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This formulation is a combination of Clonidine HCL 0.23%, Gabapentin 6%, Ketamine HCL 10%, and Nifedipine 2% in a transdermal gel. It is a semisolid formulation dispensed through a pump mechanism, which allows for easy and precise application on the skin. The gel-like consistency aids in the targeted treatment or absorption of the active ingredients.
The Clonidine HCL component is used for treating high blood pressure, reducing the risk of strokes, heart attacks, and kidney problems. Gabapentin is used to relieve nerve pain following shingles in adults. Ketamine HCL is used for inducing anesthesia (lack of sensation or feeling) before surgery or certain procedures. Nifedipine is used to treat high blood pressure and angina (chest pain).
Together, these active ingredients work synergistically to manage and treat various disease states, providing relief and improving the quality of life for patients.
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This formulation is a unique combination of Clonidine HCL 0.23%, Gabapentin 6%, Ketamine HCL 10%, and Nifedipine 2% in a transdermal gel. It is a semisolid formulation that is dispensed through a pump mechanism, which allows for easy and precise application on the skin. The gel-like consistency of the formulation ensures that the active ingredients are absorbed effectively into the skin for targeted treatment.
Clonidine HCL is a medication that is primarily used to treat high blood pressure, but it can also be used to manage withdrawal symptoms from opioids and to treat attention deficit hyperactivity disorder (ADHD). In this formulation, it is used for its potential analgesic and anti-inflammatory properties. Gabapentin is an anticonvulsant and nerve pain medication that is commonly used to treat seizures and pain caused by shingles. In this formulation, it is used for its potential to reduce neuropathic pain.
Ketamine HCL is a powerful anesthetic that is used in both human and veterinary medicine. In this formulation, it is used for its potential to provide rapid relief from severe pain, particularly in cases where other pain medications are ineffective. Nifedipine is a calcium channel blocker that is primarily used to treat high blood pressure and angina. In this formulation, it is used for its potential to improve blood flow and reduce pain and inflammation.
This formulation is designed to be applied directly to the skin, which allows for targeted treatment and reduces the risk of systemic side effects. It can be used to treat a variety of disease states, including chronic pain conditions, neuropathic pain, and certain types of skin conditions. The combination of these four active ingredients provides a multi-modal approach to pain management, which can be particularly beneficial for patients who have not responded to other treatments.
As with any medication, it is important to use this formulation as directed by a healthcare provider. Potential side effects can include skin irritation, dizziness, and changes in blood pressure. If you experience any unusual or severe side effects, contact your healthcare provider immediately. If you have any questions about this formulation, please do not hesitate to reach out to us at Bayview Pharmacy. Our knowledgeable team of compounding pharmacists is always here to help.
This compounded formulation contains Clonidine HCL, Gabapentin, Ketamine HCL, and Nifedipine, all of which can interact with other medications. Clonidine HCL, an alpha-2 adrenergic agonist, can interact with beta-blockers, causing a rebound hypertension if either medication is discontinued abruptly. It can also interact with CNS depressants, potentially enhancing their sedative effects. Patients should be advised to avoid abrupt discontinuation of any of these medications and to avoid alcohol and other CNS depressants while using this formulation.
Gabapentin, an anticonvulsant and nerve pain medication, can interact with antacids, reducing the absorption of Gabapentin. It is recommended to take Gabapentin at least 2 hours after taking an antacid. Gabapentin can also increase the effects of opioids, leading to increased sedation and respiratory depression. Patients should be monitored closely for signs of respiratory depression and sedation when this formulation is used in combination with opioids.
Ketamine HCL, a NMDA receptor antagonist, can interact with other CNS depressants, potentially enhancing their sedative effects. It can also interact with medications that affect serotonin levels in the body, potentially leading to a condition called serotonin syndrome. Patients should be monitored closely for signs of serotonin syndrome, such as agitation, hallucinations, rapid heartbeat, fever, muscle stiffness, and loss of coordination.
Nifedipine, a calcium channel blocker, can interact with beta-blockers, potentially leading to heart failure, excessive lowering of blood pressure, or an increase in angina in some patients. It can also interact with CYP3A4 inhibitors, potentially increasing the levels of Nifedipine in the body and leading to an increased risk of side effects. Patients should be monitored closely for signs of heart failure, low blood pressure, angina, and side effects of Nifedipine when this formulation is used in combination with beta-blockers or CYP3A4 inhibitors.
This formulation is designed to be applied topically for targeted treatment, reducing the systemic absorption of the active ingredients and potentially reducing the risk of drug interactions. However, some systemic absorption can still occur, especially if the formulation is applied to large areas of skin or used over a long period of time. Patients should be advised to use this formulation as directed by their healthcare provider and to report any side effects or signs of drug interactions immediately.
If you have any questions about this formulation or its potential interactions with other medications, please do not hesitate to reach out to us. We are here to help and provide you with the most accurate and up-to-date information.
This formulation combines four active ingredients: Clonidine HCL, Gabapentin, Ketamine HCL, and Nifedipine, each with a unique mechanism of action, to provide a comprehensive treatment approach for various disease states. The formulation is designed to be applied topically, allowing for targeted treatment and absorption through the skin.
