The DHEA 3.25 mg/Estriol 2 mg/Vitamin E Acetate 200 IU Vaginal Suppository is a compounded medication designed to deliver its active ingredients directly to the vaginal area. DHEA, or dehydroepiandrosterone, is a hormone that serves as a precursor to sex hormones such as estrogen and testosterone. It is believed to play a role in a variety of bodily functions, including sexual health and overall well-being. In this formulation, DHEA may help to alleviate symptoms associated with hormonal imbalances or deficiencies, particularly in postmenopausal women.

Estriol, a form of estrogen, is included at a dose of 2 mg. Estriol is known for its relatively mild but effective estrogenic effects, which can be beneficial in treating symptoms of menopause such as vaginal dryness, atrophy, and inflammation. By directly applying estriol to the vaginal area, the formulation aims to provide targeted relief with potentially fewer systemic side effects compared to oral hormone replacement therapies.

Vitamin E Acetate is incorporated at a concentration of 200 IU to serve as an antioxidant and to promote the health of the vaginal mucosa. Vitamin E can help to maintain the integrity of the vaginal tissue and may have soothing properties that can alleviate symptoms of irritation and dryness.

This solid dosage form is designed to be inserted into the vagina, where it will dissolve or melt, allowing for the local release of the active ingredients. The suppository base is typically formulated to ensure that the medication is released at a controlled rate, enhancing the efficacy and duration of the therapeutic effects. This route of administration can be particularly advantageous for patients who may not tolerate oral medications well or for those who require targeted delivery of the active ingredients with minimal systemic absorption.

The combination of DHEA, estriol, and vitamin E acetate in a vaginal suppository form is intended to address specific gynecological and hormonal conditions, such as atrophic vaginitis, vulvar atrophy, and symptoms associated with menopause. By providing a localized treatment, this formulation may help to reduce the discomfort and improve the quality of life for affected women.

As with any compounded medication, it is essential that this formulation is prescribed by a healthcare provider familiar with the patient's medical history and current health status. Patients should be instructed on the proper insertion technique and the frequency of use as directed by their prescriber. If you have any questions or require further information about this formulation, please reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is here to assist you with your specific needs and concerns.

The formulation in question contains dehydroepiandrosterone (DHEA), estriol, and vitamin E acetate as active ingredients. DHEA is a hormone produced by the adrenal glands, which can be converted into other hormones such as estrogen and testosterone. Estriol is a form of estrogen, which is one of the primary female sex hormones. Vitamin E acetate is a form of vitamin E used in various supplements and medications for its antioxidant properties.

When considering drug interactions for this vaginal suppository formulation, it is important to note that DHEA and estriol can potentially interact with other hormones or medications that affect hormone levels. For example, the use of this suppository in conjunction with oral contraceptives or hormone replacement therapy may alter the effects of these medications, potentially leading to an imbalance in hormone levels. Patients should inform their healthcare provider if they are using any other form of hormonal therapy.

Additionally, DHEA can interact with medications metabolized by the liver, as it may affect certain liver enzymes responsible for drug metabolism. This could potentially alter the effectiveness or increase the risk of side effects of medications such as anticoagulants (e.g., warfarin), anticonvulsants, and certain antidepressants. It is crucial for patients to disclose all medications they are taking, including over-the-counter drugs and herbal supplements, to their healthcare provider.

Estriol, being an estrogen, may also interact with thyroid hormone replacement therapy. Estrogens can increase thyroid-binding globulin (TBG) levels, which may alter the amount of thyroid hormone that is free and active in the body. Patients on thyroid hormone replacement therapy should be monitored for changes in thyroid function tests when starting or adjusting the dose of this suppository.

Vitamin E, in high doses, can have anticoagulant effects and may increase the risk of bleeding when taken with anticoagulant or antiplatelet medications such as warfarin, aspirin, and clopidogrel. While the dose in this formulation is unlikely to cause significant interactions, it is still important to consider this potential interaction, especially in patients with a history of bleeding disorders or those undergoing surgery.

It is also important to consider that while this formulation is designed for vaginal administration, systemic absorption of these hormones can occur. This could potentially influence the interaction profile of the formulation. Patients should be advised to report any unusual symptoms or side effects to their healthcare provider promptly.

This vaginal suppository formulation is used to treat conditions such as atrophic vaginitis, which is associated with decreased estrogen levels, and may also be used to address issues related to menopause, such as vaginal dryness and irritation. The inclusion of DHEA may help with local hormone balance, while estriol provides a direct source of estrogen to the affected tissues. Vitamin E acetate can help to maintain the health of the vaginal mucosa and provide antioxidant support.

