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Formulas

Dicloxacillin 62.5 mg/5 mL Oral Liquid

Our Dicloxacillin 62.5 mg/5 mL Oral Liquid is a specially crafted medication designed for oral use, ensuring a precise and consistent dose of the antibiotic with each administration. This formulation is particularly beneficial for patients who experience difficulty swallowing pills, including children and the elderly. Dicloxacillin, a penicillinase-resistant penicillin, is effective in treating bacterial infections such as pneumonia, bone and joint infections, skin and soft tissue infections, and otitis media. By providing this medication in a liquid form, we aim to improve patient compliance and therapeutic outcomes in managing these disease states.

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Oral Liquid
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Formula Information

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Dicloxacillin, a penicillinase-resistant penicillin, is an antibiotic that is effective in treating bacterial infections caused by susceptible Gram-positive bacteria, including Staphylococcus aureus. The Dicloxacillin 62.5 mg/5 mL Oral Liquid formulation is designed to provide a precise dose of antibiotic in a liquid form, which is particularly beneficial for patients who have difficulty swallowing pills, such as children and the elderly. This liquid medication ensures that patients receive the correct dosage in an easily ingestible form, enhancing compliance and optimizing therapeutic outcomes.

The Dicloxacillin oral liquid is typically prescribed for the treatment of infections such as impetigo, cellulitis, and other skin infections, as well as respiratory tract infections like pneumonia and pharyngitis when caused by susceptible strains of bacteria. Its efficacy is due to its ability to interfere with the synthesis of bacterial cell walls, ultimately leading to bacterial cell death. The liquid formulation allows for flexible dosing, which is particularly important in pediatric patients where doses often need to be adjusted according to body weight.

For prescribers, it is important to note that Dicloxacillin should be used with caution in patients with a history of penicillin hypersensitivity or cephalosporin allergies due to the potential for cross-reactivity. Renal function should be monitored in patients with renal impairment, as dosage adjustments may be necessary. Additionally, as with all antibiotics, it is crucial to emphasize the importance of completing the full course of therapy to prevent the development of antibiotic resistance.

Patients should be advised to take Dicloxacillin on an empty stomach, ideally 1 hour before or 2 hours after meals, to maximize absorption. Common side effects may include gastrointestinal discomfort, such as nausea, vomiting, and diarrhea. However, serious allergic reactions can occur, and patients should be instructed to seek immediate medical attention if they experience symptoms such as rash, itching, or difficulty breathing.

Bayview Pharmacy's team of compounding pharmacists is dedicated to providing high-quality, customized medications to meet the unique needs of each patient. Our Dicloxacillin 62.5 mg/5 mL Oral Liquid is prepared with the utmost care to ensure stability, efficacy, and palatability. If you have any questions or require further information about this formulation, please do not hesitate to reach out to us. We are here to support both patients and healthcare providers in achieving the best possible treatment outcomes.

Drug Interactions

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Dicloxacillin is a penicillinase-resistant, beta-lactam antibiotic that is structurally related to penicillin. It is used to treat infections caused by susceptible Gram-positive bacteria, including Staphylococcus and Streptococcus species. As with any medication, dicloxacillin can interact with other drugs, which may affect the efficacy of the treatment or increase the risk of adverse effects. It is important for both patients and prescribers to be aware of these potential interactions.

One significant interaction is with bacteriostatic antibiotics, such as tetracyclines and chloramphenicol, which can antagonize the bactericidal effect of dicloxacillin. Concurrent use of these medications should be avoided or monitored closely. Probenecid can increase the concentration of dicloxacillin by decreasing its renal tubular secretion, potentially leading to increased efficacy or toxicity. Care should be taken when co-administering these drugs, and dosage adjustments may be necessary.

Dicloxacillin may also reduce the efficacy of oral contraceptives due to its effects on the gut flora, which is involved in the recirculation of estrogens. Patients should be advised to use an additional non-hormonal form of contraception while taking dicloxacillin. Additionally, dicloxacillin can affect the absorption of other medications. For instance, it may reduce the absorption of drugs that require an acidic stomach environment, such as ketoconazole or itraconazole, because dicloxacillin can cause a transient decrease in gastric acidity.

