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Diclofenac Sodium 3%/Flurbiprofen 6%/Gabapentin 6% Topical Gel

This Diclofenac Sodium 3%/Flurbiprofen 6%/Gabapentin 6% Topical Gel is a specialized semisolid preparation intended for localized application on the skin. The formulation is dispensed through a pump mechanism, which allows for convenient and controlled administration of the medication. The combination of diclofenac sodium and flurbiprofen, both nonsteroidal anti-inflammatory drugs (NSAIDs), along with gabapentin, an anticonvulsant with analgesic effects, makes this gel particularly effective for the treatment of inflammatory pain conditions. It is commonly used to alleviate symptoms associated with osteoarthritis, rheumatoid arthritis, and neuropathic pain. The topical route of administration helps to minimize systemic side effects while providing targeted relief at the site of discomfort.

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Diclofenac Sodium
Flurbiprofen
Gabapentin
Topical Cream
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Formula Information

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The Diclofenac Sodium 3%/Flurbiprofen 6%/Gabapentin 6% Topical Gel is a specialized medication compounded by the team at Bayview Pharmacy to address various localized pain conditions. This semisolid preparation is dispensed in a pump mechanism, which allows for easy, controlled, and precise application directly to the affected area of the skin. The gel formulation is designed to facilitate the absorption of the active ingredients through the skin, providing targeted relief from pain and inflammation.

Diclofenac Sodium is a nonsteroidal anti-inflammatory drug (NSAID) that works by reducing substances in the body that cause pain and inflammation. When applied topically, it is used to treat joint pain caused by osteoarthritis. Flurbiprofen, another NSAID in this formulation, also helps to decrease inflammation and pain in the area of application. The inclusion of Gabapentin, an anticonvulsant and neuropathic pain agent, is particularly beneficial for its ability to calm nerve-related pain. This combination of Diclofenac, Flurbiprofen, and Gabapentin in a topical gel form is particularly effective for patients who require localized relief from conditions such as arthritis, muscle pain, and certain types of neuropathic pain.

The synergistic effect of these three active ingredients provides a broad spectrum of pain relief, making it a versatile option for patients with various localized pain conditions. The topical route of administration ensures that the medication acts at the site of pain with minimal systemic absorption, which can reduce the risk of systemic side effects commonly associated with oral NSAIDs and Gabapentin. This can be particularly advantageous for patients who may be at risk for or wish to avoid systemic complications.

Patients and prescribers should be aware that while this topical gel offers localized relief with a reduced risk of systemic side effects, it is still important to use the medication as directed. The pump mechanism is designed to dispense a measured dose, and patients should adhere to the prescribed amount and frequency of application to avoid overuse. As with any medication, there may be potential side effects, and it is important to monitor for any skin reactions or other adverse effects and report them to a healthcare provider.

For those interested in using this compounded formulation, or for more detailed information regarding its use, potential side effects, and suitability for specific pain conditions, please reach out to the knowledgeable team at Bayview Pharmacy. We are committed to providing comprehensive support and guidance to ensure the safe and effective use of our compounded medications.

Drug Interactions

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The topical gel formulation containing Diclofenac Sodium 3%, Flurbiprofen 6%, and Gabapentin 6% is designed for localized treatment and may be used to manage conditions such as arthritis, neuropathic pain, and musculoskeletal pain. While the risk of systemic drug interactions is generally lower with topical administration compared to oral forms, there are still potential interactions that should be considered.

Diclofenac and Flurbiprofen are both nonsteroidal anti-inflammatory drugs (NSAIDs). When used topically, they are less likely to have systemic effects; however, caution should be exercised if the patient is taking other NSAIDs orally, as this could increase the risk of systemic side effects such as gastrointestinal bleeding, ulceration, and renal impairment. Additionally, the use of multiple NSAIDs may increase the risk of cardiovascular thrombotic events, such as myocardial infarction and stroke, especially in patients with existing cardiovascular risk factors.

