Diltiazem HCl 2%/Lidocaine 1% Rectal Ointment is a compounded medication specifically formulated to provide symptomatic relief and treatment for anal fissures and associated conditions. Diltiazem, a calcium channel blocker, works by relaxing the smooth muscles in the anal sphincter, thereby reducing resting anal pressure and improving blood flow to the area, which can facilitate the healing of fissures. Lidocaine, a local anesthetic, offers immediate relief from pain and discomfort by numbing the affected area. This dual-action formulation combines the therapeutic effects of both medications to promote healing and provide analgesia.

The ointment is prepared as a semi-solid formulation, which is dispensed in a tube for ease of application. The base of the ointment is designed to be greasy or oily, which not only helps in the delivery of the active ingredients to the localized site but also provides a protective barrier that can prevent further irritation during bowel movements. This characteristic makes the ointment suitable for external application to the perianal skin and just inside the rectum, where it can exert its effects directly on the affected tissues.

Patients prescribed with this formulation can expect a reduction in pain and discomfort associated with anal fissures, as well as an environment conducive to healing. Prescribers opting for this compounded medication should consider it for patients who require a combination of muscle relaxation and analgesia for the treatment of anal fissures, particularly when standard therapies have not provided adequate relief or are not suitable. It is important to instruct patients on the correct method of application and to discuss the potential side effects, which may include local irritation or allergic reactions, although these are generally rare due to the localized action of the medication.

As compounding pharmacists at Bayview Pharmacy, we ensure that each batch of Diltiazem HCl 2%/Lidocaine 1% Rectal Ointment is prepared to the highest standards, with each ingredient carefully measured and incorporated to achieve the desired therapeutic effect. We are available to answer any questions from both patients and prescribers regarding the formulation, its use, or any other concerns related to the compounded medication. Please do not hesitate to reach out to us for further information or guidance.

The Diltiazem HCl 2%/Lidocaine 1% Rectal Ointment is a compounded medication designed for rectal application to provide relief from anal fissures and associated pain. Diltiazem is a calcium channel blocker that helps to relax the smooth muscles in the blood vessels, improving blood flow and reducing blood pressure. In the context of anal fissures, it helps by reducing the pressure in the anal sphincter, thus promoting healing. Lidocaine is a local anesthetic that provides temporary relief from pain by blocking nerve signals in the body.

When considering the use of this compounded ointment, it is important to be aware of potential drug interactions. Diltiazem is metabolized by the cytochrome P450 3A4 (CYP3A4) enzyme and can therefore interact with other drugs that are substrates, inhibitors, or inducers of this enzyme. Strong inhibitors of CYP3A4, such as ketoconazole, itraconazole, ritonavir, and clarithromycin, may increase the plasma concentration of diltiazem, potentially leading to enhanced effects and side effects. Conversely, inducers of CYP3A4, such as rifampin, phenytoin, carbamazepine, and St. John's Wort, may decrease the plasma concentration of diltiazem, reducing its efficacy.

Lidocaine, when applied topically, is generally considered to have a low risk of systemic absorption and thus a low risk of systemic drug interactions. However, caution should be exercised when lidocaine is used in conjunction with other local anesthetics or medications that affect cardiac conduction, as there may be an additive effect leading to increased risk of systemic toxicity or cardiac effects.

Patients should also be advised to avoid the concurrent use of other rectal products or those that may affect rectal mucosa, unless specifically directed by a healthcare provider, as this may alter the absorption or effects of the medication. Additionally, patients with pre-existing cardiac conditions, liver disease, or renal impairment should use this medication with caution and under the supervision of a healthcare provider, as these conditions may affect the metabolism and excretion of the drugs.

It is essential for patients to inform their healthcare providers of all medications, supplements, and herbal products they are currently taking before starting treatment with Diltiazem HCl 2%/Lidocaine 1% Rectal Ointment. This will help to identify any potential interactions and allow for appropriate monitoring or adjustments to therapy. If you have any questions or require further information regarding drug interactions with this formulation, please reach out to us at Bayview Pharmacy.

