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Formulas

Clindamycin 1%/Ketoconazole 2%/Salicylic Acid 1% Topical Liquid

This formulation is a specially designed topical liquid that combines Clindamycin 1%, Ketoconazole 2%, and Salicylic Acid 1%. It is intended for direct application to the skin or mucosal surfaces, providing targeted therapeutic benefits. This formulation is often chosen for localized treatment or when the avoidance of systemic effects is desired.

Clindamycin is an antibiotic that fights bacteria in the body, Ketoconazole is an antifungal medication that prevents fungus from growing on your skin, and Salicylic Acid is a keratolytic (peeling agent) that causes shedding of the outer layer of skin. The combination of these three active ingredients makes this formulation effective in treating various skin conditions such as acne, fungal infections, and psoriasis.

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Topical Liquid
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Formula Information

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This formulation combines Clindamycin 1%, Ketoconazole 2%, and Salicylic Acid 1% in a topical liquid preparation. Clindamycin is an antibiotic that prevents bacteria from growing on the skin. It is used to treat severe acne and helps to decrease the number of acne lesions. Ketoconazole is an antifungal medication that prevents fungus from growing on your skin. It is used to treat skin infections such as athlete's foot, jock itch, ringworm, and certain kinds of dandruff. Salicylic Acid is a keratolytic (peeling agent) that causes shedding of the outer layer of skin. It is used to treat skin conditions such as acne, dandruff, psoriasis, and seborrheic dermatitis of the skin and scalp.

The liquid preparation is designed for direct application to the skin or mucosal surfaces, offering targeted therapeutic benefits. This is often chosen for localized treatment or when avoiding systemic effects is desired. The formulation is applied topically, which means it is applied directly to the area of the skin where the treatment is needed. This can help to reduce the potential for systemic side effects, such as stomach upset or dizziness, that can occur with oral medications.

It is important to use this medication exactly as prescribed by your doctor. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Use Clindamycin, Ketoconazole, and Salicylic Acid exactly as directed. Do not use more or less of it or use it more often than prescribed by your doctor.

Before using this medication, clean the affected area with a mild soap or cleanser, rinse with warm water, and pat dry. Apply a thin layer of the medication to the affected area. Be careful not to get the medication in your eyes, nose, or mouth. If you do get the medication in these areas, rinse with plenty of water.

It is important to continue using this medication even if you feel well. Do not stop using the medication without talking to your doctor. If you stop using the medication too early, your symptoms may return.

If you have any questions about this formulation or its use, please do not hesitate to reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is here to assist you.

Drug Interactions

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This formulation combines the antibiotic Clindamycin, the antifungal Ketoconazole, and the keratolytic agent Salicylic Acid. Clindamycin is effective against a range of bacteria, including those responsible for acne. Ketoconazole is an antifungal medication that treats skin infections such as athlete's foot, jock itch, ringworm, and certain kinds of dandruff. Salicylic Acid helps to shed dead skin cells from the top layer and decrease redness and swelling (inflammation).

While this formulation is generally safe, it's important to be aware of potential drug interactions. Clindamycin, when used topically, has minimal systemic absorption and thus, the likelihood of systemic drug interactions is low. However, it may interact with neuromuscular blocking agents, so caution should be exercised if the patient is also receiving such treatments. Ketoconazole, even when used topically, can interact with many drugs due to its effect on certain liver enzymes. It can increase the levels of many drugs in the body, including certain antihistamines, benzodiazepines, calcium channel blockers, and certain statins. Salicylic Acid is also absorbed minimally through the skin, but caution should be exercised if the patient is also taking other medications that affect blood clotting or platelet function, such as aspirin, clopidogrel, or warfarin, as it may enhance their effects.

Patients should be advised to inform their healthcare provider of all the medications they are currently taking, including over-the-counter drugs, dietary supplements, and herbal products. They should also be advised to avoid using other topical products on the same area unless directed by their healthcare provider, as this may alter the effectiveness of the medication or increase the risk of side effects. If irritation or sensitivity develops with the use of this formulation, the patient should be advised to discontinue use and consult their healthcare provider.

This formulation is intended for topical use only and should not be ingested or applied to the eyes or mucous membranes. It should be used as directed by a healthcare provider, and the treated area should not be bandaged or otherwise covered or wrapped unless directed by a healthcare provider. Patients should be advised to wash their hands after applying this medication, unless the hands are the area being treated.

If you have any questions about this formulation or its use, please do not hesitate to reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is always here to help.

How Does it Work

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This formulation combines the antibiotic Clindamycin, the antifungal Ketoconazole, and the keratolytic agent Salicylic Acid in a liquid preparation designed for direct application to the skin or mucosal surfaces. Each of these active ingredients plays a crucial role in managing various skin conditions.

Clindamycin, an antibiotic, works by inhibiting bacterial protein synthesis, thereby stopping the growth of bacteria. It is particularly effective against Propionibacterium acnes, a bacterium that contributes to the pathogenesis of acne. By reducing the population of these bacteria on the skin, Clindamycin helps to reduce the inflammation and redness associated with acne.