Gabapentin, when applied topically, is less likely to have systemic interactions; however, it is important to consider its potential to cause CNS depression. If the patient is taking other CNS depressants such as opioids, benzodiazepines, or alcohol, there may be an additive effect leading to increased sedation, dizziness, and the risk of falls. Caution is advised in patients with a history of drug abuse or acute intoxication.

Patients with a history of hypersensitivity to any of the active ingredients or to other NSAIDs should not use this formulation. Additionally, patients with compromised skin barrier function or open wounds should use this product with caution, as there may be increased systemic absorption of the active ingredients.

It is also important to consider the impact of the formulation on the skin itself. Topical NSAIDs can sometimes cause local skin reactions, such as dermatitis, eczema, or photosensitivity. Patients should be advised to protect the treated area from sunlight to minimize the risk of photosensitivity reactions.

As with any medication, it is crucial to review the patient's complete medication profile for potential interactions. This includes prescription drugs, over-the-counter medications, and herbal supplements. If you have any questions or require further information regarding this topical gel formulation and its potential drug interactions, please reach out to us at Bayview Pharmacy. We are here to provide guidance and support to ensure the safe and effective use of this medication.

How Does it Work

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The Diclofenac Sodium 3%/Flurbiprofen 6%/Gabapentin 6% Topical Gel is a specially compounded medication designed to deliver a combination of anti-inflammatory and analgesic effects directly to the site of pain and inflammation. This semisolid preparation is dispensed in a pump mechanism, which allows for convenient, hygienic, and controlled application. The pump ensures that each dose is measured accurately, reducing the risk of overuse or underuse, and facilitates the application process for patients.

Diclofenac Sodium is a nonsteroidal anti-inflammatory drug (NSAID) that works by inhibiting cyclooxygenase (COX) enzymes, which are involved in the synthesis of prostaglandins. Prostaglandins are lipid compounds that play a key role in the inflammation process. By reducing their production, diclofenac sodium effectively decreases inflammation and pain in the affected area.

Flurbiprofen, another NSAID in the formulation, also inhibits COX enzymes, complementing the effects of diclofenac sodium. The dual presence of these NSAIDs provides a potent anti-inflammatory action, which can be particularly beneficial in treating conditions such as osteoarthritis, rheumatoid arthritis, and other musculoskeletal disorders. The higher concentration of flurbiprofen in this formulation is designed to enhance the overall anti-inflammatory and analgesic effects.

Gabapentin, originally developed as an anticonvulsant, has been found to be effective in the treatment of neuropathic pain. It is believed to work by binding to the alpha-2-delta subunit of voltage-gated calcium channels in the central nervous system, which reduces the release of excitatory neurotransmitters and thus diminishes the abnormal excitatory signaling that leads to neuropathic pain. When included in a topical formulation, gabapentin can target peripheral sites of pain and inflammation, providing localized relief without the systemic side effects often associated with oral administration.

This combination gel is particularly useful for patients who require localized relief from pain and inflammation associated with various disease states, including but not limited to, arthritis, tendinitis, bursitis, and neuropathic pain. The topical route of administration ensures that the active ingredients are delivered directly to the site of discomfort, potentially reducing the risk of systemic side effects and drug interactions that are more common with oral NSAIDs and gabapentin.

It is important for both patients and prescribers to understand that while this topical gel can provide significant relief, it should be used as part of a comprehensive treatment plan, which may include physical therapy, lifestyle changes, and other medications. As with any medication, there may be potential side effects, and it is essential to use this product under the guidance of a healthcare professional. If you have any questions or require further information about this formulation, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to support you with personalized care and expertise.

Other Uses

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Aside from the primary indication of managing pain and inflammation associated with conditions like arthritis, the topical gel formulation containing Diclofenac Sodium 3%, Flurbiprofen 6%, and Gabapentin 6% may offer therapeutic benefits for other local pain-related disorders. Patients suffering from tendinitis, bursitis, or localized muscle pain might find relief with the anti-inflammatory and analgesic properties of Diclofenac and Flurbiprofen, while Gabapentin's role in neuropathic pain modulation could benefit those with nerve-related pain conditions, such as diabetic neuropathy or post-herpetic neuralgia. This specific combination, due to its anti-inflammatory and analgesic effects, may also be considered for soft tissue injuries, sports-related strains, or sprains, where localized pain management is required without systemic side effects.

