This formulation is a compounded topical gel containing Clonidine HCl 0.23%, Diclofenac Sodium 10%, and Ketamine HCl 5.75%. It is a semisolid formulation that is dispensed through a pump mechanism, which allows for easy and precise application on the skin. The gel-like consistency of the formulation ensures that the active ingredients are absorbed effectively into the skin for targeted treatment.

Clonidine HCl is a medication that is primarily used to treat high blood pressure, but in this formulation, it is used for its potential analgesic and anti-inflammatory properties. It works by stimulating alpha-2 adrenergic receptors, which can help to reduce nerve signal transmission and thus decrease pain sensation. Diclofenac Sodium is a nonsteroidal anti-inflammatory drug (NSAID) that works by reducing substances in the body that cause pain and inflammation. It is commonly used to treat mild to moderate pain, or signs and symptoms of osteoarthritis or rheumatoid arthritis.

Ketamine HCl is a powerful anesthetic that is used in this formulation for its analgesic properties. It works by blocking certain receptors in the brain that are responsible for transmitting pain signals. In a topical formulation, Ketamine can provide targeted pain relief without the systemic side effects associated with oral or injectable administration.

This compounded formulation can be used to treat a variety of disease states that involve pain and inflammation. It can be particularly useful for conditions such as neuropathic pain, osteoarthritis, rheumatoid arthritis, and other conditions where targeted, topical pain relief is beneficial. As with all medications, it is important to use this formulation as directed by a healthcare provider. Side effects can occur, including skin irritation at the application site, and systemic side effects are possible if the medication is absorbed into the bloodstream. It is important to discuss any concerns or side effects with your healthcare provider.

If you have any questions about this formulation, or if you are a prescriber interested in using this formulation for your patients, please do not hesitate to reach out to us at Bayview Pharmacy. Our knowledgeable team of compounding pharmacists is always here to help.

This formulation combines Clonidine HCl, Diclofenac Sodium, and Ketamine HCl in a topical gel. Clonidine HCl is an alpha-2 adrenergic agonist that is primarily used to treat high blood pressure, but in this formulation, it can help to manage neuropathic pain. Diclofenac Sodium is a nonsteroidal anti-inflammatory drug (NSAID) that reduces pain and inflammation. Ketamine HCl is a NMDA receptor antagonist that can provide pain relief and has been used in the management of chronic pain conditions.

Patients should be aware of potential drug interactions when using this formulation. Clonidine HCl can interact with other medications that affect blood pressure or heart rate, including beta-blockers, calcium channel blockers, and digitalis. Concurrent use of these medications may result in additive effects on blood pressure and heart rate, potentially leading to bradycardia or hypotension. Diclofenac Sodium can interact with other NSAIDs, anticoagulants, and corticosteroids, potentially increasing the risk of gastrointestinal bleeding. Ketamine HCl can interact with other central nervous system depressants, including alcohol, benzodiazepines, and opioids, potentially leading to additive CNS depression.

Prescribers should consider these potential interactions when prescribing this formulation. Close monitoring of blood pressure and heart rate may be necessary when initiating or adjusting the dose of Clonidine HCl in patients taking other medications that affect these parameters. Similarly, patients using Diclofenac Sodium with other NSAIDs, anticoagulants, or corticosteroids may require monitoring for signs of gastrointestinal bleeding. Patients using Ketamine HCl with other CNS depressants should be monitored for signs of excessive sedation or respiratory depression.

This formulation is intended for topical application and should not be ingested or applied to open wounds or damaged skin. Patients should be advised to wash their hands immediately after applying the gel and to avoid contact with the eyes, mouth, and other mucous membranes. If the gel is accidentally ingested or applied to these areas, patients should seek immediate medical attention.

If you have any questions about this formulation or its potential interactions with other medications, please do not hesitate to reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is always here to help.

This formulation combines three active ingredients: Clonidine HCl, Diclofenac Sodium, and Ketamine HCl, each with a unique mechanism of action to provide relief from pain and inflammation. The gel is designed to be applied topically, directly to the area of discomfort, allowing for targeted treatment and absorption of the active ingredients.

Clonidine HCl is a medication primarily used to treat high blood pressure, but in this formulation, it is used for its analgesic properties. It works by stimulating alpha-2 adrenergic receptors in the brain, which decreases the transmission of pain signals in the body, thereby reducing the sensation of pain.

Diclofenac Sodium is a nonsteroidal anti-inflammatory drug (NSAID) that works by reducing substances in the body that cause pain and inflammation. It inhibits the enzyme cyclooxygenase (COX), which is involved in the production of prostaglandins. Prostaglandins are chemicals that promote inflammation, pain, and fever. By reducing the production of these chemicals, Diclofenac Sodium helps to alleviate pain and inflammation.

Ketamine HCl is a powerful anesthetic that provides pain relief by blocking the N-methyl-D-aspartate (NMDA) receptor, a type of glutamate receptor in the brain and spinal cord. By blocking this receptor, Ketamine HCl prevents the increase in the number of pain signals transmitted and reduces the perception of pain.

The gel formulation allows for easy and precise application of the medication directly to the area of discomfort. The active ingredients are absorbed through the skin, providing targeted treatment and reducing the potential for systemic side effects. The pump mechanism ensures that the correct dose is dispensed each time, eliminating the guesswork often associated with other dosage forms.

This formulation is particularly useful in treating conditions that involve pain and inflammation, such as arthritis, muscle strains, and nerve-related pain. By combining three different active ingredients, it provides a multi-faceted approach to pain management, addressing both the sensation of pain and the underlying inflammation that often accompanies it.

If you have any questions about this formulation, how it works, or how it can be used to treat specific conditions, please don't hesitate to reach out to us. Our team of knowledgeable compounding pharmacists at Bayview Pharmacy is always here to help.

Although primarily used for managing pain, the combination of Clonidine HCl 0.23%, Diclofenac Sodium 10%, and Ketamine HCl 5.75% in a topical gel form may also offer benefits for other medical conditions. Clonidine, initially developed as a hypertension medication, has found some use in treating withdrawal symptoms from opioids and managing part of the discontinuation process. However, we would advise consulting with a healthcare provider before using this medication for withdrawal therapy, as it would invariably need medical supervision.

Additionally, Diclofenac Sodium, as a nonsteroidal anti-inflammatory drug, might also be beneficial for symptoms associated with conditions like arthritis. This includes relieving pain, swelling, and joint stiffness. It's worth noting that Diclofenac Sodium should only be applied to intact skin and not to skin wounds or open injuries.

Ketamine HCl is generally used as an anesthetic in medical and veterinary practice. Some studies suggest that when applied topically, it can be useful in the management of neuropathic pain. Furthermore, its potential use in treating complex regional pain syndrome is currently being explored. However, this use is off-label and should be considered only under guidance from a healthcare provider.

No matter the use, patients must always follow their physician's dosing instructions for this compound. Incorrect use can lead to severe side effects such as heart problems, severe stomach pain, slow wound healing, and increasing the risk of heart attacks. This formulation is not advised for use during pregnancy due to potential fetal harm.

All mentioned uses are possibilities, but every individual is unique, and results can vary. It's critical to have a thorough discussion with a healthcare provider before embarking on any new treatment regimen. If any questions arise about this formulation, or if it's being considered for a different therapeutic use, please reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is always ready to provide guidance and support.