Sublingual Semaglutide (generic Ozempic®) now available! Get Started
Dashboard
Formulas

Estradiol 0.25 mg/Estriol 1 mg/Testosterone 2 mg/gm Transdermal Cream

The Estradiol 0.25 mg/Estriol 1 mg/Testosterone 2 mg/gm Transdermal Cream is a compounded medication that combines three hormones in a semisolid dosage form. This cream is specifically formulated for transdermal delivery, allowing the active ingredients to be absorbed through the skin. The preparation is dispensed in a pump mechanism, which ensures a convenient, hygienic, and controlled application. This dosage form is designed to provide localized treatment, which can help to minimize systemic side effects.

This hormone therapy is primarily used to treat symptoms associated with menopause, such as hot flashes, vaginal dryness, and osteoporosis prevention. Additionally, it may be prescribed for conditions that result from hormone imbalances or deficiencies, such as certain types of amenorrhea or androgen deficiency. The combination of estradiol, estriol, and testosterone in this formulation works synergistically to restore hormonal balance and alleviate the associated symptoms of these disease states.

Want a different strength?
Click the Text Us button below.
To prescribe, you must be a verified prescriber.
To prescribe, you must be in a state where we hold an active out-of-state pharmacy license.
Starting at
Must be E-Prescribed
Get Started
Generate LeafletShow Leaflet
This medication requires a prescription from your doctor
Trusted by 60,357 patients to date.
A group of faces of our past satisfied patients.
A svg symbol of a mortar and pestle with ingredients going in.
Custom made in our compounding labs.
Sliders that show the customization of ingredients.
Personalized treatment for better results.
User with a gear showing the personalization of the formulation.
All strengths and ingredients are tailored to your needs.
This medication is not available at retail pharmacies. It is compounded, and may be more effective at treating you or your patient.
Estradiol
Estriol
Testosterone
Topical Cream
655ebf9c1f0d0ee8b03843a2
Thank you! Your submission has been received!
Oops! Something went wrong while submitting the form.
Loading icon rotating.
Thank you! Your submission has been received!
Oops! Something went wrong while submitting the form.

Dosing Calculator

Get general dosing information for a patient by using this calculator.
Thank you! Your submission has been received!
Oops! Something went wrong while submitting the form.
Loading icon rotating.
Thank you! Your submission has been received!
Oops! Something went wrong while submitting the form.

Formula Information

A small arrow pointing down

The Estradiol 0.25 mg/Estriol 1 mg/Testosterone 2 mg/gm Transdermal Cream is a compounded medication specifically designed to deliver a combination of hormones directly through the skin. This semisolid preparation is dispensed in a pump mechanism, which ensures a convenient, hygienic, and controlled application. The pump is calibrated to deliver a consistent dose with each use, which is crucial for maintaining the precise dosing required for hormone replacement therapy (HRT).

The formulation combines estradiol and estriol, two forms of estrogen, with testosterone. Estrogens are primarily used in HRT for women who are experiencing symptoms of menopause, such as hot flashes, night sweats, vaginal dryness, and osteoporosis prevention. The inclusion of testosterone, a hormone that both men and women produce, can help with sexual dysfunction, general well-being, and maintaining muscle mass and bone density. The balance of these hormones is critical, as it can affect a wide range of bodily functions and overall health.

Transdermal delivery of hormones has advantages over oral administration, including the avoidance of first-pass metabolism by the liver, which can lead to more stable blood levels and reduced side effects. This is particularly important for patients who may have liver disorders or those who are at risk for thromboembolic events, as oral estrogens have been associated with an increased risk of such complications. Additionally, the transdermal route can be more convenient and may lead to better patient adherence to therapy.

It is essential for patients and prescribers to understand that this compounded formulation is tailored to individual needs and should be used under the guidance of a healthcare professional with expertise in hormone therapy. Monitoring of hormone levels and adjustment of the dose may be necessary to achieve optimal therapeutic outcomes and minimize side effects. Patients should be educated on the proper use of the pump dispenser, the application of the cream to the appropriate skin areas, and the importance of following the prescribed dosing schedule.

For prescribers considering this formulation for their patients, it is important to note that compounded medications are not reviewed by the FDA for safety or efficacy. Prescribers should ensure that they are working with a reputable compounding pharmacy that follows strict compounding guidelines and quality assurance practices. Bayview Pharmacy is committed to providing high-quality compounded medications and is available to answer any questions or concerns regarding this formulation or other compounding needs.

If you have any questions or require further information about this transdermal cream or other compounding services, please do not hesitate to reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is here to assist you.

Drug Interactions

A small arrow pointing down

The transdermal cream containing estradiol, estriol, and testosterone is a compounded medication used for hormone replacement therapy, primarily in postmenopausal women or individuals with hormonal deficiencies. The active ingredients in this formulation can interact with various medications and substances, which may alter their effectiveness or increase the risk of adverse effects. It is crucial for both patients and prescribers to be aware of these potential interactions.

