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Baclofen 2%/Ketoprofen 20% Transdermal Gel

The Baclofen 2%/Ketoprofen 20% Transdermal Gel is a semisolid formulation dispensed through a pump mechanism. This design allows for easy and precise application on the skin, ensuring targeted treatment or absorption of the active ingredients. The gel-like consistency of the formulation enhances the delivery of Baclofen and Ketoprofen, two potent drugs used in the management of various disease states.

Baclofen, a muscle relaxant and antispastic agent, is used to treat conditions such as muscle symptoms caused by multiple sclerosis, including spasm, pain, and stiffness. On the other hand, Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that is commonly used to reduce pain, swelling, and joint stiffness caused by arthritis, gout, and other inflammatory conditions. The combination of these two drugs in a transdermal gel formulation allows for direct application to the affected area, providing localized relief while minimizing systemic side effects.

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Topical Gel
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Formula Information

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This formulation combines Baclofen, a muscle relaxer and an antispastic agent, with Ketoprofen, a nonsteroidal anti-inflammatory drug (NSAID). The Baclofen 2%/Ketoprofen 20% Transdermal Gel is a semisolid formulation that is dispensed through a pump mechanism. This allows for easy and precise application on the skin, ensuring targeted treatment or absorption of the active ingredients in a gel-like consistency.

Baclofen works by helping to relax the muscles, reducing pain and discomfort in conditions such as multiple sclerosis, spinal cord injuries, or other spinal cord diseases. Ketoprofen, on the other hand, works by reducing hormones that cause inflammation and pain in the body. It is used to treat mild to moderate pain, or inflammation caused by arthritis. The combination of these two medications in a transdermal gel allows for targeted relief at the site of pain or inflammation.

Patients using this formulation should apply it to the affected area as directed by their healthcare provider. It is important to use this medication regularly to get the most benefit from it. To help you remember, use it at the same times each day. The dosage is based on your medical condition and response to treatment. Do not increase your dose or use this drug more often or for longer than prescribed. Your condition will not improve any faster, and your risk of side effects will increase.

Prescribers should note that this formulation may not be suitable for all patients, particularly those with a history of allergic reactions to NSAIDs or any ingredients in the formulation. It should also be used with caution in patients with a history of gastrointestinal bleeding or kidney disease. Regular monitoring of kidney function and blood counts may be necessary for patients on long-term treatment with this formulation.

If you have any questions about this formulation or its use in specific disease states, please do not hesitate to reach out to us. We are a team of knowledgeable compounding pharmacists at Bayview Pharmacy, and we are here to help.

Drug Interactions

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Baclofen and Ketoprofen are both medications that can interact with other drugs. It's important to inform your healthcare provider about all the medications you're currently taking, including prescription and over-the-counter drugs, vitamins, and herbal supplements.

Baclofen, a muscle relaxant and antispastic agent, can interact with drugs like antihistamines, opioids, and other muscle relaxants, potentially increasing the risk of side effects such as drowsiness, dizziness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. Avoid consuming alcohol or tobacco with Baclofen as it may also increase these side effects.

Ketoprofen, a nonsteroidal anti-inflammatory drug (NSAID), can interact with drugs like aspirin, anticoagulants (like warfarin), corticosteroids, and other NSAIDs. These interactions can increase the risk of gastrointestinal bleeding and ulcers. Ketoprofen can also interact with certain blood pressure medications and diuretics, potentially reducing their effectiveness. Avoid consuming alcohol while using Ketoprofen as it can increase the risk of stomach bleeding.

It's important to note that this formulation is a transdermal gel, meaning it's applied to the skin. This can reduce some of the potential systemic interactions, but not all. Always inform your healthcare provider about all the medications you're using, even those applied to the skin.

This formulation is used to treat conditions like muscle spasms and pain. Baclofen works by helping to relax the muscles, while Ketoprofen reduces pain and inflammation. By combining these two medications in a transdermal gel, it allows for targeted treatment directly at the site of discomfort.

Remember, it's crucial to use this medication exactly as prescribed by your healthcare provider. Do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered. If you have any questions or concerns about this medication or its potential interactions, please don't hesitate to reach out to us at Bayview Pharmacy. We're here to help.

How Does it Work

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The Baclofen 2%/Ketoprofen 20% Transdermal Gel is a unique formulation that combines the muscle relaxant properties of Baclofen and the anti-inflammatory effects of Ketoprofen. This combination is designed to provide targeted relief from pain and inflammation associated with various disease states.

Baclofen, a muscle relaxant and antispastic agent, works by restoring the normal transmission of nerve signals in certain parts of the brain. It is often used to treat muscle symptoms such as spasm, pain, and stiffness. When applied topically in a gel form, Baclofen can directly target the affected area, providing localized relief without the systemic side effects that can occur with oral administration.

Ketoprofen, on the other hand, is a nonsteroidal anti-inflammatory drug (NSAID) that works by reducing hormones that cause inflammation and pain in the body. It is commonly used to treat mild to moderate pain, or inflammation caused by conditions such as arthritis. When combined with Baclofen in a transdermal gel, Ketoprofen can provide enhanced pain relief and reduce inflammation in the targeted area.

