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Codeine Phosphate 3 mg/mL Oral Suspension

Codeine Phosphate 3 mg/mL Oral Suspension is a liquid dosage form in which codeine phosphate is uniformly dispersed throughout a liquid medium, ensuring a homogeneous mixture for precise administration. This formulation is primarily used to treat conditions such as mild to moderate pain and cough associated with respiratory conditions. It provides effective relief by acting on the central nervous system to decrease the perception of pain and suppress the cough reflex.

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Formula Information

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Codeine Phosphate 3 mg/mL Oral Suspension is a liquid medication formulated to provide effective relief from mild to moderate pain and to suppress cough reflexes associated with various respiratory conditions. As an opioid analgesic and antitussive agent, codeine works by binding to specific receptors in the brain and nervous system, altering the perception of pain and reducing the urge to cough.

The oral suspension is designed as a homogeneous liquid mixture, ensuring that the codeine phosphate is uniformly dispersed throughout the liquid medium. This uniformity allows for precise dosing and easy administration, which is particularly beneficial for patients who have difficulty swallowing tablets or require tailored dosing adjustments.

For patients, this formulation offers a convenient and palatable option for managing symptoms effectively. It is important to take the medication exactly as prescribed by a healthcare professional to minimize the risk of side effects and dependence. Common side effects may include drowsiness, dizziness, constipation, nausea, and vomiting. Patients should avoid consuming alcohol or operating heavy machinery while taking this medication due to its sedative effects.

For prescribers, Codeine Phosphate 3 mg/mL Oral Suspension provides flexibility in dosing, which is especially useful in pediatric care or for patients with specific dosing requirements. When prescribing this medication, it is crucial to consider the patient's medical history, including any respiratory conditions like asthma or chronic obstructive pulmonary disease (COPD), as codeine can depress respiration. Caution is also advised for patients with liver or kidney impairment, or those with a history of substance misuse.

Drug interactions are an important consideration. Codeine may interact with other central nervous system depressants, such as benzodiazepines, other opioids, sedatives, antihistamines, or certain antidepressants, potentially increasing the risk of respiratory depression, profound sedation, coma, or death. Therefore, a thorough review of the patient's current medications is essential to ensure safe prescribing.

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Drug Interactions

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Codeine Phosphate 3 mg/mL Oral Suspension is a liquid dosage form in which one or more ingredients are dispersed uniformly throughout a liquid medium, providing a homogeneous mixture for administration. This formulation is primarily used for the management of mild to moderate pain and as a cough suppressant. However, it is crucial to be aware of potential drug interactions that may affect the efficacy and safety of this medication.

Codeine is metabolized in the liver by the cytochrome P450 enzyme CYP2D6 to morphine, which is responsible for its analgesic effects. Therefore, any medications that inhibit or induce CYP2D6 can significantly alter the metabolism of codeine. Strong inhibitors of CYP2D6, such as fluoxetine, paroxetine, and quinidine, can reduce the conversion of codeine to morphine, potentially decreasing its effectiveness in pain relief. Conversely, CYP2D6 inducers, although less common, could increase the conversion rate, potentially leading to enhanced effects and increased risk of adverse reactions.

Concomitant use of codeine with other central nervous system (CNS) depressants, including benzodiazepines, other opioids, antihistamines, and alcohol, can result in additive CNS depression. This can lead to profound sedation, respiratory depression, coma, or even death. It is essential for prescribers to evaluate the patient's medication regimen for any CNS depressants and adjust dosages accordingly or consider alternative therapies.

Codeine may also interact with monoamine oxidase inhibitors (MAOIs), such as phenelzine and tranylcypromine. The concurrent use of codeine with MAOIs can lead to serotonin syndrome, a potentially life-threatening condition characterized by symptoms such as agitation, hallucinations, rapid heart rate, and increased body temperature. Patients should be advised to avoid MAOIs while taking codeine and for at least two weeks after discontinuing MAOI therapy.

Additionally, codeine can interact with medications that affect serotonin levels, such as selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), and tricyclic antidepressants (TCAs). These interactions can also increase the risk of serotonin syndrome. Patients should be monitored for symptoms of serotonin syndrome, and prescribers should consider the risk-benefit ratio when co-prescribing these medications.

Patients with a history of substance abuse or addiction should be closely monitored, as codeine has the potential for abuse and dependence. Prescribers should assess the patient's risk for opioid addiction, abuse, or misuse prior to prescribing codeine and continue to monitor for the development of these behaviors or conditions.

For patients and prescribers considering the use of Codeine Phosphate 3 mg/mL Oral Suspension, it is important to review the patient's complete medication profile to identify potential drug interactions. If you have any questions or need further information, please reach out to us at Bayview Pharmacy. We are here to assist you in ensuring safe and effective use of this medication.

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How Does it Work

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Codeine Phosphate 3 mg/mL Oral Suspension is a liquid dosage form designed to deliver precise and consistent doses of codeine phosphate, an opioid analgesic, for the management of mild to moderate pain and cough suppression. This formulation is particularly beneficial for patients who have difficulty swallowing tablets or capsules, as it allows for easy administration and dose adjustments. The suspension is created by dispersing codeine phosphate uniformly throughout a liquid medium, ensuring a homogeneous mixture that provides consistent therapeutic effects with each dose.