Estradiol and estriol are forms of estrogen, a hormone that can interact with thyroid hormone replacement therapy. Estrogens may decrease the effectiveness of levothyroxine by increasing thyroid-binding globulin levels, necessitating adjustments in thyroid medication dosages. Additionally, estrogens can reduce the clearance of corticosteroids, potentially leading to increased effects or side effects of corticosteroids. Patients taking anticoagulants, such as warfarin, should be monitored closely, as estrogens can increase prothrombin time, potentially requiring dosage adjustments of the anticoagulant.

Testosterone, another hormone in this formulation, can interact with oral anticoagulants, increasing the risk of bleeding. Blood coagulation parameters should be monitored, and anticoagulant dosages may need to be adjusted. Testosterone may also affect blood glucose levels, which is particularly important for patients with diabetes. Insulin or oral hypoglycemic dosages may need to be adjusted under the supervision of a healthcare provider. Additionally, testosterone can increase the action of cyclosporine, leading to increased risk of cyclosporine toxicity.

Concomitant use of this transdermal cream with other topical medications on the same skin area should be approached with caution, as there may be alterations in the absorption of either medication. Patients should inform their healthcare provider of all topical treatments they are using. Furthermore, substances such as alcohol, which can cause skin vasodilation, may affect the absorption rate of the hormones in the transdermal cream.

It is also important to note that certain herbal supplements, such as St. John's Wort, can induce hepatic enzymes and potentially reduce the effectiveness of hormonal therapies. Patients should discuss all herbal and over-the-counter medications they are taking with their healthcare provider.

This transdermal cream is used to treat symptoms associated with menopause, such as hot flashes, vaginal dryness, and osteoporosis prevention, as well as hormone deficiencies in both men and women. The combination of estrogens and testosterone can help in balancing hormone levels and alleviating these symptoms. However, the risk of hormone-sensitive cancers should be evaluated before initiating treatment, and patients with a history of such cancers should typically avoid this therapy.

Patients and prescribers should be aware that this is not an exhaustive list of all potential interactions. It is essential to review all medications, including over-the-counter drugs and supplements, with a healthcare provider before starting this transdermal cream. For any questions or concerns regarding this formulation or its interactions, please reach out to us at Bayview Pharmacy for further assistance.

How Does it Work

A small arrow pointing down

The Estradiol 0.25 mg/Estriol 1 mg/Testosterone 2 mg/gm Transdermal Cream is a compounded medication that combines three hormones, estradiol, estriol, and testosterone, in a transdermal delivery system. This semisolid preparation is specifically designed to be dispensed from a pump mechanism, which allows for a convenient, controlled, and consistent application of the medication directly onto the skin. The transdermal route of administration is chosen for its ability to deliver the active ingredients directly into the bloodstream through the skin, bypassing the gastrointestinal tract and liver, which can metabolize and reduce the effectiveness of oral medications.

Estradiol and estriol are forms of estrogen, a hormone that plays a critical role in the regulation of many processes in the female body, including the menstrual cycle and reproductive system. Estrogen is also important for maintaining the health of other tissues, including bone, skin, and cardiovascular tissues. Testosterone, while typically considered a male hormone, is also present in females and contributes to libido, energy levels, and overall well-being. In women, testosterone is produced in the ovaries and adrenal glands and has significant physiological effects.

This transdermal cream is used to treat various disease states associated with hormonal imbalances or deficiencies, such as menopausal symptoms (hot flashes, night sweats, vaginal dryness), certain cases of osteoporosis, and hypoactive sexual desire disorder. By delivering hormones directly through the skin, the cream can help to restore hormonal balance and alleviate these symptoms. The combination of estradiol, estriol, and testosterone in one formulation provides a comprehensive approach to hormone replacement therapy, targeting multiple symptoms with a single application.

The cream's base is designed to enhance the absorption of the hormones into the skin and to ensure that they are delivered at a steady rate. The pump mechanism dispenses a measured dose with each actuation, which helps to ensure that patients receive the correct amount of medication with each use. Patients are typically instructed to apply the cream to areas of thin skin, such as the inner wrists or forearms, where absorption can occur more efficiently.

It is important for both patients and prescribers to understand that this is a customized medication prepared by compounding pharmacists at Bayview Pharmacy to meet the specific needs of individual patients. The strength and combination of hormones can be adjusted based on the patient's symptoms, hormone levels, and response to therapy. As with any hormone replacement therapy, it is essential to use the lowest effective dose for the shortest duration necessary to achieve treatment goals.

If you have any questions or require further information about this transdermal cream or its use in treating hormonal imbalances and associated conditions, please do not hesitate to reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is here to provide guidance and support to both patients and healthcare providers.

