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Formulas

Clindamycin 2%/Niacinamide 5%/Tretinoin 0.05% Topical Cream

This formulation is a semisolid preparation of Clindamycin 2%, Niacinamide 5%, and Tretinoin 0.05% Topical Cream, dispensed in a pump mechanism for convenient and controlled application on the skin. The active ingredients are designed for localized treatment or absorption, providing an effective solution for various skin conditions.

Clindamycin is an antibiotic that prevents bacteria from growing on the skin. Niacinamide, also known as vitamin B3, has anti-inflammatory properties that can help ease redness from eczema, acne, and other inflammatory skin conditions. Tretinoin, a derivative of vitamin A, promotes skin cell turnover and is commonly used to treat acne and reduce the appearance of fine lines and wrinkles.

This formulation is primarily used to treat acne, rosacea, and aging-related skin conditions. It can also be beneficial for other inflammatory skin conditions and hyperpigmentation. Regular use can lead to improved skin texture, reduced inflammation, and a decrease in the appearance of wrinkles and fine lines.

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Topical Cream
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Formula Information

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This formulation is a compounded topical cream containing Clindamycin 2%, Niacinamide 5%, and Tretinoin 0.05%. It is a semisolid preparation dispensed in a pump mechanism, designed for convenient and controlled application on the skin. This formulation is intended for localized treatment or absorption of active ingredients.

Clindamycin is an antibiotic that works by stopping the growth of bacteria. It is used to treat a wide variety of bacterial infections. In this formulation, it is used to treat acne, reducing the number of acne lesions. Niacinamide, also known as vitamin B3, has anti-inflammatory properties that can help ease redness from eczema, acne, and other inflammatory skin conditions. It also helps build cells in the skin while also protecting them from environmental stresses, such as sunlight, pollution, and toxins.

Tretinoin, a derivative of vitamin A, is a common ingredient in topical skincare products that treat acne. It works by promoting the turnover of skin cells, which helps to unclog pores. Tretinoin can also reduce the appearance of fine wrinkles and mottled skin discoloration, and it can make rough facial skin feel smoother.

This formulation is typically applied once daily, or as directed by a healthcare provider. It should be applied to the affected areas of the skin, avoiding the eyes, mouth, and any areas of broken skin. It is important to use this medication regularly to get the most benefit from it. Remember to use it at the same time each day.

Side effects may include skin dryness, burning, redness, excessive flaking, or peeling. If these effects persist or worsen, notify your doctor or pharmacist promptly. It is important to note that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects.

As compounding pharmacists, we are able to customize this formulation to meet individual patient needs. If you have any questions about this formulation, or if you would like to discuss other treatment options, please do not hesitate to reach out to us at Bayview Pharmacy. We are here to help.

Drug Interactions

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This formulation combines Clindamycin, Niacinamide, and Tretinoin, all of which are active ingredients with distinct mechanisms of action. Clindamycin is an antibiotic that prevents bacteria from growing on the skin. Niacinamide, also known as vitamin B3, has anti-inflammatory properties that can help ease redness from eczema, acne, and other inflammatory skin conditions. Tretinoin, a derivative of vitamin A, promotes skin cell turnover and reduces the appearance of fine lines, wrinkles, and uneven skin tone.

When using this formulation, it's important to be aware of potential drug interactions. Clindamycin, when used topically, is generally safe and has minimal systemic absorption. However, it may interact with other antibiotics or neuromuscular blocking agents if used systemically. Niacinamide is generally well-tolerated and has minimal interactions, but it may reduce the effectiveness of certain chemotherapy drugs. Tretinoin may interact with drugs that increase your sensitivity to sunlight, such as diuretics, antibiotics, and sulfa drugs, leading to an increased risk of sunburn.

Patients should also be aware that using this formulation with other topical products that have a strong drying effect may increase the potential for skin irritation. This includes products containing sulfur, resorcinol, or salicylic acid. If you're using any other topical medications, it's important to discuss this with your healthcare provider to avoid potential interactions.

This formulation is designed to treat a variety of skin conditions. The combination of Clindamycin and Niacinamide can effectively manage acne by reducing inflammation and bacterial growth. Tretinoin is beneficial for treating signs of aging, such as fine lines and wrinkles, and can also help with acne and hyperpigmentation. However, it's important to note that Tretinoin can cause skin irritation and increase sensitivity to sunlight, so it's crucial to use sun protection while using this product.

As with any medication, it's important to use this product as directed by your healthcare provider. If you have any questions or concerns about this formulation or its potential interactions with other medications or products you're using, don't hesitate to reach out to us. We're here to help ensure that you're using this product safely and effectively.

How Does it Work

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This formulation combines three active ingredients: Clindamycin, Niacinamide, and Tretinoin, each with a unique mechanism of action to treat various skin conditions. The cream is designed to be applied topically, allowing the active ingredients to be absorbed directly into the skin where they can exert their effects.

