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Dehydroepiandrosterone 25 mg/Testosterone 12.5 mg/ml Topical Cream

The Dehydroepiandrosterone 25 mg/Testosterone 12.5 mg/ml Topical Cream is a semisolid preparation that combines two hormone active ingredients. This cream is specifically formulated for transdermal delivery through a pump mechanism, which ensures a convenient and controlled application. The cream is designed to be applied directly to the skin, where it can be used for localized treatment or systemic absorption of the hormones.

This formulation is commonly used in the management of various disease states including but not limited to androgen deficiency, certain types of sexual dysfunction, and some conditions associated with aging. The combination of dehydroepiandrosterone (DHEA) and testosterone in the cream works synergistically to replenish hormone levels in individuals who may be experiencing a deficiency or imbalance, thereby alleviating symptoms associated with these conditions.

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Topical Cream
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Formula Information

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The Dehydroepiandrosterone (DHEA) 25 mg/Testosterone 12.5 mg/ml Topical Cream is a specially compounded formulation designed to deliver a combination of hormones directly through the skin. This semisolid preparation is dispensed in a pump mechanism, which ensures a convenient, hygienic, and controlled application. The pump is calibrated to dispense a specific dose of the cream, which aids in maintaining consistent dosing for the patient. The topical route of administration is chosen for its localized treatment benefits and to facilitate the direct absorption of active ingredients into the systemic circulation through the skin.

DHEA is a naturally occurring hormone that serves as a precursor to testosterone and estrogen. It has been studied for its potential role in a variety of biological functions, including immune response, energy level improvement, and the maintenance of muscle and bone mass. Testosterone, another naturally occurring hormone, is crucial for the development and maintenance of male secondary sexual characteristics, muscle mass, bone density, and overall well-being. The combination of DHEA and Testosterone in this cream is intended to address conditions related to hormone deficiencies or imbalances.

This compounded formulation may be prescribed for individuals experiencing symptoms of low testosterone levels, such as decreased libido, fatigue, muscle weakness, and bone loss. It may also be used in certain cases of adrenal insufficiency where DHEA levels are low. The topical application allows for the hormones to be absorbed through the skin, bypassing the gastrointestinal tract, and potentially reducing the risk of systemic side effects.

It is important for both patients and prescribers to understand that the use of this cream should be based on a thorough evaluation of the patient's hormonal profile and clinical symptoms. Regular monitoring of hormone levels and clinical response is recommended to ensure the effectiveness of the treatment and to adjust the dose if necessary. Patients should be instructed on the proper use of the pump, the amount of cream to apply, and the appropriate sites of application on the body.

As with any hormone replacement therapy, there are potential risks and side effects associated with the use of DHEA and Testosterone. These may include but are not limited to, skin irritation at the site of application, acne, hair growth, and changes in mood or libido. It is crucial for patients to report any adverse effects to their healthcare provider promptly.

For further information, guidance on prescribing this formulation, or to address any specific concerns, please do not hesitate to reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is dedicated to providing support and expertise to ensure the safe and effective use of our compounded medications.

Drug Interactions

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The topical cream containing Dehydroepiandrosterone (DHEA) 25 mg and Testosterone 12.5 mg/ml is a hormone replacement therapy that can be used to treat various conditions such as certain endocrine disorders, adrenal insufficiency, sexual dysfunction, and some of the symptoms associated with aging. When considering the use of this formulation, it is important to be aware of potential drug interactions that may occur.

Both DHEA and testosterone are steroid hormones that can have systemic effects when absorbed through the skin. Therefore, they may interact with other medications that affect hormone levels or are metabolized by enzymes that could be influenced by steroids. For example, medications that are metabolized by the liver enzyme CYP3A4, such as certain statins, calcium channel blockers, and some antifungal and antibiotic drugs, could potentially have altered effects when used concurrently with this hormone cream.

Additionally, patients using insulin or oral diabetes medications should be monitored closely, as androgens like testosterone may alter blood glucose levels, potentially necessitating adjustments in antidiabetic medication dosages. Patients on anticoagulants, such as warfarin, should also be monitored as androgens may increase or decrease the blood-thinning effects, which could require dose adjustments.

