Our custom-compounded transdermal gel combines Doxepin HCl, Ketamine HCl, Pentoxifylline, and Tetracaine in a unique formulation designed to address a variety of symptoms and conditions. Doxepin HCl, a tricyclic antidepressant, is utilized in this formulation for its analgesic properties, particularly effective in treating neuropathic pain. It may also help alleviate itching associated with certain dermatological conditions. Ketamine HCl, an NMDA receptor antagonist, is included for its potent analgesic effects, especially in chronic pain syndromes that have not responded to conventional treatments. It has been shown to reduce central sensitization, which is a hallmark of neuropathic pain.

Pentoxifylline, a xanthine derivative, is incorporated for its vasodilatory action, which improves blood flow and oxygen delivery to various tissues. This can be beneficial in treating conditions like peripheral artery disease and can aid in the healing of wounds by enhancing microcirculation. Tetracaine, a local anesthetic, provides immediate topical analgesia, numbing the skin and surrounding tissues to provide relief from acute pain or procedural discomfort.

The combination of these four active ingredients in a 10%/2%/10%/8% concentration, respectively, is formulated into a semisolid gel that is dispensed through a pump mechanism. This delivery system allows for easy and precise application, ensuring consistent dosing with each use. The transdermal route of administration ensures that the medication is absorbed directly into the affected area, providing targeted relief with potentially fewer systemic side effects compared to oral medications.

This formulation is particularly suited for patients experiencing localized pain, chronic neuropathic pain, or those requiring improved blood flow to certain areas of the body. It may also be beneficial for individuals who have difficulty swallowing pills or who prefer a non-invasive treatment option. As with any medication, it is important to use this compound under the guidance of a healthcare professional who can tailor the treatment to the individual's specific needs and monitor for efficacy and safety.

If you have any questions about this formulation or how it can be integrated into a treatment plan, please do not hesitate to reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is dedicated to providing personalized care and support to both patients and prescribers.

The transdermal gel formulation containing Doxepin HCl, Ketamine HCl, Pentoxifylline, and Tetracaine is designed for targeted treatment and absorption through the skin. Each of these active ingredients has its own mechanism of action and potential drug interactions that should be considered when prescribing or using this medication.

Doxepin is a tricyclic antidepressant that has antihistaminic and analgesic properties. It is metabolized by the liver enzymes CYP2D6 and CYP2C19. Drugs that inhibit these enzymes, such as fluoxetine and paroxetine, may increase the levels of doxepin and lead to enhanced effects or toxicity. Conversely, inducers of these enzymes, such as rifampin, may decrease doxepin levels and reduce its efficacy. Additionally, because doxepin has CNS depressant effects, it may enhance the sedative effects of other CNS depressants, including alcohol, benzodiazepines, and opioids.

Ketamine is an NMDA receptor antagonist used for its anesthetic and analgesic properties. It is metabolized primarily by CYP3A4, and drugs that inhibit this enzyme, such as ketoconazole, may increase ketamine levels. Similarly, inducers of CYP3A4, such as St. John's Wort, may decrease the effectiveness of ketamine. Ketamine also has CNS depressant effects and may have additive effects with other CNS depressants.

Pentoxifylline is a methylxanthine derivative that improves blood flow and has anti-inflammatory effects. It is metabolized by CYP1A2, and drugs that inhibit this enzyme, such as ciprofloxacin and fluvoxamine, may increase pentoxifylline levels and the risk of adverse effects. Smoking tobacco may induce CYP1A2 and decrease the effectiveness of pentoxifylline. Additionally, pentoxifylline may enhance the effects of antihypertensive agents and anticoagulants, increasing the risk of hypotension and bleeding, respectively.

Tetracaine is a local anesthetic that blocks sodium channels. While systemic interactions are less likely with topical administration, there is still a potential for additive systemic effects if used concomitantly with other local anesthetics or agents that affect cardiac conduction. Caution is advised when using other topical medications that may have similar local anesthetic effects.

