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Bupivacaine HCl 3%/Ketamine HCl 5.75%/Ketoprofen 10%/Prilocaine HCl 5% Topical Cream

This formulation is a compounded topical cream containing Bupivacaine HCl 3%, Ketamine HCl 5.75%, Ketoprofen 10%, and Prilocaine HCl 5%. It is a semisolid preparation dispensed in a pump mechanism, designed for convenient and controlled application on the skin for localized treatment or absorption of active ingredients.

The cream is specifically formulated to treat a variety of disease states. Bupivacaine and Prilocaine are local anesthetics that provide relief from pain by blocking nerve signals in your body. Ketamine is a NMDA receptor antagonist that also provides pain relief, while Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that reduces inflammation and pain in the body.

Together, these active ingredients work synergistically to provide effective relief from pain and inflammation associated with conditions such as arthritis, neuropathic pain, musculoskeletal pain, and post-surgical pain. The cream is applied topically, allowing for targeted treatment of specific areas of discomfort.

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Topical Cream
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Formula Information

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This formulation is a compounded topical cream containing Bupivacaine HCl 3%, Ketamine HCl 5.75%, Ketoprofen 10%, and Prilocaine HCl 5%. It is a semisolid preparation dispensed in a pump mechanism, designed for convenient and controlled application on the skin. The purpose of this formulation is to provide localized treatment or absorption of active ingredients.

Bupivacaine HCl and Prilocaine HCl are both local anesthetics. They work by blocking nerve signals in your body, which helps to numb the area and reduce pain. Ketamine HCl is a medication primarily used for starting and maintaining anesthesia. It induces a trance-like state while providing pain relief, sedation, and memory loss. In this formulation, it is used for its analgesic properties. Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID). It works by reducing hormones that cause inflammation and pain in the body.

This combination of ingredients makes the cream particularly effective for managing pain and inflammation in localized areas. It can be used to treat a variety of disease states that cause pain and inflammation, such as arthritis, bursitis, and tendonitis. It may also be used for neuropathic pain conditions like post-herpetic neuralgia and diabetic neuropathy. Furthermore, it can be used for post-surgical pain management.

Patients should apply the cream to the affected area as directed by their healthcare provider. It is important to wash hands immediately after application unless the hands are the area being treated. Avoid contact with eyes, nose, mouth, and other sensitive areas. If the cream gets in these areas, rinse with water. Do not apply to broken or irritated skin. Also, do not cover the treated area with a bandage or heating pad unless your doctor has told you to.

Prescribers should consider the patient's overall health status, other medications, and the specific disease state being treated when deciding to use this formulation. As with all medications, there is a potential for side effects, which can include skin irritation at the application site, dizziness, or nausea. If these occur and are bothersome, the patient should be advised to contact their healthcare provider.

If you have any questions about this formulation, please do not hesitate to reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is here to assist you.

Drug Interactions

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This topical cream formulation contains Bupivacaine HCl, Ketamine HCl, Ketoprofen, and Prilocaine HCl. These active ingredients work together to provide localized pain relief, particularly for conditions such as neuropathic pain, post-herpetic neuralgia, and other types of chronic pain. The cream is designed to be applied directly to the skin, where it can be absorbed to provide targeted relief.

Bupivacaine HCl and Prilocaine HCl are local anesthetics that work by blocking nerve signals in your body, thereby reducing pain sensation. Ketamine HCl is a NMDA receptor antagonist that helps in reducing neuropathic pain. Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that reduces inflammation and pain in the body by reducing the production of certain substances that cause inflammation and pain.

It's important to be aware of potential drug interactions when using this formulation. Here are some key interactions to consider:

Bupivacaine HCl and Prilocaine HCl: These local anesthetics may interact with other local anesthetics or drugs that are known to have additive effects on the cardiovascular system. This could potentially lead to increased risk of cardiovascular side effects such as arrhythmias.

Ketamine HCl: This drug may interact with CNS depressants, including alcohol, opioids, and sedatives, potentially leading to increased sedation and respiratory depression. It may also interact with drugs that affect serotonin levels in the body, potentially leading to serotonin syndrome.

Ketoprofen: This NSAID may interact with anticoagulants, antiplatelet drugs, and other NSAIDs, potentially increasing the risk of bleeding. It may also interact with ACE inhibitors, angiotensin II receptor blockers, or diuretics, potentially reducing their effectiveness or increasing the risk of kidney problems.

It's crucial to inform your healthcare provider about all medications, supplements, and herbal products you are currently taking before starting this treatment. This will help to minimize the risk of potential drug interactions.

As with any medication, this formulation should be used as directed by your healthcare provider. If you experience any side effects or have any concerns, contact your healthcare provider immediately. If you have any questions about this formulation or its use, don't hesitate to reach out to us at Bayview Pharmacy. We're here to help.

How Does it Work

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This topical cream is a compounded medication that contains four active ingredients: Bupivacaine HCl, Ketamine HCl, Ketoprofen, and Prilocaine HCl. Each of these ingredients plays a unique role in the treatment of various disease states, primarily those involving pain and inflammation.

