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Formulas

Bupivacaine HCl 0.75%/Ketoprofen 15% Transdermal Gel

The Bupivacaine HCl 0.75%/Ketoprofen 15% Transdermal Gel is a semisolid formulation that is dispensed through a pump mechanism. This design allows for easy and precise application on the skin, ensuring targeted treatment or absorption of the active ingredients. The gel-like consistency of the formulation enhances the comfort and ease of use for the patient.

This formulation combines the local anesthetic properties of Bupivacaine HCl and the anti-inflammatory effects of Ketoprofen. Bupivacaine HCl provides relief from pain by blocking nerve signals in your body, while Ketoprofen reduces inflammation, swelling, and pain by inhibiting the production of certain substances that cause inflammation and pain in the body.

As a result, the Bupivacaine HCl 0.75%/Ketoprofen 15% Transdermal Gel is effective in treating various disease states that involve pain and inflammation. These include conditions like post-operative pain, sports injuries, arthritis, and other musculoskeletal disorders. The transdermal delivery allows for direct application to the affected area, providing localized relief while minimizing systemic side effects.

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Topical Gel
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Formula Information

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This formulation of Bupivacaine HCl 0.75%/Ketoprofen 15% Transdermal Gel is a semisolid preparation designed for easy and precise application on the skin. The pump mechanism allows for targeted treatment, ensuring that the active ingredients are absorbed directly into the affected area. This formulation is particularly beneficial for patients who require consistent and localized pain relief.

Bupivacaine HCl is a local anesthetic that works by blocking nerve impulses, thereby reducing pain and discomfort in the applied area. It is commonly used in various types of surgical procedures and for pain management. On the other hand, Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that reduces hormones causing inflammation and pain in the body. The combination of these two active ingredients provides both immediate and long-lasting relief from pain and inflammation.

This transdermal gel formulation is used to treat various disease states that involve pain and inflammation. These include conditions like arthritis, bursitis, and tendonitis. It can also be used for post-surgical pain management, sports injuries, and other conditions as directed by a healthcare provider. The transdermal delivery allows for the medication to be absorbed directly into the bloodstream through the skin, providing targeted relief without the systemic side effects often associated with oral medications.

Patients using this formulation should apply it as directed by their healthcare provider, typically to the affected area up to four times a day. It's important to wash hands before and after application and avoid contact with eyes, mouth, and open wounds. Some common side effects may include skin irritation at the application site, but if these persist or worsen, contact your healthcare provider immediately.

Prescribers should consider the patient's overall health status, other medications, and potential drug interactions before prescribing this formulation. It's also important to educate patients about the proper application technique and potential side effects. Regular follow-ups are recommended to monitor the patient's response to treatment and adjust the dosage if necessary.

If you have any questions about this formulation or its use, please don't hesitate to reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is always here to assist you.

Drug Interactions

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Bupivacaine HCl 0.75%/Ketoprofen 15% Transdermal Gel is a unique formulation designed to provide targeted pain relief. Bupivacaine HCl is a local anesthetic that works by blocking nerve signals in your body, thereby reducing pain sensation. Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that reduces hormones that cause inflammation and pain in the body. Together, these two active ingredients work synergistically to provide effective pain relief.

However, like all medications, this formulation can interact with other drugs, potentially altering their effects or increasing the risk of side effects. It is crucial to inform your healthcare provider about all the medications you are currently taking, including prescription drugs, over-the-counter medicines, vitamins, and herbal supplements.

Specifically, Bupivacaine HCl may interact with certain medications such as antiarrhythmics (e.g., amiodarone, lidocaine), beta-blockers (e.g., atenolol, metoprolol), and other local anesthetics. These interactions may increase the risk of serious side effects such as slow or irregular heartbeat.

Ketoprofen, on the other hand, may interact with anticoagulants (e.g., warfarin), antiplatelet drugs (e.g., clopidogrel), corticosteroids (e.g., prednisone), and other NSAIDs (e.g., ibuprofen, naproxen). These interactions can increase the risk of bleeding or stomach ulcers. Ketoprofen may also interact with angiotensin-converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs), or diuretics, potentially reducing their effectiveness or increasing the risk of kidney problems.

Furthermore, this formulation should not be used with other topical products, including creams, lotions, or gels, as this may alter the absorption of the active ingredients. Avoid applying this medication to broken or irritated skin or open wounds.

It is also important to note that alcohol and tobacco can interact with many medications, including this formulation. Therefore, it is advisable to discuss your use of these substances with your healthcare provider.

Remember, this is not a complete list of possible drug interactions. Always consult with your healthcare provider or pharmacist for more information. If you have any questions or concerns about this formulation or its potential interactions, please do not hesitate to reach out to us at Bayview Pharmacy. We are a team of knowledgeable compounding pharmacists, and we are here to help.

How Does it Work

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The Bupivacaine HCl 0.75%/Ketoprofen 15% Transdermal Gel is a unique formulation that combines the analgesic and anti-inflammatory properties of Bupivacaine HCl and Ketoprofen, respectively. This formulation is designed to be applied topically, directly to the skin, where it is absorbed into the underlying tissues to provide targeted pain relief and inflammation reduction.