When using this transdermal gel, it is important to consider all potential drug interactions with the patient's current medications. The risk of systemic absorption and interactions may be lower with topical administration compared to oral or parenteral routes, but they can still occur, especially with prolonged use or application to large areas of skin. Patients should be advised to inform their healthcare providers of all medications they are taking, including over-the-counter drugs and herbal supplements. Prescribers should monitor for signs of drug interactions and adjust therapy as needed. If you have any questions or concerns about this formulation and its potential interactions, please reach out to us at Bayview Pharmacy for further assistance.

The Doxepin HCl 10%/Ketamine HCl 2%/Pentoxifylline 10%/Tetracaine 8% Transdermal Gel is a compounded medication designed to deliver a combination of active ingredients directly through the skin to the affected area. This semisolid formulation is dispensed through a pump mechanism, which allows for easy and precise application. The gel-like consistency ensures that the medication stays in place and facilitates the absorption of the active ingredients into the skin.

Doxepin is a tricyclic antidepressant that also has potent antihistamine and anti-itch properties. When applied topically, Doxepin can help alleviate itching and pain associated with various dermatological conditions. It works by blocking histamine receptors and stabilizing neuronal membranes, which reduces the sensation of itch and discomfort.

Ketamine, a well-known anesthetic, provides analgesic effects when used in a transdermal formulation. It acts as an N-methyl-D-aspartate (NMDA) receptor antagonist, which plays a role in pain modulation. By blocking these receptors, Ketamine can help reduce chronic pain and has been used in the management of neuropathic pain conditions.

Pentoxifylline is a xanthine derivative that improves blood flow and has anti-inflammatory properties. It works by inhibiting phosphodiesterase, leading to an increase in cyclic AMP levels, which results in vasodilation and improved microcirculation. This can be particularly beneficial in treating conditions like stasis dermatitis or other circulatory disorders affecting the skin.

Tetracaine is a local anesthetic that provides temporary relief from pain by blocking sodium channels on neuronal membranes, which prevents the initiation and conduction of nerve impulses. When included in a transdermal gel, Tetracaine can help numb the area of application, providing relief from pain and discomfort.

This unique combination of medications in a transdermal gel form is used to treat a variety of conditions, including chronic pain, neuropathic pain, and skin conditions with an inflammatory or circulatory component. The transdermal route allows for localized treatment, which can reduce systemic side effects and provide targeted relief. It is important for patients and prescribers to understand that this is a specialized medication prepared by compounding pharmacists to meet specific patient needs. If you have any questions or require further information about this formulation and its use in treating specific disease states, please reach out to us at Bayview Pharmacy.

The compounded transdermal gel combining Doxepin HCl, Ketamine HCl, Pentoxifylline, and Tetracaine is specifically formulated to target certain chronic pain and inflammation states. Beyond the primary indications, this uniquely blended preparation may also have additional uses due to the pharmacological actions of its individual components. Doxepin, an antidepressant with potent antihistamine properties, may provide some relief in pruritic conditions or aid in cases of neuropathic itching. Ketamine, known for its NMDA antagonist effects, may not only be beneficial for pain but could also potentially be used off-label for the management of certain mood disorders when other treatments have failed, although such use would be experimental and involve close psychiatric supervision.

Pentoxifylline, a xanthine derivative known to improve blood flow and reduce viscosity, may be beneficial in peripheral vascular diseases or in conditions requiring improved microcirculation, such as diabetic neuropathy or Raynaud's phenomenon. Tetracaine is a potent local anesthetic that could aid in temporary relief of localized pain such as from minor skin irritations or procedures. This multi-faceted gel is thus potentially beneficial for various pathologies involving pain, inflammation, circulatory disturbances, or skin irritations, although its use should be careful and precise as per the guidelines for compounded medications.

It is important to note that while the compounded transdermal gel may present these additional uses, its application should be strictly according to a physician's prescription, and any off-label use should be approached with caution and under strict medical supervision. Patients interested in exploring these other potential uses for the gel should consult with their healthcare provider. Similarly, prescribers considering this formulation for alternative uses should rely on clinical judgment and available medical literature. Safety, efficacy, and dosage for uses outside of the primary indications are not guaranteed and should be evaluated on a case-by-case basis. If any questions arise regarding the potential for other uses of this transdermal gel formulation, please feel free to reach out to Bayview Pharmacy for more information.