The Diltiazem HCl 2%/Lidocaine 1% Rectal Ointment is a specially compounded formulation that combines two active pharmaceutical ingredients, Diltiazem Hydrochloride and Lidocaine, in a semi-solid base suitable for rectal application. This ointment is designed to provide localized relief from specific conditions such as anal fissures, which are small tears in the lining of the anus that can cause pain and bleeding during bowel movements.

Diltiazem Hydrochloride is a calcium channel blocker that works by relaxing the smooth muscles in the walls of blood vessels, which in the case of anal fissures, helps to increase blood flow to the affected area, promoting healing and providing pain relief. The vasodilatory effect of Diltiazem also helps to reduce the resting pressure of the internal anal sphincter, which can alleviate the spasm and discomfort associated with anal fissures.

Lidocaine, on the other hand, is a local anesthetic that provides immediate relief from pain by blocking the transmission of pain signals along the nerves. When applied to the affected area, Lidocaine numbs the region, offering a soothing effect and making bowel movements less painful. This can be particularly beneficial in allowing the fissure to heal without the constant interruption of pain during defecation.

The ointment is formulated in a greasy or oily base, which not only ensures that the active ingredients are delivered directly to the site of pain and inflammation but also provides a protective layer that can prevent further irritation during bowel movements. This base also helps to maintain the hydration of the skin, which is essential for the healing process.

When using this compounded ointment, it is important to follow the directions provided by the prescriber. Typically, a small amount of the ointment is applied to the perianal area and gently massaged in, usually before and after bowel movements and at bedtime. This regimen helps to ensure that the medication is consistently delivered to the affected area, optimizing the healing environment and providing sustained pain relief.

As with any medication, there may be potential side effects, and it is important to monitor for any adverse reactions. If you experience any unusual symptoms or have concerns about the use of this ointment, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to provide guidance and support to both patients and prescribers to ensure the safe and effective use of this formulation.

While Diltiazem HCl 2%/Lidocaine 1% Rectal Ointment is specifically formulated for rectal application, primarily intended to treat conditions such as anal fissures and accompanying pain or spasms, its unique combination of ingredients allows for some additional uses. Please note that any alternative use should only be considered under the guidance and prescription of a healthcare provider.

The formulation's active components have properties that may be beneficial beyond the rectal area. Diltiazem, a calcium channel blocker, can help to relax smooth muscles and improve blood flow. Although the concentration in this ointment is tailored for rectal use, it may have potential off-label applications in other areas of the body where muscle relaxation is desired. However, such use must be approached with caution due to the systemic absorption and the risk of adverse effects.

Lidocaine, on the other hand, is a well-known local anesthetic and can also act as an antiarrhythmic agent. In this ointment, it helps alleviate pain by numbing the area of application. This analgesic effect may be beneficial in managing localized pain in other dermal or mucosal areas. Healthcare providers sometimes use lidocaine formulations for superficial skin procedures or to soothe other painful conditions, with caution to prevent systemic toxicity.

It is essential to understand that the off-label use of diltiazem and lidocaine for conditions like superficial thrombophlebitis, other smooth muscle spasms, or localized pain management outside of the rectal area is not the primary purpose of this product. The safety and efficacy of such applications have not been established for this particular formulary concentration and vehicle. Patients or prescribers considering any alternate use must discuss potential risks and benefits thoroughly, consider individual patient circumstances, and adhere to regulatory guidelines.

Given the specialized nature of this rectal ointment, patients and prescribers are encouraged to reach out to us at Bayview Pharmacy with any questions or to discuss appropriate uses. Our compounding pharmacy team is dedicated to providing accurate and comprehensive information to ensure the safe and effective use of all our formulations. We are here to support our patients' healthcare needs and collaborate with prescribers to optimize therapeutic outcomes.