This formulation is a compounded topical gel containing Cyclobenzaprine HCl 2%, Gabapentin 6%, Ketamine HCl 11.5%, and Lidocaine HCl 3.5%. It is a semisolid formulation dispensed through a pump mechanism, which allows for easy and precise application on the skin. The gel-like consistency ensures that the active ingredients are absorbed effectively into the skin for targeted treatment.

Cyclobenzaprine HCl is a muscle relaxant that works by blocking nerve impulses (or pain sensations) that are sent to your brain. Gabapentin is an anticonvulsant and nerve pain medication that is often used to treat nerve pain caused by shingles (herpes zoster) or other nerve diseases. Ketamine HCl is a potent analgesic that provides relief from severe pain. Lidocaine HCl is a local anesthetic that works by causing temporary numbness/loss of feeling in the skin and mucous membranes.

This unique combination of ingredients works synergistically to provide relief from various disease states. It is particularly effective in managing neuropathic pain, a type of chronic pain that is often difficult to treat. Neuropathic pain can be caused by various conditions such as diabetes, shingles, fibromyalgia, or spinal cord injury. The gel can also be used to manage musculoskeletal pain, such as that caused by arthritis or injury. The topical application allows for targeted treatment, reducing systemic side effects often associated with oral medications.

Patients using this formulation should apply it as directed by their healthcare provider, typically to the affected area(s) several times a day. It is important to wash hands immediately after application unless the hands are the area being treated. Avoid contact with eyes, mouth, nose, or other sensitive areas. If irritation or adverse reactions occur, discontinue use and consult with your healthcare provider.

Prescribers should consider this formulation for patients who have not responded to traditional oral medications or who cannot tolerate them due to side effects. It may also be a suitable option for patients who prefer a topical treatment over oral medications. As with all medications, it is important to consider the patient's overall health status, other medications, and potential for drug interactions when prescribing this formulation.

If you have any questions about this formulation, its use, or compounding in general, please do not hesitate to reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is here to assist you.

This formulation contains four active ingredients: Cyclobenzaprine HCl, Gabapentin, Ketamine HCl, and Lidocaine HCl. Each of these ingredients can interact with other medications, potentially altering their effects or increasing the risk of adverse reactions.

Cyclobenzaprine HCl is a muscle relaxant that can interact with monoamine oxidase inhibitors (MAOIs), causing serious side effects such as high fever, convulsions, and even death. It can also interact with central nervous system depressants like alcohol, barbiturates, benzodiazepines, and narcotics, potentially causing excessive sedation, respiratory depression, or hypotension.

Gabapentin, an anticonvulsant and nerve pain medication, can interact with antacids containing magnesium or aluminum, potentially reducing the absorption of gabapentin and decreasing its effectiveness. It can also interact with central nervous system depressants, potentially causing excessive sedation or respiratory depression.

Ketamine HCl, an anesthetic, can interact with barbiturates and narcotics, potentially causing excessive sedation, respiratory depression, or hypotension. It can also interact with medications that affect heart rhythm, such as amiodarone, dofetilide, and quinidine, potentially causing serious heart problems.

Lidocaine HCl, a local anesthetic, can interact with other local anesthetics or medications that are similar to lidocaine, potentially causing excessive sedation, slow or irregular heartbeat, or other serious side effects. It can also interact with medications that affect liver enzymes that break down lidocaine, potentially increasing the risk of lidocaine toxicity.

This formulation is used topically, which may reduce the risk of systemic drug interactions. However, significant systemic absorption can occur, especially when the formulation is applied over large areas of the body, used for prolonged periods, or used on broken or inflamed skin. Therefore, it's important to use this formulation as directed by your healthcare provider and to inform your healthcare provider of all the medications you are currently taking, including prescription and over-the-counter medications, vitamins, and herbal supplements.

