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Baclofen 5%/Gabapentin 6%/Ketoprofen 10%/Lidocaine HCl 10% Transdermal Gel

This formulation is a combination of Baclofen 5%, Gabapentin 6%, Ketoprofen 10%, and Lidocaine HCl 10% in a transdermal gel. It is a semisolid formulation dispensed through a pump mechanism, which allows for easy and precise application on the skin. The gel-like consistency ensures targeted treatment or absorption of the active ingredients.

The formulation is designed to treat a variety of disease states. Baclofen is a muscle relaxer and an antispastic agent, often used in the treatment of muscle symptoms caused by multiple sclerosis. Gabapentin is used to treat nerve pain and seizures. Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that reduces hormones causing inflammation and pain in the body. Lidocaine HCl is a local anesthetic that works by causing temporary numbness/loss of feeling in the skin and mucous membranes.

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Topical Gel
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Formula Information

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This formulation is a combination of Baclofen 5%, Gabapentin 6%, Ketoprofen 10%, and Lidocaine HCl 10% in a transdermal gel. It is a semisolid formulation that is dispensed through a pump mechanism, which allows for easy and precise application on the skin. The gel-like consistency ensures that the active ingredients are absorbed effectively for targeted treatment.

Baclofen is a muscle relaxant and antispasmodic agent that helps to relieve muscle spasms, tightness, and pain. Gabapentin is an anticonvulsant and nerve pain medication that is used to treat nerve pain and discomfort. Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that reduces inflammation and pain in the body. Lidocaine HCl is a local anesthetic that works by causing temporary numbness/loss of feeling in the skin and mucous membranes. Together, these ingredients work synergistically to provide relief from various disease states.

This formulation is particularly effective in treating conditions such as neuropathic pain, fibromyalgia, and musculoskeletal pain. The transdermal application allows for targeted treatment, reducing systemic side effects and providing relief directly to the affected area. It can also be used in the management of post-herpetic neuralgia, diabetic neuropathy, and other conditions characterized by nerve-related pain or inflammation.

It is important to use this medication as directed by your healthcare provider. Apply the gel to the affected area as instructed, usually 3-4 times daily or as directed by your doctor. Do not apply this medication to broken or irritated skin. Avoid contact with eyes, nose, mouth, and other sensitive areas. If you experience any side effects such as rash, itching/swelling, severe dizziness, or trouble breathing, contact your healthcare provider immediately.

As compounding pharmacists, we are committed to providing high-quality, personalized medications to meet the unique needs of our patients. If you have any questions about this formulation or how it can benefit you, please do not hesitate to reach out to us at Bayview Pharmacy. We are here to help.

Drug Interactions

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This compounded formulation contains Baclofen, Gabapentin, Ketoprofen, and Lidocaine HCl. Each of these active ingredients has its own potential for drug interactions, which can be amplified when used in combination. It's important to consider these interactions when prescribing or using this medication.

Baclofen is a muscle relaxant and antispastic agent. It may interact with other central nervous system depressants like alcohol, benzodiazepines, opioids, and antihistamines, potentially leading to increased sedation or respiratory depression. Concurrent use with monoamine oxidase inhibitors (MAOIs) may result in hypotension.

Gabapentin, an anticonvulsant and nerve pain medication, may have its absorption reduced by antacids containing magnesium or aluminum. It may also increase the effects of other drugs that cause sedation, including opioids, antihistamines, and alcohol.

Ketoprofen, a nonsteroidal anti-inflammatory drug (NSAID), may interact with anticoagulants, increasing the risk of bleeding. It may also reduce the effectiveness of certain blood pressure medications and can increase the risk of kidney problems when used with other NSAIDs or diuretics. Concurrent use with lithium or methotrexate may increase the levels and toxicity of these drugs.

Lidocaine HCl, a local anesthetic, has few systemic interactions but may interact with other local anesthetics or medications with similar metabolic pathways, potentially leading to increased systemic absorption and toxicity.

This formulation is designed to treat a variety of disease states. Baclofen and Gabapentin are often used for their nerve pain and muscle relaxant properties, making this formulation potentially useful for conditions like neuropathic pain, fibromyalgia, and spasticity. Ketoprofen provides anti-inflammatory and analgesic effects, which can be beneficial in conditions like arthritis or other inflammatory diseases. Lidocaine HCl provides local numbing, which can help with localized pain relief.

It's important to note that while this formulation is designed for transdermal use, systemic absorption can still occur, especially with prolonged use or application to large areas of skin. This can increase the risk of systemic side effects and interactions.

As always, it's crucial to inform your healthcare provider of all medications you're currently taking, including over-the-counter drugs and supplements, to avoid potential interactions. If you have any questions or concerns about this formulation, don't hesitate to reach out to us at Bayview Pharmacy. We're here to help.

How Does it Work

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This formulation is a combination of four active ingredients: Baclofen, Gabapentin, Ketoprofen, and Lidocaine HCl, each playing a unique role in managing pain and inflammation. The formulation is designed to be applied topically, directly to the area of discomfort, allowing for targeted treatment.

