This compounded topical gel combines Cyclobenzaprine Hydrochloride (5 mg/mL), Ketamine Hydrochloride (46 mg/mL), and Ketoprofen (100 mg/mL) to provide a multifaceted approach to managing pain and inflammation. The semisolid formulation is designed for easy and precise application through a pump mechanism, allowing targeted delivery of active ingredients directly to the affected area.

Cyclobenzaprine Hydrochloride is a muscle relaxant that helps alleviate muscle spasms associated with acute, painful musculoskeletal conditions. By blocking nerve impulses sent to the brain, it assists in reducing muscle hyperactivity, leading to decreased pain and improved mobility.

Ketamine Hydrochloride, at a concentration of 46 mg/mL, acts as an N-methyl-D-aspartate (NMDA) receptor antagonist. It is utilized in pain management for its analgesic properties, particularly in neuropathic pain conditions. Topically applied ketamine may help reduce pain signaling in peripheral nerves, thereby diminishing pain perception without significant systemic effects.

Ketoprofen, a potent nonsteroidal anti-inflammatory drug (NSAID), is included at a concentration of 100 mg/mL to reduce inflammation and provide analgesic effects. By inhibiting cyclooxygenase enzymes (COX-1 and COX-2), ketoprofen decreases the synthesis of prostaglandins, which are mediators of inflammation and pain.

The combination of these three active ingredients in a topical gel allows for synergistic effects in managing pain and inflammation. The localized application minimizes systemic absorption, potentially reducing the risk of systemic side effects commonly associated with oral administration of these medications.

This formulation may be considered for patients experiencing localized musculoskeletal pain, neuropathic pain, or inflammatory conditions where topical therapy is appropriate. Prescribers may find it beneficial for patients who require a multimodal analgesic approach but need to avoid systemic side effects or have contraindications to oral medications.

Patients should apply the gel as directed by their healthcare provider, typically to clean, intact skin over the affected area. It is important to avoid contact with broken skin, eyes, and mucous membranes. Patients should monitor for any signs of skin irritation or allergic reactions and notify their healthcare provider if such effects occur.

Before using this compounded topical gel, patients should inform their healthcare provider of their full medical history, including any allergies, existing conditions, and

This topical gel formulation combines Cyclobenzaprine HCl, Ketamine HCl, and Ketoprofen, each contributing to its therapeutic effects. Cyclobenzaprine is a muscle relaxant, Ketamine is an NMDA receptor antagonist with analgesic properties, and Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID). Together, they are used to manage conditions such as musculoskeletal pain, neuropathic pain, and inflammation. However, it is crucial to consider potential drug interactions when using this formulation.

Cyclobenzaprine, when absorbed systemically, can interact with central nervous system (CNS) depressants such as alcohol, benzodiazepines, and opioids, potentially enhancing their sedative effects. Patients should be advised to avoid or limit the use of these substances while using the gel. Additionally, Cyclobenzaprine may interact with monoamine oxidase inhibitors (MAOIs), leading to serious side effects such as hypertensive crisis. It is recommended to avoid concurrent use with MAOIs and to allow a 14-day washout period after discontinuing MAOIs before starting Cyclobenzaprine.

Ketamine, although primarily used for its analgesic properties in this formulation, can also interact with CNS depressants, potentially leading to enhanced sedation or respiratory depression. Patients should be monitored for signs of excessive sedation or respiratory issues, especially if they are using other CNS depressants. Ketamine may also interact with medications that affect the cytochrome P450 enzyme system, particularly CYP3A4 inhibitors or inducers, which can alter its metabolism and efficacy.

Ketoprofen, as an NSAID, can interact with other medications that increase the risk of gastrointestinal bleeding, such as anticoagulants (e.g., warfarin) and other NSAIDs. Patients should be advised to use caution when combining these medications. Additionally, Ketoprofen may reduce the antihypertensive effects of certain blood pressure medications, such as ACE inhibitors and beta-blockers, and may increase the risk of renal impairment when used with diuretics or other nephrotoxic agents.

It is important for both patients and prescribers to be aware of these potential interactions to ensure safe and effective use of the topical gel. Patients should inform their healthcare provider of all medications they are currently taking, including over-the-counter drugs and supplements, to assess for possible interactions. If you have any questions or concerns about using this formulation, please reach out to us for further guidance.

