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DHEA 5 mg/Estradiol 0.35 mg/Estriol 2 mg/Progesterone 30 mg/Testosterone 0.15 mg/ml Topical Cream

Description: This topical cream is a compounded hormone replacement therapy (HRT) formulation that combines dehydroepiandrosterone (DHEA) 5 mg, estradiol 0.35 mg, estriol 2 mg, progesterone 30 mg, and testosterone 0.15 mg per milliliter. The cream is designed to be dispensed from a pump mechanism, ensuring a consistent and controlled dose with each application. The semisolid preparation is intended for transdermal delivery, where the active ingredients are absorbed through the skin to exert their effects locally or systemically. This formulation is typically used in the management of menopausal symptoms, such as hot flashes, night sweats, vaginal dryness, and osteoporosis prevention. It may also be used to address hormone imbalances in conditions like hypoestrogenism, hypogonadism, and certain cases of infertility. The combination of hormones aims to mimic the body's natural hormone levels, providing relief from the aforementioned disease states while minimizing the risk of side effects associated with hormone replacement therapy.

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Topical Cream
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Formula Information

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This compounded formulation combines dehydroepiandrosterone (DHEA), estradiol, estriol, progesterone, and testosterone into a topical cream designed to deliver a precise dosage of hormones directly through the skin. Each milliliter of the cream contains 5 mg of DHEA, 0.35 mg of estradiol, 2 mg of estriol, 30 mg of progesterone, and 0.15 mg of testosterone. The cream is dispensed in a pump mechanism, which ensures a consistent and controlled dose with each application, enhancing patient compliance and ease of use.

The combination of these hormones is often used in hormone replacement therapy (HRT) for individuals experiencing symptoms associated with menopause or hormonal imbalances. DHEA is a precursor to both estrogen and testosterone and may help improve sexual function, mood, and overall well-being. Estradiol and estriol are forms of estrogen that can alleviate menopausal symptoms such as hot flashes, vaginal dryness, and bone loss. Progesterone is included to counterbalance the effects of estrogen and reduce the risk of endometrial hyperplasia, which can occur with estrogen therapy alone. Testosterone in this formulation may contribute to libido, mood stabilization, and muscle maintenance.

It is important for patients and prescribers to understand that this formulation is tailored for individual needs and should be used under the guidance of a healthcare professional experienced in hormone replacement therapy. Monitoring hormone levels and adjusting the dosage may be necessary to achieve optimal therapeutic outcomes while minimizing potential side effects. Patients should apply the cream as directed to clean, intact skin, typically on areas such as the inner arms or thighs, where absorption is efficient and consistent.

For prescribers considering this formulation for their patients, it is crucial to take a comprehensive medical history and conduct a thorough evaluation to ensure the appropriateness of this HRT approach. Potential interactions with other medications, contraindications, and the patient's individual risk factors for hormone-sensitive conditions should be assessed. As compounding pharmacists at Bayview Pharmacy, we are available to collaborate with healthcare providers to customize this formulation to meet the specific needs of their patients. If you have any questions or require further information about this compounded hormone therapy, please reach out to us for professional guidance and support.

Drug Interactions

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The formulation described contains a combination of hormones: dehydroepiandrosterone (DHEA), estradiol, estriol, progesterone, and testosterone, which are intended for topical application. Each of these hormones can have interactions with other medications, supplements, or conditions, and it is important to consider these when prescribing or using this formulation.

DHEA is a precursor to sex hormones and may interact with medications that affect hormone levels. It can potentially alter the effects of hormone replacement therapy (HRT) and should be used cautiously in patients receiving other forms of estrogen or androgen therapy. DHEA may also interact with anticoagulants, antiplatelet drugs, and supplements such as garlic, ginkgo, and fish oil, which can increase the risk of bleeding. Additionally, DHEA can affect insulin sensitivity and glucose metabolism, so caution is advised in patients with diabetes or metabolic syndrome.

Estradiol and estriol are forms of estrogen and can interact with drugs that are metabolized by liver enzymes, particularly cytochrome P450 enzymes such as CYP3A4. Medications that induce or inhibit these enzymes may affect the levels and efficacy of the estrogens. Concurrent use with other estrogens or progestins should be monitored for additive effects. Estrogens can also increase the risk of thromboembolic events, so caution is advised when used with drugs that affect coagulation, such as warfarin or heparin. Additionally, thyroid hormone levels may be altered when taking estrogens, necessitating adjustments in thyroid medication dosages.

