The Diphenhydramine 12.5 mg/Lorazepam 0.5 mg/Metoclopramide 10 mg Rectal Suppository is a compounded medication designed to provide relief from various symptoms associated with different medical conditions. This solid dosage form is specifically created for rectal administration, where it dissolves or melts to release the active ingredients for both local and systemic absorption. The combination of these three medications offers a multi-faceted approach to treatment, targeting different aspects of the patient's condition.

Diphenhydramine is an antihistamine that can help alleviate allergic reactions and provide sedation. It is beneficial for patients experiencing allergic symptoms or those who require assistance with sleep due to discomfort or restlessness. Lorazepam, a benzodiazepine, is included for its anxiolytic and sedative effects, which can be particularly useful in reducing anxiety and providing a calming effect for patients undergoing stressful situations or procedures. Metoclopramide is a prokinetic agent that enhances gastrointestinal motility, making it effective in treating nausea, vomiting, and gastroparesis. It can also enhance the absorption of the other two medications when administered rectally.

This combination suppository is particularly useful in palliative care settings, where patients may have multiple, complex symptoms that require a multifaceted treatment approach. It can also be beneficial for patients who have difficulty swallowing oral medications or where nausea and vomiting prevent effective oral administration. The rectal route provides an alternative that can ensure the patient receives the necessary medication even when oral administration is not possible.

It is important for both patients and prescribers to understand the potential side effects and interactions associated with this combination medication. Diphenhydramine may cause drowsiness, dry mouth, or dizziness. Lorazepam can also cause sedation and may lead to dependence with long-term use. Metoclopramide may cause extrapyramidal symptoms or drowsiness. Patients should be monitored for these effects, and the use of this suppository should be individualized based on the patient's specific needs and existing medical conditions.

As compounding pharmacists at Bayview Pharmacy, we are committed to providing high-quality, customized medications to meet the unique needs of our patients. We encourage patients and prescribers to reach out to us with any questions regarding this formulation or its appropriate use. Our team is here to support and guide you through the treatment process with the expertise and care you deserve.

The combination of diphenhydramine, lorazepam, and metoclopramide in a rectal suppository form is designed to provide symptomatic relief from various conditions such as allergies, anxiety, and nausea or vomiting. However, it is important to consider potential drug interactions when using this formulation.

Diphenhydramine is an antihistamine that can cause sedation and has anticholinergic effects. It can interact with other CNS depressants such as opioids, benzodiazepines, muscle relaxants, and alcohol, potentially enhancing sedation and respiratory depression. Additionally, the anticholinergic effects of diphenhydramine can be additive with other anticholinergic drugs, increasing the risk of side effects like dry mouth, urinary retention, constipation, and confusion, especially in the elderly.

Lorazepam is a benzodiazepine that acts on the central nervous system to produce a calming effect. It can also cause sedation and respiratory depression, especially when combined with other CNS depressants. The use of lorazepam with opioid medications can lead to profound sedation, respiratory depression, coma, or death. Caution is advised when co-administering lorazepam with other drugs that have CNS depressant effects, including other benzodiazepines, barbiturates, antipsychotics, sedative/hypnotics, anxiolytics, antidepressants, narcotic analgesics, sedating antihistamines, anticonvulsants, and anesthetics.

Metoclopramide is a prokinetic agent that enhances gastrointestinal motility and is also used to treat nausea and vomiting. It can interact with drugs that are dopamine antagonists, such as antipsychotics, which may increase the risk of extrapyramidal symptoms. Metoclopramide can also interact with serotonergic drugs, including SSRIs and SNRIs, which may increase the risk of serotonin syndrome, a potentially life-threatening condition. Additionally, metoclopramide may increase the absorption of other drugs taken concurrently due to its prokinetic effects, which could lead to altered plasma levels of those drugs.

Patients and prescribers should be aware that this combination suppository may also interact with antidiabetic drugs, antihypertensives, and other medications that require careful titration or have a narrow therapeutic index. It is crucial to review all current medications, including over-the-counter drugs and herbal supplements, with a healthcare provider to assess for potential interactions before starting this formulation.

For any questions or concerns regarding this formulation and its potential drug interactions, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is available to provide detailed information and guidance to ensure safe and effective use of this medication.

