Sublingual Semaglutide (generic Ozempic®) now available! Get Started
Dashboard
Formulas

Carbidopa 1.25 mg/mL Oral Suspension

Carbidopa 1.25 mg/mL Oral Suspension is a liquid dosage form in which carbidopa is uniformly dispersed throughout a liquid medium, ensuring a homogeneous mixture for precise administration. This formulation is primarily used in the management of Parkinson's disease and other related movement disorders. By inhibiting the peripheral metabolism of levodopa, carbidopa enhances the availability of levodopa to the central nervous system, thereby improving the control of symptoms associated with these conditions.

Want a different strength?
Click the Text Us button below.
To prescribe, you must be a verified prescriber.
To prescribe, you must be in a state where we hold an active out-of-state pharmacy license.
Starting at
Must be E-Prescribed
Get Started
Generate LeafletShow Leaflet
This medication requires a prescription from your doctor
Trusted by 60,357 patients to date.
A group of faces of our past satisfied patients.
A svg symbol of a mortar and pestle with ingredients going in.
Custom made in our compounding labs.
Sliders that show the customization of ingredients.
Personalized treatment for better results.
User with a gear showing the personalization of the formulation.
All strengths and ingredients are tailored to your needs.
This medication is not available at retail pharmacies. It is compounded, and may be more effective at treating you or your patient.
Carbidopa
Suspension
Thank you! Your submission has been received!
Oops! Something went wrong while submitting the form.
Loading icon rotating.
Thank you! Your submission has been received!
Oops! Something went wrong while submitting the form.

Dosing Calculator

Get general dosing information for a patient by using this calculator.
Thank you! Your submission has been received!
Oops! Something went wrong while submitting the form.
Loading icon rotating.
Thank you! Your submission has been received!
Oops! Something went wrong while submitting the form.

Formula Information

A small arrow pointing down

Carbidopa 1.25 mg/mL Oral Suspension is a customized liquid formulation designed to deliver precise dosing of carbidopa for patients requiring individualized therapy. This suspension ensures that the active ingredient is uniformly dispersed throughout the liquid medium, providing a homogeneous mixture for administration.

Carbidopa is a medication that inhibits the enzyme aromatic L-amino acid decarboxylase. By doing so, it prevents the peripheral conversion of levodopa to dopamine, increasing the availability of levodopa in the central nervous system. This mechanism enhances the efficacy of levodopa therapy, which is commonly used in the management of Parkinson's disease and other movement disorders.

This oral suspension offers an alternative for patients who have difficulty swallowing tablets or require dosing adjustments not available in commercial tablet forms. The liquid form allows for more flexible and precise dosing, which is particularly beneficial for pediatric patients or those with swallowing difficulties.

The homogeneous nature of the suspension ensures consistent dosing with each administration. Patients should use a calibrated oral syringe or dosing device to measure each dose accurately. It is important to shake the suspension well before each use to maintain the uniform distribution of the medication.

For prescribers, this compounded formulation provides an option to tailor therapy to the specific needs of each patient. It enables adjustments in dosing that align more closely with the patient's therapeutic response and tolerance. This can improve treatment outcomes and enhance patient adherence to the medication regimen.

The suspension should be stored according to the pharmacist's instructions, typically in a refrigerator, and used within the recommended time frame to ensure potency and safety. Patients should be advised to keep the medication out of reach of children and to follow the dosing schedule as prescribed.

If you

Drug Interactions

A small arrow pointing down

Carbidopa 1.25 mg/mL Oral Suspension is a liquid dosage form designed to provide a homogeneous mixture for administration, ensuring consistent dosing and ease of use. Carbidopa is primarily used in combination with levodopa to treat symptoms of Parkinson's disease and Parkinson-like symptoms that may occur in other conditions. It works by inhibiting the enzyme aromatic L-amino acid decarboxylase, which is responsible for the peripheral conversion of levodopa to dopamine, thereby increasing the availability of levodopa for transport to the brain.

When considering the use of Carbidopa 1.25 mg/mL Oral Suspension, it is crucial to be aware of potential drug interactions that may affect the efficacy and safety of the treatment. Carbidopa itself does not have significant pharmacological activity, but it can influence the metabolism and effectiveness of levodopa. Therefore, interactions primarily concern the combination of carbidopa and levodopa.