Progesterone can interact with benzodiazepines, some anticonvulsants, and certain antidepressants, potentially leading to increased sedation or other side effects. It may also interact with drugs that induce or inhibit hepatic enzymes, such as CYP3A4, affecting its metabolism and serum levels. Progesterone, like estrogens, can also affect coagulation, so caution is advised when used with anticoagulant or antiplatelet medications.

Testosterone can interact with oral anticoagulants, altering the anticoagulant effect and potentially requiring dose adjustments. It may also affect blood glucose levels, necessitating monitoring and possible adjustments of antidiabetic medications. Testosterone can be affected by drugs that induce or inhibit hepatic enzymes, such as CYP3A4, which can alter its metabolism and effectiveness.

This hormone combination cream is used to treat various conditions related to hormone deficiencies or imbalances, such as menopausal symptoms, androgen deficiency, and certain cases of premenstrual syndrome (PMS). It is important to note that the use of hormone therapy should be individualized and based on a thorough evaluation of the patient's medical history, current medications, and specific treatment goals. Patients should be monitored for side effects and response to therapy, and the risk-benefit profile should be regularly reassessed.

It is crucial for patients and prescribers to be aware of potential interactions and to monitor for any adverse effects or changes in efficacy when using this formulation. If you have any questions or require further information, please reach out to us at Bayview Pharmacy for assistance.

How Does it Work

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The DHEA 5 mg/Estradiol 0.35 mg/Estriol 2 mg/Progesterone 30 mg/Testosterone 0.15 mg/ml Topical Cream is a compounded formulation that combines several hormones to address various conditions related to hormonal imbalances or deficiencies. This cream is designed to be applied topically, which allows for the hormones to be absorbed directly through the skin into the bloodstream, providing a more targeted approach to therapy with potentially fewer systemic side effects compared to oral administration.

DHEA, or dehydroepiandrosterone, is a hormone produced by the adrenal glands that serves as a precursor to other sex hormones, including estrogen and testosterone. Supplementing with DHEA can help improve overall hormonal balance, support adrenal function, and may have benefits for mood, energy, and skin health. Estradiol and estriol are forms of estrogen, the primary female sex hormone. They are used to alleviate symptoms of menopause such as hot flashes, vaginal dryness, and bone loss. By combining estradiol with estriol, the formulation aims to provide a balanced estrogenic effect that can be beneficial for hormone replacement therapy.

Progesterone is another key hormone for women's health, particularly in balancing the effects of estrogen and supporting the menstrual cycle and pregnancy. In this formulation, progesterone can help to counteract potential side effects of estrogen therapy and is often used in hormone replacement therapy to mimic the natural cyclical production of hormones. Testosterone, while typically considered a male hormone, is also important for women in small amounts. It can contribute to libido, bone density, and muscle strength. The inclusion of testosterone in this formulation is to ensure a comprehensive approach to hormone balance.

The cream is dispensed in a pump mechanism, which allows for precise dosing and ease of use. Patients are typically instructed to apply the cream to areas of thin skin, such as the inner arms or thighs, where absorption can be maximized. The dose and frequency of application will depend on the individual's specific needs and the guidance of their healthcare provider.

This hormone combination cream may be used to treat symptoms associated with menopause, perimenopause, andropause, or other conditions where hormone replacement therapy is indicated. It is important to note that hormone therapy should be personalized and closely monitored by a healthcare provider to ensure safety and efficacy. Regular follow-up and adjustments to the formulation may be necessary based on patient response and laboratory results.

If you have any questions about this formulation or how it might be beneficial for your specific condition, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to provide you with the information and support you need to make informed decisions about your health.

Other Uses

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The combination of DHEA, estradiol, estriol, progesterone, and testosterone in a topical cream formulation is primarily prescribed for hormone replacement therapy, particularly in perimenopausal, menopausal, and postmenopausal women, or for those experiencing symptoms related to hormonal imbalances or deficiencies. However, this formulation can have a range of other potential uses that arise from the properties of its individual components. For example, DHEA has been studied for its potential effects on mood enhancement, adrenal support, and its ability to improve the skin's appearance by increasing its thickness and decreasing facial skin pigmentation.