Upon administration, codeine phosphate is absorbed through the gastrointestinal tract and metabolized primarily in the liver. It is converted into morphine, which is the active metabolite responsible for its analgesic and antitussive effects. Codeine works by binding to specific opioid receptors in the central nervous system, altering the perception of pain and reducing the urge to cough. This makes it effective in treating conditions such as post-operative pain, injury-related pain, and persistent coughs associated with respiratory infections or chronic conditions.

For prescribers, it is important to consider the patient's overall health status, including liver function, as this can affect the metabolism and efficacy of codeine. Additionally, the potential for dependence and abuse should be evaluated, especially in patients with a history of substance use disorders. The liquid suspension form allows for flexible dosing, which can be particularly advantageous in pediatric or geriatric populations where precise dosing is crucial.

Patients should be advised to measure the suspension accurately using a dosing syringe or cup to ensure they receive the correct amount. It is also important to follow the prescribed dosing schedule and not to exceed the recommended dose to minimize the risk of adverse effects such as drowsiness, constipation, or respiratory depression. Patients should be informed about potential interactions with other medications, particularly those that depress the central nervous system, and advised to avoid alcohol while taking this medication.

If you have any questions or need further information about Codeine Phosphate 3 mg/mL Oral Suspension, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to assist you with any inquiries or concerns you may have regarding this formulation.

Other Uses

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Codeine Phosphate 3 mg/mL Oral Suspension is primarily utilized for its analgesic and antitussive properties, often prescribed for the relief of mild to moderate pain and the suppression of cough. However, beyond these common indications, this formulation may have other potential uses that can be considered by healthcare providers based on individual patient needs and clinical judgment. One such use is in the management of diarrhea, particularly when it is symptomatic of irritable bowel syndrome (IBS) or other gastrointestinal disorders. Codeine's ability to slow intestinal motility can be beneficial in reducing the frequency and urgency of bowel movements, providing relief to patients experiencing chronic diarrhea.

Additionally, Codeine Phosphate may be employed in palliative care settings to address multifaceted symptoms in patients with terminal illnesses. Its sedative properties can help alleviate anxiety and promote relaxation, contributing to overall comfort. In some cases, it may be used as an adjunct therapy in managing dyspnea, or shortness of breath, particularly in patients with advanced chronic obstructive pulmonary disease (COPD) or heart failure, where it can help reduce the sensation of breathlessness.

For patients with chronic pain conditions, such as fibromyalgia or osteoarthritis, Codeine Phosphate Oral Suspension can be considered as part of a multimodal pain management strategy. Its liquid form allows for easy dose adjustments and administration, which can be particularly advantageous for patients with swallowing difficulties or those requiring precise titration of their medication. Furthermore, the suspension form ensures uniform distribution of the active ingredient, providing consistent therapeutic effects with each dose.

It is important for both patients and prescribers to be aware of the potential for dependence and the risk of adverse effects associated with codeine use, including drowsiness, constipation, and respiratory depression. Therefore, careful consideration and monitoring are essential when using this medication for off-label purposes. As always, if you have any questions or require further information about the use of Codeine Phosphate 3 mg/mL Oral Suspension, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to assist you with any inquiries or concerns you may have.

Frequently Asked Questions

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What is Codeine Phosphate 3 mg/mL Oral Suspension?

Codeine Phosphate 3 mg/mL Oral Suspension is a liquid dosage form where codeine phosphate is uniformly dispersed in a liquid medium, creating a homogeneous mixture for easy administration.

How should I take Codeine Phosphate 3 mg/mL Oral Suspension?

Take the prescribed dose of Codeine Phosphate 3 mg/mL Oral Suspension using a proper measuring device, such as a dosing syringe or cup, to ensure accurate dosing. Follow your healthcare provider's instructions carefully.

What is the purpose of Codeine Phosphate in this formulation?

Codeine Phosphate is an opioid used to treat mild to moderate pain and to reduce coughing. It works by altering the way the brain and nervous system respond to pain and by decreasing the activity in the part of the brain that causes coughing.

Can I take Codeine Phosphate 3 mg/mL Oral Suspension with other medications?

Before taking Codeine Phosphate 3 mg/mL Oral Suspension with other medications, consult your healthcare provider or pharmacist. Codeine can interact with other drugs, potentially causing harmful effects.

What are the potential side effects of Codeine Phosphate 3 mg/mL Oral Suspension?

Common side effects may include drowsiness, dizziness, constipation, nausea, and vomiting. If you experience severe side effects such as difficulty breathing, seek medical attention immediately.

How should I store Codeine Phosphate 3 mg/mL Oral Suspension?

Store Codeine Phosphate 3 mg/mL Oral Suspension at room temperature, away from light and moisture. Keep it out of reach of children and pets.

What should I do if I miss a dose of Codeine Phosphate 3 mg/mL Oral Suspension?

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.

Is Codeine Phosphate 3 mg/mL Oral Suspension safe for children?

Codeine Phosphate should be used with caution in children and only if prescribed by a healthcare provider. It is important to follow the prescribed dosage and monitor for any adverse effects.

Can I drive or operate machinery while taking Codeine Phosphate 3 mg/mL Oral Suspension?

Codeine Phosphate can cause drowsiness and impair your ability to drive or operate machinery. Avoid these activities until you know how the medication affects you.

What should I do in case of an overdose of Codeine Phosphate 3 mg/mL Oral Suspension?

In case of an overdose, seek emergency medical attention immediately. Symptoms of overdose may include severe drowsiness, slow breathing, or loss of consciousness.

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Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.