This compounded suppository combines Dexamethasone 10 mg, Diphenhydramine HCl 25 mg, Haloperidol 1 mg, and Metoclopramide HCl 20 mg to provide a comprehensive approach to managing severe nausea and vomiting. Designed for rectal administration, this formulation allows for absorption when oral intake is compromised due to persistent emesis or when patients are unable to swallow medications.

Dexamethasone, a potent corticosteroid, contributes anti-inflammatory and antiemetic effects, particularly beneficial in chemotherapy-induced nausea and vomiting (CINV) and in palliative care settings. Its ability to reduce inflammation and inhibit prostaglandin synthesis helps alleviate symptoms associated with certain medical conditions.

Diphenhydramine HCl is an antihistamine that provides antiemetic properties by blocking H1 receptors in the brain's vomiting center. It also offers sedative effects, which can help reduce discomfort and anxiety associated with severe nausea.

Haloperidol, an antipsychotic agent with antiemetic effects, works by blocking dopamine receptors in the chemoreceptor trigger zone (CTZ) of the brain, effectively reducing nausea and vomiting. Its inclusion in this formulation enhances the antiemetic coverage, especially in patients unresponsive to other treatments.

Metoclopramide HCl serves both as an antiemetic and a prokinetic agent. It increases gastrointestinal motility and accelerates gastric emptying, which helps in reducing nausea by decreasing gastric stasis. Additionally, it blocks dopamine receptors in the CTZ, complementing the action of Haloperidol.

The combination of these four medications targets multiple pathways involved in nausea and vomiting, providing a synergistic effect that enhances overall efficacy. This makes the suppository particularly useful for patients undergoing chemotherapy, experiencing postoperative nausea, or those in palliative care with refractory symptoms.

For prescribers, this compounded formulation offers a customizable treatment option for patients who require multi-faceted antiemetic therapy but cannot tolerate oral medications. The rectal route ensures medication delivery even when gastrointestinal absorption is compromised. Dosages can be adjusted according to patient-specific needs and tolerability.

Patients using this suppository may experience relief from severe nausea and vomiting, improving their quality of life and allowing for better management of their underlying condition. It is important to follow administration instructions carefully and report any side effects to your healthcare provider.

If you have any questions, please reach out to us.

This compounded formulation of Dexamethasone 10 mg, Diphenhydramine HCl 25 mg, Haloperidol 1 mg, and Metoclopramide HCl 20 mg in suppository form is designed to provide therapeutic benefits through local or systemic absorption when inserted into a body cavity such as the rectum. Each active ingredient in this formulation has the potential to interact with other medications, which is crucial for both patients and prescribers to consider when using this treatment.

Dexamethasone, a corticosteroid, can interact with a wide range of medications. It may enhance the effects of anticoagulants, increasing the risk of bleeding. Concurrent use with nonsteroidal anti-inflammatory drugs (NSAIDs) can heighten the risk of gastrointestinal ulcers. Dexamethasone can also reduce the effectiveness of vaccines and may interact with medications that affect liver enzymes, such as certain antifungals and antibiotics, potentially altering their metabolism and efficacy.

Diphenhydramine HCl, an antihistamine, can cause sedation and should be used cautiously with other central nervous system depressants, such as benzodiazepines, opioids, and alcohol, as it may enhance their sedative effects. It can also interact with monoamine oxidase inhibitors (MAOIs), potentially leading to increased anticholinergic side effects. Patients with glaucoma, urinary retention, or prostate hypertrophy should use diphenhydramine with caution due to its anticholinergic properties.

Haloperidol, an antipsychotic, has a known interaction profile that includes the potential for QT interval prolongation. It should be used cautiously with other medications that can prolong the QT interval, such as certain antiarrhythmics, antibiotics, and antidepressants, as this can increase the risk of serious cardiac arrhythmias. Haloperidol can also interact with medications that affect the cytochrome P450 enzyme system, particularly CYP3A4 and CYP2D6 inhibitors, which can alter its metabolism and increase the risk of side effects.

Metoclopramide HCl, a prokinetic agent, can interact with medications that affect dopamine pathways, such as antipsychotics, potentially increasing the risk of extrapyramidal symptoms. It can also enhance the sedative effects of CNS depressants and may interact with medications that affect gastrointestinal motility, such as anticholinergics, which can counteract its prokinetic effects. Additionally, metoclopramide can alter the absorption of other orally administered drugs by changing gastrointestinal transit time.