Patients and prescribers should be aware that while this formulation can be beneficial for treating certain conditions, it is essential to consider the potential for drug interactions and to manage them appropriately. If you have any questions or require further information regarding this formulation and its interactions, please reach out to us at Bayview Pharmacy for personalized advice and support.

The DHEA 3.25 mg/Estriol 2 mg/Vitamin E Acetate 200 IU Vaginal Suppository is a specially compounded medication designed to deliver its active ingredients directly to the vaginal tissue. DHEA, or dehydroepiandrosterone, is a hormone that is naturally produced by the adrenal glands. In this formulation, DHEA serves as a precursor to estrogen and is thought to improve the thickness and elasticity of the vaginal mucosa, which can be beneficial for women experiencing symptoms of vaginal atrophy, often associated with menopause. The inclusion of estriol, a weak form of estrogen, further supports the health of the vaginal tissue by potentially alleviating symptoms such as dryness, itching, and burning. Estriol is considered to have fewer side effects compared to other forms of estrogen, making it a safer option for some women.

Vitamin E acetate acts as an antioxidant and is included in this formulation for its potential to promote healing and provide additional moisture to the vaginal area. It may also have anti-inflammatory properties, which can help soothe irritated tissues. When compounded into a vaginal suppository, these ingredients are designed to be released slowly as the suppository base dissolves at body temperature after insertion into the vagina. This allows for localized action of the hormones and vitamin E, targeting the site where the medication is needed most, which can lead to fewer systemic side effects compared to oral administration.

This compounded medication is typically used to manage symptoms of vaginal atrophy and dryness, particularly in postmenopausal women or those with certain hormonal imbalances. By improving the health of the vaginal mucosa, it can also indirectly enhance the quality of life and sexual health. It is important to note that hormone replacement therapy, including the use of DHEA and estriol, should be used under the guidance of a healthcare provider, as it may not be suitable for all patients and requires monitoring for potential side effects and contraindications.

Patients and prescribers considering the use of this compounded formulation should be aware of the individual components and their actions, as well as the potential benefits and risks associated with hormone therapy. As compounding pharmacists at Bayview Pharmacy, we are available to answer any questions and provide additional information to ensure safe and effective use of this medication. Please reach out to us if you require further assistance or clarification regarding this formulation.

Dear valued clients and healthcare providers, the compounded medication combining DHEA, Estriol, and Vitamin E Acetate in a vaginal suppository format has been designed primarily for use in treating certain conditions related to hormonal deficiencies or imbalances. The DHEA in the formulation serves as a precursor to sex hormones and may aid in improving sexual function and libido as well as potentially offering benefits for conditions like adrenal insufficiency. Estriol, a weak form of estrogen, is often used for its role in alleviating menopausal symptoms such as vaginal dryness and atrophy, providing a gentler approach to estrogen replacement therapy. Additionally, the inclusion of Vitamin E Acetate works as an antioxidant, which might help in promoting healthy skin and mucous membranes, potentially facilitating tissue healing and reducing inflammation.

Apart from the primary indications, this compounded suppository may also have other uses based on its constituents' properties. DHEA, for instance, has been investigated for its possible role in bone density maintenance, immune function support, and mood improvement, though these uses are not as well established and more research is needed in these areas. Additionally, Vitamin E is known for its moisturizing properties and could, therefore, provide some symptomatic relief for various forms of vulvovaginal atrophy or irritation aside from its intended antioxidant action.

It's important to note that while the suppository is designed for vaginal administration, the systemic absorption of its components may produce off-target effects, and thus, it is crucial that this formulation is used under strict medical guidance. Physicians must carefully consider the patient's overall hormonal balance and medical history before recommending this treatment. Moreover, patients should be monitored for any adverse effects, especially those with a history of hormone-sensitive conditions.

We advise prescribers and patients to use this compounding formulation with a clear understanding of the potential benefits and risks. Although evidence supporting other uses of these compounds is evolving, this preparation should primarily be used for the disease states for which it is intended, unless new evidence emerges or it is prescribed off-label by a healthcare practitioner. If you have any questions about this formulation or its alternative uses, please do not hesitate to reach out to us at Bayview Pharmacy. We are committed to ensuring the safe and effective use of compounded medications and are happy to provide you with the information and support you need.