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Cisapride 25 mg/ml Transdermal Gel (Vet)

Cisapride 25 mg/ml Transdermal Gel (Vet) is a semisolid formulation designed for easy and precise application on the skin of animals. Dispensed through a pump mechanism, this formulation ensures targeted treatment or absorption of the active ingredient, Cisapride, in a gel-like consistency. This veterinary medication is primarily used to treat gastrointestinal disorders such as chronic constipation, gastroesophageal reflux disease (GERD), and other conditions related to impaired gastric motility in animals.

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Cisapride Monohydrate
Topical Gel
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Formula Information

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Cisapride 25 mg/ml Transdermal Gel (Vet) is a specialized formulation designed for easy and precise application on the skin. This semisolid formulation is dispensed through a pump mechanism, which allows for targeted treatment or absorption of the active ingredients. The gel-like consistency ensures that the medication is absorbed effectively into the skin, providing optimal therapeutic benefits.

The active ingredient in this formulation, Cisapride, is a prokinetic agent that works by enhancing the motility of the gastrointestinal tract. It is commonly used in veterinary medicine to treat a variety of gastrointestinal disorders, including gastroesophageal reflux disease (GERD), chronic constipation, and certain forms of megacolon. By increasing the movement of the stomach and intestines, Cisapride helps to speed up the passage of food and reduce symptoms such as heartburn and regurgitation.

Transdermal delivery of Cisapride offers several advantages over oral administration. It bypasses the first-pass metabolism in the liver, which can lead to a more predictable and sustained therapeutic effect. It also reduces the risk of gastrointestinal side effects, which can be particularly beneficial for animals with sensitive stomachs or those who are prone to vomiting. Furthermore, transdermal application can be more convenient and less stressful for both the pet and the owner, especially in cases where oral administration is difficult or refused.

It's important to note that while Cisapride Transdermal Gel can be highly effective, it's not suitable for all animals. Certain precautions should be taken when using this medication, particularly in animals with known hypersensitivity to Cisapride or those with certain heart conditions. As with any medication, it's crucial to follow the prescribing veterinarian's instructions closely and monitor the animal for any potential side effects.

At Bayview Pharmacy, we are committed to providing high-quality, personalized care for all our patients. Our team of compounding pharmacists has extensive knowledge and experience in formulating and dispensing veterinary medications. If you have any questions about Cisapride 25 mg/ml Transdermal Gel (Vet) or any other aspect of your pet's medication, please don't hesitate to reach out to us. We're here to help.

Drug Interactions

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Cisapride is a prokinetic agent that enhances the motility of the gastrointestinal tract. It is commonly used in veterinary medicine to treat conditions such as chronic constipation, megacolon, and gastroesophageal reflux disease. However, it's important to note that Cisapride can interact with several other medications, potentially altering their effects or increasing the risk of adverse reactions.

One of the most significant interactions is with drugs that inhibit the cytochrome P450 3A4 enzyme system, such as ketoconazole, itraconazole, erythromycin, and certain antifungal drugs. These medications can increase the concentration of Cisapride in the body, potentially leading to serious cardiac side effects such as arrhythmias. Therefore, concurrent use of these drugs with Cisapride should be avoided.

Additionally, Cisapride can interact with certain anticholinergic drugs, which are often used to treat conditions like asthma, COPD, gastrointestinal disorders, and certain types of urinary incontinence. These drugs can reduce the effectiveness of Cisapride, potentially necessitating a dosage adjustment or alternative treatment.

Drugs that alter the pH of the stomach, such as proton pump inhibitors and H2 blockers, can also interact with Cisapride. These medications can affect the absorption of Cisapride, potentially reducing its effectiveness. If a patient is receiving one of these medications, the prescriber may need to adjust the dose of Cisapride or monitor the patient more closely for signs of reduced efficacy.

Lastly, Cisapride can interact with certain sedatives and tranquilizers, such as benzodiazepines and barbiturates. These drugs can enhance the sedative effects of Cisapride, potentially leading to excessive sedation or respiratory depression. If a patient is receiving one of these medications, the prescriber may need to adjust the dose of Cisapride or monitor the patient more closely for signs of excessive sedation.

It's important for patients and prescribers to be aware of these potential interactions and to monitor for signs of adverse reactions. If you have any questions about these interactions or about the use of Cisapride in general, please don't hesitate to reach out to us at Bayview Pharmacy. We're here to help ensure that your pet receives the safest and most effective treatment possible.

How Does it Work

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Cisapride 25 mg/ml Transdermal Gel (Vet) is a specially formulated medication designed for easy application and targeted treatment. The active ingredient, Cisapride, is suspended in a gel-like consistency that is dispensed through a pump mechanism. This allows for precise dosing and application, ensuring that the medication is delivered directly to the area where it is needed most.

The active ingredient, Cisapride, works by enhancing the movement of the gastrointestinal tract. It is a prokinetic agent that increases the release of acetylcholine, a neurotransmitter that stimulates the smooth muscles in the gastrointestinal tract. This action helps to speed up the passage of food through the stomach, improving digestion and reducing symptoms such as bloating, heartburn, and nausea.

