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Baclofen 2%/Ketoprofen 20%/Lidocaine HCl 5%/Verapamil HCl 10% Topical Gel

This formulation is a compounded topical gel containing Baclofen 2%, Ketoprofen 20%, Lidocaine HCl 5%, and Verapamil HCl 10%. It is a semisolid formulation dispensed through a pump mechanism, which allows for easy and precise application on the skin. The gel-like consistency aids in the targeted treatment or absorption of the active ingredients.

The combination of these active ingredients is designed to treat a variety of disease states. Baclofen is a muscle relaxant and antispasmodic agent used to relieve muscle symptoms caused by multiple sclerosis and spinal cord injuries. Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that helps to reduce inflammation and pain. Lidocaine HCl is a local anesthetic that provides temporary relief from pain and discomfort. Verapamil HCl is a calcium channel blocker that is used to treat high blood pressure, angina (chest pain), and certain heart rhythm disorders.

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Topical Gel
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Formula Information

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This formulation is a compounded topical gel containing Baclofen 2%, Ketoprofen 20%, Lidocaine HCl 5%, and Verapamil HCl 10%. It is a semisolid formulation dispensed through a pump mechanism, which allows for easy and precise application on the skin. The gel-like consistency ensures that the active ingredients are absorbed effectively for targeted treatment.

Baclofen is a muscle relaxant and antispasmodic agent that helps to relieve muscle spasms, pain, and stiffness. Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that reduces inflammation and pain in the body. Lidocaine HCl is a local anesthetic that works by blocking nerve signals in your body, thus providing temporary relief of pain or discomfort. Verapamil HCl is a calcium channel blocker that relaxes the muscles of your heart and blood vessels. It is used to treat hypertension, angina (chest pain), and certain heart rhythm disorders.

This unique combination of ingredients works synergistically to provide relief from various disease states. The anti-inflammatory properties of Ketoprofen, combined with the muscle-relaxing effects of Baclofen, can be particularly beneficial for conditions such as arthritis, muscle sprains, and strains. Lidocaine provides immediate relief from pain, making this formulation suitable for acute conditions or flare-ups. Verapamil's ability to relax blood vessels can be beneficial in treating conditions like Raynaud's disease, where blood vessels in the hands and feet can spasm, causing pain and discomfort.

It's important to note that this is a topical formulation, meaning it's applied directly to the skin over the area of discomfort. This allows for targeted treatment and can reduce the risk of systemic side effects often associated with oral medications. However, as with any medication, it's important to use this product as directed by your healthcare provider and report any adverse effects immediately.

If you have any questions about this formulation, its uses, or how it may benefit you, please don't hesitate to reach out to us at Bayview Pharmacy. Our knowledgeable team of compounding pharmacists is here to help.

Drug Interactions

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This compounded formulation contains Baclofen, Ketoprofen, Lidocaine HCl, and Verapamil HCl. Each of these active ingredients has its own potential for drug interactions, which can be amplified when used in combination. It's important to consider these interactions when prescribing or using this medication.

Baclofen is a muscle relaxant and antispastic agent. It may interact with other central nervous system depressants like alcohol, benzodiazepines, opioids, and antihistamines, potentially leading to increased sedation or respiratory depression. Concurrent use with monoamine oxidase inhibitors (MAOIs) may result in hypotension.

Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID). It may increase the risk of bleeding when used with other drugs that have this effect, such as anticoagulants (e.g., warfarin), antiplatelet drugs (e.g., clopidogrel), and selective serotonin reuptake inhibitors (SSRIs). It may also reduce the effectiveness of antihypertensive drugs and diuretics. Concurrent use with other NSAIDs or corticosteroids can increase the risk of gastrointestinal ulcers or bleeding.

Lidocaine HCl is a local anesthetic. It may interact with other local anesthetics or drugs that are structurally similar, such as antiarrhythmic drugs (e.g., mexiletine), leading to additive systemic toxicity. It may also interact with drugs that inhibit cytochrome P450 3A4 enzymes, potentially increasing the risk of systemic toxicity.

Verapamil HCl is a calcium channel blocker. It may interact with other drugs that affect heart rhythm, such as beta-blockers, digoxin, and other antiarrhythmics, potentially leading to heart block or heart failure. It may also interact with drugs metabolized by cytochrome P450 3A4 enzymes, potentially leading to increased levels of these drugs and their associated side effects.

This formulation is intended for topical use, which may reduce the risk of systemic drug interactions. However, systemic absorption can still occur, especially with prolonged use or application to large areas of skin. Therefore, it's important to consider potential drug interactions when prescribing or using this medication.

This formulation is used to treat various disease states. Baclofen can help with muscle spasms and spasticity. Ketoprofen can reduce inflammation and pain. Lidocaine HCl can provide local anesthesia, reducing pain and discomfort. Verapamil HCl can help with conditions like Raynaud's disease and Peyronie's disease by improving blood flow and reducing the formation of fibrous tissue.

If you have any questions about this formulation or its potential drug interactions, please don't hesitate to reach out to us. We're here to help ensure that you can use this medication safely and effectively.

How Does it Work

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This formulation is a combination of four active ingredients: Baclofen, Ketoprofen, Lidocaine HCl, and Verapamil HCl, each playing a unique role in managing various disease states. The formulation is designed to be applied topically, directly to the skin, where it can be absorbed to provide targeted treatment.

