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Formulas

Clindamycin 1%/Niacinamide 4%/Tretinoin 0.035% Topical Cream

This formulation is a compounded topical cream containing Clindamycin 1%, Niacinamide 4%, and Tretinoin 0.035%. It is a semisolid preparation dispensed in a pump mechanism, designed for convenient and controlled application on the skin. The active ingredients are intended for localized treatment or absorption.

Clindamycin is an antibiotic that prevents bacteria from growing on the skin. Niacinamide, also known as vitamin B3, has anti-inflammatory properties that can help ease redness from eczema, acne, and other inflammatory skin conditions. Tretinoin is a form of vitamin A that helps the skin renew itself more quickly.

This formulation is used to treat various disease states including acne, rosacea, and other inflammatory skin conditions. It can also be used to improve the appearance of the skin by reducing fine lines and wrinkles, improving skin texture, and reducing discoloration and brown spots caused by sun damage.

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Niacinamide
Tretinoin
Clindamycin Hydrochloride
Topical Cream
653f3de7244f02c2d3b6c8a8
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Formula Information

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This formulation is a topical cream containing Clindamycin 1%, Niacinamide 4%, and Tretinoin 0.035%. It is a semisolid preparation dispensed in a pump mechanism, designed for convenient and controlled application on the skin. This formulation is intended for localized treatment or absorption of active ingredients.

Clindamycin is an antibiotic that works by stopping the growth of bacteria. It is used to treat a wide variety of bacterial infections. In this formulation, it is used to treat acne, reducing the number of acne lesions. Niacinamide, also known as vitamin B3, has anti-inflammatory properties that can help ease redness from eczema, acne, and other inflammatory skin conditions. It also helps build keratin, a type of protein that keeps your skin firm and healthy.

Tretinoin, a derivative of vitamin A, is used to treat acne and reduce the appearance of fine wrinkles and mottled skin discoloration. It works by affecting the growth of skin cells. The combination of these three active ingredients makes this formulation effective in treating various skin conditions, including acne, rosacea, and signs of aging.

It is important to note that this formulation should be used as directed by a healthcare professional. It should be applied to the affected area once a day, preferably at bedtime. The area should be clean and dry before application. Avoid contact with the eyes, mouth, or open cuts. Wash your hands before and after applying this medication. It may take several weeks to months to notice improvement in your skin.

Side effects may include skin redness, dryness, itching, scaling, mild burning, or worsening of acne during the first 2 to 4 weeks of using the medication. If any of these effects persist or worsen, notify your doctor or pharmacist promptly. It is also important to protect your skin from the sun and avoid sunlamps or tanning booths while using this medication.

If you have any questions about this formulation or its use, please do not hesitate to reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is always ready to assist you.

Drug Interactions

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This formulation combines Clindamycin, Niacinamide, and Tretinoin, all of which are active ingredients with distinct mechanisms of action and potential interactions. Clindamycin is an antibiotic that prevents bacteria from growing on the skin. Niacinamide, also known as vitamin B3, has anti-inflammatory properties that can help ease redness from eczema, acne, and other inflammatory skin conditions. Tretinoin, a derivative of vitamin A, promotes skin cell turnover and is commonly used to treat acne and reduce the appearance of fine lines and wrinkles.

Clindamycin, when used topically, has minimal systemic absorption and thus, systemic drug interactions are unlikely. However, it may antagonize the effects of neuromuscular blocking agents. Caution should be exercised when used concurrently with such agents. Niacinamide is generally well-tolerated and has minimal interactions. However, it may enhance the effects of antihypertensive medications, potentially leading to hypotension. Tretinoin may increase the toxicity of drugs that are photosensitizing, such as thiazide diuretics, sulfonylureas, fluoroquinolones, and phenothiazines. Concurrent use with these medications should be done with caution.

This formulation is primarily used to treat acne vulgaris, a common skin condition characterized by the presence of blackheads, whiteheads, and pimples. Clindamycin works by reducing the bacterial population on the skin, Niacinamide reduces inflammation, and Tretinoin promotes the turnover of skin cells to prevent the formation of acne lesions. It may also be used off-label to treat rosacea, a skin condition that causes redness and visible blood vessels in the face.

Patients should be advised to apply this cream as directed by their healthcare provider, usually once daily at bedtime. The cream should be applied to the areas of the skin where acne lesions appear, using enough to cover the entire affected area lightly. Patients should be cautioned against applying this medication to the eyes, mouth, angles of the nose, or mucous membranes as it may cause irritation. They should also be advised to avoid unnecessary sun exposure and to use a sunscreen during the day, as Tretinoin can make the skin more sensitive to sunlight.

Prescribers should be aware that this formulation may cause skin irritation, dryness, and peeling, especially during the first few weeks of treatment. These side effects usually decrease with continued use of the medication. If they become severe or persist, the prescriber should be contacted. Additionally, prescribers should be aware of the potential interactions of each component of this formulation and adjust the treatment plan accordingly.

If you have any questions about this formulation, its uses, potential side effects, or interactions, please do not hesitate to reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is always here to assist you.

