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Dehydroepiandrosterone 15 mg/g/Testosterone 3 mg/g Topical Cream

The Dehydroepiandrosterone 15 mg/g/Testosterone 3 mg/g Topical Cream is a semisolid preparation that combines two hormone active ingredients. This cream is specifically formulated for transdermal delivery through a pump mechanism, which ensures a convenient, controlled, and consistent application to the skin. The inclusion of dehydroepiandrosterone (DHEA) and testosterone in the cream is intended for the treatment of various disease states, including but not limited to, conditions associated with hormone deficiencies such as certain types of adrenal insufficiency, androgen deficiency in men, and to address symptoms related to hormonal imbalances in postmenopausal women. The topical route of administration targets localized treatment areas, allowing for direct absorption of the active ingredients into the skin, potentially minimizing systemic side effects.

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Topical Cream
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Formula Information

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Dehydroepiandrosterone (DHEA) 15 mg/g and Testosterone 3 mg/g Topical Cream is a compounded medication specifically formulated to address conditions related to hormonal imbalances or deficiencies. DHEA is a naturally occurring hormone that serves as a precursor to testosterone and other sex hormones. The inclusion of DHEA in this cream aims to elevate the levels of this hormone in the body, potentially improving a range of health issues such as adrenal insufficiency, depression, osteoporosis, and sexual dysfunction. The addition of testosterone, a key male sex hormone, is intended to treat conditions associated with low testosterone levels, including hypogonadism, decreased libido, and certain types of erectile dysfunction.

The cream is compounded into a semisolid preparation that is dispensed in a pump mechanism. This delivery system is designed for ease of use, allowing for convenient and controlled application on the skin. The topical route of administration is chosen for its ability to provide localized treatment, which may reduce systemic side effects and improve the targeted delivery of the active ingredients. The cream facilitates the absorption of DHEA and testosterone directly through the skin, where they can exert their effects locally or be absorbed into the bloodstream for systemic distribution.

Patients using this cream may experience an improvement in symptoms associated with hormonal deficiencies, such as increased energy levels, improved mood, enhanced libido, and better overall well-being. Prescribers may consider this formulation for patients who have not responded to conventional treatments or who may benefit from a localized application of hormones. It is important to note that hormone replacement therapy with DHEA and testosterone should be closely monitored by a healthcare professional to ensure safety and efficacy, and to adjust dosing as necessary based on patient response and hormone levels.

As with any compounded medication, this formulation is prepared in a pharmacy setting where pharmacists can tailor the strength and dosage form to the specific needs of the patient. Compounding pharmacists at Bayview Pharmacy are equipped to provide guidance on the appropriate use of this cream, potential side effects, and any other concerns that patients or prescribers may have. For more detailed information or to discuss individual patient needs, please reach out to us. Our team is committed to supporting both patients and healthcare providers in the safe and effective use of compounded medications.

Drug Interactions

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Dehydroepiandrosterone (DHEA) and testosterone are both hormones that play a crucial role in various physiological processes. When compounded in a topical cream, they are primarily used to address conditions related to hormone deficiencies or imbalances, such as certain types of adrenal insufficiency, menopausal symptoms, or as part of hormone replacement therapy in males with hypogonadism. The topical application of these hormones aims to provide a localized or systemic effect, depending on the condition being treated.

When using a topical cream containing DHEA and testosterone, it is important to consider potential drug interactions. Both DHEA and testosterone can interact with a variety of medications and substances. For instance, they may interact with anticoagulants such as warfarin, potentially altering the effects of the anticoagulant and necessitating closer monitoring of coagulation parameters. Additionally, patients using insulin or oral hypoglycemic agents should be monitored for changes in blood glucose levels, as androgens may alter the metabolism of glucose and insulin sensitivity.

Concomitant use of other hormones, such as estrogen or progestins, may require dosage adjustments due to the additive or synergistic effects of combined hormone therapy. Patients should also be aware that the use of DHEA and testosterone may influence the metabolism of certain medications through their effects on liver enzymes, particularly those in the cytochrome P450 family. This can lead to either increased or decreased levels of other drugs, potentially impacting their efficacy or increasing the risk of adverse effects.

