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Carbamazepine 5%/Ketamine HCl 2.3%/Ketoprofen 20%/Lidocaine HCl 10% Topical Gel

This formulation is a compounded topical gel containing Carbamazepine 5%, Ketamine HCl 2.3%, Ketoprofen 20%, and Lidocaine HCl 10%. It is a semisolid formulation dispensed through a pump mechanism, which allows for easy and precise application on the skin. The gel-like consistency ensures targeted treatment or absorption of the active ingredients.

The Carbamazepine component is an anticonvulsant and mood stabilizer, often used in the treatment of epilepsy and bipolar disorder. Ketamine HCl, a powerful anesthetic, provides rapid relief from pain and depression. Ketoprofen, a nonsteroidal anti-inflammatory drug (NSAID), is effective in treating pain and inflammation caused by various conditions such as arthritis, gout, and menstrual cramps. Lidocaine HCl, a local anesthetic, provides relief from pain and discomfort by numbing the skin and surrounding area.

Together, these ingredients create a potent formulation designed to treat a variety of disease states, including neuropathic pain, post-herpetic neuralgia, complex regional pain syndrome, and other conditions that cause chronic pain. This topical gel formulation provides targeted relief right where it's needed, minimizing systemic side effects often associated with oral medications.

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Topical Gel
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Formula Information

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This formulation is a compounded topical gel containing Carbamazepine 5%, Ketamine HCl 2.3%, Ketoprofen 20%, and Lidocaine HCl 10%. It is a semisolid formulation that is dispensed through a pump mechanism, allowing for easy and precise application on the skin. The gel-like consistency ensures that the active ingredients are absorbed effectively for targeted treatment.

Carbamazepine is an anticonvulsant and mood stabilizer, often used in the treatment of epilepsy and bipolar disorder. In this formulation, it is used for its analgesic properties to help manage nerve pain. Ketamine HCl is a powerful anesthetic that provides rapid pain relief. It works by blocking the NMDA receptors in the brain which are involved in pain sensation.

Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that reduces inflammation and pain by inhibiting the production of prostaglandins, substances in the body that cause inflammation. Lidocaine HCl is a local anesthetic that works by blocking nerve signals in your body, providing numbing relief to the area of application.

This combination of ingredients makes the formulation particularly effective for managing conditions that involve inflammation and pain, such as arthritis, neuropathic pain, and certain skin conditions. The topical application allows for targeted treatment, reducing systemic side effects often associated with oral medications.

Patients should apply the gel to the affected area as directed by their healthcare provider. It is important to wash hands before and after application and avoid contact with eyes, mouth, and open wounds. Side effects may include skin irritation at the application site. If these persist or worsen, contact your healthcare provider immediately.

Prescribers should consider this formulation for patients who have not responded to traditional oral medications or who cannot tolerate them due to side effects. As with all medications, it is important to consider the patient's overall health status, other medications, and potential drug interactions.

If you have any questions about this formulation or its use, please do not hesitate to reach out to us at Bayview Pharmacy. Our knowledgeable team of compounding pharmacists is here to assist you.

Drug Interactions

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This formulation contains Carbamazepine, Ketamine HCl, Ketoprofen, and Lidocaine HCl. Each of these active ingredients has its own potential for drug interactions, which can be amplified when used in combination. It's important to consider these interactions when prescribing or using this medication.

Carbamazepine is an anticonvulsant and mood stabilizer. It can interact with a wide range of medications, including other anticonvulsants, certain antidepressants, anticoagulants, and some antifungal medications. These interactions can lead to changes in the effectiveness of either medication, or increase the risk of side effects.

Ketamine HCl is a powerful anesthetic and analgesic. It can interact with other central nervous system depressants, including alcohol, benzodiazepines, and opioids. These interactions can lead to an increased risk of respiratory depression, sedation, and potentially, overdose.

Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID). It can interact with other NSAIDs, corticosteroids, anticoagulants, and certain blood pressure medications. These interactions can increase the risk of gastrointestinal bleeding and ulcers, and may affect kidney function.

Lidocaine HCl is a local anesthetic. It can interact with other local anesthetics and certain heart medications. These interactions can lead to an increased risk of serious heart problems, including irregular heartbeat.

This formulation is designed to be applied topically, which can reduce the risk of systemic drug interactions. However, it's still important to consider potential interactions, especially in patients who are using other medications or have underlying health conditions. The combined use of these medications can be beneficial for treating certain conditions, such as neuropathic pain, but should be used with caution.

Patients should inform their healthcare provider of all medications they are currently taking, including prescription drugs, over-the-counter medications, and dietary supplements. Healthcare providers should carefully consider the potential for drug interactions when prescribing this medication, and monitor patients closely for any signs of adverse effects.

If you have any questions about this formulation or its potential interactions, please don't hesitate to reach out to us. We're here to help ensure that you and your patients are using this medication safely and effectively.

How Does it Work

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This formulation is a combination of four active ingredients: Carbamazepine, Ketamine HCl, Ketoprofen, and Lidocaine HCl, each playing a unique role in managing various disease states.

Carbamazepine is an anticonvulsant and mood stabilizer. It works by reducing the spread of seizure activity in the brain and restoring the normal balance of nerve activity. In this formulation, it is used to manage nerve-related pain or discomfort.

Ketamine HCl is a potent analgesic that works by blocking the NMDA receptors in the brain, which are involved in pain signaling. This action helps to reduce the perception of pain, providing relief to the patient.

Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that works by reducing hormones that cause inflammation and pain in the body. It is used to relieve pain, swelling, and joint stiffness caused by arthritis, bursitis, and gout attacks.

Lidocaine HCl is a local anesthetic that works by blocking nerve signals in your body. It is used to relieve pain and discomfort caused by skin irritations, such as sunburn, insect bites, poison ivy, poison oak, poison sumac, and minor cuts, scratches, or burns.

The semisolid formulation dispensed through a pump mechanism allows for easy and precise application on the skin. The gel-like consistency ensures that the active ingredients are absorbed effectively into the skin, providing targeted treatment for the affected area. This formulation is particularly beneficial for patients who have difficulty swallowing pills or those who prefer a topical treatment option.

It's important to note that while this formulation can provide significant relief for various disease states, it should be used under the guidance of a healthcare provider. Always follow the prescribed dosage and application instructions to ensure the best possible outcome.

If you have any questions about this formulation or how it works, please don't hesitate to reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is always here to help.

Other Uses

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This compounded formulation of Carbamazepine 5%/Ketamine HCl 2.3%/Ketoprofen 20%/Lidocaine HCl 10% in a topical gel is primarily formulated to help manage pain and inflammation associated with various conditions such as neuropathic pain disorders, arthritis, sports injuries, post-surgical pain, and other musculoskeletal conditions. However, there are additional uses for this formulation, leveraging the unique characteristics of the individual components.

Carbamazepine, primarily used as an anticonvulsant, can also manage certain types of neuropathic pain and psychiatric disorders, offering potential benefit in topical form for skin-related nerve pain conditions and postherpetic neuralgia. Ketamine, typically employed as an anesthetic, has been recognized for neuropathic pain relief in topical formulations. It may also have benefits for treating itching and inflammation associated with certain skin conditions.

Ketoprofen, a nonsteroidal anti-inflammatory drug (NSAID), while typically used for pain and inflammation associated with arthritis or injury, may also be beneficial in this formulation for managing dermatologic conditions characterized by inflammation, like psoriasis or eczema. Lidocaine, a local anesthetic, is extensively used in topical formulations for its numbing effect. This can provide symptomatic relief for a myriad of conditions that involve skin irritation or pain such as burns, insect bites, or minor cuts and scrapes.

This Carbamazepine/Ketamine/Ketoprofen/Lidocaine HCl gel formulation could potentially be exploited for other indications, all within the prescribing physician's discretion, based on their assessment of the patient's specific condition and the known pharmacological profiles of the drugs utilized. It offers the convenience of easy application, targeted delivery, and precise dosing, making it a versatile option for various therapeutic needs.

Please note that all uses of compounded medications should be reviewed and approved by a healthcare professional. Patient experience can vary based on individual health status, severity of the condition, other treatments utilized, and individual response to medication. Always consult your healthcare provider before beginning any new treatment.

If you have further questions or need additional information about this formulation or potential uses, please do not hesitate to reach out to us at Bayview Pharmacy. Our team of trained compounding pharmacists is here to provide expert assistance.

Frequently Asked Questions

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What is Carbamazepine 5%/Ketamine HCl 2.3%/Ketoprofen 20%/Lidocaine HCl 10% Topical Gel?

This is a compounded medication in the form of a semisolid gel, designed for topical application on the skin. It combines the therapeutic effects of Carbamazepine, Ketamine HCl, Ketoprofen, and Lidocaine HCl to target specific symptoms and conditions.

How do I apply this medication?

Using the pump mechanism integrated into the bottle, dispense the medication onto the desired area of your skin and smooth it out evenly. Ensure that it is fully absorbed for maximum effectiveness.

What is the consistency of the gel?

The gel has a semi-solid consistency, which makes it easy to apply precisely on the part of the skin where treatment is needed.

Who can use this medication?

This medication should only be used by the person for whom it was prescribed. It should not be shared with others. Additionally, it should only be used for the indication prescribed.

Is this medication safe for everyone?

While this medication is safe for most people, it's important to inform your healthcare provider of all over-the-counter and prescription medications you're currently taking, as well as any allergies or medical conditions. Your provider will assess whether this treatment is safe for you.

What are the possible side effects?

While not everyone will experience side effects, common ones noted with these active ingredients may include mild skin irritation, redness or itching. If you experience severe side effects or prolonged discomfort, please seek medical attention immediately.

Does this medication get absorbed into the body?

Yes, the active ingredients in the gel get absorbed through the skin into the body to provide targeted treatment. Ensure that it is fully absorbed and do not wash or wipe off immediately after application.

What is the role of each active ingredient in the formulation?

Each ingredient plays a significant role. Carbamazepine is used to control certain types of seizures and relieve certain types of nerve pain. Ketamine HCl provides pain relief. Ketoprofen is a type of non-steroidal anti-inflammatory drug (NSAID) used to treat aches and pains. Lidocaine HCl is a local anesthetic, which helps to numb the treatment area.

Can I stop using the medication once I feel better?

No, you should complete the prescribed course of treatment even if you start to feel better. Stopping the medication prematurely may return your symptoms or cause a relapse of your condition.

Can I use this gel with other topicals?

It's important to consult with your healthcare provider before using other topical treatments with this gel. Mixing medications may affect how well they work or increase the risk of side effects.

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Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.