Bupivacaine HCl is a local anesthetic that works by blocking nerve impulses in your body, thereby reducing pain sensations. It is often used in surgical procedures or for post-operative pain management. In this formulation, Bupivacaine HCl is used to provide immediate and localized pain relief.

Ketoprofen, on the other hand, is a nonsteroidal anti-inflammatory drug (NSAID) that works by reducing hormones that cause inflammation and pain in the body. It is commonly used to relieve pain, swelling, and joint stiffness caused by arthritis. In this formulation, Ketoprofen is used to reduce inflammation and further alleviate pain.

The gel formulation allows for easy and precise application, and the pump mechanism ensures that the correct dose is dispensed each time. The gel is designed to be absorbed through the skin, delivering the active ingredients directly to the area of pain or inflammation. This targeted delivery system can provide faster relief and reduce the potential for systemic side effects that can occur with oral medications.

This formulation can be used to treat a variety of disease states that involve pain and inflammation, including but not limited to post-operative pain, arthritis, sports injuries, and other musculoskeletal conditions. It is important to note that while this formulation can provide significant relief, it is not a cure for these conditions and should be used as part of a comprehensive treatment plan.

If you have any questions about the Bupivacaine HCl 0.75%/Ketoprofen 15% Transdermal Gel, or if you would like more information about how it works or how it can be used to treat specific conditions, please don't hesitate to reach out to us. We are here to help and provide you with the information you need to make informed decisions about your health.

Other Uses

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Bupivacaine HCl 0.75%/Ketoprofen 15% Transdermal Gel is most commonly employed for the management of local/regional anesthesia and inflammation because of the numbing properties of Bupivacaine and anti-inflammatory attributes of Ketoprofen. This semisolid formulation is often used to manage pain related to nerve and muscle conditions, due to its efficacy in soothing discomfort at a local level.

Apart from these, this gel may be useful in a variety of other scenarios. It might be employed by doctors in cases where temporary numbing of the skin is needed during minor surgical procedures. This could reduce procedural discomfort and enhance the patient's general comfort. Similarly, it could be used in aesthetic medicine for numbing the skin prior to conducting treatments such as laser resurfacing or skin biopsies, minimizing discomfort and helping the patient endure the process better.

Furthermore, due to Ketoprofen's anti-inflammatory properties, the compounded gel could be beneficial for topical management of mild to moderate musculoskeletal pain, including sprains, strains, and other minor injuries. It may also have a role in managing joint pain related to arthritis when applied to the affected joints. Bupivacaine's local anesthetic effect can provide pain relief, while ketoprofen's anti-inflammatory activity may help reduce swelling and inflammation, thereby improving mobility.

It should be noted that this formulation should be used as directed under the supervision of a healthcare professional and is not intended for long-term use or for treating chronic conditions without medical consultation. Potential side effects and drug interactions should be well understood before use. Compounding pharmacists at Bayview Pharmacy are available to discuss any questions or concerns regarding this formulation.

The safety and efficacy of the gel for off-label uses should also be confirmed by clinical studies or a healthcare provider's clinical experience. As always, the benefits and risks of any medication should be carefully weighed together with a potentially beneficial role in the individual patient's treatment plan. For any questions or further information, feel free to reach out to us at Bayview Pharmacy.

Frequently Asked Questions

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What exactly is Bupivacaine HCl 0.75%/Ketoprofen 15% Transdermal Gel?

This is a semisolid formulation, which combines two active ingredients, Bupivacaine HCl at 0.75% and Ketoprofen at 15%. It's dispensed through a pump and administered directly onto the skin, where it releases its active components to provide targeted treatment.

What does the term 'transdermal' mean?

'Transdermal' refers to a method of drug delivery through the skin for systemic use. It allows for targeted and continuous release of medication without requiring invasive measures like injections.

How does the pump mechanism work?

The pump mechanism facilitates easy and precise dispensing of the gel. It helps in getting a controlled amount of medication which reduces wastage and ensures optimal therapeutic effect.

What is the texture of Bupivacaine HCl 0.75%/Ketoprofen 15% Transdermal Gel like?

As it is a semisolid formulation, it has a gel-like consistency. This makes it easy and comfortable to apply on the skin.

What is the benefit of having a gel-like consistency?

A gel-like consistency means the product will sit on the skin and not be absorbed too quickly. This allows for prolonged, continuous delivery of the active ingredients directly to the area needing treatment.

Can I apply this transdermal gel anywhere on the body?

It is designed for external use and should be applied on the area specified by the healthcare provider. Always follow your healthcare professional's instructions for use.

Can I use this product if I have a skin condition?

If you have a particular skin condition, you should consult your healthcare professional before using this product. Direct application to affected skin may cause irritation or other adverse reactions.

What is Bupivacaine HCl for?

Bupivacaine HCl is a local anesthetic. It is used to numb specific areas and reduce pain and discomfort associated with surgical procedures or related conditions.

What is the purpose of Ketoprofen in the gel?

Ketoprofen is a non-steroidal anti-inflammatory drug (NSAID). It is included in the gel to reduce swelling, inflammation, and pain.

Are there any side effects associated with Bupivacaine HCl 0.75%/Ketoprofen 15% Transdermal Gel?

Like any medication, potential side effects can occur. These may include skin reactions at the application site such as redness, itching, or irritation. Always consult your healthcare professional if you encounter any adverse reactions.

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Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.