Cimetidine 100 mg/g and Deoxyglucose 2.5 mg/g Topical Cream is a specially compounded formulation designed for topical application to the skin. Packaged in a convenient pump mechanism, it allows for controlled and precise dosing directly to affected areas, ensuring optimal absorption of the active ingredients and ease of use for patients.

Cimetidine is an H2 histamine receptor antagonist commonly used orally to reduce gastric acid secretion. However, when applied topically, cimetidine has immunomodulatory properties that can enhance the body's immune response against certain skin conditions, such as viral-induced warts. By inhibiting suppressor T-cell function, cimetidine may promote the activity of immune cells that target and eliminate virus-infected cells in the skin.

Deoxyglucose, particularly 2-deoxy-D-glucose, is a glucose analog that interferes with glycolysis within cells. Virally infected cells often have increased glucose metabolism; therefore, deoxyglucose can inhibit the energy supply required for viral replication and survival of infected cells. When used topically, deoxyglucose may suppress the growth of virus-infected cells, aiding in the resolution of skin lesions.

The combination of cimetidine and deoxyglucose in this topical cream provides a synergistic effect that targets viral skin conditions from multiple angles—modulating the immune response and disrupting viral metabolism. This formulation is especially beneficial for patients seeking a non-invasive treatment option for conditions like warts, who may have not responded to conventional therapies such as cryotherapy or salicylic acid.

For patients, this topical cream offers a painless and convenient method of treatment. The pump mechanism ensures accurate dosing and minimal wastage, promoting adherence to the therapy regimen. Regular application as prescribed can lead to gradual improvement of skin lesions with a reduced risk of scarring or discomfort associated with more aggressive treatments.

Prescribers may find this formulation valuable for patients with contraindications to systemic therapies or those who prefer topical treatments. Due to the minimal systemic absorption of cimetidine and deoxyglucose when applied topically, the risk of systemic side effects is low. However, it is important to monitor patients for local skin reactions such as irritation, redness, or allergic responses at the application site.

Patients should be instructed on proper application techniques: apply a measured dose directly to the affected area, usually once or twice daily, as directed by the healthcare provider. Consistency in application is key to achieving the desired therapeutic outcomes. They should also be advised to report any adverse effects or lack of improvement over a specified period.

If you have any questions, please reach out to us.

Cimetidine 100 mg/g/Deoxyglucose 2.5 mg/g Topical Cream is a compounded formulation designed for localized application on the skin, utilizing a pump mechanism for precise dosing. This formulation combines cimetidine, a histamine H2-receptor antagonist, with deoxyglucose, a glucose analog, to potentially address specific dermatological conditions. While the topical application of these agents may reduce systemic exposure compared to oral administration, it is crucial to consider potential drug interactions that could affect the efficacy and safety of the treatment.

Cimetidine is known to inhibit several cytochrome P450 enzymes, particularly CYP1A2, CYP2C19, and CYP2D6. This inhibition can lead to increased plasma concentrations of drugs metabolized by these pathways, potentially resulting in enhanced effects or adverse reactions. Although the systemic absorption of cimetidine from topical application is expected to be minimal, caution is advised when patients are concurrently using medications with a narrow therapeutic index that are metabolized by these enzymes. Examples include theophylline, warfarin, phenytoin, and certain antidepressants such as amitriptyline and clomipramine. Patients should be monitored for signs of toxicity or altered therapeutic effects, and dose adjustments may be necessary.

Deoxyglucose, as a glucose analog, may interfere with glucose metabolism. While its systemic absorption from topical application is likely limited, patients with diabetes or those on medications affecting glucose levels should be monitored for potential alterations in blood glucose control. It is important to consider the cumulative effects of deoxyglucose when used in conjunction with other agents that impact glucose metabolism, such as insulin or oral hypoglycemic agents. Regular monitoring of blood glucose levels is recommended to ensure optimal management of the patient's condition.

Additionally, the use of cimetidine in combination with other topical agents should be approached with caution. The potential for local skin reactions or interactions with other topical medications, such as corticosteroids or retinoids, should be considered. Patients should be advised to report any unusual skin reactions or irritation to their healthcare provider promptly.