Baclofen is a muscle relaxant and antispastic agent. It works by restoring the normal transmission of nerve signals in certain parts of the brain. In this formulation, it helps to relieve muscle spasms, tightness, and pain.

Gabapentin is an anticonvulsant and nerve pain medication. It works by affecting the chemicals and nerves in the body that are involved in the cause of seizures and some types of pain. In this formulation, it helps to reduce nerve pain.

Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID). It works by reducing hormones that cause inflammation and pain in the body. In this formulation, it helps to reduce inflammation and pain.

Lidocaine HCl is a local anesthetic. It works by blocking nerve signals in your body. In this formulation, it helps to numb the area of discomfort, providing immediate relief from pain.

The transdermal gel formulation allows for the active ingredients to be absorbed directly through the skin, providing targeted relief. The gel is dispensed through a pump mechanism, which allows for easy and precise application. The gel-like consistency ensures that the formulation stays on the skin, allowing for optimal absorption of the active ingredients.

This formulation can be used to treat a variety of disease states that involve pain and inflammation, including but not limited to: neuropathic pain, musculoskeletal pain, arthritis, and post-herpetic neuralgia. It is important to note that this formulation should only be used under the supervision of a healthcare provider, and the dosage and frequency of application should be determined by the provider based on the individual patient's condition and response to treatment.

If you have any questions about this formulation, please do not hesitate to reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is always here to help.

Other Uses

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The Baclofen 5%/Gabapentin 6%/Ketoprofen 10%/Lidocaine HCl 10% Transdermal Gel is primarily used as a multimodal approach for pain management. However, this formulation may also have other potential uses.

Research has indicated that such a formulation can be used to manage neuropathic pain, a condition often seen in patients with diabetes, post-herpetic neuralgia, and other neurological disorders. Furthermore, gabapentin combined with baclofen, has been found to effectively treat symptoms of Restless Legs Syndrome (RLS), providing a novel approach to a difficult-to-treat condition.

Moreover, this compound can be employed to alleviate minor sports injuries, like muscle sprains or bruises, due to the anti-inflammatory action of ketoprofen. The presence of lidocaine, a local anaesthetic, affords immediate relief from such acute pain scenarios. This ‘all-round’ action makes it a valuable adjunct in sports medicine, carrying out multiple therapeutic effects in one formulation.

With regards to dermatologic conditions, lidocaine's anaesthetic properties make this formulation potentially useful to relieve pain or discomfort caused by certain skin conditions, like burns, insect bites, or minor cuts.

It needs to be noted that although these uses are plausible, they may not have been endorsed by health regulatory bodies in all regions. Therefore, it's essential to consult a healthcare provider to assess the potential efficacy and safety of the compounded formulation before use.

If you have any further questions or specific concerns about this formulation, please do not hesitate to contact us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is always here to assist you with any of your medication-related needs.

Frequently Asked Questions

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What is Baclofen 5%/Gabapentin 6%/Ketoprofen 10%/Lidocaine HCl 10% Transdermal Gel?

This is a compounded medication that is designed to deliver four different medications through the skin, in a gel form. It includes Baclofen, Gabapentin, Ketoprofen, and Lidocaine HCl, all active ingredients used to treat various conditions such as severe pain or nerve issues.

What is the use of this compounded gel?

The gel is used to provide targeted treatment or absorption of these active ingredients. This could be for pain relief, reducing inflammation or treating nerve-related symptoms.

How is this medication applied?

The gel is applied directly onto the skin. Its semisolid formulation is easily dispensed through a pump mechanism ensuring an accurate and smooth application.

What is the consistency of this gel?

The gel has a semisolid consistency, which is not as liquid as a lotion but not as solid as a cream. It is easily spread on the skin and facilitates better absorption of all the active ingredients in it.

Do I need a prescription for this medication?

Yes, you will need a prescription from a medical professional. Please consult your healthcare provider to see if this medication is suitable for you.

What do Baclofen, Gabapentin, Ketoprofen, and Lidocaine HCl do?

Baclofen is a muscle relaxant and antispastic agent. Gabapentin is used to treat nerve pain. Ketoprofen is a nonsteroidal anti-inflammatory drug that reduces inflammation and pain in the body. Lidocaine HCl is a local anesthetic that causes temporary numbness in the skin and mucous membranes.

Does it have any side effects?

As with any medication, this compounded gel may have side effects such as local skin irritation or allergic reactions. If you experience any unusual symptoms after application, discontinue use, and contact your healthcare provider immediately.

How should this medication be stored?

Store the medication in a cool, dry place, away from sunlight. Do not store in freezing temperatures. Always keep the cap tightly closed when not in use.

Can I apply this medication on open wounds or cuts?

No, this medication is only for application on unbroken skin. Do not apply it to wounds, cuts or irritated skin, as it may cause more irritation or infection.

Can I use this medication while pregnant or breastfeeding?

It's highly advisable to consult your healthcare provider before using this medication if you are pregnant or breastfeeding. They can assess whether the potential benefits outweigh the possible risks.

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Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.