The transdermal gel formulation allows for the active ingredients to be absorbed through the skin directly into the affected area. This targeted approach can provide faster relief and minimize potential side effects. The gel is dispensed through a pump mechanism, which allows for easy and precise application. This can be particularly beneficial for patients who have difficulty swallowing pills or for those who prefer a non-invasive method of medication administration.

It's important to note that while this formulation can provide significant relief from pain and inflammation, it should be used as part of a comprehensive treatment plan under the guidance of a healthcare provider. As with any medication, it's crucial to use this product as directed to ensure its safety and effectiveness.

If you have any questions about the Baclofen 2%/Ketoprofen 20% Transdermal Gel, or if you would like more information about how it can be used to treat specific disease states, please don't hesitate to reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is always here to help.

Other Uses

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Beyond the primary indications of pain and muscle spasticity relief, Baclofen 2%/Ketoprofen 20% Transdermal Gel could have uses in other therapies due to its transdermal delivery and potent ingredients. It might potentially be used for patients suffering from neuropathic pain, a pain arising following nerve damage, as some studies suggest both baclofen and ketoprofen might be beneficial in this condition. Additionally, it might serve as a potential treatment for conditions that involve inflammation, given ketoprofen's potent anti-inflammatory effect.

Fibromyalgia, a chronic condition characterized by widespread pain, could possibly benefit from this formulation. Some fibromyalgia patients have found relief under treatment with both baclofen and ketoprofen. This pharmaceutical formulation's non-systemic application can also provide a directed relief with a lowered risk of systemic side effects common in oral medications. The transdermal delivery method further ensures that the medication is directly delivered to the painful area, increasing its effectiveness while minimizing potential side effects.

This formulation might also be applicable for patients experiencing pain due to osteoarthritis. Ketoprofen is a non-steroidal anti-inflammatory drug (NSAID) that has demonstrated efficacy in the treatment of this condition. Coupled with baclofen, a muscle relaxant, this preparation could potentially serve as an alternative treatment to classical oral management, especially for patients with gastrointestinal issues or difficulty swallowing oral medications.

Beyond these possible extended uses, the combination of baclofen and ketoprofen could be explored in other chronic pain conditions, such as myofascial pain syndrome or certain types of headaches. However, more specific and thorough studies might be needed. It's also crucial to remember that all of these uses are based on the individual prescription from a healthcare professional. This compound should not be used without direct and explicit direction from a qualified prescriber.

Please note that all these potential other uses are based on individual studies and prescribing practices, and may not be approved by federal health regulators. A health care provider, considering the patient's overall condition and other treatments, may choose to use this medication for other purposes. Safety, potential drug interactions, and individual patient responses should be taken into consideration, and an experienced health care provider should closely monitor the patient.

If you have any questions about this formulation, or if you are a prescriber that wants to discuss a patient's case, do not hesitate to reach out to us. As your compounding pharmacy team, we are here to provide information and support to both prescribers and patients.

Frequently Asked Questions

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What is the Baclofen 2%/Ketoprofen 20% Transdermal Gel?

This is a compounded formulation of two active ingredients, Baclofen and Ketoprofen. It's a semisolid gel-like substance that's typically applied topically on the skin for targeted treatment. The formulation is dispensed through an easy-to-use pump mechanism providing precise application.

How does the pump mechanism work to facilitate application?

The pump mechanism is designed in a way that allows a set amount of the medication to be dispensed with each pump. This helps ensure the correct dosage is applied each time for effective treatment. A gentle press is usually enough to dispense the right amount of gel.

What is the consistency of this compounded formulation?

The Baclofen 2%/Ketoprofen 20% Transdermal Gel has a semisolid or gel-like consistency. This makes the formulation easy to apply to the skin and facilitates effective absorption of the active ingredients.

What makes this transdermal formulation unique?

This transdermal formulation is unique because it's designed to deliver medication directly to the target area through the skin. This can make treatment more effective by reducing systemic side effects that may be seen with oral or injection medications.

How should Baclofen 2%/Ketoprofen 20% Transdermal Gel be stored?

This medication should ideally be stored at room temperature, away from moisture and heat. It's also important to keep it out of reach of children to prevent accidental ingestion or application.

What's the role of Baclofen in this compounded formulation?

Baclofen is a muscle relaxer and an anti-spasmodic agent. In this formulation, it's used to relieve muscle symptoms caused by multiple sclerosis, including spasm, pain, and stiffness.

What's the role of Ketoprofen in this compounded formulation?

Ketoprofen is a type of medication known as a non-steroidal anti-inflammatory drug (NSAID). It's used to relieve pain, reduce inflammation and swelling in conditions like arthritis.

What are the potential side effects of this transdermal gel?

Some potential side effects of this gel may include skin irritation at the site of application, nausea, headache, dizziness, or gastrointestinal problems. It's important to notify your healthcare provider if any of these symptoms persist or become bothersome.

How often should I apply Baclofen 2%/Ketoprofen 20% Transdermal Gel?

The frequency of application would depend on your healthcare provider’s recommendation. This is usually based on your medical condition, response to treatment, and other factors.

Can I apply other lotion or creams on top of this gel?

Before applying other skin products on the same area as this gel, always consult with your healthcare provider as they may interfere with the absorption of the active ingredients in the gel.

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Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.