Warfarin and other oral anticoagulants may have increased effects when used with dicloxacillin due to alterations in the gut flora and vitamin K production, as well as potential displacement from plasma proteins. Patients on anticoagulant therapy should have their prothrombin time or INR monitored closely when starting or stopping dicloxacillin treatment. Methotrexate toxicity may be increased when administered concurrently with dicloxacillin due to reduced renal clearance, necessitating careful monitoring of methotrexate levels.

It is also important to note that dicloxacillin may cause false-positive results in glucose tests in urine using copper reduction methods and may interfere with the direct antiglobulin (Coombs') test. Patients should inform their healthcare providers about all medications, supplements, and herbal products they are taking to avoid potential drug interactions. If you have any questions or concerns regarding the use of dicloxacillin oral liquid or its interactions with other medications, please reach out to us at Bayview Pharmacy for further assistance.

How Does it Work

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The Dicloxacillin 62.5 mg/5 mL Oral Liquid is a specially designed medication that is administered orally. This formulation is particularly beneficial for patients who have difficulty swallowing pills, such as children and the elderly, or for those who prefer a liquid dosage form. The liquid formulation ensures that the active ingredient, dicloxacillin, is dissolved in a suitable liquid vehicle, which allows for accurate dosing and easy administration.

Dicloxacillin is a penicillinase-resistant, beta-lactam antibiotic that belongs to the penicillin class of antibiotics. It works by inhibiting the synthesis of bacterial cell walls, which are essential for their survival. By binding to and inactivating penicillin-binding proteins located inside the bacterial cell wall, dicloxacillin disrupts the cross-linking of peptidoglycan chains, which is a critical step in cell wall biosynthesis. This action ultimately leads to the lysis and death of the bacteria.

This antibiotic is particularly effective against Gram-positive bacteria, including Staphylococcus aureus, which are known to produce enzymes called beta-lactamases that can inactivate other penicillins. Dicloxacillin's resistance to these enzymes makes it a valuable treatment option for infections caused by these organisms. It is commonly used to treat conditions such as pneumonia, pharyngitis, skin and soft tissue infections, and osteomyelitis, among others, that are caused by susceptible strains of bacteria.

For optimal results, the Dicloxacillin 62.5 mg/5 mL Oral Liquid should be taken on an empty stomach, ideally 1 hour before or 2 hours after meals, to enhance absorption. It is important to shake the bottle well before each use to ensure the medication is evenly distributed throughout the liquid. Patients should use the provided measuring device to ensure they are taking the correct dose as prescribed by their healthcare provider.

As with any antibiotic, it is crucial to complete the full course of treatment even if symptoms improve before the medication is finished. Stopping the medication early can lead to the development of antibiotic-resistant bacteria. Patients should be advised of potential side effects, which may include gastrointestinal upset, allergic reactions, or yeast infections. Any severe or persistent side effects should be reported to a healthcare professional immediately.

If you have any questions or require further information about the Dicloxacillin 62.5 mg/5 mL Oral Liquid formulation, please do not hesitate to reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to provide guidance and support to both patients and prescribers to ensure the safe and effective use of this medication.

Other Uses

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Dicloxacillin, a semi-synthetic antibiotic of the penicillin class, is predominately prescribed to combat infections caused by penicillinase-producing staphylococci. Its broad spectrum of activity includes its use for treating mild to moderate bacterial infections, such as impetigo, cellulitis, and other skin infections. However, aside from these well-documented indications, dicloxacillin may also have off-label uses which should only be considered when prescribed by a healthcare professional familiar with the patient's medical history. Off-label uses could potentially include the treatment of other infections caused by susceptible organisms, which do not produce penicillinase enzymes.

The 62.5 mg/5 mL oral liquid formulation of dicloxacillin further extends its potential utility in patient populations that require specialized dosing or have difficulty swallowing pills, such as young children, the elderly, or patients with dysphagia. It's important to note that the efficacy of dicloxacillin for any uses beyond those approved by regulatory authorities is less well established, and such use would require close monitoring and a thorough understanding of the disease being treated. The oral liquid formulation allows for easier dose adjustments and is particularly valuable in situations where precise dosing is necessary to avoid over or under-medicating, which can be particularly significant when treating infections in young children who are more sensitive to dose variations.