The Diphenhydramine 12.5 mg/Lorazepam 0.5 mg/Metoclopramide 10 mg Rectal Suppository is a compounded medication designed to provide relief from various symptoms such as nausea, vomiting, anxiety, and allergic reactions. This solid dosage form is specifically created for rectal administration, where it is inserted into the rectum. Upon insertion, the suppository base, typically made from substances like cocoa butter or a synthetic substitute, begins to melt or dissolve due to the warmth of the body. As the base dissolves, it releases the active medications for local and systemic absorption through the rectal mucosa.

Diphenhydramine is an antihistamine that works by blocking the action of histamine, a substance in the body that causes allergic symptoms. It is effective in treating allergic reactions and can also provide sedative effects, helping to calm and relax the patient. Lorazepam, a benzodiazepine, acts on the central nervous system to produce a calming effect. It is commonly used to manage anxiety disorders and can also help alleviate nausea and vomiting when used in combination with other medications. Metoclopramide is a prokinetic agent that increases the motility of the upper gastrointestinal tract, which helps with the movement of stomach contents and prevents nausea and vomiting. It works by blocking dopamine receptors in the chemoreceptor trigger zone of the brain, which is involved in the sensation of nausea and the action of vomiting.

This combination of medications in a rectal suppository form can be particularly useful for patients who are unable to take oral medications due to vomiting, surgery, or gastrointestinal disorders. The rectal route provides an alternative that can bypass the gastrointestinal system, allowing for the absorption of the medications even when oral administration is compromised. This formulation is often used in palliative care settings or in patients with severe nausea and vomiting caused by chemotherapy, where rapid and effective symptom control is necessary.

For patients and prescribers considering the use of this formulation, it is important to understand the pharmacokinetics and pharmacodynamics of each component, as well as their potential interactions and side effects. The compounding pharmacists at Bayview Pharmacy are equipped to provide detailed information on the proper use and handling of this medication, as well as to answer any questions regarding its suitability for specific patients and disease states. If you have any questions or require further information, please do not hesitate to reach out to us.

The combination of diphenhydramine, lorazepam, and metoclopramide in a rectal suppository form is primarily indicated for the management of symptoms associated with various conditions such as severe nausea and vomiting. This can often be related to chemotherapy, postoperative recovery, or other medical treatments that induce these symptoms. Diphenhydramine, an antihistamine with sedative properties, contributes to the reduction of nausea and can provide relief from allergic reactions and motion sickness. Lorazepam, a benzodiazepine, not only reduces nausea but also provides anxiolytic effects, reducing anxiety that may accompany nausea or vomiting. Metoclopramide, a dopamine antagonist, is specifically included for its prokinetic effects, enhancing gastrointestinal motility, and for its antiemetic properties.

Beyond these primary indications, this rectal suppository formulation may be beneficial in other scenarios where alternative routes of administration are required. Patients with difficulty swallowing, gastrointestinal obstructions, or those who are unable to take oral medications may find rectal administration a useful alternative. This may include palliative care settings where ease of administration and patient comfort are paramount. While the combination of these drugs aims to address symptoms of nausea, vomiting, and anxiety, the sedative properties of both diphenhydramine and lorazepam may be helpful in inducing sleep or reducing agitation in certain situations where oral administration is not feasible or is less effective.

It should be noted, however, that this formulation should be used with caution due to the presence of lorazepam, which may cause dependency with long-term use. Prescribers are advised to carefully consider the patient's medical history, including any history of substance abuse, before recommending this treatment. Patients should be monitored for signs of sedation, respiratory depression, or other adverse effects. The use of this suppository in pediatric or elderly patients, or those with renal or hepatic impairment, requires careful consideration and possible dose adjustments. Additionally, it is essential to consider potential drug interactions, given the psychotropic nature of lorazepam and the possible anticholinergic effects of diphenhydramine, when administering this formulation.

For further information or questions about the use of this specific rectal suppository formulation, whether for its primary indications or potential off-label uses, please reach out to us at Bayview Pharmacy. Our knowledgeable team of compounding pharmacists can provide guidance on the appropriate use, potential side effects, and monitoring parameters to ensure safe and effective treatment for your patients.