It is also important to consider the impact on other hormonal therapies, including thyroid medications, as hormone levels can influence each other. Patients using corticosteroids or adrenocorticotropic hormone should be aware that DHEA and testosterone may enhance the effects of these medications, potentially leading to increased risk of side effects.

Patients should avoid using this cream in conjunction with other topical medications on the same skin area without prior consultation with a healthcare provider, as there may be interactions at the site of application that could alter the absorption or effectiveness of either medication.

Given the potential for systemic absorption, it is advisable to use caution when combining this hormone cream with other systemic hormones, such as oral contraceptives or hormone replacement therapies, as there may be additive effects or increased risk of side effects such as changes in libido, hair growth, or mood alterations.

Lastly, it is important to note that the use of any supplements or over-the-counter medications should be discussed with a healthcare provider, as these can also interact with hormone therapies. For example, certain herbal supplements, such as St. John's Wort, may affect hormone metabolism and could potentially reduce the effectiveness of the topical cream.

Patients and prescribers are encouraged to review all medications, including over-the-counter drugs and supplements, with a healthcare provider to ensure safety and efficacy when using this topical hormone cream. If you have any questions or require further information regarding drug interactions with this formulation, please reach out to us at Bayview Pharmacy for personalized advice and support.

How Does it Work

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The Dehydroepiandrosterone (DHEA) 25 mg/Testosterone 12.5 mg/ml Topical Cream is a specially compounded formulation that combines two androgens, DHEA and testosterone, in a cream base for topical application. DHEA is a naturally occurring hormone that serves as a precursor to testosterone and other sex hormones. When applied topically, DHEA is absorbed through the skin and can be converted into testosterone and other hormones within the body. This conversion can help to supplement low levels of these hormones, which may occur due to aging or certain medical conditions.

Testosterone, the second active ingredient in this formulation, is a key male sex hormone that plays a crucial role in muscle mass, bone density, and the regulation of mood and energy levels. When applied topically, testosterone is absorbed directly into the local tissue, which can lead to an increase in the hormone's levels in the body. This can be beneficial for individuals experiencing symptoms of low testosterone, such as decreased libido, fatigue, and loss of muscle mass.

The cream is designed to be dispensed from a pump mechanism, which allows for precise dosing and ease of application. The pump dispenses a consistent amount of cream with each use, ensuring that patients receive the correct dose of medication. The topical application allows the active ingredients to be absorbed through the skin, directly into the bloodstream, bypassing the gastrointestinal tract and potentially reducing systemic side effects.

This formulation is used to treat various disease states associated with low levels of DHEA and testosterone, such as adrenal insufficiency, hypogonadism, and certain conditions that cause muscle wasting. By providing a localized treatment, the cream can help to alleviate symptoms associated with these conditions, such as weakness, depression, and decreased sexual function. It is important to note that the use of this cream should be guided by a healthcare professional, as hormone replacement therapy can have significant effects on the body and requires careful monitoring.

For patients and prescribers interested in using this formulation, it is essential to understand that individual responses to hormone therapy can vary. Regular follow-up and monitoring of hormone levels are necessary to ensure the treatment is effective and to adjust dosages as needed. If you have any questions or require further information about the Dehydroepiandrosterone 25 mg/Testosterone 12.5 mg/ml Topical Cream, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to provide support and guidance tailored to your specific needs.

Other Uses

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The Dehydroepiandrosterone (DHEA) 25 mg/Testosterone 12.5 mg/ml topical cream is primarily indicated for conditions associated with low or deficient levels of these hormones, such as certain endocrine disorders, androgen deficiency, or skin conditions where androgens may play a role in therapy. However, there may be alternative uses for this formulation worth exploring. Some patients and prescribers have found an off-label application for this cream in the management of age-related skin changes, given that DHEA has been purported to have anti-aging effects on the skin, potentially leading to its enhanced appearance, elasticity, and moisture content. Moreover, Testosterone is occasionally considered for its possible role in improving libido and sexual function in postmenopausal women as part of a hormone replacement therapy strategy, although this is a much-debated and less-common use of the medication.