Other Uses

A small arrow pointing down

The estradiol 0.25 mg/estriol 1 mg/testosterone 2 mg/gm transdermal cream is primarily used for hormone replacement therapy (HRT) in individuals undergoing menopausal symptoms or hormonal imbalances, providing a combination of estrogen and testosterone that may help in alleviating symptoms such as hot flashes, night sweats, mood swings, and vaginal dryness. This cream's unique formulation leveraging the benefits of both estrogens and testosterone can also offer potential advantages in other applications, both for males and females.

For instance, in females, this transdermal cream might be used off-label to address conditions such as fibromyalgia or chronic pain syndromes where hormonal imbalances play a role in the exacerbation of symptoms. With the controlled delivery of hormones directly through the skin, some patients may find relief in overall pain and improvement in their quality of life. Additionally, for women experiencing low sexual desire as a result of low testosterone levels, this cream may be considered as a treatment option to help improve libido due to its testosterone content.

For males, though this is less common, the testosterone component may be useful in managing symptoms associated with male hypogonadism, such as fatigue, loss of muscle mass, and reduced libido when careful consideration is given to balancing the effects of estrogens. Although not typically prescribed for men, under the guidance of a healthcare provider, it may be tailored to suit individual therapeutic needs. It is vital to be aware that the use of any hormonal products in males should be approached with caution and under strict medical supervision to avoid potential adverse effects, such as gynecomastia or exacerbation of hormone-sensitive conditions.

Beyond these clinical scenarios, research has been exploring the neuroprotective effects of estrogens and testosterone in cognitive functions. There have been suggestions that hormone replacement may play a role in the management of neurodegenerative diseases like Alzheimer's disease, although this application is not well established and warrants further study before it can be routinely recommended.

In any case, it is essential that the use of this transdermal cream, for indications other than the primary ones, is based on a thorough evaluation and under the advice of a healthcare professional. The safety and effectiveness of the off-label uses have not been established by regulatory agencies, and careful monitoring for side effects is necessary. We remind patients and prescribers that individual responses to hormone therapy can vary; hence, dosage adjustments and adherence to monitoring protocols are crucial. If you have any questions or concerns regarding the use of this specific transdermal hormone formulation for conditions other than those mentioned, please reach out to us for more personalized information and guidance.

Frequently Asked Questions

A small arrow pointing down

What is Estradiol/Estriol/Testosterone Transdermal Cream?

This cream is a compounded formulation that combines Estradiol 0.25 mg, Estriol 1 mg, and Testosterone 2 mg per gram in a semisolid base. It is designed for transdermal delivery of these hormones through the skin to provide localized treatment or systemic absorption.

How should I use this transdermal cream?

Apply the cream as directed by your healthcare provider. It typically involves pressing the pump mechanism to dispense the prescribed amount of cream, which is then spread evenly on clean, dry skin in the area specified by your doctor.

Where on my body should I apply this cream?

Your healthcare provider will instruct you on specific areas of your body to apply the cream. Common areas include the inner arms, thighs, or abdomen, away from sensitive areas like the eyes and mucous membranes.

How often should I apply this compounded cream?

The frequency of application will be determined by your healthcare provider based on your individual needs and hormonal levels. Follow the prescribed regimen and do not alter the dosage without consulting your doctor.

Can men use this Estradiol/Estriol/Testosterone cream?

This cream may be prescribed for men in certain clinical situations, but it is important for any patient to use it only under the direct supervision and prescription of a healthcare provider.

What are the potential side effects of using this transdermal cream?

Side effects can include skin irritation at the application site, hormonal imbalance symptoms such as mood swings or weight changes, and other individual reactions. If you experience any severe side effects, contact your healthcare provider.

What should I do if I miss a dose?

If you miss a dose, apply it as soon as you remember. However, if it's close to the time for your next dose, skip the missed dose and resume your normal dosing schedule. Do not double the dose to catch up.

How do I store the Estradiol/Estriol/Testosterone cream?

Store the cream at room temperature away from light and moisture. Keep the pump mechanism closed when not in use. Do not refrigerate or freeze the medication and keep it out of reach of children and pets.

Can I use other medications or creams with this compounded formulation?

Before using any additional medications or topical agents, consult with your healthcare provider to ensure they are compatible with the hormones in your transdermal cream and that there is no risk of interactions.

Is this transdermal cream safe to use during pregnancy or breastfeeding?

This compounded cream contains hormones that may not be safe during pregnancy or while breastfeeding. Always inform your healthcare provider if you are pregnant, planning to become pregnant, or are breastfeeding before using this medication.

Can I be exposed to sunlight after applying this cream?

Normal exposure to sunlight is generally acceptable, but you should avoid exposing the treated area to strong sunlight or UV light, as it might alter the effectiveness of the product. Always consult your healthcare provider for specific advice.

Related Formulas

Related Products
Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.