Clonidine HCL is an alpha-2 adrenergic agonist that works by stimulating receptors in the brain that reduce nerve signal transmission. This results in a decrease in nerve signals that cause blood vessels to constrict, thereby reducing blood pressure. In a topical formulation, Clonidine can provide localized relief from inflammation and pain.
Gabapentin is an anticonvulsant and nerve pain medication. It works by affecting the chemicals and nerves in the body that are involved in the cause of seizures and some types of pain. Gabapentin is particularly effective in treating nerve pain caused by shingles or herpes virus, diabetic neuropathy, and fibromyalgia.
Ketamine HCL is a powerful anesthetic that works by blocking the NMDA receptors in the brain, which are involved in pain transmission. This can provide significant pain relief, particularly for chronic and neuropathic pain conditions. In a topical formulation, Ketamine can provide targeted pain relief with minimal systemic side effects.
Nifedipine is a calcium channel blocker that works by relaxing the muscles of your heart and blood vessels. It is commonly used to treat hypertension (high blood pressure) and angina (chest pain). In a topical formulation, Nifedipine can help improve blood flow and reduce pain and inflammation in the applied area.
The semisolid formulation dispensed through a pump mechanism allows for easy and precise application on the skin. The gel-like consistency ensures that the active ingredients are absorbed effectively into the skin for targeted treatment. This formulation is particularly beneficial for patients who have difficulty swallowing pills or who require localized treatment for their condition.
As compounding pharmacists, we are committed to providing personalized medication solutions to meet the unique needs of each patient. If you have any questions about this formulation or how it may benefit you, please don't hesitate to reach out to us at Bayview Pharmacy. We are here to help.
This specific formulation of Clonidine HCL 0.23%/Gabapentin 6%/Ketamine HCL 10%/Nifedipine 2% Transdermal Gel is primarily prescribed for the management of certain pain conditions including neuropathic pain, fibromyalgia and hyperalgesia. However, it has various other uses as well.
Apart from its application in pain management, this formula can also be prescribed to manage certain types of angina (chest pain), high blood pressure, and Raynaud's syndrome; the latter being a condition where spasm of arteries cause episodes of reduced blood flow. Nutidipine in particular plays a key role in these conditions, as it's used to help relax the muscles of your heart and blood vessels.
Gabapentin is often used off-label for the treatment of anxiety disorders and insomnia. It works by stabilizing electrical activity in the brain and influences the release of excitatory neurotransmitters which can reduce symptoms of anxiety and aid sleep.
Lastly, Clonidine HCL is used for behavioral issues such as attention deficit hyperactivity disorder (ADHD), Tourette's syndrome, and conduct disorders in addition to its usage in hypertensive crises and withdrawal symptoms from opioids and smoking.
It's important to note that this formula should be used as per the doctor's directions. Misuse or overuse may reduce efficacy and may increase side effects including but not limited to redness, itching, and rash at the application site. Unlikely but serious side effects may include slow heartbeat, lightheadedness, mental/mood changes like depression, and severe abdominal pain or constipation. In case of any such side effects, patients are advised to consult their healthcare provider immediately. Additionally, the regular consumption of grapefruit or grapefruit juice should be avoided during treatment as it may increase the maturation of such medications leading to increased side effects.
If you have any additional questions about this or any other formulation, don't hesitate to reach out to us at Bayview Pharmacy. Our team of skilled compounding pharmacists will be more than happy to assist you.
It is a compounded medication that combines Clonidine HCL, Gabapentin, Ketamine HCL, and Nifedipine in a gel form that is dispensed through a pump mechanism to ensure easy and accurate application on the skin for the absorption of its active ingredients.
The gel should be applied directly to the area directed by your healthcare provider in the exact quantity prescribed. Always ensure your hands are clean before application and afterwards, unless your hands are the area being treated.
Yes, the gel is designed to facilitate easy and efficient absorption of the active ingredients directly into the skin.
If a dose is missed, apply it as soon as you remember. However, if it's close to the time for your next dose, skip the missed one and continue with your regular schedule. Never use double doses.
Each ingredient serves a specific purpose. Clonidine HCL is often used to treat high blood pressure, Gabapentin for nerve pain and seizures, Ketamine HCL for pain management, and Nifedipine relaxes the muscles of your heart and blood vessels.
It's crucial to inform your healthcare provider about any other medications you're taking as some medicines may interact with this gel. Your doctor will then make an informed decision regarding its use.
It's important to discuss the risks and benefits of this medication with your healthcare provider if you're pregnant or breastfeeding, as each individual's circumstances are unique.
As with any medication, there might be possible side effects which can range from mild to severe. Some side effects might include skin irritation at the application site or systemic side effects related with each active ingredient. Always notify your doctor if you experience any unusual effects after using this medication.
Never stop using the medication without consulting with your healthcare provider, even if your condition improves. Sudden discontinuation may lead to withdrawal symptoms or a relapse of your condition.
This medication should be stored in a closed container at room temperature, away from heat, moisture, and direct light. Always keep medication out of sight and reach of children.
