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Clopidogrel 37.5 mg/ml Oral Liquid

Clopidogrel 37.5 mg/ml Oral Liquid is a specially formulated medication designed for oral administration. This liquid formulation provides a convenient and easily ingested dosage form, ensuring accurate delivery of medication. It is particularly beneficial for individuals who find swallowing solid dosage forms challenging, such as pediatric and geriatric populations.

This formulation is used to treat various disease states that require antiplatelet therapy. Clopidogrel is a potent antiplatelet agent that helps prevent blood clots, reducing the risk of heart attacks and strokes. It is often prescribed for patients with recent heart attack, stroke, or diagnosed peripheral artery disease.

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Clopidogrel Bisulfate
Oral Liquid
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Formula Information

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Clopidogrel 37.5 mg/ml Oral Liquid is a specially formulated medication designed for oral administration. This liquid formulation provides a convenient and easily ingested dosage form, ensuring accurate delivery of medication. It is particularly beneficial for patients who find swallowing solid dosage forms challenging, such as children and the elderly. The liquid formulation allows for easy dose adjustments, which is especially important in pediatric and geriatric populations where individualized dosing is often required.

Clopidogrel is an antiplatelet medication that works by preventing platelets in your blood from sticking together to form an unwanted blood clot that could block an artery. It is used to prevent heart attacks and strokes in persons with heart disease (recent heart attack), recent stroke, or blood circulation disease (peripheral vascular disease). It can also be used in combination with aspirin in certain patients with heart disease and following a recent heart attack or stroke.

It's important to note that Clopidogrel should be used under the supervision of a healthcare provider. Patients should inform their healthcare provider of all medications they are currently taking, as Clopidogrel can interact with certain other medications. Side effects can include bleeding, bruising, allergic reactions, and others. Patients should seek immediate medical attention if they experience any unusual symptoms.

As compounding pharmacists, we are able to customize this medication to meet the unique needs of each patient. This includes adjusting the strength of the medication, altering its form to make it easier to ingest, and adding flavor to make it more palatable. We work closely with healthcare providers to ensure that each patient receives the most effective treatment.

If you have any questions about Clopidogrel 37.5 mg/ml Oral Liquid or any other medication, please don't hesitate to reach out to us. We are here to provide you with the information and support you need to manage your health.

Drug Interactions

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Clopidogrel is an antiplatelet medication that works by preventing platelets in your blood from sticking together to form an unwanted blood clot that could block an artery. It is often used to prevent heart attacks and strokes in persons with heart disease, recent stroke, or blood circulation disease (peripheral vascular disease). However, it's important to be aware of potential drug interactions when using this medication.

Concurrent use of Clopidogrel with other drugs that increase the risk of bleeding should be approached with caution. These include nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen and naproxen, blood thinners like warfarin, and selective serotonin reuptake inhibitors (SSRIs) such as fluoxetine and sertraline. The risk of bleeding may be increased when these medications are used with Clopidogrel.

Some medications may decrease the effectiveness of Clopidogrel in preventing heart attack or stroke. These include proton pump inhibitors (PPIs) such as omeprazole and esomeprazole. If you are taking a PPI, your doctor may choose to switch you to a different medication to treat your stomach acid.

It's also important to note that certain other medications may have an effect on the way Clopidogrel works. For example, certain antifungal medications (such as ketoconazole and itraconazole), HIV protease inhibitors (such as ritonavir), and macrolide antibiotics (such as erythromycin) can increase the blood levels of Clopidogrel, potentially leading to increased side effects.

On the other hand, certain medications can decrease the blood levels of Clopidogrel, potentially making it less effective. These include certain anticonvulsants (such as phenytoin, carbamazepine), barbiturates, and rifampin.

It's crucial to inform your healthcare provider about all the medications you are currently taking, including prescription drugs, over-the-counter medications, vitamins, and herbal supplements. This will help your healthcare provider to manage potential drug interactions effectively.

Remember, this is not a complete list of possible drug interactions. Always consult your healthcare provider to ensure the information applies to your personal circumstances. If you have any questions about Clopidogrel or its potential interactions with other medications, please don't hesitate to reach out to us at Bayview Pharmacy. We're here to help.

How Does it Work

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Clopidogrel is an antiplatelet medication that works by preventing platelets in your blood from sticking together to form an unwanted blood clot that could block an artery. It is often prescribed to patients who have recently experienced a heart attack or stroke, or who have peripheral artery disease (PAD). The active ingredient, clopidogrel, is a prodrug, which means it is inactive when ingested and must be metabolized by the body into its active form.

When Clopidogrel is administered in the form of a 37.5 mg/ml oral liquid, it is absorbed in the gastrointestinal tract and then metabolized in the liver by the enzyme CYP2C19. The metabolites of clopidogrel selectively inhibit the binding of adenosine diphosphate (ADP) to its platelet P2Y12 receptor and the subsequent ADP-mediated activation of the glycoprotein GPIIb/IIIa complex, thereby inhibiting platelet aggregation. This action helps to keep the blood flowing smoothly in your body, reducing the risk of harmful clot formation.

