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Bupivacaine HCl 0.5%/Gabapentin 8%/Ketoprofen 20% Topical Gel

This formulation is a semisolid compound of Bupivacaine HCl 0.5%, Gabapentin 8%, and Ketoprofen 20% dispensed as a topical gel. The gel is designed to be easily applied through a pump mechanism, ensuring precise application on the skin for targeted treatment. The active ingredients in the gel are absorbed through the skin, providing relief from various disease states.

Bupivacaine HCl is a local anesthetic that numbs specific areas of the body, reducing pain and discomfort. Gabapentin is an anticonvulsant that is often used to manage nerve pain. Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that reduces inflammation and pain in the body. Together, these ingredients work to manage and alleviate symptoms associated with various disease states.

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Bupivacaine Hydrochloride
Gabapentin
Ketoprofen
Topical Gel
653574f72bd12ee831592b0e
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Formula Information

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This formulation combines Bupivacaine HCl 0.5%, Gabapentin 8%, and Ketoprofen 20% in a topical gel. Bupivacaine HCl is a local anesthetic that works by blocking nerve impulses, thereby reducing pain sensation. Gabapentin is an anticonvulsant and nerve pain medication that is often used to treat nerve pain conditions. Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that reduces inflammation and pain in the body.

The gel is a semisolid formulation that is dispensed through a pump mechanism. This allows for easy and precise application on the skin, ensuring targeted treatment or absorption of the active ingredients. The gel-like consistency ensures that the medication stays on the skin for a longer period, allowing for better absorption and effectiveness.

This formulation is used to treat various disease states. Bupivacaine HCl is often used for local anesthesia in surgical procedures, and in this formulation, it can provide localized pain relief. Gabapentin is used to treat nerve pain conditions such as postherpetic neuralgia and diabetic neuropathy. In this formulation, it can provide targeted relief for nerve pain. Ketoprofen is used to treat pain or inflammation caused by arthritis. In this formulation, it can provide targeted relief for inflammation and pain.

Patients using this formulation should apply it as directed by their healthcare provider. It is important to use this medication regularly to get the most benefit from it. Patients should also inform their healthcare provider if their condition persists or worsens.

Prescribers should consider the patient's overall health status, other medications, and potential drug interactions when prescribing this formulation. It is also important to educate patients about the potential side effects of each active ingredient and monitor their response to treatment.

If you have any questions about this formulation, please reach out to us. We are a team of knowledgeable compounding pharmacists at Bayview Pharmacy, and we are here to help.

Drug Interactions

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This formulation contains Bupivacaine HCl, Gabapentin, and Ketoprofen, all of which can interact with other medications. It's important to inform your healthcare provider about all the medications you're currently taking, including prescription and over-the-counter drugs, vitamins, and herbal supplements.

Bupivacaine HCl is a local anesthetic that can interact with other local anesthetics, sedatives, and certain heart medications. It can also interact with monoamine oxidase inhibitors (MAOIs), tricyclic antidepressants, and phenothiazines, potentially leading to serious side effects such as slow heart rate, low blood pressure, and seizures.

Gabapentin, an anticonvulsant and nerve pain medication, can interact with antacids containing magnesium or aluminum, as they can affect the absorption of gabapentin. It can also interact with opioids, increasing the risk of severe side effects such as respiratory distress and sedation. Other medications that can interact with gabapentin include certain antihistamines, sleeping pills, muscle relaxants, and drugs for anxiety or depression.

Ketoprofen, a nonsteroidal anti-inflammatory drug (NSAID), can interact with blood thinners, aspirin, other NSAIDs, and certain high blood pressure medications. It can also interact with lithium, methotrexate, and certain heart medications. These interactions can increase the risk of serious side effects such as stomach bleeding, kidney problems, and heart failure.

This formulation is used topically, which generally reduces the risk of systemic drug interactions. However, significant absorption can still occur, especially when applied over large areas of skin or for prolonged periods. Therefore, it's important to use this medication as directed by your healthcare provider.

This formulation is designed to treat various disease states, including localized pain, inflammation, and neuropathic conditions. Bupivacaine HCl provides local anesthesia, numbing the treated area. Gabapentin helps manage nerve pain, while Ketoprofen reduces inflammation and pain. The combined effect of these three active ingredients provides targeted relief for a variety of conditions.

If you have any questions about this formulation or its potential interactions with other medications, please don't hesitate to reach out to us. We're here to help ensure that your treatment is safe and effective.

How Does it Work

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The Bupivacaine HCl 0.5%/Gabapentin 8%/Ketoprofen 20% Topical Gel is a unique formulation that combines the analgesic and anti-inflammatory properties of three active ingredients to provide targeted relief from pain and inflammation. This formulation is designed to be applied topically, directly to the skin, where it can be absorbed into the underlying tissues to exert its therapeutic effects.

Bupivacaine HCl is a local anesthetic that works by blocking nerve signals in your body. When applied topically, it numbs the specific area and reduces pain sensations. This can be particularly beneficial for localized pain conditions, such as post-surgical pain or pain associated with certain skin conditions.

Gabapentin is a medication primarily used to treat seizures and neuropathic pain. It works by affecting the chemicals and nerves in the body that are involved in the cause of seizures and some types of pain. In a topical formulation, gabapentin can provide targeted relief from neuropathic pain, such as that caused by shingles or diabetic neuropathy.

Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that works by reducing hormones that cause inflammation and pain in the body. When applied topically, ketoprofen can provide localized relief from pain and inflammation, making it useful for conditions such as arthritis, bursitis, or tendonitis.

The semisolid formulation of this gel allows for easy and precise application, ensuring that the medication can be applied directly to the area where it is needed most. The pump mechanism also allows for controlled dosing, reducing the risk of over-application and potential side effects.

Overall, the Bupivacaine HCl 0.5%/Gabapentin 8%/Ketoprofen 20% Topical Gel provides a targeted, multi-modal approach to pain and inflammation management. By combining the local anesthetic effects of bupivacaine, the neuropathic pain relief of gabapentin, and the anti-inflammatory properties of ketoprofen, this formulation can provide comprehensive relief for a variety of pain conditions.

If you have any questions about this formulation, or if you would like more information about how it can be used to manage specific conditions, please don't hesitate to reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is always here to help.

Other Uses

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The Bupivacaine HCl 0.5%/Gabapentin 8%/Ketoprofen 20% Topical Gel formulation is primarily devised to deliver local analgesia, nerve pain reduction, and anti-inflammatory effects. This is particularly beneficial for those experiencing certain types of chronic and acute pain conditions, and miscellaneous dermatological complications.

Other possible uses for this compound include the management of neuropathic pain disorders like Postherpetic Neuralgia (PHN), and diabetic peripheral neuropathy. Its ingredients work synergistically to not just alleviate pain, but also to decrease inflammation at the site. This might provide some relief for patients suffering from disorders like eczema, psoriasis, or other skin conditions that involve inflammation.

Additionally, this formulation could also be used off-label for managing musculoskeletal and joint-related discomfort due to its potent anti-inflammatory properties, provided it is prescribed and supervised by a healthcare professional. Disorders like arthritis, tendonitis, bursitis, and similar conditions may potentially benefit from this treatment.

This formulation has also been used in sports medicine for topical pain relief associated with muscle strains and sprains, and other minor injuries. It offers a localized treatment option, minimizing systemic side effects which are common with oral medication. Healthcare professionals may use it as an adjunct therapy in conjunction with other treatments for enhanced patient comfort and pain management.

Please note that while these other uses have been observed, they should be pursued under the supervision of a healthcare professional who can assess the appropriateness and safety for the individual patient's needs. Also, while the formulation is generally well-tolerated, there may be potential side effects, such as local skin irritation, burning, or itching. It is essential that both physician and patient monitor for these potential adverse reactions.

If you have any other questions or inquiries regarding this formulation or its potential other uses, we encourage you to reach out to us at Bayview Pharmacy. Our knowledgeable team of compounding pharmacists is always ready to assist you with your healthcare needs.

Frequently Asked Questions

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What is Bupivacaine HCl 0.5%/Gabapentin 8%/Ketoprofen 20% Topical Gel?

This is a formulated topical gel containing Bupivacaine HCl, Gabapentin and Ketoprofen. It is applied to the skin, where it offers targeted treatment by direct absorption of the active ingredients.

Can you explain the mechanism of this topical gel?

When applied directly on the skin, the active ingredients in the gel are absorbed into the targeted area. This allows for pain relief and anti-inflammatory effects that are specifically localized to the region where the gel is applied.

How do you apply Bupivacaine HCl 0.5%/Gabapentin 8%/Ketoprofen 20% Topical Gel?

The gel is dispensed through a pump mechanism that helps for an accurate and precise application on the skin. Apply it directly onto the area needing treatment.

What's in this topical gel's formulation?

This topical gel contains three active ingredients: Bupivacaine HCl, which is an anaesthetic; Gabapentin, a nerve pain medication; and Ketoprofen, an anti-inflammatory drug. The combination of these three provides targeted relief from pain and inflammation.

What is the dose form description of Bupivacaine HCl 0.5%/Gabapentin 8%/Ketoprofen 20% Topical Gel?

It is a semi-solid formulation that comes as a gel with a pump mechanism for easy and accurate application. The consistency of the gel makes it easy for the skin to absorb the active ingredients it contains.

Who can use Bupivacaine HCl 0.5%/Gabapentin 8%/Ketoprofen 20% Topical Gel?

This product is typically prescribed by a healthcare provider and should be used under their direction. It is generally used by individuals suffering from localized pain or inflammation that can be managed with topical application of these active ingredients.

Can I overdose on the said topical gel?

As with any medication, this topical gel should only be used as directed by your healthcare provider. Overuse or misuse may lead to side effects. Strictly adhere to your prescribed dosage and schedule to avoid any complications.

Will this gel work instantly?

Topical gels typically work faster than oral medications because they are applied directly to the area in need of treatment. However, the exact time it takes to experience relief can vary among individuals and depends on factors such as the severity of the condition and skin absorption rates.

How is this gel stored?

This gel should be stored at room temperature, away from heat, light, and moisture. It should be kept out of reach from children and pets to prevent accidental ingestions.

What are possible side effects of Bupivacaine HCl 0.5%/Gabapentin 8%/Ketoprofen 20% Topical Gel?

Some potential side effects could include skin irritation or allergic reactions at the application site. If you experience severe side effects or your symptoms worsen after using the gel, consult with your healthcare provider immediately.

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Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.