Estradiol and estriol, two forms of estrogen, have been used topically not just for menopausal symptoms, but also for promoting skin health and potentially improving skin elasticity and moisture. Some studies suggest that topical estrogen might promote collagen production and help in the prevention of skin aging. Progesterone, beyond its role in hormone replacement therapy, may exert a calming effect on the mood and facilitate sleep when applied in the evening due to its metabolites that have a sedative effect.

Testosterone, although typically associated with male hormone replacement, is also important in female hormone therapy. In a topical cream form, it could improve libido, muscle strength, and overall sense of well-being in women. In addition, given that the skin often shows the first signs of hormone deficiencies, such as elasticity loss, dryness, and thinning, this combination cream might help in maintaining a healthier skin structure and function.

It's important to note that while this formulation may have these additional uses, the majority of the evidence for benefits outside of traditional hormone replacement therapy is still evolving, and more research is needed to fully understand and verify these potential effects. Patients should use this treatment under the supervision of a healthcare provider, as it is tailored to address specific hormonal imbalances and should be used according to the individual needs and response to therapy. Prescribers should monitor patient progress and make adjustments as necessary. If you are considering this formulation for uses other than the prescribed indication or if you have any questions or concerns about its use, do not hesitate to reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is here to provide guidance and support tailored to your unique health needs.

Frequently Asked Questions

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What is the purpose of this topical cream?

This compounded formulation is designed to deliver a combination of hormones: DHEA, Estradiol, Estriol, Progesterone, and Testosterone directly through the skin, which can provide a range of therapeutic benefits. Each hormone can play a role in addressing different health concerns, including menopausal symptoms, hormonal imbalances, and deficiency states. Always consult a healthcare provider for specific medical advice and to know if this product is right for you.

How do I use this topical hormone cream?

Apply the cream as directed by your healthcare provider. The exact amount and application site can vary based on individual needs, but generally, the cream should be applied to clean, dry skin on areas where it can be rubbed in and absorbed, such as the thighs, abdomen, or inner arms. Do not apply to the breasts or face unless instructed by your physician.

Can men use this compounded hormone cream?

While some of the hormones in this cream are typically associated with female health, men may be prescribed such a cream for certain conditions under the careful guidance of a healthcare provider. It's important to use this cream only as prescribed and consult with your provider regarding suitability and dosage.

Are there any side effects associated with this hormone cream?

As with any hormonal product, side effects can occur and may include skin irritation at the application site, headaches, mood swings, and changes in menstrual periods or sexual desire. More serious side effects can occur but are less common. If you experience side effects or have concerns, contact your healthcare provider.

How should this cream be stored?

Store the cream at room temperature away from moisture, heat, and direct light. Keep the pump tightly closed when not in use and keep out of reach of children and pets. Do not freeze.

Can I apply moisturizer over this cream?

It is typically recommended to allow the hormone cream to fully absorb before applying other products like moisturizers. Wait at least a few minutes after application. To avoid any interference with absorption, consult with your healthcare provider regarding the timing and use of other skin products.

How does the pump mechanism work?

The pump mechanism is designed for convenient and controlled dosing. Prime the pump as directed by the specific product instructions or your pharmacist. Each pump dispenses a measured dose of cream, which aids in consistent application. If you are unsure of how to use the pump or if it appears to be malfunctioning, contact your pharmacy.

Can this cream be applied at any time of day?

The best time to apply this cream should be determined by your healthcare provider, as hormone levels can fluctuate throughout the day, and some may find it more beneficial to apply it at a certain time. Always follow the prescribed schedule.

What should I do if I miss a dose of the cream?

If you miss a dose, apply the cream as soon as you remember. However, if it's near the time of your next dose, skip the missed dose and continue on your regular schedule. Do not double the dose to catch up. If you miss multiple doses, consult your healthcare provider for guidance.

Is this hormone cream safe to use during pregnancy or while breastfeeding?

Hormonal products can have effects on pregnancy and breastfeeding, and their safety will depend on individual circumstances. It is essential to consult with a healthcare provider before using this cream if you are pregnant, planning to become pregnant, or are breastfeeding.

Can I use this cream concurrently with other medications?

Hormones can interact with other medications, so it's important to inform your healthcare provider of all the medications, supplements, and herbal products you're using. They can provide guidance on potential interactions and whether this compounded cream is safe to use with your other treatments.

Do I need a prescription to obtain this cream?

Yes, this is a compounded hormonal formulation and requires a prescription from a licensed healthcare provider. The ingredients and their concentrations are specifically tailored to your health needs, and it is illegal to obtain or use this without a prescription.

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Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.