuable component of the formulation. Progesterone complements the effects of estrogens by regulating the menstrual cycle and supporting the endometrium, which can help prevent the risk of endometrial hyperplasia that can occur with estrogen therapy alone.

The topical application of this cream allows for the hormones to be absorbed through the skin, bypassing the gastrointestinal tract and liver, which can reduce the potential for metabolic side effects. The cream is designed to be applied to areas of thin skin, such as the inner arms or thighs, where absorption can be maximized. The pump mechanism ensures that a controlled dose is delivered with each application, which helps to maintain consistent hormone levels in the body and reduces the risk of over- or under-dosing.

This hormone combination is primarily used to treat symptoms associated with menopause, such as hot flashes, night sweats, and vaginal atrophy. It may also be used for the prevention of osteoporosis in postmenopausal women. Additionally, it can be prescribed for hormone imbalances or deficiencies in women who are not menopausal. The specific dose and regimen are tailored to the individual needs of the patient, based on their symptoms and hormone levels.

It is important for patients and prescribers to understand that hormone replacement therapy, including the use of this topical cream, carries potential risks and should be used under the guidance of a healthcare professional. Regular monitoring and adjustments to the treatment may be necessary to ensure the best outcomes and to minimize side effects.

If you have any questions about this formulation or how it can be integrated into a treatment plan, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to provide the necessary support and information to both patients and prescribers.

Other Uses

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While the primary use of our compounded topical cream formulation containing Estradiol 0.5 mg, Estriol 2 mg, and Progesterone 20 mg per milliliter is often associated with hormone replacement therapy during menopause or for the treatment of specific hormone deficiencies, there are other potential uses that healthcare providers may consider for their patients. However, it is crucial to note that any alternative applications should be carefully evaluated for safety and efficacy and should always be under the direction and prescription of a licensed healthcare provider.

Beyond menopausal symptom management, this cream may help address conditions such as primary ovarian insufficiency, certain cases of amenorrhea, or even some skin aging concerns linked to hormonal changes, considering the role of estrogen in skin elasticity and moisture. Estrogens, for instance, have been found to increase collagen production, which might confer a benefit in reducing the appearance of fine lines and wrinkles. Moreover, estrogen has properties that may improve skin hydration by increasing hyaluronic acid in the skin and maintaining its barrier function.

Additionally, the constituents of this formulation may offer therapeutic benefits in situations where there is a need for topical hormonal balance, for example, in addressing vulvovaginal atrophy, which is often characterized by vaginal dryness, itching, and irritation. Nonetheless, these uses may require clinical judgment as their effectiveness and safety profile in such conditions may not be well-established and are highly individualized.

It is also worth mentioning that progesterone in the cream has been hypothesized to provide certain skin benefits, possibly exerting an anti-inflammatory effect and a counteractive balance to the proliferative effects of estrogen. However, such claims are to be understood in the context of limited scientific evidence and should therefore be interpreted with caution.

Patients and prescribers should be aware that off-label uses of hormone creams have variable support in clinical literature, and their application should be backup up with a thorough understanding of patient-specific factors and needs. For specific advice, dosing information, or to address any questions regarding this formulation's wider applications, healthcare providers and patients are encouraged to reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is prepared to support and provide in-depth knowledge on our products, ensuring that each formulation is tailored to the individual requirements of the patients we serve.

Frequently Asked Questions

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What is the purpose of this compounded hormone cream?

This compounded hormone cream is designed to provide a localized treatment through the skin by leveraging the therapeutic effects of estradiol, estriol, and progesterone, which may help balance hormones in individuals who have deficiencies or imbalances.

How do I use this hormone cream?

Apply the cream as directed by your healthcare provider. To use, simply press the pump to dispense the prescribed amount of cream and apply it to the area of skin as indicated by your health professional. Ensure the area is clean and dry before application.

Is the dosing for this cream consistent?

Yes, the pump mechanism is designed for controlled dosing. Each pump dispenses a fixed amount of cream, ensuring a consistent dosage with each use. Your healthcare provider will instruct you on the exact number of pump presses needed for your individual dose.

Can I apply this cream anywhere on my body?

The application site for this cream should be directed by your healthcare provider. Certain areas of the body may better facilitate the absorption of the active ingredients.

How often should I apply this hormone cream?

The frequency of application will be determined by your healthcare provider based on your individual needs and response to treatment. Follow the prescribed regimen exactly as instructed.

What should I do if I miss a dose of my hormone cream?

If you miss a dose, apply it as soon as you remember. However, if it's almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double up to compensate for the missed dose.

Are there any side effects associated with this hormone cream?

Like all medications, this hormone cream may cause side effects. Common side effects can include skin irritation at the application site, headaches, and hormonal changes. If you experience any severe side effects or signs of an allergic reaction, contact your healthcare provider immediately.

How should I store this hormone cream?

The cream should be stored at room temperature, away from direct sunlight and heat. Do not refrigerate or freeze the cream. Keep the pump bottle securely closed when not in use.

Can this hormone cream be used during pregnancy?

The safety of this hormone cream during pregnancy has not been established. It is crucial to consult your healthcare provider before using this medication if you are pregnant, planning to become pregnant, or breastfeeding.

Will this cream interact with my other medications?

There is a potential for this hormone cream to interact with other medications. It is important to discuss all medications, supplements, and herbal products you are taking with your healthcare provider to avoid potential interactions.

Can men use this compounded hormone cream?

This cream is typically formulated for women; however, if a healthcare provider determines that a man may benefit from its use, they will provide specific instructions and monitoring. Always use this cream as directed by a healthcare provider.

What should I do if the pump stops working?

If the pump mechanism becomes clogged or stops working, refer to the leaflet provided with the medication or consult your pharmacist. Do not try to repair the pump mechanism yourself, as this may affect the dosage of the cream.

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Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.