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Formulas

Diclofenac Sodium 10%/Lidocaine HCl 2%/Menthol 2% Transdermal Gel

The Diclofenac Sodium 10%/Lidocaine HCl 2%/Menthol 2% Transdermal Gel is a specialized semisolid formulation designed for targeted topical application. This unique compound combines the anti-inflammatory and analgesic properties of Diclofenac Sodium with the local anesthetic effects of Lidocaine HCl and the cooling sensation provided by Menthol. The gel is dispensed through a pump mechanism, which ensures ease of use and precise dosing. The consistency of the gel allows for optimal skin adherence and gradual release of the active ingredients.

This formulation is primarily used to treat localized musculoskeletal pain, including conditions such as osteoarthritis, tendinitis, and bursitis. It may also be beneficial for the relief of pain associated with neuropathic conditions and sports-related injuries. The combination of active ingredients works synergistically to reduce inflammation, numb the affected area, and provide a soothing effect, thereby enhancing patient comfort and aiding in the management of pain.

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Diclofenac Sodium
Lidocaine Hydrochloride
Menthol
Topical Gel
654e586eb1ae0d84aa1ed987
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Formula Information

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The Diclofenac Sodium 10%/Lidocaine HCl 2%/Menthol 2% Transdermal Gel is a specialized semisolid formulation designed for topical application. This unique compound combines the anti-inflammatory and analgesic properties of Diclofenac Sodium with the local anesthetic effects of Lidocaine HCl and the cooling sensation provided by Menthol. The gel is dispensed through a pump mechanism, which ensures that patients can apply a consistent and precise dose to the affected area. The gel base allows for the active ingredients to be absorbed through the skin, targeting the site of pain or inflammation directly.

Diclofenac Sodium is a nonsteroidal anti-inflammatory drug (NSAID) that works by reducing substances in the body that cause pain and inflammation. It is commonly used for the treatment of conditions such as osteoarthritis, rheumatoid arthritis, and other musculoskeletal disorders. Lidocaine HCl is a local anesthetic that provides temporary relief of pain by blocking nerve signals in the body, making it useful for numbing the skin to treat conditions like post-herpetic neuralgia or other neuropathic pain states. Menthol adds a cooling effect that can help soothe irritated skin and provide additional pain relief through its counterirritant properties.

This transdermal gel formulation is particularly beneficial for patients seeking targeted relief from localized pain without the systemic side effects associated with oral medications. It is suitable for patients who may have difficulty swallowing pills or for those who prefer a non-invasive treatment option. The combination of Diclofenac, Lidocaine, and Menthol in a gel form allows for a multimodal approach to pain management, addressing inflammation, pain signaling, and providing a soothing sensation to the affected area.

For prescribers, it is important to note that this formulation should be used with caution in patients with a history of allergic reactions to any of the active ingredients or to aspirin or other NSAIDs. The transdermal gel should be applied as directed, typically to the affected area up to four times a day, depending on the patient's condition and the prescriber's recommendation. It is also crucial to advise patients to avoid contact with eyes, mucous membranes, and to wash their hands thoroughly after application.

Bayview Pharmacy is committed to providing high-quality compounded medications tailored to the specific needs of patients. Our team of knowledgeable compounding pharmacists is available to answer any questions and provide additional information regarding the use and benefits of the Diclofenac Sodium 10%/Lidocaine HCl 2%/Menthol 2% Transdermal Gel. If you have any questions or require further assistance, please do not hesitate to reach out to us.

Drug Interactions

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The transdermal gel formulation containing Diclofenac Sodium 10%, Lidocaine HCl 2%, and Menthol 2% is designed for topical application and is intended to provide localized relief from pain and inflammation. Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID) that works by reducing substances in the body that cause pain and inflammation. Lidocaine is a local anesthetic that provides temporary relief from pain by blocking nerve signals in the body. Menthol provides a cooling sensation that can help to soothe and relieve minor muscle or joint pain.