How Does it Work

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This formulation combines three active ingredients: Clindamycin, Niacinamide, and Tretinoin, each with a unique mechanism of action to treat various skin conditions. Clindamycin is an antibiotic that works by stopping the growth of bacteria that cause acne. It reduces the number of acne lesions by killing the bacteria that infects pores and by decreasing certain natural oily substances that lead to acne.

Niacinamide, also known as vitamin B3, has anti-inflammatory properties that can help ease redness from eczema, acne, and other inflammatory skin conditions. It also helps build proteins in the skin and lock in moisture to prevent environmental damage. Niacinamide can also minimize pore appearance, keep skin smooth, and reduce the impact of environmental damage because of its ability to improve skin's resilience.

Tretinoin, a derivative of vitamin A, works by affecting the growth of skin cells. It promotes the turnover of cells and helps to expel the dead cells from the skin surface. This prevents the formation of acne and allows quicker healing of acne that does develop. Tretinoin is also known to improve the appearance of fine wrinkles and roughness of facial skin.

The formulation is dispensed in a pump mechanism, which allows for convenient and controlled application on the skin. This ensures that the right amount of medication is applied to the affected area, enhancing the effectiveness of the treatment. The cream is designed to be absorbed by the skin, delivering the active ingredients directly to the site of the skin condition.

This formulation is used to treat a variety of skin conditions, including acne, rosacea, and signs of aging. The combination of these three active ingredients works synergistically to reduce inflammation, kill bacteria, and promote skin cell turnover, leading to clearer, healthier skin over time.

As with any medication, it's important to use this formulation as directed by your healthcare provider. Side effects can include skin irritation, dryness, and peeling. If you experience any severe side effects or if your condition does not improve, contact your healthcare provider immediately.

If you have any questions about this formulation, how to use it, or if it's the right treatment for your skin condition, don't hesitate to reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is here to help.

Other Uses

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This formulation primarily composes three active ingredients: Clindamycin, Niacinamide, and Tretinoin. Although these are most commonly used for treating acne vulgaris, they may have other beneficial applications as well.

Clindamycin is an antibiotic that prevents bacteria from growing on the skin, hence, it may aid in conditions where bacterial growth is a contributing factor. It could be prescribed for treating bacterial skin infections. The anti-inflammatory properties of Clindamycin can make it applicable in the management of skin conditions like rosacea.

Niacinamide, also known as vitamin B3, has a wide range of uses. It helps reduce redness and swelling, and thus could be prescribed for inflammatory skin conditions. It is also well known for its anti-aging properties and can help to rebuild healthy skin cells while also protecting them from environmental damages including UV-induced skin cancer. Recent studies suggest that the consistent use of niacinamide can help to brighten the skin and reduce hyperpigmentation, fine lines and wrinkles. Therefore, this formulation may also be of interest in addressing concerns related to skin ageing and sun damage.

Tretinoin is a derivative of Vitamin A, and is often used for treating acne and signs of aging, thanks to its ability to speed up skin cell turnover. Aside from acne, tretinoin can also be used for enhancing overall skin appearance, bringing about a more youthful glow by reducing fine lines, sun spots, and uneven skin tone.

In some cases, this distinctive blend of clindamycin, niacinamide, and tretinoin may be potentially beneficial for off-label uses, based on doctor's discretion and after individual patient assessment. Each of the components has strong evidence supporting their use in various dermatological conditions, and their combined action may offer an enhanced benefit in some cases.

However, with any medication, it's essential to carefully consider possible side effects and interactions. Your doctor or pharmacist can provide more comprehensive information based on individual patient's health history. Please reach out to us, at Bayview Pharmacy, if you have any further questions or concerns related to your prescription. As always, any new treatment regimen should be closely monitored by a healthcare professional.

Frequently Asked Questions

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What is the active ingredient in this product?

The active ingredients in this formulation are Clindamycin 1%, Niacinamide 4% and Tretinoin 0.035%.

What is the form of this compounded formulation?

This product is a semisolid preparation intended to be applied on the skin.

What is unique about the dispense mechanism of this cream?

This product is dispensed through a pump mechanism, which provides convenient and controlled application on the skin.

How does this product function?

When applied, this cream treats or absorbs in the localized area due to its active ingredients.

How should this product be stored?

Store this preparation in a cool, dry place and out of direct sunlight. Please refer to the packaging for specific storage instructions.

Is this product safe to use with other skincare products?

Generally, this preparation is safe to use with other skincare products. However, it is advisable to consult with a healthcare provider or pharmacist about potential interactions.

How should this product be applied?

This product is designed to be applied to the affected areas of the skin. Follow the instructions given by your healthcare provider on how much to use.

What are the indications for this product?

This compounded formulation is typically prescribed to patients with certain specific skin conditions. A healthcare provider would be best to determine if this product is appropriate for a patient's specific situation and condition.

Can I use this product if I am pregnant or breastfeeding?

Consult with a healthcare provider before using this product if you are pregnant or breastfeeding.

What should I do if I experience any side-effects?

If any side effects occur, stop using the product and immediately contact your healthcare provider.

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Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.