This formulation is used to treat various disease states, including muscle spasms, nerve pain, and localized pain. Cyclobenzaprine HCl relaxes muscles to reduce spasms, gabapentin reduces nerve pain, ketamine HCl provides anesthesia to numb the area, and lidocaine HCl provides local anesthesia to reduce pain. The combined effects of these ingredients can provide significant relief for these conditions.

If you have any questions about this formulation or its potential interactions with other medications, please reach out to us. We are here to help ensure that you use this formulation safely and effectively.

This formulation is a combination of four active ingredients: Cyclobenzaprine HCl, Gabapentin, Ketamine HCl, and Lidocaine HCl, each playing a unique role in managing pain and inflammation. The formulation is designed to be applied topically, directly to the skin, where it can be absorbed and exert its effects locally. This method of administration can help to reduce systemic side effects that may be associated with oral administration of these medications.

Cyclobenzaprine HCl is a muscle relaxant that works by blocking nerve impulses (or pain sensations) that are sent to your brain. It is particularly effective in treating muscle spasm associated with acute musculoskeletal conditions. Gabapentin is an anticonvulsant and nerve pain medication. It is believed to work by affecting the way the body senses pain. It is commonly used to treat nerve pain conditions such as postherpetic neuralgia and peripheral neuropathy.

Ketamine HCl is a powerful anesthetic that provides pain relief by blocking the NMDA receptors in the brain and spinal cord, which play a role in transmitting pain signals. It is often used in the management of chronic pain conditions, including neuropathic pain and complex regional pain syndrome (CRPS). Lidocaine HCl is a local anesthetic that works by causing temporary numbness in the area where it is applied. It works by blocking nerve signals in your body and is commonly used to relieve minor discomfort and itching caused by skin irritations.

The combination of these four active ingredients in a single topical gel formulation provides a multi-modal approach to pain management. The gel formulation allows for easy application and targeted treatment, delivering the medication directly to the area of pain or inflammation. This can result in more effective pain relief with potentially fewer side effects compared to systemic administration of these medications.

It's important to note that while this formulation can provide significant relief for many patients, it may not be suitable for everyone. Patients with certain medical conditions or who are taking certain other medications may not be able to use this formulation. As always, it's important to discuss your medical history and any other medications you are taking with your healthcare provider before starting a new medication. If you have any questions about this formulation, please don't hesitate to reach out to us at Bayview Pharmacy. We are here to help.

Outside of the primary aims of treating disease states, this complex formulation of Cyclobenzaprine HCl 2%/Gabapentin 6%/Ketamine HCl 11.5%/Lidocaine HCl 3.5% Topical Gel has been found beneficial in a number of other scenarios. As these medications are topically applied, they can be used in localized regions to manage a variety of pain syndromes. This includes but is not limited to conditions such as fibromyalgia, diabetic peripheral neuropathy, postherpetic neuralgia and complex regional pain syndrome. The unique combination of ingredients provides a multifaceted approach to pain management, with each active component playing a crucial role.

Cyclobenzaprine and gabapentin, both muscle relaxants, have found off-label uses in the mitigation of symptoms related to restless legs syndrome and withdrawal symptoms from opioids, respectively. Lidocaine, a local anesthetic, is often used off-label for conditions such as neuropathic pain and post-surgical wound pain. Ketamine has seen off-label use in treating depression, though in this instance it would be more pertinent to its use in managing acute and chronic pain.

Despite their additional benefits, it’s important to remember that off-label use should always be under the direction and supervision of a physician or another qualified healthcare professional. Not all off-label uses for these drugs have been approved by the FDA, and the safety and efficacy for these uses have not always been established. As a team of compounding pharmacists, we are here to help guide you and answer any questions you might have. It's also worth noting that topical gels such as the one being discussed are best for localized symptomatic relief, and systemic effects might not be experienced the way they would be with oral or IV administration of the same drugs.

Whether you’re a patient or prescriber, please don't hesitate to reach out with further inquiries. We’re here to provide as much information as possible to ensure safe and efficacious use of this formulation. Our team at Bayview Pharmacy is committed to your wellbeing and ensuring the right approach is taken to manage your health needs.