Another potential area of interest for the DHEA/Testosterone cream is in the field of bodybuilding or sports to support muscle strength and performance, although this particular application can carry significant risks and is not generally medically approved. It's important to note that the illicit use of testosterone, even topically, can result in serious legal and health consequences, including hormonal imbalances, mood alterations, and other endocrine disruptions. This formulation might also be considered for research purposes in clinical trials studying the systemic effects of transdermal hormones on various aspects of health such as metabolism, cardiovascular health, and neuroprotective effects. However, such uses should always be approached with caution, under the guidance of appropriate regulatory authorities and ethical standards.

While some research has suggested that DHEA and Testosterone have immunomodulatory properties, their use as immune system modulators in practice is limited and not well established. As with any medication, especially those involving hormones, the off-label use of the Dehydroepiandrosterone 25 mg/Testosterone 12.5 mg/ml topical cream should be considered carefully, weighing the potential benefits against the risks and possible side effects. It is critical for patients and prescribers to engage in a thorough risk-benefit analysis and to consult the latest research and clinical guidelines before using this formulation for non-standard applications.

For any inquiries or more information about the extended applications of this DHEA/Testosterone topical cream, prescribers and patients are encouraged to reach out to us at Bayview Pharmacy. Our trained compounding pharmacists are on hand to help ensure the safe and effective use of compounded medications, including providing detailed guidance about the best practices for their application and potential side effects to monitor.

Frequently Asked Questions

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What is Dehydroepiandrosterone/Testosterone Topical Cream used for?

This compounded formulation combines dehydroepiandrosterone (DHEA) and testosterone, which are both hormones that can influence a variety of body functions. The cream is typically used to address certain medical conditions under the guidance of a healthcare provider, which may include hormone imbalances or deficiencies. It's vital to follow your healthcare provider's instructions on how and when to use this medication.

How do you apply the Dehydroepiandrosterone/Testosterone Topical Cream?

To apply the cream, use the pump mechanism to dispense the prescribed amount of topical cream onto your skin. Apply a thin layer to the area as directed by your healthcare provider, usually once daily. The pump design helps to ensure that each dose is consistent and controlled.

Can the Dehydroepiandrosterone/Testosterone Topical Cream be applied anywhere on the body?

No, you should not apply the cream just anywhere. Your healthcare provider will give you specific instructions on where to apply the cream, as the application site can affect how the medication is absorbed into your body. It is generally applied to areas with thinner skin, such as the inner thighs or inner arms.

Is the Dehydroepiandrosterone/Testosterone Topical Cream safe for everyone?

No, the cream is not safe for everyone. It should be used under a physician's supervision, especially for people with hormone-sensitive conditions, pregnant women, or in individuals with a history of liver problems, heart disease, or prostate issues. Always discuss your health conditions with your healthcare provider before starting any new medication.

How should I store the compounded cream?

The cream should be stored at room temperature away from light and moisture. Do not store it in the bathroom. Keep the container closed when not in use and keep it out of reach of children and pets. Refer to the storage instructions provided by your compounding pharmacy for any specific details.

Are there any side effects of using the Dehydroepiandrosterone/Testosterone Topical Cream?

As with any medication, there may be side effects. Potential side effects can include local irritation at the application site, acne, hair growth or loss, changes in libido, and mood fluctuations. Systemic side effects are less common with topical application but can occur. If you experience any side effects, contact your healthcare provider promptly.

Can you shower or swim immediately after applying the cream?

You should avoid showering, swimming, or washing the application area for a certain period after applying the cream to ensure proper absorption. Your healthcare provider will give you specific instructions, but typically, it's best to wait at least 1-2 hours before getting the treated area wet.

How long does it take for the cream to work?

The time needed to see results can vary depending on the individual and their condition. It's important to use the medicine as directed and allow some time for the hormones to adjust within your body. Some people may notice effects in a few weeks, while for others, it might take longer. Consistently follow up with your healthcare provider to gauge the effectiveness of the treatment.

Will the use of Dehydroepiandrosterone/Testosterone Topical Cream affect hormonal labs or tests?

Yes, using this compounded cream can affect lab results, particularly tests that measure hormone levels. It's important to inform any healthcare provider who is ordering labs that you are using this medication. They will need this information to accurately interpret your test results.

Can I use other topical products with Dehydroepiandrosterone/Testosterone Topical Cream?

You should consult your healthcare provider before using other topical products in conjunction with this cream. Certain products may interact and affect the absorption and effectiveness of the hormones or could cause additional irritation.

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Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.