The oral liquid formulation of clopidogrel provides a convenient and easily ingested dosage form for accurate delivery of medication. This is particularly beneficial for patients who have difficulty swallowing solid dosage forms, such as tablets or capsules. The liquid formulation can be easily measured and administered, ensuring the patient receives the correct dose. It is also suitable for use in pediatric and geriatric populations, who may have difficulty swallowing or require lower doses of medication.

It's important to note that while clopidogrel can prevent a heart attack or stroke, it does not cure these conditions. It is typically used as part of a comprehensive treatment plan, which may include lifestyle changes, other medications, and sometimes surgery. As with any medication, it's important to take clopidogrel exactly as prescribed by your healthcare provider, and to discuss any side effects or concerns you may have.

If you have any questions about clopidogrel or its oral liquid formulation, please don't hesitate to reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is here to help you understand your medication and how it works to manage your health condition.

Other Uses

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Clopidogrel 37.5 mg/ml Oral Liquid is primarily indicated for the prevention of thrombotic cardiovascular events in patients with various underlying medical conditions such as atherosclerosis, previous history of myocardial infarction, stroke, and peripheral arterial disease. However, its pharmacological property of inhibiting platelet aggregation has also suggested other potential uses in different clinical scenarios.

Some studies have suggested that Clopidogrel may have off-label uses in cardiovascular diseases other than those for which its use is primarily indicated. For instance, it can be considered in the management of patients with coronary artery disease undergoing percutaneous coronary intervention (PCI), a procedure often done to open narrowed or blocked coronary arteries. In this situation, the antiplatelet effect of the drug can minimize the risk of stent thrombosis.

Clopidogrel has also been used as a part of dual or triple therapy for atrial fibrillation, where it serves to reduce the risk of systemic embolism. Some evidence suggests it may be an effective option in patients at moderate risk who cannot tolerate long-term anticoagulation. Furthermore, there is preliminary data that suggest Clopidogrel might have potential in treating conditions involving platelet activation and aggregation, like sickle cell disease, although further studies are needed to validate these indications.

However, it is crucial for prescribers and patients to understand that these other uses of Clopidogrel are off-label, meaning they are not approved by the Food and Drug Administration (FDA). Therefore, decision making about such uses should involve careful consideration of risks and benefits and usually require consultation with a specialist. It is also important to mention that while there is emerging evidence for these potential uses, more robust scientific data and larger clinical trials are needed to support these indications.

If you have further questions regarding this topic, we invite you to reach out to our team at Bayview Pharmacy. As experienced compounding pharmacists, we provide expertise in the safe and effective use of medications, including their off-label uses, side effects, interactions, and potential alternatives. We are always available to answer your inquiries and provide assistance.

Frequently Asked Questions

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What is Clopidogrel 37.5 mg/ml Oral Liquid?

Clopidogrel 37.5 mg/ml Oral Liquid is a specifically formulated medication in fluid form intended for oral administration. It is designed to provide an easily ingested and accurately delivered dosage, particularly useful for individuals experiencing difficulty swallowing solid dosage forms or for pediatric and geriatric populations.

Who is this medication intended for?

This liquid form of Clopidogrel is typically beneficial for individuals that have difficulty swallowing tablets or capsules like children or older adults. However, it can be used by any patient prescribed Clopidogrel and prefers liquid medications.

How do I administer Clopidogrel 37.5 mg/ml Oral Liquid?

This medication is intended for oral administration. The exact dose and frequency will be noted by your healthcare provider. Please follow their instructions closely. It's typically taken using a special measuring device such as a dosing syringe.

How should I store this medication?

Store the medication in a closed container at room temperature, away from heat, moisture, and direct light. Ensure children cannot reach it.

What if I miss a dose?

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.

What should I do in case of an overdose?

If you suspect an overdose, get in touch with a healthcare professional immediately or call your local poison control center.

Can I crush or chew Clopidogrel tablets instead of using the liquid form?

No, never crush or chew Clopidogrel tablets unless instructed by your healthcare provider. The oral liquid dosage form is available for those who cannot swallow whole tablets.

Are there any side effects to Clopidogrel 37.5 mg/ml Oral Liquid?

All medications can cause side effects. With Clopidogrel, you may experience symptoms like diarrhea, rash, or headache. Always consult your healthcare provider about potential side effects and what actions to take if they occur.

Can I drink alcohol while on this medication?

It is always best to consult with your healthcare provider regarding the safe consumption of alcohol when taking any medication. Alcohol can interact with certain medications, altering their effectiveness or leading to side effects.

Can Clopidogrel 37.5 mg/ml Oral Liquid be used by pregnant or breastfeeding women?

Your healthcare provider should be notified if you are pregnant or planning to get pregnant, or if you are breastfeeding. It is crucial to discuss the benefits and risks associated with the medication to ensure the safety of both mother and baby.

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Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.