This formulation is a unique combination of Clonidine HCl 0.232%, Dextromethorphan HBr 2%, Nifedipine 2%, and Verapamil HCl 6% in a transdermal gel. It is a semisolid formulation that is dispensed through a pump mechanism, which allows for easy and precise application on the skin. The gel-like consistency of the formulation ensures that the active ingredients are absorbed effectively into the skin for targeted treatment.

Clonidine HCl is an alpha-2 adrenergic agonist that is commonly used to treat high blood pressure. It works by relaxing and widening blood vessels, which helps to lower blood pressure. Dextromethorphan HBr is a cough suppressant that works by decreasing the feeling of needing to cough. Nifedipine is a calcium channel blocker that relaxes the muscles of your heart and blood vessels, which can help to treat chest pain (angina) and high blood pressure. Verapamil HCl is also a calcium channel blocker, and it works by relaxing the muscles of your heart and blood vessels. It is used to treat hypertension, angina, and certain heart rhythm disorders.

The combination of these four active ingredients in a transdermal gel allows for targeted treatment of the above-mentioned conditions. The gel is applied directly to the skin, which allows for the active ingredients to be absorbed directly into the bloodstream. This can result in a faster onset of action compared to oral medications, and it can also reduce the risk of systemic side effects. The pump mechanism of the gel dispenser allows for precise dosing, which can help to ensure that the correct amount of medication is applied each time.

It is important to use this medication exactly as prescribed by your healthcare provider. Do not use more or less of it, or use it more often than prescribed by your doctor. If you have any questions about this medication or how to use it, please reach out to us. We are a team of knowledgeable compounding pharmacists at Bayview Pharmacy, and we are here to help.

This formulation contains four active ingredients: Clonidine HCl, Dextromethorphan HBr, Nifedipine, and Verapamil HCl. Each of these medications can interact with other drugs, potentially altering their effects or increasing the risk of adverse reactions.

Clonidine HCl is an alpha-2 adrenergic agonist used to treat high blood pressure. It can interact with beta-blockers, causing a rebound hypertension if either drug is discontinued abruptly. It can also interact with CNS depressants like alcohol, barbiturates, or benzodiazepines, potentially enhancing their sedative effects. Additionally, it can interact with tricyclic antidepressants, potentially reducing their effectiveness.

Dextromethorphan HBr is a cough suppressant that can interact with monoamine oxidase inhibitors (MAOIs), potentially causing a serious condition called serotonin syndrome. It can also interact with other medications that affect serotonin levels, such as selective serotonin reuptake inhibitors (SSRIs) and serotonin and norepinephrine reuptake inhibitors (SNRIs). Furthermore, it can interact with certain pain medications, potentially increasing the risk of side effects like confusion, hallucination, and slow or shallow breathing.

Nifedipine is a calcium channel blocker used to treat high blood pressure and angina. It can interact with beta-blockers, potentially causing heart failure or increasing the risk of low blood pressure. It can also interact with CYP3A4 inhibitors, potentially increasing the levels of nifedipine in the body and increasing the risk of side effects. Additionally, it can interact with grapefruit juice, potentially increasing the levels of nifedipine in the body.

Verapamil HCl is another calcium channel blocker that can interact with beta-blockers, potentially causing heart failure or increasing the risk of low blood pressure. It can also interact with CYP3A4 inhibitors, potentially increasing the levels of verapamil in the body and increasing the risk of side effects. Furthermore, it can interact with certain heart rhythm medications, potentially increasing the risk of side effects like slow heart rate and low blood pressure.

This formulation is designed to be applied topically, which can reduce the risk of systemic drug interactions. However, it's still important to inform your healthcare provider of all medications you're currently taking, including prescription drugs, over-the-counter drugs, and dietary supplements. If you have any questions about this formulation or its potential interactions, please don't hesitate to reach out to us.

This unique formulation combines Clonidine HCl, Dextromethorphan HBr, Nifedipine, and Verapamil HCl in a transdermal gel. Each of these active ingredients plays a crucial role in managing various disease states. The gel is designed to be easily applied to the skin, where it is absorbed into the body to provide targeted treatment.

Clonidine HCl is an alpha-2 adrenergic agonist that works by stimulating receptors in the brain that help to lower blood pressure. It reduces the amount of norepinephrine available to stimulate the receptors, which in turn reduces nerve signal transmission, leading to decreased blood pressure. It is commonly used to treat hypertension.

Dextromethorphan HBr is a cough suppressant that affects the signals in the brain that trigger cough reflex. It is used to treat a nonproductive cough. It works by decreasing activity in the part of the brain that causes coughing.

Nifedipine is a calcium channel blocker that relaxes (widens) your blood vessels (veins and arteries), which makes it easier for the heart to pump and reduces its workload. It is commonly used to treat high blood pressure and angina (chest pain).

Verapamil HCl is also a calcium channel blocker. It works by relaxing the muscles of your heart and blood vessels. Verapamil is used to treat hypertension (high blood pressure), angina (chest pain), and certain heart rhythm disorders.

The transdermal gel formulation allows for the active ingredients to be absorbed through the skin directly into the bloodstream. This method of delivery bypasses the digestive system, reducing the risk of gastrointestinal side effects and allowing for a more steady absorption of the medication. The pump mechanism allows for easy and precise application of the medication.

This formulation is a powerful combination of medications that can effectively manage hypertension, angina, and nonproductive cough. As with any medication, it is important to use this product under the guidance of a healthcare professional. If you have any questions about this formulation, please do not hesitate to reach out to us at Bayview Pharmacy. We are a team of knowledgeable compounding pharmacists who are here to help.

Clonidine HCl, Dextromethorphan HBr, Nifedipine, and Verapamil HCl in a transdermal gel have multiple uses beyond the primary indications. Clonidine is an alpha-2 adrenergic agonist which, aside from reducing blood pressure, can be used to mitigate withdrawal symptoms associated with opioids. Dextromethorphan acts as a cough suppressant, but it also demonstrates properties that can help in managing neuropathic pain and neurodegenerative disorders due to its NMDA antagonizing effects.

Nifedipine is a calcium channel blocker that reduces blood pressure but it also exhibits vasodilatory effects which may be beneficial in the management of Raynaud's phenomenon, a condition characterized by spasms of small vessels typically in fingers and toes. Verapamil, in addition to its role in controlling hypertension and arrhythmias, may also help alleviate symptoms of migraines and cluster headaches.

This synergistic mix in a transdermal gel negates the systemic side effects typically associated with oral administration. Being a topical application, it more effectively manages localized symptoms. It's important to note that this formulation is not a one-size-fits-all, thus, should be customized in ratio and dosage to the patient's specific needs and conditions.

Always ensure to consult your prescribing physician before using this formulation for an indication other than what it is primarily prescribed for. It should not be used without the specific guidance of a healthcare provider. Also, bear in mind that individual patient response and tolerability may vary, and periodic monitoring may be necessary to determine the effectiveness and safety of the treatment. Hence, reach out to us with questions about the uses, benefits, and side effects to make informed decisions about medication therapy. Remember, inappropriate or non-guided use can lead to avoidable adverse events, drug interactions, or therapeutic failures.