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Formulas

Baclofen 2%/Ketoprofen 20%/Loperamide HCl 5% Topical Gel

This formulation is a combination of Baclofen 2%, Ketoprofen 20%, and Loperamide HCl 5% in a topical gel. It is a semisolid formulation dispensed through a pump mechanism, which allows for easy and precise application on the skin. The gel-like consistency ensures targeted treatment or absorption of the active ingredients.

The Baclofen component is a muscle relaxant and antispastic agent, used to alleviate symptoms associated with muscle spasms and pain. Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that helps to reduce inflammation and pain. Loperamide HCl is an opioid agonist that can help manage diarrhea by slowing down the movement of the gut.

This formulation is typically used to treat disease states such as muscle spasms, pain, inflammation, and diarrhea. It provides targeted relief by delivering the active ingredients directly to the affected area, reducing systemic side effects.

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Topical Gel
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Formula Information

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This formulation is a compounded medication that combines Baclofen 2%, Ketoprofen 20%, and Loperamide HCl 5% in a topical gel. It is designed to be dispensed through a pump mechanism, which allows for easy and precise application on the skin. The gel-like consistency of the formulation ensures that the active ingredients are absorbed effectively into the targeted area.

Baclofen is a muscle relaxant and antispasmodic agent that works by calming the nerves and reducing muscle tension. It is commonly used to treat conditions such as multiple sclerosis and spinal cord injuries. In this formulation, it helps to alleviate muscle spasms and associated pain.

Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that works by reducing hormones that cause inflammation and pain in the body. It is often used to treat conditions such as arthritis, acute pain, and menstrual pain. In this formulation, it helps to reduce inflammation and associated pain in the targeted area.

Loperamide HCl is an opioid agonist that works by slowing the movement of the intestines. It is commonly used to treat diarrhea. In this formulation, it helps to reduce the frequency of bowel movements and the urgency to have them, providing relief from conditions such as irritable bowel syndrome (IBS).

This formulation is designed to provide targeted treatment for a variety of conditions, including muscle spasms, inflammation, and IBS. By applying the gel directly to the affected area, patients can experience relief from their symptoms without the systemic side effects often associated with oral medications.

As with any medication, it is important to use this formulation as directed by your healthcare provider. If you have any questions about this formulation or how to use it, please reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is here to help.

Drug Interactions

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This compounded formulation contains Baclofen, Ketoprofen, and Loperamide HCl. Each of these active ingredients has its own potential for drug interactions, which can be amplified when used in combination. It's important to consider these interactions when prescribing or using this medication.

Baclofen is a muscle relaxant and antispastic agent. It may interact with other central nervous system depressants like alcohol, benzodiazepines, opioids, and antihistamines, potentially leading to increased sedation or respiratory depression. Concurrent use with antihypertensive drugs may lead to additive hypotensive effects.

Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID). It may interact with anticoagulants, increasing the risk of bleeding. It can also interact with other NSAIDs, corticosteroids, or alcohol, increasing the risk of gastrointestinal ulcers or bleeding. Ketoprofen may reduce the effectiveness of antihypertensive drugs and diuretics. It can also increase levels of lithium and methotrexate, potentially leading to toxicity.

Loperamide HCl is an antidiarrheal agent. It may interact with drugs that are substrates of P-glycoprotein, such as digoxin, potentially leading to increased levels and toxicity. Concurrent use with other central nervous system depressants, including alcohol, benzodiazepines, and opioids, may increase the risk of sedation and respiratory depression.

This formulation is intended for topical use, which may reduce the risk of systemic drug interactions. However, systemic absorption can still occur, especially with prolonged use, large application areas, or damaged skin. Therefore, it's important to consider potential drug interactions even with topical use.

This formulation is used for its analgesic and anti-inflammatory effects, making it useful in conditions like musculoskeletal pain, inflammation, and spasticity. Baclofen can help reduce muscle spasticity, Ketoprofen can reduce pain and inflammation, and Loperamide can help reduce gastrointestinal motility, which can be beneficial in certain conditions.

It's important to use this medication as directed by your healthcare provider and to inform them of all other medications you're taking, including prescription drugs, over-the-counter medications, and dietary supplements. If you have any questions about this formulation or its potential interactions, please reach out to us at Bayview Pharmacy. We're here to help.

How Does it Work

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The Baclofen 2%/Ketoprofen 20%/Loperamide HCl 5% Topical Gel is a unique formulation that combines three active ingredients to provide targeted relief for various disease states. This semisolid formulation is dispensed through a pump mechanism, which allows for easy and precise application on the skin. The gel-like consistency ensures that the active ingredients are absorbed effectively into the skin for maximum therapeutic effect.