Moreover, the gel's unique tri-agent formulation could potentially be used off-label, under the guidance of a healthcare provider, for complex regional pain syndrome (CRPS), or certain dermatologic conditions with pain manifestations, given its ability to penetrate the skin and act at localized sites. The semisolid preparation provided in a pump mechanism facilitates precise dosing and offers ease of application, ensuring that the medication is delivered directly to the affected area, thus maximizing the therapeutic effects while minimizing systemic absorption and related side effects.

Although not extensively studied, some patients with neuropathic pain conditions not fully relieved by conventional oral medications might find adjunctive benefit from the use of this topical preparation. However, it is important to note that the uses mentioned beyond the primary indication are based on the pharmacological actions of the individual ingredients and might not be supported by clinical trials. Caution is advised, and a thorough evaluation by a healthcare professional is crucial before initiating any off-label use. If you have any questions or require further assistance on the potential uses of this topical gel or need more information on prescribing this formulation, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is always ready to provide support and guidance to ensure the safe and effective use of compounded medications.

Frequently Asked Questions

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What is the purpose of the compounded Diclofenac Sodium/Flurbiprofen/Gabapentin Topical Gel?

This compounded medication is designed for the localized treatment of pain and inflammation. It combines the effects of an anti-inflammatory drug (Diclofenac Sodium), another anti-inflammatory (Flurbiprofen), and a medication that can help manage neuropathic pain (Gabapentin). Applied on the skin, it is meant to provide relief in a targeted area without the need for systemic treatment.

How do I use this topical gel?

To use this gel, press the pump mechanism to dispense a small amount onto your finger or directly onto the affected area. Spread the gel over the area gently and thoroughly. Always wash your hands after application unless you are treating the hands. Use the gel as directed by your healthcare provider.

How often should I apply the gel?

The frequency of application will depend on your individual condition and the recommendations of your healthcare provider. Typically, it may be used two to four times daily, but follow your healthcare professional's specific instructions.

Can I cover the area after applying the gel?

Yes, you can cover the area with clothing if desired. However, avoid using occlusive dressings or bandages unless directed by your healthcare provider, as this may increase absorption of the medications.

Are there any side effects of using this gel?

All medications can cause side effects. With topical application, you may experience local skin irritation, redness, rash, or itching. If you notice any systemic side effects such as digestive issues, difficulty breathing, or other unusual symptoms, contact your healthcare provider immediately.

What should I do if I miss a dose?

If you miss a dose, apply the gel as soon as you remember. If it's almost time for the next application, skip the missed dose and continue with your regular dosing schedule. Do not apply extra gel to make up for a missed dose.

Is this topical gel safe to use with other medications?

While this gel is for topical use and less likely to interact with other medications, it's still important to inform your healthcare provider about all the medications you are taking, including over-the-counter drugs and supplements. Certain medications, especially other anti-inflammatories or blood thinners, may interact with the active ingredients in this gel.

Can I use this gel during pregnancy or while breastfeeding?

As with any medication, you should use this gel during pregnancy or while breastfeeding only under the direction of your healthcare provider. Some of the active ingredients could potentially have effects on a developing fetus or a nursing infant.

How should I store this compounded gel?

Store the gel at room temperature, away from heat and direct light, and keep it out of reach of children. Do not freeze the gel. Make sure the pump mechanism is locked or covered to prevent accidental dispensing when not in use.

What should I do in case of an overdose?

An overdose is unlikely to occur with proper use of this topical gel. However, if you suspect that you have used too much or if someone has ingested the gel, seek emergency medical attention or contact a poison control center immediately.

How long can I use the gel, and what do I do with expired or unused gel?

The duration of use for the gel will be determined by your healthcare provider. Do not use the gel past its expiration date. For disposal of expired or unused gel, consult with your pharmacy or healthcare provider for proper disposal methods, following local regulations and guidelines.

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Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.