Our Diphenhydramine HCl 20 mg/g, Hydrocortisone 10 mg/g, and Lidocaine HCl 20 mg/g Topical Cream is a specialized formulation designed for localized application on the skin. This semisolid preparation is dispensed through a pump mechanism, allowing for convenient and controlled dosing of active ingredients directly to the affected area.

Diphenhydramine HCl is an antihistamine that works by blocking the action of histamine, a substance in the body that contributes to allergic symptoms. When applied topically, it helps relieve itching and discomfort associated with allergic skin reactions, insect bites, and minor skin irritations. By reducing histamine activity at the site of application, it provides targeted relief from pruritus (itching).

Hydrocortisone is a corticosteroid that possesses anti-inflammatory, antipruritic, and vasoconstrictive properties. It reduces inflammation by suppressing the migration of polymorphonuclear leukocytes and reversing capillary permeability. This action helps alleviate redness, swelling, and discomfort associated with various inflammatory skin conditions such as eczema, dermatitis, and psoriasis.

Lidocaine HCl is a local anesthetic that stabilizes neuronal membranes by inhibiting the ionic fluxes required for the initiation and conduction of nerve impulses. When applied to the skin, it provides rapid pain relief by numbing the area, making it effective for conditions that involve pain or discomfort from procedures, burns, or abrasions.

The combination of these three active ingredients offers a synergistic effect, addressing multiple symptoms simultaneously. This makes the topical cream suitable for treating a variety of dermatological conditions that involve inflammation, itching, and pain. Conditions such as allergic reactions, contact dermatitis, insect bites, and localized skin irritations may benefit from this multifaceted approach.

For optimal use, apply the cream to the affected area as directed by your healthcare provider, usually a thin layer two to four times daily depending on the severity of the condition. The pump mechanism ensures precise dosing and maintains the integrity of the formulation by minimizing exposure to air and contaminants, which can degrade the active ingredients over time.

Patients should be aware of potential side effects, including but not limited to skin irritation, dryness, redness, or allergic reactions at the site of application. If symptoms persist, worsen, or signs of skin infection develop, discontinue use and consult your healthcare provider promptly. Avoid applying the cream to broken skin, open wounds, or mucous membranes unless specifically directed by a physician.

For prescribers, this compounded formulation provides a tailored therapeutic option for patients requiring targeted relief from

This topical cream formulation contains Diphenhydramine HCl, Hydrocortisone, and Lidocaine HCl, each of which can interact with other medications or substances. It is crucial for both patients and prescribers to be aware of these potential interactions to ensure safe and effective use of the cream.

Diphenhydramine HCl, an antihistamine, can interact with other central nervous system depressants, such as alcohol, benzodiazepines, opioids, and certain antidepressants, potentially leading to increased sedation or respiratory depression. Patients should be advised to avoid or limit the use of these substances while using the cream. Additionally, diphenhydramine may interact with monoamine oxidase inhibitors (MAOIs), potentially enhancing anticholinergic effects, which could lead to increased heart rate, dry mouth, urinary retention, or blurred vision.

Hydrocortisone, a corticosteroid, may interact with other medications that affect the immune system, such as immunosuppressants or other corticosteroids, potentially increasing the risk of infections or reducing the effectiveness of vaccines. Patients using this cream should inform their healthcare provider if they are receiving any vaccinations or are on immunosuppressive therapy. Furthermore, prolonged use of topical corticosteroids can lead to systemic absorption, which may interact with medications for diabetes, hypertension, or other conditions affected by corticosteroid use.

Lidocaine HCl, a local anesthetic, can interact with antiarrhythmic drugs, such as amiodarone or mexiletine, potentially leading to additive cardiac effects. Patients with cardiac conditions should use this cream with caution and under the guidance of a healthcare provider. Additionally, lidocaine may interact with other local anesthetics or medications that affect liver enzyme activity, potentially altering its metabolism and effectiveness.

It is important for patients to inform their healthcare providers of all medications, supplements, and herbal products they are currently using to assess potential interactions. Prescribers should carefully evaluate the patient's medication profile and medical history before recommending this topical cream. If you have any questions or concerns about drug interactions with this formulation, please reach out to us at Bayview Pharmacy for further assistance.