Baclofen is a muscle relaxant and antispastic agent. It works by inhibiting the transmission of reflexes at the spinal level, which can help to alleviate muscle spasms, pain, and stiffness. This makes it particularly useful in conditions such as multiple sclerosis and spinal cord injuries.

Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID). It works by reducing the production of prostaglandins, substances in the body that cause inflammation and pain. This makes it effective in treating conditions such as arthritis, where inflammation is a key issue.

Lidocaine HCl is a local anesthetic. It works by blocking nerve signals in your body, providing temporary relief from pain and discomfort. It is often used to relieve pain caused by skin irritations, sunburn, insect bites, poison ivy, poison oak, poison sumac, and minor cuts, scratches, or burns.

Verapamil HCl is a calcium channel blocker. It works by relaxing the muscles of your heart and blood vessels, which can help to lower blood pressure and control an irregular heartbeat. In a topical formulation, it may also help to improve blood flow to the area where it is applied, which can aid in the healing process.

Together, these four ingredients provide a comprehensive approach to pain management, inflammation reduction, and muscle relaxation. The gel formulation allows for easy application and targeted treatment, making it a versatile option for a variety of conditions. As with any medication, it is important to use this product as directed by your healthcare provider, and to discuss any potential side effects or interactions with other medications you may be taking.

If you have any questions about this formulation, or if you would like more information on how it can be used to treat specific conditions, please don't hesitate to reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is always here to help.

Other Uses

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This specially compounded formulation- Baclofen 2%/Ketoprofen 20%/Lidocaine HCl 5%/Verapamil HCl 10% Topical Gel, is infused with ingredients known for their muscle relaxing, anti-inflammatory, anesthetic, and vasodilatory properties. Most commonly utilized for the treatment of neuropathic pain, muscle spasms, and inflammation, this product could offer other potential uses.

For instance, this topical gel could also be used in treating conditions like Peyronie's Disease or other fibromatous disorders. The verapamil present can inhibit the production of collagen, thus potentially reducing plaque formation. Peyronie's disease, for example, is characterized by fibrous scar tissue that forms beneath the surface of the penis, leading to curved and painful erections. By relaxing smooth muscles and reducing fibrosis, this formulation can ease the symptoms of such diseases.

Lidocaine, being a local anesthetic, can be beneficial in managing postherpetic neuralgia - a debilitating complication of shingles. This condition is characterized by severe pain that lingers long after the shingles rash has cleared. Lidocaine numbs the area, providing temporary relief.

Moreover, baclofen, a muscle relaxant, can potentially be helpful in case of hiccups. Persistent hiccups could be due to nerve damage or irritation in the muscles that control your diaphragm. Baclofen can assist in managing and suppressing such involuntary muscle activities.

Importantly, the use of this formulation for purposes other than its primary indication should be done under the guidance of a qualified healthcare professional. It's necessary to consider the individual therapeutic responses, potential side effects, and drug interactions, and these can vary widely among different patients. Unsuitable use can lead to undesirable effects. Therefore, prior consultation with physicians is advised.

Additionally, it's always advised to apply this compound formulation as instructed by the healthcare provider for optimal results. If you have any questions, don't hesitate to reach out to us at Bayview Pharmacy. Our knowledgeable team of compounding pharmacists is always here to guide and assist you.

Frequently Asked Questions

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What is Baclofen 2%/Ketoprofen 20%/Lidocaine HCl 5%/Verapamil HCl 10% Topical Gel?

This is a compounded formulation of four active ingredients, including Baclofen, Ketoprofen, Lidocaine HCl, and Verapamil HCl. This semisolid formulation is dispensed through a pump mechanism for easy and precise topical application.

How does the pump mechanism work?

The pump mechanism facilitates an easy and precise application of the gel onto your skin. Simply press down on the pump to dispense the prescribed amount of gel.

What is the intended use of this gel?

It is used for targeted treatment or absorption of the active ingredients into the skin. The medication provides relief from various conditions, depending on the active ingredients and their individual therapeutic benefits.

What does each active ingredient do?

Baclofen is a muscle relaxer and an antispasmodic agent. Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that reduces pain and inflammation. Lidocaine HCl is a local anesthetic that causes temporary numbness/loss of feeling in the skin and mucous membranes. Verapamil HCl is used to treat high blood pressure and other heart complications.

What is the texture of this gel?

This gel has a semisolid, gel-like consistency that is easy to apply and spread over the skin's surface.

How often should I use this gel?

Usage will depend on the instructions provided by your healthcare provider. Always follow your doctor's orders or the directions on the label.

Can anyone use this gel?

This gel should only be used as prescribed by a healthcare provider. Always consult your doctor before starting a new medication.

Can this gel cause allergic reactions?

Yes, as with most medications, this gel can cause allergic reactions in some individuals. If you experience any unusual symptoms such as rash, itchiness, swelling, severe dizziness, or difficulty breathing, seek immediate medical attention.

What should I do if I miss a dose?

Apply the missed dose as soon as you remember. If it is close to the time for your next dose, skip the missed dose and go back to your normal time. Do not apply twice at the same time or extra doses unless instructed by a healthcare provider.

How should I store this gel?

Store this medication at room temperature away from moisture and heat. Do not freeze. Keep the container tightly closed when not in use.

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Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.