It is also important to consider the impact of DHEA and testosterone on certain medical conditions. For example, patients with hormone-sensitive cancers, such as breast or prostate cancer, should avoid using this cream unless specifically directed by a healthcare provider, as it may exacerbate the condition. Additionally, patients with liver disease, heart disease, or a history of thromboembolic disorders should use this medication with caution and under close medical supervision.

Topical application of hormones may also interact with over-the-counter supplements and herbal products. For example, products containing soy or phytoestrogens may alter the effects of DHEA and testosterone. Patients should inform their healthcare provider of all medications, supplements, and herbal products they are using to avoid potential interactions.

It is essential for patients to follow the prescribed dosage and application instructions to minimize the risk of systemic absorption and potential interactions. The cream should be applied to clean, intact skin, and patients should wash their hands thoroughly after application to prevent the accidental transfer of hormones to others.

Patients and prescribers should be aware that this is not an exhaustive list of all potential drug interactions. It is important to consult with a healthcare provider or pharmacist before starting any new medications, including over-the-counter drugs and supplements, while using this topical hormone cream. If you have any questions or concerns regarding the use of this formulation or potential drug interactions, please reach out to us at Bayview Pharmacy for further assistance.

How Does it Work

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The Dehydroepiandrosterone (DHEA) 15 mg/g and Testosterone 3 mg/g Topical Cream is a compounded medication that combines two androgens, DHEA and testosterone, in a cream base for topical application. The cream is designed to be applied directly to the skin, where it is absorbed into the local tissue and potentially into the systemic circulation. The inclusion of both DHEA and testosterone is intended to address conditions related to hormone deficiencies or imbalances.

DHEA is a naturally occurring hormone produced by the adrenal glands, which serves as a precursor to testosterone and other sex hormones. It is involved in a wide range of biological functions, including immune response, energy level, mood regulation, and sexual function. As people age, DHEA levels naturally decline, which can lead to various health issues. By supplementing with DHEA topically, it is thought to help restore more youthful levels of the hormone, potentially improving the symptoms associated with its deficiency.

Testosterone, the primary male sex hormone, plays a crucial role in maintaining muscle mass, bone density, and sexual function. It also has significant effects on mood and overall well-being. In both men and women, testosterone levels can decrease due to age or other factors, leading to symptoms such as decreased libido, fatigue, and loss of muscle strength. Topical application of testosterone can help to alleviate these symptoms by providing a direct source of the hormone to the body.

The cream is formulated in a semisolid base that allows for easy application and absorption through the skin. The pump mechanism is designed to dispense a controlled amount of the cream with each actuation, ensuring consistent dosing. This dosage form is particularly beneficial for patients who may have difficulties with oral administration or for those who prefer to avoid the hepatic first-pass effect associated with oral androgens.

When applied as directed, the cream facilitates the absorption of DHEA and testosterone into the skin, where they can exert their effects locally. Some of the medication may also enter the systemic circulation, potentially providing broader benefits. This formulation is commonly used to treat conditions such as adrenal insufficiency, where DHEA production is low, and hypogonadism, where the body does not produce enough testosterone. It may also be used in certain cases of sexual dysfunction and to improve general well-being in individuals with low levels of these hormones.

It is important for patients and prescribers to understand that the use of this compounded formulation should be based on a thorough evaluation of the patient's hormonal status and clinical needs. Regular monitoring of hormone levels and clinical response is recommended to ensure the treatment is effective and to adjust the dosage as necessary. As with any medication, there may be potential side effects, and patients should be counseled on what to expect and when to seek medical advice.

If you have any questions or require further information about this formulation, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to provide guidance and support to ensure the safe and effective use of this medication.