When using this transdermal gel, it is important to consider potential drug interactions. Diclofenac, being an NSAID, may interact with anticoagulants such as warfarin, increasing the risk of bleeding. It may also interact with other NSAIDs (including aspirin), selective serotonin reuptake inhibitors (SSRIs), and serotonin-norepinephrine reuptake inhibitors (SNRIs), which can further increase the risk of gastrointestinal bleeding. Additionally, diclofenac may affect renal function and interact with drugs such as ACE inhibitors, angiotensin receptor blockers (ARBs), and diuretics, potentially leading to kidney damage. Patients should avoid using other topical products containing NSAIDs while using this gel.

Lidocaine, on the other hand, may interact with antiarrhythmic drugs such as amiodarone or sotalol, potentially altering cardiac function. Caution is advised when using this gel in conjunction with other local anesthetics or medications that affect cardiac conduction. The systemic absorption of lidocaine from topical application is generally low; however, the risk of systemic side effects increases if applied to large areas of skin, broken skin, or if used for prolonged periods.

Menthol does not typically have significant drug interactions; however, it may enhance the penetration of other drugs applied topically, which could potentially increase their absorption and systemic effects. Patients should be cautious when using other topical medications in conjunction with this gel.

It is essential for patients to inform their healthcare provider of all medications they are currently taking, including prescription drugs, over-the-counter medications, and herbal supplements, to avoid potential drug interactions. Additionally, patients with a history of allergic reactions to NSAIDs, asthma, urticaria, or other allergic-type reactions after taking aspirin or other NSAIDs should not use this product. Pregnant or breastfeeding women should consult with their healthcare provider before using this gel.

This transdermal gel is indicated for the treatment of localized musculoskeletal pain and can be beneficial in conditions such as arthritis, sprains, strains, and other injuries. The combination of diclofenac, lidocaine, and menthol provides both anti-inflammatory and analgesic effects, as well as a cooling sensation that can improve patient comfort.

If you have any questions or require further information regarding drug interactions or the appropriate use of this transdermal gel formulation, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to provide guidance and support to ensure the safe and effective use of this medication.

How Does it Work

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The Diclofenac Sodium 10%/Lidocaine HCl 2%/Menthol 2% Transdermal Gel is a specially compounded medication designed to deliver its active ingredients directly through the skin to the affected area. This semisolid formulation is dispensed through a pump mechanism, which allows for easy and precise application. The gel-like consistency ensures that the medication stays on the skin where it is applied, facilitating targeted treatment and absorption.

Diclofenac Sodium is a nonsteroidal anti-inflammatory drug (NSAID) that works by reducing substances in the body that cause pain and inflammation. When applied topically, it is used to treat joint pain caused by osteoarthritis. The 10% concentration in this formulation helps to relieve pain directly at the site of discomfort without the systemic side effects often associated with oral NSAIDs.

Lidocaine HCl is a local anesthetic that provides temporary relief of pain by causing a numbing effect on the skin and surrounding tissues. At a 2% concentration, it works by blocking nerve signals in the specific area where it is applied, making it particularly useful for localized pain relief. This can be beneficial for patients experiencing sharp, shooting pains or those undergoing minor surgical procedures.

Menthol is included at a 2% concentration and offers a cooling sensation upon application. This cooling effect helps to soothe the skin and can provide additional pain relief. Menthol also acts as a counterirritant by causing the skin to feel cool and then warm, distracting from the deeper pain in the muscles or joints.

This transdermal gel is indicated for the relief of pain and inflammation associated with conditions such as osteoarthritis, muscle strains, or sprains. The combination of diclofenac sodium, lidocaine, and menthol provides a multi-modal approach to pain management, addressing inflammation, pain signaling, and providing symptomatic relief through sensory distraction.

For patients and prescribers considering this formulation, it is important to understand that the transdermal delivery system allows for the active ingredients to penetrate the skin and exert their effects locally with reduced systemic exposure. This can be particularly advantageous for patients who may be at risk for systemic side effects or those who prefer a targeted approach to pain management. As with any medication, it is essential to use this product under the guidance of a healthcare professional and it should be applied as directed to the affected area.

If you have any questions about this formulation or its appropriateness for your condition, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to provide you with the information and support you need to make an informed decision about your pain management options.