One of the most significant interactions occurs with non-selective monoamine oxidase inhibitors (MAOIs), such as phenelzine and tranylcypromine. Concurrent use of these MAOIs with carbidopa/levodopa can lead to hypertensive crises due to excessive accumulation of catecholamines. It is recommended to discontinue non-selective MAOIs at least two weeks prior to initiating carbidopa/levodopa therapy.

Additionally, the absorption of levodopa can be affected by dietary proteins and certain medications. High-protein meals may compete with levodopa for absorption in the gastrointestinal tract, potentially reducing its effectiveness. Patients should be advised to maintain a consistent diet and discuss any significant dietary changes with their healthcare provider.

Iron supplements and multivitamins containing iron can also interfere with the absorption of levodopa. It is advisable to separate the administration of carbidopa/levodopa and iron supplements by at least two hours to minimize this interaction.

Anticholinergic drugs, such as trihexyphenidyl and benztropine, may reduce the absorption of levodopa, although they can be used to manage certain symptoms of Parkinson's disease. The timing of administration should be carefully considered to optimize therapeutic outcomes.

Other medications that may interact with carbidopa/levodopa include dopamine antagonists, such as certain antipsychotics (e.g., haloperidol, risperidone), which can reduce the effectiveness of levodopa by blocking dopamine receptors. Patients should be monitored for reduced therapeutic effects if these medications are used concurrently.

Furthermore, antihypertensive drugs may have an additive effect with carbidopa/levodopa, potentially leading to orthostatic hypotension. Patients should be monitored for symptoms of low blood pressure, such as dizziness or lightheadedness, especially when initiating or adjusting doses.

It is essential for both patients and prescribers to be aware of these potential interactions to ensure the safe and effective use of Carbidopa 1.25 mg/mL Oral Suspension. Patients should be encouraged to inform their healthcare provider of all medications they are taking, including over-the-counter drugs and supplements. If you have any questions or concerns regarding drug interactions or the use of this formulation, please reach out to us for further assistance.

How Does it Work

A small arrow pointing down

Carbidopa 1.25 mg/mL Oral Suspension is a liquid dosage form designed to provide a uniform and homogeneous mixture of the active ingredient, carbidopa, dispersed throughout a liquid medium. This formulation is particularly beneficial for patients who may have difficulty swallowing tablets or capsules, ensuring ease of administration and accurate dosing. The suspension allows for flexible dosing adjustments, which can be particularly advantageous in managing conditions that require precise titration of medication.

Carbidopa is primarily used in the management of Parkinson's disease and other conditions characterized by low levels of dopamine in the brain. It works by inhibiting the enzyme aromatic L-amino acid decarboxylase (AADC) outside the central nervous system. This enzyme is responsible for the peripheral conversion of levodopa to dopamine. By inhibiting this conversion, carbidopa increases the availability of levodopa to cross the blood-brain barrier, where it can then be converted to dopamine, thus enhancing its therapeutic effects in the brain.

In the context of Parkinson's disease, the combination of carbidopa with levodopa is crucial. Levodopa is the precursor to dopamine and is the primary treatment for replenishing dopamine levels in the brain. However, when administered alone, a significant portion of levodopa is converted to dopamine outside the brain, leading to reduced efficacy and increased peripheral side effects such as nausea and cardiovascular issues. Carbidopa's role is to prevent this peripheral conversion, allowing more levodopa to reach the brain and reducing unwanted side effects.

The oral suspension form of carbidopa provides several advantages. It allows for rapid absorption and onset of action, which can be particularly beneficial for patients experiencing acute symptoms. The liquid form also facilitates easier administration for patients with dysphagia or those who require enteral feeding. Additionally, the suspension can be precisely measured to accommodate individualized dosing regimens, which is essential for optimizing therapeutic outcomes and minimizing side effects.

For prescribers, it is important to consider the patient's overall treatment plan, including the use of levodopa and other medications, when prescribing carbidopa oral suspension. Monitoring for potential side effects and adjusting the dosage as needed is crucial for achieving the desired therapeutic effect. Patients should be advised on the proper storage and handling of the suspension to maintain its stability and efficacy.

If you have any questions or require further information about Carbidopa 1.25 mg/mL Oral Suspension, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to assist you with any inquiries or concerns you may have regarding this formulation.