For both patients and prescribers, it is essential to maintain open communication regarding all medications being used, including over-the-counter products and supplements, to assess the risk of interactions effectively. If you have any questions or require further information about this formulation and its potential interactions, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to assist you in ensuring safe and effective use of this topical cream.

The Cimetidine 100 mg/g/Deoxyglucose 2.5 mg/g Topical Cream is a specialized formulation designed to deliver active ingredients directly to the skin for targeted therapeutic effects. This semisolid preparation is dispensed through a pump mechanism, ensuring precise dosing and ease of application. The formulation is intended for localized treatment, allowing the active compounds to be absorbed through the skin and exert their effects directly at the site of application.

Cimetidine, a histamine H2-receptor antagonist, is primarily known for its role in reducing stomach acid production. However, when applied topically, cimetidine has been explored for its potential in treating viral infections, such as warts, due to its immunomodulatory effects. By inhibiting histamine action, cimetidine may help modulate immune responses, potentially enhancing the body's ability to combat viral pathogens present in the skin. This mechanism can be particularly beneficial in conditions where immune response modulation is desired.

Deoxyglucose, on the other hand, is a glucose analog that interferes with glycolysis, the metabolic pathway that breaks down glucose for energy. By inhibiting glycolysis, deoxyglucose can disrupt the energy supply of rapidly proliferating cells, such as those found in certain skin conditions. This disruption can lead to a reduction in cell proliferation, making deoxyglucose a valuable component in the treatment of hyperproliferative skin disorders. Additionally, deoxyglucose may enhance the penetration and efficacy of cimetidine by altering the metabolic environment of the skin.

The combination of cimetidine and deoxyglucose in this topical cream provides a dual mechanism of action, targeting both immune modulation and metabolic disruption. This synergistic approach can be particularly effective in treating conditions where both viral activity and abnormal cell proliferation are present. The pump mechanism of the cream ensures that patients and prescribers can apply the formulation with precision, minimizing waste and maximizing therapeutic outcomes.

For patients and prescribers considering this formulation, it is important to understand the potential benefits and mechanisms of action of the active ingredients. The topical application allows for localized treatment, reducing systemic exposure and potential side effects. As with any medication, it is crucial to follow the prescribed dosing regimen and consult with a healthcare professional if there are any questions or concerns regarding its use.

If you have any questions or need further information about this formulation, please do not hesitate to reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to assist you with any inquiries you may have.

The Cimetidine 100 mg/g/Deoxyglucose 2.5 mg/g Topical Cream, dispensed in a pump mechanism, offers a versatile approach for localized treatment or absorption of active ingredients through the skin. While primarily formulated for specific dermatological conditions, this preparation may have other potential uses that could be of interest to both patients and prescribers. Cimetidine, a histamine H2-receptor antagonist, is traditionally used for its acid-reducing properties in gastrointestinal conditions. However, when applied topically, it may exhibit immunomodulatory effects that could be beneficial in treating viral skin infections such as warts, particularly those caused by the human papillomavirus (HPV). This off-label use leverages cimetidine's ability to modulate immune responses, potentially enhancing the body's ability to clear viral infections.

Deoxyglucose, a glucose analog, is primarily known for its role in inhibiting glycolysis, which can be particularly useful in targeting rapidly proliferating cells. In a topical formulation, deoxyglucose may be explored for its potential in managing certain skin conditions characterized by abnormal cell growth or metabolism. This could include applications in dermatological conditions where modulation of cellular energy pathways might provide therapeutic benefits. The combination of cimetidine and deoxyglucose in a topical cream could offer a synergistic approach, where the immunomodulatory effects of cimetidine complement the metabolic interference provided by deoxyglucose, potentially broadening the scope of treatable conditions.

For prescribers considering this formulation for off-label uses, it is crucial to weigh the potential benefits against any risks, keeping in mind the individual patient's medical history and current condition. Patients should be informed about the nature of off-label use and the rationale behind choosing this treatment option. As with any compounded medication, the efficacy and safety profile may vary, and close monitoring is advised to assess therapeutic outcomes and any adverse effects. If you have any questions or require further information about this formulation and its potential uses, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to assist you with any inquiries or support you may need.