Our custom-compounded formulation of Epinephrine 0.18%/Lidocaine HCl 4%/Tetracaine 0.5% Topical Gel is a specialized medication designed for targeted topical application. This semisolid preparation is uniquely dispensed through a pump mechanism, which ensures ease of use and precise dosing. The gel base provides a suitable medium for the active ingredients to be applied directly to the skin, allowing for localized effect and absorption.

The combination of active ingredients in this formulation serves multiple therapeutic purposes. Epinephrine, a potent vasoconstrictor, helps to reduce local blood flow and swelling, and can prolong the duration of action of local anesthetics. Lidocaine HCl and Tetracaine are both local anesthetics that provide a numbing effect to the area of application. Lidocaine HCl is known for its rapid onset of action and intermediate duration, while Tetracaine is a longer-acting anesthetic, enhancing the overall efficacy of the gel.

This compounded gel is particularly useful in various medical settings, including minor surgical procedures, dermatological interventions, and as part of pain management strategies. It can be applied to numb the skin before procedures such as needle insertions, superficial surgical procedures, or other interventions where local anesthesia is required. The addition of epinephrine to the formulation not only extends the duration of anesthesia but also minimizes bleeding at the site of application due to its vasoconstrictive properties.

Patients and prescribers should be aware that the use of this formulation should be tailored to individual needs and medical conditions. It is important to consider the potential for allergic reactions, especially in patients with a history of hypersensitivity to local anesthetics. The use of this gel should be monitored closely in patients with cardiovascular diseases due to the presence of epinephrine. Additionally, the precise application and dosage are crucial to maximize therapeutic effects while minimizing systemic absorption and potential side effects.

At Bayview Pharmacy, we are committed to providing high-quality, customized medications to meet the specific needs of our patients. Our team of knowledgeable compounding pharmacists is available to answer any questions and provide guidance on the use of this topical gel formulation. If you have any questions or require further information, please do not hesitate to reach out to us.

The topical gel formulation containing Epinephrine 0.18%, Lidocaine HCl 4%, and Tetracaine 0.5% is designed for local application and is intended to provide local anesthesia and vasoconstriction. While systemic absorption is generally minimal with topical application, there are potential drug interactions that should be considered when using this formulation.

Epinephrine is a vasoconstrictor and can interact with certain medications that affect blood pressure and heart rate. It should be used with caution in patients taking beta-blockers, as these medications can blunt the effects of epinephrine, potentially leading to unopposed alpha-adrenergic effects such as hypertension and bradycardia. Conversely, epinephrine may potentiate the effects of beta-agonists and other sympathomimetics, increasing the risk of side effects such as tachycardia and hypertension. Monoamine oxidase inhibitors (MAOIs) can also prolong and intensify the effects of epinephrine, leading to hypertensive crises. Patients on antihypertensive medications, including alpha-blockers, may experience reduced efficacy of their blood pressure control when using this gel.

Lidocaine and Tetracaine are both local anesthetics and share similar interaction profiles. They should be used with caution in patients taking Class I antiarrhythmic drugs (such as mexiletine and tocainide) due to the additive effects on cardiac conduction and the potential for increased risk of systemic toxicity. The use of other local anesthetics concurrently with this formulation may increase the systemic absorption and risk of cumulative toxicity, particularly in patients with hepatic impairment where the metabolism of lidocaine and tetracaine is reduced. Caution is also advised when using this formulation with drugs that can potentiate the effects of local anesthetics, such as cimetidine and beta-blockers, which can decrease hepatic blood flow and thus drug clearance.

Patients should be advised to inform their healthcare provider of all medications they are taking, including over-the-counter drugs and herbal supplements, to assess for potential interactions. The use of this formulation in patients with pre-existing cardiac conditions, liver disease, or in those taking medications with potential for interaction should be carefully considered and monitored.

This topical gel is used for the treatment of conditions that require local anesthesia or analgesia, such as minor surgical procedures, wound care, or other dermatological uses. The addition of epinephrine to the formulation provides vasoconstriction, which can prolong the duration of anesthesia, reduce bleeding at the site of application, and limit the systemic absorption of the anesthetics.

If you have any questions or require further information regarding the use of this formulation or potential drug interactions, please reach out to us at Bayview Pharmacy. Our team is committed to ensuring the safe and effective use of our compounded medications.

The Epinephrine 0.18%/Lidocaine HCl 4%/Tetracaine 0.5% Topical Gel is a compounded medication designed to provide localized action with a combination of active ingredients, each serving a specific therapeutic purpose. The gel is formulated to be applied topically, where it exerts its effects directly at the site of application, minimizing systemic absorption and potential side effects.