When applied to the skin, the Cisapride Transdermal Gel is absorbed directly into the bloodstream, bypassing the digestive system. This allows for a more rapid onset of action and reduces the risk of side effects associated with oral administration. The gel formulation also allows for a more controlled release of the medication, providing sustained relief over a longer period of time.

This formulation is particularly useful in treating a variety of gastrointestinal disorders in animals, including gastroesophageal reflux disease (GERD), gastroparesis, and chronic idiopathic constipation. By improving the movement of the gastrointestinal tract, Cisapride helps to alleviate the symptoms associated with these conditions and improve the overall quality of life for the animal.

It is important to note that while Cisapride Transdermal Gel is a powerful and effective medication, it should only be used under the supervision of a veterinarian. The dosage and frequency of application will depend on the specific condition being treated and the individual needs of the animal. As with any medication, it is important to monitor the animal closely for any signs of adverse reactions or side effects.

If you have any questions about Cisapride 25 mg/ml Transdermal Gel (Vet), or if you would like more information about how this medication can benefit your animal, please do not hesitate to reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is always here to help.

Other Uses

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While Cisapride is most commonly prescribed for the treatment of gastroesophageal reflux and gastrointestinal motility disorders in animals, it has been used for other purposes as well. These include the treatment of chronic constipation, idiopathic megaesophagus, and even diabetic gastroparesis. Due to its promotility effects, it aids in the faster movement of food through the digestive tract. A Transdermal version of this medication can be particularly beneficial as it allows for absorption of the active ingredients directly through the skin, rather than having to be ingested orally – a versatile method that has been found useful especially for animals that have difficulty in swallowing medication.

In addition to improved GI motility, cisapride may also stimulate an increase in lower esophageal sphincter pressure, which can reduce incidences of stomach acid backing up into the esophagus (reflux). Keep in mind that although this medication may be used for the above mentioned conditions, your veterinarian may prescribe this for other conditions as well. Always follow your veterinarian's precise instructions on how to administer this medication.

While the transdermal delivery system is generally well-tolerated, side effects can occur and you should monitor your pet closely for any unusual symptoms. Seek veterinary attention if your pet exhibits signs of an allergic reaction, such as rash, itching, swelling, severe dizziness or trouble breathing. Since cisapride is sometimes used for off-label purposes, it's important for veterinarians and pet owners alike to stay informed about potential risks and contraindications. A consultation with a veterinary professional is vital for an understanding of personalized risks and benefits, prior to beginning any new treatment plan.

With any questions about Cisapride 25 mg/ml Transdermal Gel or about its use for conditions not mentioned here, please get in touch with us at Bayview Pharmacy. Our team of compounding pharmacists is always available to provide comprehensive information, in our continuous pursuit of promoting the best-quality care for your pets.

Frequently Asked Questions

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What is this Cisapride 25 mg/ml Transdermal Gel (Vet) formulation?

This formulation is a semisolid preparation of Cisapride, dispensed through a pump mechanism. It's intended for easy application on the skin for targeted treatment or absorption of active ingredients that are in a gel-like consistency.

What is the primary use of this formulation?

This formulation is designed for veterinary use, specifically for the targeted delivery and absorption of the active ingredient, Cisapride, through the skin.

How does the pump mechanism work?

The pump mechanism facilitates the precise dispensation and application of the formulation onto the skin. By pressing down on the pump, a fixed dose of the gel is released.

What is the texture and consistency of this gel?

The gel has a consistency that's semi-solid, somewhat similar to jelly. It's designed this way for easy application and absorption through the skin.

How is Cisapride absorbed by the skin?

Cisapride present in the gel formulation is absorbed into the skin due to the matrix of the gel and the permeability of the skin. Once applied, the active ingredient slowly penetrates the skin layers to exert its therapeutic effect.

How is this product administered?

The product is typically applied to a clean, non-irritated area of skin. The amount required depends on the prescribed dose. Always read the packaging for specific applicational guidelines and recommendations.

What are the benefits of transdermal drug delivery?

Transdermal drug delivery allows for targeted treatment, reducing systemic side effects commonly associated with orally administered drugs. It also allows for continuous drug release over a prolonged period, thereby improving the drug's overall effectiveness.

What is Cisapride used for?

Cisapride is a prokinetic agent used primarily to aid gastrointestinal motility in animals. It is often prescribed to animals with gastrointestinal disorders like gastroesophageal reflux or chronic constipation.

What should I do if a dose is missed?

If a dose is missed, it should be applied as soon as remembered. If it is close to the time for the next dose, skip the missed dose and go back to the regular dosing schedule. Do not apply two doses at one time.

What are potential side effects of this formulation?

As with all medications, the use of this formulation can lead to side effects, though they are relatively rare. These may include skin irritation at the application site or, in some rare cases, an allergic reaction to Cisapride. Always discuss potential side effects with your vet.

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Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.