Given the complexity of potential drug interactions with this compounded formulation, it is essential for prescribers to thoroughly review a patient's current medication regimen and medical history before initiating treatment. Patients should be advised to inform their healthcare provider of all medications they are taking, including over-the-counter drugs and supplements, to avoid adverse interactions. If you have any questions or need further information, please reach out to us at Bayview Pharmacy.

This compounded formulation combines Dexamethasone, Diphenhydramine HCl, Haloperidol, and Metoclopramide HCl into a suppository form, designed for insertion into a body cavity such as the rectum. Upon insertion, the suppository dissolves or melts, allowing the active ingredients to be absorbed either locally or systemically, depending on the intended therapeutic effect. This method of administration can be particularly beneficial for patients who have difficulty swallowing oral medications or require rapid absorption through the rectal mucosa.

Dexamethasone is a potent corticosteroid that works by reducing inflammation and suppressing the immune response. It is often used to treat conditions involving inflammation and immune system overactivity. In this formulation, Dexamethasone can help manage symptoms associated with inflammatory diseases, providing relief from pain and swelling.

Diphenhydramine HCl is an antihistamine that blocks the action of histamine, a substance in the body that causes allergic symptoms. It is commonly used to relieve symptoms of allergy, hay fever, and the common cold, such as itching, sneezing, and runny nose. In this suppository form, Diphenhydramine can also help alleviate nausea and vomiting, as it has antiemetic properties.

Haloperidol is an antipsychotic medication that works by altering the effects of chemicals in the brain. It is used to treat a variety of psychiatric disorders, including schizophrenia and acute psychosis. In this formulation, Haloperidol can help manage symptoms of agitation and severe nausea, providing a calming effect and reducing the urge to vomit.

Metoclopramide HCl is a prokinetic agent that enhances gastrointestinal motility and accelerates gastric emptying. It is used to treat nausea and vomiting, as well as conditions like gastroparesis. By promoting the movement of the stomach and intestines, Metoclopramide helps reduce symptoms of nausea and vomiting, making it a valuable component of this combination therapy.

The combination of these four active ingredients in a suppository form allows for a multifaceted approach to treating conditions that involve inflammation, allergic reactions, psychiatric symptoms, and gastrointestinal disturbances. The rectal administration ensures that the medications are absorbed efficiently, bypassing the gastrointestinal tract and reducing the risk of degradation by stomach acids. This can lead to a more rapid onset of action and improved patient compliance, especially in those who are unable to take oral medications.

If you have any questions about this formulation or its use, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to provide you with the information and support you need.

This compounded formulation of Dexamethasone 10 mg, Diphenhydramine HCl 25 mg, Haloperidol 1 mg, and Metoclopramide HCl 20 mg in suppository form is primarily designed for rectal or vaginal administration, where it dissolves or melts to facilitate local or systemic absorption of the active ingredients. While the primary indications for this combination may include managing severe nausea and vomiting, particularly in patients undergoing chemotherapy or experiencing postoperative symptoms, there are several other potential uses that healthcare providers might consider based on the pharmacological properties of the individual components.

Dexamethasone, a potent corticosteroid, can be utilized for its anti-inflammatory and immunosuppressive effects, making this formulation potentially beneficial in managing inflammatory conditions of the lower gastrointestinal tract or pelvic region. Diphenhydramine, an antihistamine, may provide additional relief from allergic reactions or motion sickness, which could be advantageous in patients with concurrent allergic symptoms or those who are unable to tolerate oral medications due to severe nausea. Haloperidol, an antipsychotic, is effective in controlling agitation and delirium, which might be useful in palliative care settings where patients experience these symptoms alongside nausea. Metoclopramide, a prokinetic agent, enhances gastrointestinal motility and can be beneficial in treating gastroparesis or other motility disorders, offering an alternative route of administration when oral intake is compromised.

For prescribers, it is important to consider the synergistic effects of these medications when used in combination, as well as the potential for adverse effects such as sedation, extrapyramidal symptoms, or gastrointestinal disturbances. The rectal or vaginal route of administration can be particularly advantageous in patients who are unable to take oral medications due to vomiting, dysphagia, or other contraindications. Patients should be informed about the proper insertion technique for suppositories and advised to remain lying down for a short period after administration to ensure optimal absorption. As with any compounded medication, the decision to use this formulation should be based on a thorough assessment of the patient's clinical condition and a careful consideration of the benefits and risks. If you have any questions or need further information, please reach out to us at Bayview Pharmacy.