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Formulas

Dehydroepiandrosterone 10 mg/Estradiol 0.65 mg/Estriol 2.75 mg/Progesterone 15 mg/Testosterone 1 mg/g Topical Cream

The Dehydroepiandrosterone 10 mg/Estradiol 0.65 mg/Estriol 2.75 mg/Progesterone 15 mg/Testosterone 1 mg/g Topical Cream is a compounded medication formulated to address symptoms associated with various hormonal imbalances and deficiencies. This cream is specifically designed to deliver a combination of hormones directly through the skin, which may be beneficial in treating conditions such as menopausal symptoms, including hot flashes, night sweats, and vaginal dryness. Additionally, it may be used in the management of age-related decreases in hormone levels, supporting overall hormonal balance and well-being.

The cream is a semisolid preparation that is dispensed in a pump mechanism, ensuring a convenient and controlled application. The pump allows for consistent dosing, which is critical for maintaining the precise hormone levels required for effective treatment. The topical route of administration provides localized treatment, which can minimize systemic side effects and improve patient compliance. This formulation is intended for use under the guidance of a healthcare professional with expertise in hormone replacement therapy.

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Dehydroepiandrosterone
Estradiol
Estriol
Progesterone
Testosterone
Topical Cream
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Formula Information

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This topical cream formulation combines dehydroepiandrosterone (DHEA), estradiol, estriol, progesterone, and testosterone in specific concentrations to address a variety of hormone-related conditions. The cream is designed to deliver 10 mg of DHEA, 0.65 mg of estradiol, 2.75 mg of estriol, 15 mg of progesterone, and 1 mg of testosterone per gram of cream. The semisolid preparation is dispensed in a pump mechanism, which ensures a convenient, hygienic, and controlled application. This delivery system is particularly beneficial for patients requiring consistent dosing and those who may have difficulty with other dosage forms.

The combination of hormones in this cream is often used in hormone replacement therapy (HRT) for menopausal and perimenopausal women, as well as for individuals with hormone deficiencies or imbalances. DHEA is a precursor to sex hormones and is believed to have a role in improving skin health and sexual function, as well as potentially enhancing mood and energy levels. Estradiol and estriol are forms of estrogen that can alleviate symptoms of estrogen deficiency such as hot flashes, vaginal dryness, and bone loss. Progesterone is included to counterbalance the effects of estrogen and reduce the risk of endometrial hyperplasia in women with an intact uterus. Testosterone, although typically considered a male hormone, plays a crucial role in female health as well, contributing to libido, mood stabilization, and muscle maintenance.

The topical route of administration allows for the hormones to be absorbed directly into the bloodstream through the skin, bypassing the gastrointestinal tract and liver, which can minimize potential side effects and improve hormonal uptake. This can be particularly advantageous for patients who have contraindications for oral hormone therapies or those who experience gastrointestinal side effects. The cream is intended for localized treatment, which can be beneficial for targeting specific areas of the body where hormone absorption is optimal, such as the inner arms, thighs, or abdomen.

It is important for both patients and prescribers to understand that hormone therapy should be tailored to an individual's specific needs and regularly monitored through clinical evaluation and laboratory tests to ensure safety and efficacy. The use of this compounded formulation should be guided by a healthcare professional with expertise in hormone replacement therapy. If you have any questions or require further information about this formulation and its use in treating hormone-related conditions, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is committed to providing support and guidance to ensure optimal patient care.

Drug Interactions

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The formulation you have described contains a combination of hormones: dehydroepiandrosterone (DHEA), estradiol, estriol, progesterone, and testosterone, which are intended for topical application. When considering drug interactions for this formulation, it is important to note that each component may interact with other medications or substances in different ways. As a result, the potential for drug interactions is complex and multifaceted.

Dehydroepiandrosterone (DHEA) is a precursor to sex steroids and may interact with medications that are also metabolized by the liver's cytochrome P450 enzymes, such as CYP3A4. This could potentially alter the metabolism of other drugs. Patients taking medications that are substrates, inhibitors, or inducers of these enzymes should be monitored for altered drug effects or side effects. Additionally, DHEA may influence insulin sensitivity and glucose metabolism, so caution is advised when used with antidiabetic drugs.

Estradiol and estriol are forms of estrogen and can interact with substances that affect hormone levels or their metabolism. For instance, certain anticonvulsants, such as phenobarbital and phenytoin, and some antibiotics, like rifampicin, may decrease the effectiveness of estrogens by increasing their metabolism. Conversely, drugs such as ketoconazole, which inhibit cytochrome P450 enzymes, may increase estrogen levels. Estrogens may also interfere with the pharmacokinetics of other hormones, such as thyroid agents, necessitating adjustments in dosing. Additionally, estrogens can potentiate the effects of corticosteroids and may alter the coagulation profile, especially in patients taking anticoagulants like warfarin.