Clindamycin is an antibiotic that works by stopping the growth of bacteria that cause acne. It does this by binding to the 50S subunit of the bacterial ribosome, inhibiting protein synthesis and thus bacterial growth. This helps to reduce the number of acne-causing bacteria on the skin, reducing the inflammation and redness associated with acne.

Niacinamide, also known as vitamin B3, has anti-inflammatory properties that can help ease redness from eczema, acne, and other inflammatory skin conditions. It also helps to build proteins in the skin and lock in moisture to prevent environmental damage. Niacinamide can also minimize pore appearance, keep skin smooth, and reduce the impact of environmental damage because of its ability to improve skin's barrier (its first line of defense), plus it also plays a role in helping the skin repair signs of past damage.

Tretinoin, a derivative of vitamin A, works by affecting the growth of skin cells. It is commonly used to treat acne and reduce the appearance of fine wrinkles and mottled skin discoloration, and to make rough facial skin feel smoother. Tretinoin promotes the peeling of affected skin areas and unclogs pores. This helps to reduce the formation of blackheads, whiteheads, and other acne lesions, and allows faster healing of acne that does develop.

Together, these three ingredients provide a comprehensive treatment for acne and other inflammatory skin conditions. The cream is dispensed in a pump mechanism, which allows for convenient and controlled application of the product. This ensures that the correct amount of product is applied each time, maximizing its effectiveness while minimizing potential side effects.

If you have any questions about this formulation, its uses, or how it works, please don't hesitate to reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is always here to help.

Other Uses

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This formulation of Clindamycin 2%/Niacinamide 5%/Tretinoin 0.05% Topical Cream is not solely restricted for the treatment of certain dermatological conditions. Clindamycin, an antibiotic, works by stopping the growth of bacteria that may cause skin infections. Therefore, it may also be utilized in the management of other less common bacterial skin infections. Niacinamide, or vitamin B3, has anti-inflammatory properties and can improve the skin's barrier function, therefore, it can be potentially beneficial for patients suffering from inflammatory skin disorders such as rosacea, atopic dermatitis, or even psoriasis. Its ability to regulate oil production might also make it advantageous in management of acne. Additionally, Niacinamide is known to reduce skin hyperpigmentation, so it can be used in the treatment of melasma or post-inflammatory hyperpigmentation.

Tretinoin, a form of vitamin A, helps the skin to renew itself more quickly and therefore, aside from treating acne, it is often used to improve the appearance of the skin, including reducing fine wrinkles and mottled skin discoloration. It can also be used to smooth rough facial skin, a condition primarily caused by sun damage. Given Tretinoin's functionality, it is also used off-label for addressing skin damage caused by aging or excessive sun exposure.

It's always recommended to talk to your healthcare provider to discuss additional uses of this preparation. It's crucial that this formulation is used strictly under medical supervision since misuse can lead to unwanted side effects. As compounding pharmacists at Bayview Pharmacy, we are here to help answer any questions you may have and to work closely with healthcare providers to ensure this formulation is appropriate for your particular needs. Feel free to reach out to us at any time.

Frequently Asked Questions

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What is Clindamycin 2%/Niacinamide 5%/Tretinoin 0.05% Topical Cream?

This is a compounded formulation made up of Clindamycin, Niacinamide, and Tretinoin. It's designed to be topically applied on the skin for local treatment, and is dispensed through a pump mechanism for easy and controlled application.

What are the active ingredients in this cream?

The active ingredients are Clindamycin (2%), Niacinamide (5%), and Tretinoin (0.05%).

How should I apply this cream?

This cream should be applied to the affected areas in a thin layer as directed by your physician. It comes in a pump mechanism for handy and controlled application.

What are the potential side effects of this cream?

Side effects may include skin irritation, dryness, peeling, or redness. Please consult your doctor if you notice anything unusual or if the side effects persist.

Can I use this cream with other skincare products?

It depends on the other skincare products you're using. You should consult your dermatologist before mixing it with other skincare preparations. Certain products may interfere with the efficacy of this cream.

How should I store this cream?

Store this cream at room temperature, away from heat and direct sunlight. Ensure not to freeze the cream. Keep the bottle tightly closed when not in use.

Can this cream be used to treat acne?

Yes. The active ingredients in this cream are commonly used in the treatment of acne. However, your dermatologist will determine the correct treatment course based on your skin condition.

What should I do if I miss a dose?

If you miss a dose, apply it as soon as you remember. However, if it's near the time for the next dose, skip the missed one and go back to your regular schedule. Do not double the dose to catch up.

Who should avoid using this cream?

This cream is generally safe for most people to use. However, individuals who are allergic to any of the active ingredients, pregnant or breastfeeding should consult their doctor before using this medication.

Can this cream bleach or discolour my skin or clothes?

The cream does not have any bleaching properties and should not discolour your skin. However, it's always a good idea to let it dry completely before dressing to avoid any potential transfer or staining of clothing.

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Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.