This compounded topical cream formulation combines three active ingredients: Diphenhydramine HCl, Hydrocortisone, and Lidocaine HCl, each contributing to the treatment of various dermatological conditions through distinct mechanisms of action. The semisolid preparation is dispensed via a pump mechanism, ensuring a convenient and controlled application directly onto the skin, allowing for localized treatment and absorption of the active ingredients.

Diphenhydramine HCl, an antihistamine, works by blocking the action of histamine, a substance in the body that causes allergic symptoms. When applied topically, Diphenhydramine HCl helps alleviate itching and discomfort associated with allergic skin reactions, insect bites, and minor skin irritations. By inhibiting histamine receptors in the skin, it reduces the sensation of itchiness and provides symptomatic relief.

Hydrocortisone, a corticosteroid, exerts its effects by reducing inflammation, redness, and swelling in the affected area. It works by inhibiting the release of inflammatory mediators and suppressing the immune response in the skin. This action is particularly beneficial in treating conditions such as eczema, psoriasis, and dermatitis, where inflammation is a primary concern. By decreasing the inflammatory response, Hydrocortisone helps to soothe irritated skin and promote healing.

Lidocaine HCl, a local anesthetic, provides pain relief by blocking nerve signals in the skin. It works by inhibiting sodium channels in the neuronal cell membrane, preventing the initiation and conduction of nerve impulses. This action results in a numbing effect on the skin, which is particularly useful for alleviating pain and discomfort associated with minor skin irritations, burns, and insect bites. By providing localized pain relief, Lidocaine HCl enhances the overall comfort of the patient during the healing process.

The combination of these three active ingredients in a single topical cream allows for a multifaceted approach to treating various skin conditions. The pump mechanism ensures precise dosing and minimizes waste, making it an efficient option for patients and prescribers. The formulation is designed to be applied directly to the affected area, allowing for targeted treatment and minimizing systemic absorption, which reduces the risk of side effects commonly associated with oral administration of these medications.

For patients and prescribers considering this formulation, it is important to follow the recommended application guidelines and consult with a healthcare professional if there are any questions or concerns regarding its use. The team at Bayview Pharmacy is available to provide further information and support to ensure optimal treatment outcomes. If you have any questions, please reach out to us.

The Diphenhydramine HCl 20 mg/g, Hydrocortisone 10 mg/g, and Lidocaine HCl 20 mg/g topical cream is a versatile formulation that can be utilized for a variety of off-label uses beyond its primary indications. This semisolid preparation, dispensed in a pump mechanism, is designed for convenient and controlled application on the skin, allowing for localized treatment or absorption of active ingredients. While the primary use of this formulation is to alleviate symptoms associated with allergic reactions, inflammation, and pain, its unique combination of active ingredients makes it suitable for other therapeutic purposes.

Diphenhydramine HCl, an antihistamine, can be beneficial in managing pruritus (itching) associated with various dermatological conditions, such as eczema or contact dermatitis, by blocking histamine receptors and reducing itchiness. Hydrocortisone, a corticosteroid, is effective in reducing inflammation and can be used to manage mild to moderate inflammatory skin conditions, including psoriasis and seborrheic dermatitis. Lidocaine HCl, a local anesthetic, provides temporary relief from pain and discomfort, making this formulation useful for conditions that involve nerve pain or irritation, such as post-herpetic neuralgia or localized neuropathic pain.

Additionally, this combination cream may be considered for use in managing symptoms of insect bites or stings, where the antihistamine can reduce allergic reactions, the corticosteroid can decrease inflammation, and the anesthetic can alleviate pain. It may also be used in minor skin irritations or rashes caused by exposure to irritants or allergens, providing a multi-faceted approach to symptom relief. For patients experiencing discomfort from minor burns or sunburns, the lidocaine component can offer soothing pain relief, while the hydrocortisone can help reduce inflammation and redness.

For prescribers, it is important to consider the patient's overall health status, potential allergies, and the specific condition being treated when recommending this formulation for off-label uses. Patients should be advised to apply the cream as directed, typically in a thin layer to the affected area, and to avoid using it on broken or infected skin unless specifically instructed by a healthcare provider. As with any medication, monitoring for potential side effects, such as skin irritation or allergic reactions, is crucial. If you have any questions or need further information about the potential uses of this formulation, please reach out to us at Bayview Pharmacy.