Beyond therapeutic uses, the 62.5 mg/5 mL oral liquid formulation of dicloxacillin might be employed as a prophylactic measure to prevent infection in individuals who are at an elevated risk of bacterial infection due to a weakened immune system, though such preventative uses should be carefully reviewed and authorized only by a healthcare professional. Also, in rare cases, the solution can be used in a diluted form for topical application under specific medical guidance, although this is not a standard practice and should only be done with professional recommendation.

For the avoidance of doubt, this oral liquid formulation of dicloxacillin should not be used to treat infections that are viral in origin, such as colds or the flu, as antibiotics like dicloxacillin are ineffective against viruses. Additionally, patients with known allergies to penicillin or cephalosporin antibiotics should avoid using this medication unless it has been deemed safe and necessary by a healthcare provider. If you have any questions regarding the use of dicloxacillin 62.5 mg/5 mL oral liquid for other indications or any concerns about dosing and administration, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is always ready to provide further information and assist with your pharmaceutical needs.

Frequently Asked Questions

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What is Dicloxacillin 62.5 mg/5 mL Oral Liquid used for?

Dicloxacillin 62.5 mg/5 mL Oral Liquid is an antibiotic medication used to treat certain bacterial infections caused by penicillinase-producing organisms. It is effective in treating mild to moderately severe conditions such as respiratory tract infections, skin and soft tissue infections, and other bacterial illnesses.

How should Dicloxacillin Oral Liquid be administered?

The oral liquid formulation should be taken as prescribed by your healthcare provider. It is intended for oral use and should be measured with an accurate dosing instrument, such as an oral syringe or a dosing spoon, to ensure the correct dose is administered. Shake the bottle well before each use.

Who can take Dicloxacillin Oral Liquid?

Dicloxacillin Oral Liquid is generally prescribed for patients who have difficulty swallowing solid dosage forms, such as tablets or capsules. This includes pediatric and geriatric populations or individuals with conditions that impair their ability to swallow pills.

Can Dicloxacillin Oral Liquid be taken with food?

It is usually recommended to take Dicloxacillin on an empty stomach, ideally 1 hour before or 2 hours after meals, to maximize its absorption. However, if stomach upset occurs, it may be taken with meals. Always follow the advice of your healthcare provider.

Are there any side effects associated with Dicloxacillin Oral Liquid?

As with any medication, side effects can occur. Common side effects include nausea, vomiting, diarrhea, and abdominal pain. If you experience any severe side effects or signs of an allergic reaction, such as rash, hives, or difficulty breathing, seek medical attention immediately.

How should this medication be stored?

Dicloxacillin Oral Liquid should be stored in a cool, dry place, away from direct sunlight. After reconstitution (if applicable), it may need to be stored in the refrigerator; check the label or ask your pharmacist for specific storage instructions. Always keep the bottle tightly closed and out of reach of children.

What should I do if I miss a dose?

If you miss a dose, take it as soon as you remember. If it is near the time for the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

Can Dicloxacillin Oral Liquid be used for viral infections like the common cold or flu?

No, Dicloxacillin Oral Liquid is an antibiotic and is only effective against bacterial infections. It will not work for viral infections such as the common cold or flu. Using antibiotics when they are not needed can lead to their decreased effectiveness.

Is it safe to consume alcohol while taking Dicloxacillin?

It is generally advised to avoid alcohol while taking antibiotics like Dicloxacillin, as it may increase the risk of certain side effects or reduce the effectiveness of the medication. Consult your healthcare provider for specific recommendations.

What should I discuss with my healthcare provider before taking Dicloxacillin Oral Liquid?

Before starting treatment with Dicloxacillin Oral Liquid, discuss your medical history with your healthcare provider, especially if you have any allergies, kidney disease, liver disease, asthma, or a history of gastrointestinal issues. Also, inform your provider about any other medications, supplements, or herbal products you are currently taking.

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Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.