Baclofen is a muscle relaxant and antispastic agent. It works by restoring the normal transmission of nerve signals in certain parts of the body. This helps to reduce muscle spasms, which can be beneficial in conditions such as multiple sclerosis and spinal cord injuries. In this formulation, the baclofen is applied topically to provide targeted relief at the site of discomfort.

Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that works by reducing hormones that cause inflammation and pain in the body. It is commonly used to relieve pain, swelling, and joint stiffness caused by arthritis. When applied topically in this gel formulation, ketoprofen can provide targeted relief to the affected area without the systemic side effects that can occur with oral NSAIDs.

Loperamide HCl is an opioid agonist that works by slowing the movement of the intestines. This helps to reduce the frequency of bowel movements and makes the stools more solid. In this formulation, loperamide is used topically to help manage conditions such as diarrhea-predominant irritable bowel syndrome (IBS-D).

Together, these three active ingredients work synergistically to provide targeted relief for a variety of disease states. The topical application allows for the active ingredients to be absorbed directly into the affected area, providing faster and more effective relief than oral medications. Furthermore, the pump mechanism allows for easy and precise dosing, ensuring that patients receive the optimal amount of medication for their individual needs.

If you have any questions about this formulation, please don't hesitate to reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is always here to help.

Other Uses

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The Baclofen 2%/Ketoprofen 20%/Loperamide HCl 5% Topical Gel is primarily used for managing various forms of pain, including severe, acute, or chronic inflammatory and neuropathic pain. However, this particular formulation may also have other uses due to the combined effects of its main components.

Baclofen, a muscle relaxant, is often used to help relieve muscle spasms or stiffness in conditions such as multiple sclerosis or spinal cord injuries. When used topically, it can potentially provide focused relief to specific areas of discomfort. Topical usage can minimize systemic side effects commonly associated with oral usage, making it an option for those who cannot tolerate oral baclofen.

Ketoprofen, a potent nonsteroidal anti-inflammatory drug (NSAID), is known for its effective management of inflammation and pain affiliated with conditions like arthritis, gout, and various strains or sprains. Beyond its conventional usage, Ketoprofen can potentially be employed in other chronic pain conditions resulted from inflammation - providing localized relief without significant systemic side effects.

Loperamide hydrochloride, although primarily an anti-diarrheal agent, exhibits unique peripheral opioid receptor effects when used in a topical formulation. Its potential vascular impacts could make it beneficial in managing conditions such as Raynaud's disease and chilblains, which involve hypersensitivity to cold in the extremities.

While the above mentioned uses of individual components are possible, its ultimate usage depends on the practitioner's discretion, considering the patient's overall health profile, the nature of the condition, response to treatment and potential side effects. It is advisable that both patients and prescribers contact a Bayview Pharmacy compounding pharmacist for additional information about this formulation and its potential benefits.

Frequently Asked Questions

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What is Baclofen 2%/Ketoprofen 20%/Loperamide HCl 5% Topical Gel?

It's a compounded formulation containing Baclofen, Ketoprofen, and Loperamide that is applied topically onto the skin. This semisolid formulation comes in a pump for easy and precise application and is designed to absorbed into the skin to provide targeted treatment.

What are the active ingredients in this formulation?

The active ingredients in this formulation are Baclofen 2%, Ketoprofen 20%, and Loperamide HCl 5%.

How should I apply this topical gel?

You apply it directly to the skin in the area needing treatment. The pump allows for direct and precise application, reducing the risk of waste or misapplication.

What does "semisolid" formulation mean?

The "semisolid" term means the consistency of the formulation is neither purely solid nor purely liquid. It's in a form that can be easily spread and absorbed by the skin.

Does this gel have a certain texture?

Yes, the gel has a specific consistency, similar to a gel, that helps facilitate the absorption of the active ingredients in the skin and aid in the application.

Can this topical gel be used for any kind of skin treatment?

This gel is specifically formulated for targeted treatment. Therefore, its use should be limited to the area and condition specified by your healthcare provider.

What is the purpose of the pump mechanism in the gel's container?

The pump mechanism is designed to facilitate easy and precise application of the gel onto the skin, minimizing waste and allowing for accurate dosage.

Do I need a prescription to use this topical gel?

As this is a compounded formulation that contains active ingredients, you will likely need a prescription from your healthcare provider to use it.

Can I apply this topical gel to broken or irritated skin?

You should only apply this gel to the skin as directed by your healthcare provider. If you have broken or irritated skin, it's best to consult your doctor before applying any medication.

What should I do if I experience side effects after applying the gel?

If you experience any side effects after applying the gel, you should stop using it and consult your healthcare provider immediately for guidance.

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Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.