This formulation combines Caffeine (100 mg) and Ergotamine Tartrate (2 mg) in a rectal suppository. The suppository is a solid dosage form that is inserted into the rectum, where it dissolves or melts to release the medication. This allows for local or systemic absorption of the drugs.

Caffeine is a central nervous system stimulant that can help to increase alertness and reduce fatigue. It is often used in combination with other medications to enhance their effects. In this formulation, it is combined with Ergotamine Tartrate, a drug that constricts blood vessels in the brain and inhibits the transmission of nerve signals to reduce pain.

Ergotamine Tartrate is commonly used to treat migraines and cluster headaches. It works by narrowing the blood vessels around the brain, which helps to decrease the severity of the headache. The addition of caffeine helps to increase the absorption of Ergotamine Tartrate, making it more effective.

This formulation is particularly useful for patients who are unable to take oral medication or who need rapid relief from severe headaches. The rectal administration allows for quick absorption and onset of action, providing relief from symptoms in a timely manner.

It is important to note that this medication should be used as directed by a healthcare provider. Overuse can lead to medication overuse headaches, withdrawal symptoms, or other side effects. Patients should also be aware that this medication can cause dizziness or drowsiness, and they should avoid driving or operating heavy machinery until they know how the medication affects them.

If you have any questions about this formulation, please don't hesitate to reach out to us. We are a team of knowledgeable compounding pharmacists at Bayview Pharmacy, and we are here to help.

This formulation combines caffeine and ergotamine tartrate in a rectal suppository form. Both of these active ingredients have their own unique pharmacological properties and potential interactions with other medications.

Caffeine is a central nervous system stimulant that can interact with numerous medications. It can increase the effects of certain medications such as clozapine, dipyridamole, and theophylline, potentially leading to increased side effects. Conversely, it can decrease the effectiveness of certain drugs such as lithium and pentobarbital. Caffeine can also interact with medications that affect liver enzymes, potentially altering the metabolism and effectiveness of these drugs.

Ergotamine tartrate is an ergot alkaloid used to treat migraines and cluster headaches. It can interact with a number of medications, including certain antibiotics (such as macrolides), antifungal agents, protease inhibitors, and other drugs that inhibit the cytochrome P450 3A4 enzyme system. These interactions can lead to an increased risk of ergotism, a serious condition characterized by vasospasm and ischemia. Ergotamine should not be used with potent CYP 3A4 inhibitors.

It's important to note that the rectal route of administration can alter the absorption and metabolism of these drugs, potentially affecting their interactions with other medications. For example, rectal administration can bypass the first-pass metabolism in the liver, potentially increasing the systemic availability of these drugs and their potential for interactions.

This formulation is primarily used to treat migraines and cluster headaches. Caffeine can enhance the vasoconstrictive effect of ergotamine, making it more effective in treating these conditions. However, due to the potential for serious drug interactions, it's important to use this formulation under the supervision of a healthcare provider and to inform them of all other medications you are taking.

If you have any questions about this formulation or its potential interactions with other medications, please don't hesitate to reach out to us. We are here to help ensure that your medication is safe and effective for you.

The Caffeine 100 mg/Ergotamine Tartrate 2 mg Rectal Suppository is a solid dosage form that is inserted into the rectum, where it dissolves or melts to release the medication. This formulation is designed for local or systemic absorption, depending on the specific needs of the patient.

Caffeine and ergotamine work together to treat or prevent certain types of headaches (vascular headaches including migraine and cluster headaches). Ergotamine works by constricting blood vessel walls in the head, relieving the throbbing pain of vascular headaches. Caffeine increases the absorption of ergotamine and also narrows the blood vessels in the brain. Together, they reduce the substances in the body that can trigger headache pain, sensitivity to light and sound, and other migraine symptoms.

Once the suppository is inserted into the rectum, it begins to dissolve, releasing the caffeine and ergotamine. The rectal tissue absorbs these medications, allowing them to enter the bloodstream. From there, they travel to the brain, where they can begin to take effect. This method of administration can be particularly beneficial for patients who are unable to take oral medication due to nausea or vomiting, which are common symptoms of severe headaches and migraines.

It's important to use this medication exactly as directed by your healthcare provider. Overuse can lead to medication-overuse headaches, or 'rebound headaches', and other side effects. If your symptoms do not improve or if they worsen, contact your healthcare provider. Also, this medication should not be used for routine headaches or on an as-needed basis, as it is meant for severe headache episodes.

As compounding pharmacists, we can customize this formulation to meet the specific needs of individual patients. This can include adjusting the dosage of caffeine and ergotamine, or adding other medications to the suppository to further enhance its effectiveness. We can also provide advice on how to properly use and store this medication.

If you have any questions about the Caffeine 100 mg/Ergotamine Tartrate 2 mg Rectal Suppository, or if you would like more information on how it can be customized to meet your specific needs, please don't hesitate to reach out to us at Bayview Pharmacy. We are here to help.

The Caffeine 100mg/Ergotamine Tartrate 2mg Rectal Suppository has been primarily prescribed for its potent analgesic properties in the management of moderate to severe acute and chronic pain, particularly migraine pain. The combination acts synergistically where caffeine enhances the analgesic effect of ergotamine. But outside treating such conditions, this formulation can have a few other possible uses. Although not typically the first line of treatment, they represent potential off-label uses and should always be considered under professional supervision.

This suppository could potentially be used for vascular headaches, such as cluster headaches, which are less frequent but more severe than migraines. Ergotamine present in the formulation constricts dilated blood vessels within the brain, providing reprieve from the severe pain associated with such conditions.

The second potential use could be in managing some cases of postural orthostatic tachycardia syndrome (POTS). Some patients with POTS have issues with blood pooling in their legs, and the vasoconstrictive action of Ergotamine could help by tightening the blood vessels. However, this use must be approached with caution and direct consultation with a healthcare practitioner.

Another possible application could be to relief episodic tension headaches that are not associated with an underlying condition. The caffeine component works to relieve these headaches by blocking adenosine receptors, thus constricting the dilated blood vessels that may lead to a tension headache.

As always, the utility of such a compound for purposes other than its typical usage would require the consideration of a healthcare professional to successfully weigh potential benefits against risks. In some circumstances, the side effects, potential for overuse, and risk of dependency might overshadow the potential benefits. Both patients and prescribers considering the use of this formulation for other treatments should consult with a compounding pharmacist or other healthcare provider to discuss potential impacts. We encourage you to reach out to us with any questions or concerns you may have about this medication. We are here to assist you with all your pharmaceutical needs.