Other Uses

A small arrow pointing down

Carbidopa 1.25 mg/mL Oral Suspension is primarily used in the management of Parkinson's disease and other related disorders by inhibiting the peripheral metabolism of levodopa, thereby increasing its availability to the central nervous system. However, beyond its primary indications, this formulation may have other potential uses that could be of interest to both patients and prescribers. One such use is in the management of certain types of dystonia, a movement disorder characterized by involuntary muscle contractions, which can cause repetitive movements or abnormal postures. In some cases, carbidopa can be used as an adjunct to levodopa therapy to enhance its efficacy in treating dystonia symptoms, particularly in patients who may not respond adequately to standard treatments.

Additionally, carbidopa may be explored for its potential benefits in managing certain off-label conditions where dopaminergic pathways are implicated. For instance, there is ongoing research into its use in treating Restless Legs Syndrome (RLS), a neurological disorder characterized by an uncontrollable urge to move the legs, often accompanied by uncomfortable sensations. While not a first-line treatment, carbidopa, in combination with levodopa, may offer symptomatic relief for patients who do not respond to conventional therapies.

Furthermore, carbidopa's role in reducing peripheral side effects of levodopa, such as nausea and vomiting, makes it a valuable component in combination therapies for various neurological conditions where levodopa is utilized. This can be particularly beneficial in pediatric or geriatric populations, where the tolerability of medications is a significant concern. The liquid suspension form of carbidopa provides an advantage in these populations, offering ease of administration and the ability to tailor dosing more precisely than solid dosage forms.

It is important for prescribers to consider the pharmacokinetic properties of carbidopa when contemplating its use for off-label purposes. The liquid suspension form allows for flexible dosing adjustments, which can be crucial in achieving optimal therapeutic outcomes while minimizing potential side effects. Patients and caregivers should be informed about the proper administration techniques and storage conditions to maintain the stability and efficacy of the suspension.

As with any medication, the decision to use carbidopa for off-label purposes should be based on a thorough evaluation of the patient's specific condition, potential benefits, and risks. Healthcare providers should engage in shared decision-making with patients, discussing the available evidence and considering individual patient preferences and circumstances. If you have any questions or need further information about the use of Carbidopa 1.25 mg/mL Oral Suspension, please reach out to us at Bayview Pharmacy. We are here to assist you with any inquiries or concerns you may have.

Frequently Asked Questions

A small arrow pointing down

What is Carbidopa 1.25 mg/mL Oral Suspension?

Carbidopa 1.25 mg/mL Oral Suspension is a liquid dosage form where Carbidopa is uniformly dispersed in a liquid medium, creating a homogeneous mixture for easy administration.

How should I store Carbidopa 1.25 mg/mL Oral Suspension?

Store the suspension in a cool, dry place away from direct sunlight. Ensure the bottle is tightly closed when not in use. Follow any specific storage instructions provided by your pharmacist or healthcare provider.

How do I administer Carbidopa 1.25 mg/mL Oral Suspension?

Use a calibrated measuring device, such as an oral syringe or dosing cup, to ensure accurate dosing. Shake the bottle well before each use to ensure the medication is evenly distributed.

What should I do if I miss a dose of Carbidopa 1.25 mg/mL Oral Suspension?

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.

Can Carbidopa 1.25 mg/mL Oral Suspension be taken with food?

Carbidopa can be taken with or without food. However, taking it with food may help reduce any potential stomach upset. Follow your healthcare provider's instructions regarding food intake.

Are there any side effects associated with Carbidopa 1.25 mg/mL Oral Suspension?

Common side effects may include nausea, dizziness, headache, and dry mouth. If you experience any severe or persistent side effects, contact your healthcare provider immediately.

Is Carbidopa 1.25 mg/mL Oral Suspension suitable for children?

The suitability of Carbidopa for children depends on the specific medical condition and the healthcare provider's recommendation. Always follow the guidance of a healthcare professional regarding pediatric use.

Can I drive or operate machinery while taking Carbidopa 1.25 mg/mL Oral Suspension?

Carbidopa may cause dizziness or drowsiness. Avoid driving or operating heavy machinery until you know how the medication affects you. Consult your healthcare provider for personalized advice.

What should I do if I experience an allergic reaction to Carbidopa 1.25 mg/mL Oral Suspension?

If you experience symptoms of an allergic reaction, such as rash, itching, swelling, severe dizziness, or difficulty breathing, seek immediate medical attention.

Can I take other medications while using Carbidopa 1.25 mg/mL Oral Suspension?

Inform your healthcare provider about all the medications you are taking, including prescription, over-the-counter, and herbal supplements. Some medications may interact with Carbidopa, affecting its efficacy or increasing the risk of side effects.

Related Formulas

Related Products
Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.