Ketoconazole is an antifungal medication that works by disrupting the cell membrane of fungi, causing the cell contents to leak out and leading to the death of the fungus. It is effective against a wide range of fungi, including those that cause conditions such as seborrheic dermatitis and tinea versicolor. By eliminating the fungal infection, Ketoconazole helps to alleviate symptoms such as itching, redness, and scaling.

Salicylic Acid is a keratolytic agent, which means it works by softening and loosening the top layer of skin, allowing the removal of dead skin cells. This helps to unclog pores and reduce the formation of comedones, which are often a precursor to acne lesions. Salicylic Acid also has mild anti-inflammatory properties, which can help to reduce the redness and swelling associated with acne and other inflammatory skin conditions.

By combining these three active ingredients in a single formulation, this product offers a comprehensive approach to the management of various skin conditions. The liquid preparation allows for easy application and ensures that the active ingredients are delivered directly to the affected area, providing targeted therapeutic benefits. This formulation is often chosen for localized treatment or when avoiding systemic effects is desired.

As with any medication, it is important to use this product as directed by a healthcare professional. Side effects may include dryness, peeling, or irritation at the application site. If these side effects persist or worsen, or if you have any questions about this formulation, please reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is always here to help.

Other Uses

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This topical formulation containing Clindamycin, Ketoconazole, and Salicylic Acid has therapeutic efficacy beyond those traditionally known. Aside from treating skin and mucosal surface infections, it now emerges as a practical alternative for several other skin conditions.

Clindamycin, an antibiotic, serves to inhibit bacterial protein synthesis, making it potentially effective for acne, folliculitis, and wounds infected with susceptible Gram-positive bacteria. In addition to its commonly known purpose, it has been used off-label in treating hidradenitis suppurativa, a condition characterized by chronic inflammation of hair follicles.

Ketoconazole, an antifungal medication, is traditionally used to treat fungal skin infections such as athlete's foot, ringworm, and seborrheic dermatitis. Beyond that, it may manage condition-related symptoms with persistent inflammation and pruritus, due to its anti-inflammatory properties. Ketoconazole might also work as an adjunct treatment for hair loss conditions, including androgenetic alopecia and alopecia areata.

The addition of salicylic acid, a keratolytic (peeling) agent, assists in skin conditions where the reduction of keratin buildup is helpful. This includes psoriasis, calluses, keratosis pilaris and common warts. Salicylic acid can enhance the penetration of other topical medications, potentially improving their therapeutic effectiveness.

Individual responses can vary, and these uses may not be suited to all patients, potentially causing skin irritation or other localized side effects in a small subset of individuals. We strongly advise consultation with a healthcare provider before using this formulation for any off-label purposes. You are welcome to direct any questions or concerns towards us, so we can provide necessary and timely assistance.

Frequently Asked Questions

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What is the purpose of Clindamycin 1%/Ketoconazole 2%/Salicylic Acid 1% Topical Liquid?

This is a specially formulated topical treatment. It's designed for direct application to skin or mucosal surfaces, providing targeted therapeutic benefits. It is often chosen for localized treatments when trying to avoid systemic effects.

What are the main ingredients in this formulation?

This formulation combines Clindamycin 1%, Ketoconazole 2%, and Salicylic Acid 1% to provide a comprehensive topical treatment.

Why should I use a topical treatment instead of systemic medication?

Topical treatments like Clindamycin/Ketoconazole/Salicylic Acid Liquid may have fewer systemic side effects than oral medications. They work primarily at the site of application, limiting their impact on the rest of your body.

How do I apply this formulation on my skin?

Using clean hands, apply the liquid directly to the affected area of the skin. Avoid contact with the eyes, nostrils or mouth. For specific instructions, consult with your healthcare provider.

How often should I use this treatment?

Frequency of use depends on the exact condition being treated, your medical history, and your healthcare provider's instructions. Always follow your healthcare provider's guidance on frequency and duration of use.

What happens if I miss an application?

If you forget an application, apply it as soon as you remember. However, if it's near the time for the next dose, skip the missed dose and go back to your regular schedule. Don't double the dose to catch up.

What side effects can be experienced from this topical liquid?

Most common side effects include mild burning or stinging, redness or dryness of the treated skin area. If you experience more serious side effects such as severe skin irritation, or signs of systemic absorption like stomach discomfort, contact your healthcare provider immediately.

Can I use other skincare products after applying the topical liquid?

This depends on the specific product and situation. In general, you should let the topical liquid dry completely before applying other products. Your healthcare provider can provide you with tailored advice.

Can I apply this topical treatment to broken or sensitive skin?

No, this treatment should only be applied to intact skin. Avoid application on broken skin unless directed to do so by your healthcare provider.

Is this formulation safe for use during pregnancy or breastfeeding?

Always consult your healthcare provider before using any medication during pregnancy or breastfeeding. The risk and benefits should be discussed and considered thoroughly with your provider.

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Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.