Bupivacaine HCl and Prilocaine HCl are both local anesthetics. They work by blocking nerve signals in your body, which helps to numb the area and reduce pain. Bupivacaine HCl is a long-acting anesthetic, providing prolonged pain relief, while Prilocaine HCl is a shorter-acting anesthetic, providing immediate pain relief. Together, they provide both immediate and long-lasting pain relief.

Ketamine HCl is a powerful anesthetic that also has analgesic (pain-relieving) properties. It works by blocking the NMDA receptors in the brain and spinal cord, which play a key role in transmitting pain signals. By blocking these receptors, Ketamine HCl helps to reduce the perception of pain.

Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID). It works by reducing hormones that cause inflammation and pain in the body. This makes it particularly effective in treating conditions that involve inflammation, such as arthritis or injury.

When applied topically, this cream is designed to deliver these active ingredients directly to the area of pain or inflammation. The semisolid preparation allows for convenient and controlled application, and the pump mechanism ensures that the correct dose is dispensed each time. The active ingredients are then absorbed through the skin, providing localized treatment without the systemic side effects that can occur with oral medications.

This formulation can be used to treat a variety of disease states, including but not limited to: localized pain (such as back pain, neck pain, or joint pain), inflammation (such as arthritis or tendonitis), and certain types of nerve pain. It may also be used as part of a multimodal pain management strategy, in conjunction with other treatments.

As with any medication, it's important to use this cream as directed by your healthcare provider. If you have any questions about this formulation, or if you're interested in using it as part of your treatment plan, please don't hesitate to reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is here to help.

Other Uses

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This compounded preparation, a combination of Bupivacaine HCl, Ketamine HCl, Ketoprofen, and Prilocaine HCl in a topical cream formulation, is mainly administered for localized pain management. Primarily it is formulated to treat neuropathic pain conditions including postherpetic neuralgia, peripheral neuropathy, and complex regional pain syndrome. However, there are other uses for this formulation.

Firstly, due to the analgesic properties of Ketamine and Bupivacaine, this compounded cream can be useful in the management of acute and chronic pain disorders. It can be used in post-surgical pain control, to help reduces the need for stronger, often narcotic, oral pain medications. This cream's topical application allow a directed application to the specific area of pain.

Secondly, as this formulation includes Ketoprofen, a nonsteroidal anti-inflammatory drug (NSAID), it can be applied to regions of inflammation resulting from conditions like osteoarthritis, rheumatoid arthritis or other musculoskeletal disorders. Ketoprofen helps to reduce inflammation, and therefore pain, in these areas.

In the field of dermatology, this cream finds application in the treatment of painful skin conditions such as burns or certain types of dermatitis, offering both analgesic and anti-inflammatory benefits.

This preparation is also sometimes used by pain management specialists off-label to assist in treating other pain disorders, for example, migraines or pain associated with certain forms of cancer. Before using it for these or other uses it’s best to consult with a healthcare provider to ensure the safety and efficacy of treatment.

It's important to stress that this cream should be applied sparingly and only on the affected area, following the directions of a healthcare provider. The use of this cream may lead to systemic absorption of the medications, which could potentially result in side effects. It's therefore vital to monitor any changes or adverse reactions while using this compounded cream and to report these to the prescriber promptly.

If you have any questions about this formulation and its uses, please don't hesitate to reach out to us, here at Bayview Pharmacy. Our team of compounding pharmacists is always ready to assist and provide detailed information tailored to your needs.

Frequently Asked Questions

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What is the purpose of the Bupivacaine HCl 3%/Ketamine HCl 5.75%/Ketoprofen 10%/Prilocaine HCl 5% Topical Cream?

This cream is designed to be applied on the skin for localized treatment. It is formulated to assist with pain management by combining the effects of four active ingredients: Bupivacaine, Ketamine, Ketoprofen and Prilocaine.

Why does this cream come in a pump mechanism?

This cream is dispensed in a pump mechanism for convenience and controlled application. This makes it easy to get the exact amount of cream you need without any mess or wastage.

What are the active ingredients in this compounded formulation?

The cream contains Bupivacaine HCl at 3%, Ketamine HCl at 5.75%, Ketoprofen at 10% and Prilocaine HCl at 5% as its active ingredients. These ingredients work together to provide relief from pain.

How often should I use this cream?

The frequency and duration of use should be determined by a healthcare provider based on your specific needs and condition. Always follow the instructions provided by your healthcare provider.

How should I store this cream?

Store this cream at room temperature, away from heat and direct light. Do not freeze. Keep out of the reach of children.

Can I use this cream if I am pregnant or breastfeeding?

Consult your doctor before using this medication if you are pregnant or breastfeeding, since the active ingredients can be absorbed through the skin.

Can this cream be used on broken or irritated skin?

No, you should avoid applying the cream to broken or irritated skin unless directed by a healthcare professional.

What should I do if I miss a dose?

If you miss a dose, use it as soon as you remember. If it is close to the time for your next dose, skip the missed dose and go back to your normal time. Do not use extra to make up for a missed dose.

What side effects can this cream cause?

Common side effects could include mild irritation or redness at the application site. If you experience any severe or persistent side effects, get medical help right away.

Can I use the cream with other medicines?

Inform your doctor about any other medications you are using before you start using this cream. Some drugs could interact with the active ingredients in this cream.

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Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.