This compounded topical gel formulation combines Cyclobenzaprine HCl, Ketamine HCl, and Ketoprofen to provide a multifaceted approach to pain management and inflammation reduction. Each active ingredient plays a distinct role in addressing the symptoms associated with musculoskeletal pain, neuropathic pain, and inflammatory conditions, offering a comprehensive treatment option for patients.

Cyclobenzaprine HCl is a muscle relaxant that works by blocking nerve impulses, or pain sensations, that are sent to the brain. By doing so, it helps to alleviate muscle spasms and discomfort associated with acute musculoskeletal conditions. When applied topically, Cyclobenzaprine HCl can provide localized relief, minimizing systemic side effects that are often associated with oral administration.

Ketamine HCl is an NMDA receptor antagonist that has been shown to have analgesic properties, particularly in the treatment of neuropathic pain. By blocking the NMDA receptors, Ketamine HCl can help to modulate pain pathways and reduce the perception of pain. Its inclusion in this topical gel allows for targeted application, which can be particularly beneficial for patients experiencing localized neuropathic pain, as it may reduce the need for systemic pain medications.

Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that works by inhibiting the production of prostaglandins, which are chemicals in the body responsible for inflammation, pain, and fever. By reducing the levels of prostaglandins, Ketoprofen helps to decrease inflammation and alleviate pain. The topical application of Ketoprofen in this gel formulation allows for direct delivery to the affected area, providing effective relief while minimizing potential gastrointestinal side effects associated with oral NSAIDs.

The semisolid gel formulation is designed for easy and precise application through a pump mechanism, ensuring that patients can apply the medication directly to the site of pain or inflammation. This targeted approach not only enhances the efficacy of the active ingredients but also reduces the risk of systemic side effects. The gel-like consistency ensures that the formulation is absorbed efficiently into the skin, allowing the active ingredients to penetrate the underlying tissues where they exert their therapeutic effects.

For both patients and prescribers, this compounded topical gel offers a customizable and effective treatment option for managing pain and inflammation. By combining these three active ingredients, the formulation addresses multiple pathways involved in pain and inflammation, providing a synergistic effect that can enhance patient outcomes. If you have any questions or need further information about this formulation, please reach out to us at Bayview Pharmacy.

The Cyclobenzaprine HCl 5 mg/mL, Ketamine HCl 46 mg/mL, and Ketoprofen 100 mg/mL topical gel formulation is primarily designed for the management of pain and inflammation associated with musculoskeletal conditions. However, this unique combination of active ingredients may offer additional therapeutic benefits beyond its primary indications. Cyclobenzaprine, a muscle relaxant, can be beneficial in alleviating muscle spasms and discomfort in conditions such as fibromyalgia, where muscle pain and tenderness are prevalent. Ketamine, known for its NMDA receptor antagonism, has been explored for its potential in treating neuropathic pain, which can arise from nerve damage or dysfunction, offering relief in conditions like post-herpetic neuralgia or diabetic neuropathy. Ketoprofen, a nonsteroidal anti-inflammatory drug (NSAID), can be effective in reducing inflammation and pain in localized areas, making it useful for conditions such as tendonitis or bursitis.

For patients and prescribers considering this formulation, it is important to understand the potential for off-label uses that may provide relief in complex pain syndromes where traditional therapies have been insufficient. The topical delivery system allows for targeted application, minimizing systemic exposure and potentially reducing the risk of systemic side effects commonly associated with oral administration of these medications. This can be particularly advantageous for patients who are sensitive to systemic side effects or those who are on multiple medications and wish to avoid drug interactions. The gel formulation, dispensed through a pump mechanism, ensures precise dosing and ease of application, enhancing patient compliance and convenience.

While the formulation holds promise for various pain-related conditions, it is crucial for prescribers to evaluate each patient's specific medical history, current medications, and overall treatment goals to determine the appropriateness of this therapy. Patients should be advised to apply the gel as directed, typically to clean, dry skin, and to avoid contact with mucous membranes or broken skin to prevent irritation. As with any compounded medication, the efficacy and safety of this formulation should be monitored closely, and any adverse reactions should be reported to the healthcare provider promptly.

If you have any questions or need further information about this formulation, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to assist you with any inquiries or concerns you may have regarding the use of this topical gel.