Progesterone can interact with drugs that induce or inhibit hepatic enzymes, particularly CYP3A4. Similar to estrogens, progesterone may also affect the metabolism of other drugs. It is important to monitor patients taking progesterone in combination with other medications metabolized by the liver for changes in therapeutic and adverse effects. Progesterone may also interact with benzodiazepines and some anesthetics, potentially altering their effects.

Testosterone, being an androgen, may interact with anticoagulants, such as warfarin, by altering the synthesis of clotting factors and thus may necessitate dose adjustments. Testosterone may also affect blood glucose levels, which is particularly relevant for patients on antidiabetic medications. Additionally, drugs that affect testosterone metabolism, such as those affecting the CYP3A4 enzyme, can lead to altered levels of testosterone and should be used with caution.

It is important to note that the systemic absorption of these hormones from a topical cream can vary, and the potential for interactions may be different compared to oral or parenteral formulations. Patients should be advised to inform their healthcare providers of all medications, supplements, and herbal products they are taking to assess for potential interactions. Prescribers should closely monitor patients for any signs of adverse effects or changes in the efficacy of their medications when initiating or adjusting therapy with this hormone combination cream.

This hormone combination cream is used to treat various conditions related to hormone deficiencies or imbalances, such as menopausal symptoms, certain cases of infertility, and specific endocrine disorders. The effectiveness and safety of this formulation depend on proper dosing, application, and monitoring for side effects and interactions. If you have any questions or require further information, please reach out to us at Bayview Pharmacy for assistance.

How Does it Work

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The formulation of Dehydroepiandrosterone (DHEA) 10 mg/Estradiol 0.65 mg/Estriol 2.75 mg/Progesterone 15 mg/Testosterone 1 mg/g in a topical cream is a compounded bioidentical hormone replacement therapy (BHRT) designed to alleviate symptoms associated with hormonal imbalances or deficiencies. Each of the active ingredients plays a crucial role in the body's endocrine system and contributes to the overall effectiveness of the treatment.

DHEA is a hormone produced by the adrenal glands and is a precursor to both estrogen and testosterone. Supplementation with DHEA can help improve energy levels, mood, and libido, as well as support bone density and immune function. Estradiol and estriol are forms of estrogen, the primary female sex hormone. Estradiol is the most potent form of estrogen and is crucial for reproductive health, bone density, and cardiovascular health. Estriol, being a weaker estrogen, is thought to provide some of the benefits of estrogen replacement with a lower risk of side effects. Together, these estrogens can help alleviate symptoms of menopause such as hot flashes, vaginal dryness, and mood swings.

Progesterone is another key female hormone that works in tandem with estrogen to regulate the menstrual cycle and maintain the lining of the uterus. In a postmenopausal woman or in cases where estrogen therapy is prescribed, progesterone is added to counterbalance the effects of estrogen and reduce the risk of endometrial hyperplasia and cancer. Progesterone can also aid in improving sleep quality and reducing anxiety and mood swings.

Testosterone, while typically considered a male hormone, is also present in females and plays a role in maintaining muscle mass, bone density, and sexual function. In women, low levels of testosterone can lead to decreased libido, fatigue, and loss of muscle strength. By including a small amount of testosterone in the formulation, it can help address these issues without the side effects associated with higher doses.

The cream is formulated to be applied topically, which allows for the hormones to be absorbed directly through the skin into the bloodstream, bypassing the gastrointestinal tract and liver, which can alter hormone levels and increase the risk of side effects. The pump mechanism ensures a consistent and accurate dose with each application, which is important for maintaining stable hormone levels. The cream is typically applied to areas of thin skin, such as the inner arms or thighs, to facilitate absorption.

This compounded formulation is used to treat various disease states related to hormonal imbalances, including menopausal symptoms, premenstrual syndrome (PMS), and certain cases of infertility. It may also be used in hormone therapy for transgender individuals. The specific combination and dosage of hormones are tailored to the individual patient's needs, based on their symptoms and hormone levels.

It is important for patients and prescribers to understand that this is a customized medication prepared by a compounding pharmacy and should be used under the guidance of a healthcare professional. Regular monitoring of hormone levels and clinical response is recommended to ensure the treatment is effective and to adjust the dosage as necessary. If you have any questions or require further information about this formulation, please reach out to us at Bayview Pharmacy.