Other Uses

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The combination of Diclofenac Sodium, Lidocaine HCl, and Menthol in a transdermal gel formulation offers a multifaceted approach to pain management that may extend beyond the typical indications such as osteoarthritis, muscle strains, or sports injuries. While the primary use of this gel is to alleviate inflammation and provide analgesic effects directly at the site of pain, this formulation has found utility in other various therapeutic contexts owing to the individual properties of its components.

Diclofenac Sodium is a nonsteroidal anti-inflammatory drug (NSAID) that can also be beneficial for conditions like tendinitis, bursitis, neuropathic pain, and certain types of joint pain associated with chronic conditions such as rheumatoid arthritis. Lidocaine, a local anesthetic, can help to manage localized neuropathic pain or post-herpetic neuralgia by numbing the affected area. Menthol provides a cooling sensation and can serve as a counterirritant, thereby offering symptomatic relief for minor aches, sprains, or even conditions like fibromyalgia where a cooling effect might improve discomfort.

Recently, there has been an increasing interest in using such formulations off-label for migraine relief by applying the gel to the forehead or temples for the transdermal absorption of the active ingredients; however, additional studies are required to fully endorse this practice. This gel could also potentially be used in the preventive care of repetitive stress injuries through its anti-inflammatory properties, and as a supportive treatment in pain management regimens that aim to reduce the systemic use of NSAIDs or opioids.

When considering the application of this gel for other uses, it is critical that patients consult with a healthcare professional to ensure the appropriateness of this treatment for their specific condition. Each ingredient in the formulation could carry potential risks, such as skin irritation or systemic absorption leading to adverse effects, particularly in those with pre-existing medical conditions or in combination with other medications.

For targeted, alternative uses or any questions regarding the suitability of this transdermal gel for a specific patient's care, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is ready to provide you with the necessary guidance and information to optimize patient outcomes through safe and effective use of compounded medications.

Frequently Asked Questions

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What is Diclofenac Sodium/Lidocaine HCl/Menthol Transdermal Gel used for?

This compounded transdermal gel is used for providing targeted relief from pain and inflammation. The combination of diclofenac sodium, lidocaine HCI, and menthol works together to reduce pain, numb the affected area, and provide a cooling sensation, respectively.

How do you apply this transdermal gel?

To use the gel, simply press the pump to dispense a small amount onto your fingers and gently apply onto the affected area with a thin layer. Make sure to wash your hands before and after the application, unless your hands are the area being treated.

How often should I use this medication?

The frequency of use should be determined by your healthcare provider based on your specific condition. Do not apply the gel more often than prescribed, as this could increase the risk of side effects.

Can this gel be used with other medications?

Before using this medication, inform your healthcare provider of all the medications you are taking, including over-the-counter drugs and herbal supplements, to prevent potential interactions. Do not use any other topical products on the same area without medical advice.

Are there any side effects associated with this gel?

While most people do not experience serious side effects, some may experience skin irritation, redness, or a burning sensation at the application site. If these symptoms persist or worsen, contact your healthcare provider immediately.

What should I do if I miss a dose?

If you miss a dose, apply it as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.

How should I store the transdermal gel?

Store the medication at room temperature away from light and moisture. Do not freeze it, and keep this and all other medications out of reach of children and pets.

Can I use this medication if I am pregnant or breastfeeding?

The safety of this medication for use during pregnancy or while breastfeeding has not been established. Consult your healthcare provider before use if you are pregnant or nursing to weigh the potential benefits and risks.

What precautions should I take when using this compounding gel?

Avoid contact with eyes, mucous membranes, and other sensitive areas. If contact occurs, rinse thoroughly with water. Do not apply to wounds, damaged, or irritated skin. Also, do not use occlusive dressings or heat pads over the treated areas as this may increase absorption or cause burns.

Is it normal for the gel to cause a cooling or tingling sensation?

Yes, the presence of menthol in the formulation may cause a mild cooling or tingling sensation upon application. This is a normal effect of menthol and is part of its analgesic action to provide symptomatic relief.

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Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.