Other Uses

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The combination formulation of Dehydroepiandrosterone (DHEA) 15 mg/g and Testosterone 3 mg/g as a topical cream is primarily employed for its potential benefits in addressing certain medical conditions like hormone deficiencies and certain conditions of menopause, as well as testosterone replacement therapy. However, beyond these specific disease states, this topical preparation has been subjected to research for its potential off-label uses which may include improving skin health and quality, given the role of these hormones in maintaining skin structure and function. Furthermore, some users might explore the cream for its purported anti-aging effects, as both DHEA and Testosterone may influence the appearance of the skin and body composition.

There is evidence suggesting that this hormone combination could have mood and energy-boosting effects, which could be attributed to the role of DHEA and Testosterone in neurological health. Patients experiencing mood fluctuations or fatigue sometimes seek out this hormone therapy. Another potential but less documented use could be for enhancing sexual function and libido, as these hormones can influence sexual desire and performance. In addition, some studies have proposed the application of these hormones in wound healing due to their potential involvement in cellular repair processes, though this use would require further investigation before it can be routinely recommended.

While this formulation provides promising applications, it is critical to approach its use with caution, primarily due to the powerful nature of hormone therapy and the potential for side effects or hormone imbalances. Patients interested in utilizing this topical cream for conditions other than those it has been prescribed for should consult with their healthcare provider to discuss the potential risks and benefits. Prescribers pondering the prescription of this formulation for non-established indications should ensure thorough patient evaluation and rely on the best available clinical evidence. For further inquiries or detailed information, patients and healthcare providers are encouraged to reach out to us at Bayview Pharmacy for assistance.

Frequently Asked Questions

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What is the purpose of this topical cream containing Dehydroepiandrosterone (DHEA) and Testosterone?

This compounded topical cream is designed to facilitate the absorption of Dehydroepiandrosterone (DHEA) and Testosterone through the skin. It may be used for various conditions where the administration of these hormones is indicated, such as certain hormonal deficiencies, and it should only be used under the guidance of a healthcare provider.

How should I apply the Dehydroepiandrosterone/Testosterone cream?

Apply a thin layer of the cream to clean, dry skin in the area as directed by your healthcare provider. Use the pump mechanism to get a controlled amount of the cream for each application to ensure consistent dosing.

How often should I apply this topical cream?

The frequency of application will be based on your individual treatment plan prescribed by your healthcare provider. Follow their instructions carefully and do not apply more often than recommended.

Can this Dehydroepiandrosterone/Testosterone cream be applied to any area of the skin?

No, you should only apply the cream to areas of the skin that your healthcare provider has specified. Certain areas may allow for better absorption or reduce the risk of transferring the hormones to others.

What should I do if I miss a dose of the Dehydroepiandrosterone/Testosterone cream?

If you miss a dose, apply it as soon as you remember. However, if it's almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.

Are there any side effects associated with this compounded hormone cream?

As with any medication, side effects may occur. These can include skin irritation, changes in hair growth, changes in libido, or other systemic effects. Contact your healthcare provider if you experience any unusual symptoms.

Should I avoid any activities or exposure to certain conditions while using this cream?

It is important to let the cream dry before dressing or coming into contact with other people to avoid hormone transfer. You may need to avoid activities that involve water or excessive sweating until the cream has fully absorbed.

How should I store this compounded cream?

Store the cream at room temperature away from light and moisture. Keep out of reach of children and pets. Do not freeze the cream, and do not store it in the bathroom where it can be exposed to heat and humidity.

Can this cream be used by both men and women?

This compounded cream may be prescribed to both men and women, but the conditions treated in each sex may differ. Use by individuals should only be under the guidance and prescription of a healthcare provider who has taken into account the specific hormonal needs of the patient.

What should I do if someone else accidentally comes into contact with my Dehydroepiandrosterone/Testosterone cream?

If someone else comes into contact with your cream, they should wash the area thoroughly with soap and water. Contact a healthcare provider if you are concerned about potential effects, especially in cases of contact with children or pets.

Is it safe to use this topical cream during pregnancy or while breastfeeding?

The safety of this hormone cream during pregnancy or lactation has not been established. Therefore, it is crucial to consult your healthcare provider before using this medication if you are pregnant, planning to become pregnant, or breastfeeding.

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Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.