Other Uses

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Welcome to Bayview Pharmacy, where expert compounding pharmacists are dedicated to catering to individualized patient needs. While the primary indication of our compounded topical cream containing Dehydroepiandrosterone (DHEA) 10 mg, Estradiol 0.65 mg, Estriol 2.75 mg, Progesterone 15 mg, and Testosterone 1 mg is for hormone replacement therapy (HRT) in women, especially during menopause or perimenopause, this unique formulation may have additional applications.

Aside from its use in addressing symptoms of estrogen deficiency, such as hot flashes, night sweats, vaginal dryness, and osteoporosis prevention, this custom-compounded hormone preparation might be used to support general skin health and quality. For example, the components in this cream potentially contribute to improving skin elasticity and moisture, as well as reducing the appearance of wrinkles. These aesthetic benefits, however, are secondary and not the primary reason for prescribing this formulation.

Moreover, while not the main purpose, a formulation like ours could be considered for off-label use in certain cases of primary or secondary adrenal insufficiency, where DHEA supplementation is indicated to counter the effects of low endogenous steroid production. On that note, the testosterone component, albeit in a low dosage, may be utilized to aid in libido enhancement in certain women diagnosed with sexual dysfunction due to a testosterone deficiency. The blend of hormones in this cream works synergistically to maintain a hormonal balance, which is crucial for overall wellbeing.

Importantly, patients should not use this medication for any of these additional uses without first consulting a healthcare provider. A comprehensive evaluation and the provider's clinical judgement are paramount in deciding whether this product could be beneficial for uses other than its main indication. Close monitoring for side effects, such as skin irritation or systemic hormonal effects, is also necessary for safety purposes.

Please note that the effectiveness and safety of this formulation for uses beyond those initially intended have not been established by rigorous clinical studies. Therefore, prescribing this cream for alternative uses should be approached with caution and under the guidance of a qualified healthcare professional well-versed in hormone replacement therapy and compounding medications.

We, at Bayview Pharmacy, prioritize the health and safety of our patients above all else. If you have any questions about this formulation or its potential uses, or if you need guidance on dosage and administration, do not hesitate to reach out to us. Our team of knowledgeable compounding pharmacists is here to support practitioners and patients alike in ensuring optimal treatment efficacy and safety.

Frequently Asked Questions

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What is this topical cream used for?

This compounded formulation is designed to provide hormone replacement therapy for individuals who may benefit from the combination of these hormones. It is commonly used to manage symptoms associated with menopause, androgen deficiency, or other hormonal imbalances.

How do I apply this topical cream?

The cream should be applied to clean, dry skin, usually on the arms, thighs, or abdomen. Follow your healthcare provider's instructions regarding the exact area for application. Use the pump mechanism to dispense the prescribed amount of cream, and gently rub it into the skin until fully absorbed.

How often should I use this compounded formulation?

The frequency of application will depend on your specific treatment plan as determined by your healthcare provider. Do not alter the prescribed dosage without consulting them.

What are the benefits of using a pump mechanism for this cream?

The pump mechanism is designed to provide a controlled and consistent dose with each application, reducing the variability of dosing and the potential for error. It also helps to prevent contamination of the product.

Can this cream cause any side effects?

As with any hormonal treatment, side effects can occur. These may include skin irritation at the site of application, changes in mood or libido, and other hormone-related effects. Please consult your healthcare provider if you experience any adverse effects.

Does this cream interact with other medications?

This hormonal cream may potentially interact with other medications. It is important to discuss all prescription and over-the-counter medications, as well as supplements you are taking, with your healthcare provider to prevent adverse drug interactions.

Should I apply the cream at a particular time of day?

Your healthcare provider will advise you on the best time of day to apply the cream, which may be based on your daily routine or whether you are using other medications or therapies.

How should I store this topical hormone cream?

Store the cream at room temperature, away from direct sunlight and heat. Do not freeze the medication. Keep the container tightly closed when not in use to protect it from contamination or spoilage.

What should I do if I miss a dose?

If you miss a dose, apply the cream as soon as you remember, unless it is almost time for your next scheduled dose. Do not double up on doses to make up for a missed application. For more guidance, contact your healthcare provider.

Can I use this cream if I am pregnant or breastfeeding?

Due to the hormonal content, this cream is generally not recommended for use during pregnancy or while breastfeeding. Please consult with your healthcare provider before using this medication if you are pregnant or nursing.

How long does it take to see the effects of this hormonal cream?

The onset of the cream’s effects can vary from person to person. Some individuals may notice improvements within a few weeks, while for others, it may take longer. Consistent use as directed by your healthcare provider is key to achieving the best results.

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Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.