Epinephrine, also known as adrenaline, is a vasoconstrictor that works by narrowing blood vessels. In this topical formulation, the 0.18% concentration of epinephrine reduces local blood flow, which can help to control bleeding and prolong the duration of action of the local anesthetics in the gel. This is particularly useful in minor surgical or dental procedures where bleeding control and prolonged anesthesia are desired.

Lidocaine HCl and Tetracaine are both local anesthetics, but they differ in their onset and duration of action. Lidocaine, at a 4% concentration, is a well-known amide local anesthetic that provides rapid onset of numbness, typically within minutes of application. It works by blocking sodium channels in the neuronal membrane, which prevents the initiation and conduction of nerve impulses, leading to a loss of sensation in the applied area.

Tetracaine, present at 0.5%, is an ester local anesthetic that complements Lidocaine by providing a longer duration of action. It also works by inhibiting sodium influx through nerve membranes, but it is more potent and has a slower onset than Lidocaine. The combination of Lidocaine and Tetracaine in the gel ensures both immediate and prolonged numbing effects, making the formulation suitable for procedures that require extended periods of anesthesia.

The semisolid gel formulation is designed for ease of use and precise application. The pump mechanism allows for controlled dispensing, reducing the risk of contamination and ensuring consistent dosing. The gel base facilitates adherence to the skin and mucous membranes, ensuring that the active ingredients remain in contact with the treatment area for effective absorption and action.

This compounded gel is commonly used in dermatological and dental procedures, such as skin biopsies, laser treatments, minor surgeries, and dental extractions, where both rapid onset and prolonged duration of local anesthesia are beneficial. It can also be used in the management of chronic pain conditions where localized relief is needed.

It is important for both patients and prescribers to understand that this is a specially compounded medication and should be used under the guidance of a healthcare professional familiar with its use and indications. If you have any questions or require further information about this formulation and its suitability for specific treatments, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to provide the necessary support and guidance.

The topical gel formulation combining Epinephrine, Lidocaine HCl, and Tetracaine offers a unique profile of effects due to the properties of its individual components. Epinephrine, a vasoconstrictor, can help to reduce local blood flow and minimize bleeding, which is particularly valuable during minor surgical procedures or after superficial skin trauma. It also prolongs the anesthetic effect by delaying systemic absorption. Lidocaine and Tetracaine, both local anesthetics, provide a rapid and prolonged numbing effect to the area of application, which is beneficial for pain relief and during minor surgical interventions of the skin.

In addition to these properties, this formulation may have utility in other clinical scenarios. For instance, it could be considered for use during dermatological procedures like punch biopsies, shave biopsies, or excision of skin lesions, where both hemostasis and local anesthesia are desired. It may also be used in laser treatments, where the epinephrine could reduce the risk of bleeding, and the anesthetic components could minimize discomfort during the procedure.

Another potential off-label use could be in the treatment of superficial thrombophlebitis, where the application of a vasoconstrictive and anesthetic gel might help to alleviate symptoms such as swelling and pain. However, it's critical to note that while the formulation could help with symptom relief, it is not a cure for the underlying condition, and further medical evaluation would be necessary.

Patients with needle phobia undergoing injections or blood draws might find application of this topical anesthetic gel helpful in reducing procedural anxiety and discomfort. In sports medicine, the formulation could temporarily relieve pain from minor injuries such as contusions or sprains where skin integrity isn't compromised, but its utility should be cautiously considered against systemic absorption and the potential for masking significant injury.

It is important for prescribers and patients alike to understand that while the formulation's primary indication is for topical anesthesia, its use in other situations should be carefully considered with respect to the systemic effects of the drugs, potential for allergic reactions, and the specifics of the condition being treated. Any off-label use should be backed by clinical judgment and, where available, evidence-based practice.

Despite the potential versatility of the Epinephrine/Lidocaine/Tetracaine formulation, users should remain vigilant for any adverse effects such as local irritation, systemic toxicity, or anaphylaxis. In addition, the gel should be used with caution in patients with cardiovascular disease due to the presence of epinephrine.

For further information and guidance on the use of this topical gel formulation for indications other than those listed, be sure to consult with health care professionals who are knowledgeable in compounding and the therapeutic use of these medications. We at Bayview Pharmacy are committed to providing comprehensive support and welcome any questions regarding potential uses, contraindications, and precautions necessary to ensure safe and effective treatment outcomes.