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Baclofen 2%/Gabapentin 6%/Ketamine 10%/Ketoprofen 10% Topical Gel

This formulation is a compounded topical gel containing Baclofen 2%, Gabapentin 6%, Ketamine 10%, and Ketoprofen 10%. It is a semisolid formulation dispensed through a pump mechanism, which allows for easy and precise application on the skin. The gel-like consistency aids in the targeted treatment or absorption of the active ingredients.

The combination of these four active ingredients is designed to treat a variety of disease states. Baclofen is a muscle relaxer and an antispastic agent, Gabapentin is used to treat nerve pain and seizures, Ketamine is a general anesthetic, and Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID). Together, they provide a comprehensive approach to pain management, particularly for conditions such as neuropathic pain, chronic pain, and inflammation.

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Topical Gel
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Formula Information

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This formulation is a compounded topical gel containing Baclofen 2%, Gabapentin 6%, Ketamine 10%, and Ketoprofen 10%. It is a semisolid formulation dispensed through a pump mechanism, which allows for easy and precise application on the skin. The gel-like consistency ensures that the active ingredients are absorbed effectively for targeted treatment.

Baclofen is a muscle relaxant and antispasmodic agent used to relieve spasms, pain, and stiffness caused by multiple sclerosis, spinal cord injuries, or other spinal cord disorders. Gabapentin is an anticonvulsant and nerve pain medication used to treat seizures and pain caused by shingles. Ketamine is a general anesthetic used to prevent pain and discomfort during certain medical tests or procedures. Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve pain, swelling, and joint stiffness caused by arthritis.

When combined in a topical gel, these medications can provide targeted relief for a variety of conditions. The gel can be applied directly to the area of discomfort, allowing the active ingredients to be absorbed through the skin and provide localized relief. This can be particularly beneficial for patients who have difficulty swallowing pills or who experience gastrointestinal side effects from oral medications.

It's important to note that this is a compounded medication, meaning it is made specifically for you based on a doctor's prescription. It is not a commercially available product and should only be used under the supervision of a healthcare professional. As with any medication, it's important to use this product as directed by your healthcare provider. Side effects may include skin irritation at the application site. If you experience any unusual symptoms, contact your healthcare provider immediately.

If you have any questions about this formulation, please don't hesitate to reach out to us at Bayview Pharmacy. Our knowledgeable team of compounding pharmacists is here to help you understand your medication and how to use it effectively.

Drug Interactions

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This compounded formulation contains Baclofen, Gabapentin, Ketamine, and Ketoprofen. Each of these medications has its own potential for drug interactions, which can be amplified when used in combination. It's important to inform your healthcare provider of all medications you are currently taking, including over-the-counter drugs and dietary supplements.

Baclofen, a muscle relaxant and antispastic agent, may interact with other central nervous system depressants like alcohol, benzodiazepines, and opioids, potentially leading to increased sedation or respiratory depression. It may also interact with medications that affect kidney function, as it is primarily excreted via the kidneys.

Gabapentin, an anticonvulsant and nerve pain medication, may interact with antacids containing magnesium or aluminum, as they can reduce the absorption of gabapentin. It may also interact with drugs that cause sedation, including opioids, antihistamines, and alcohol, potentially leading to increased drowsiness or respiratory depression.

Ketamine, an anesthetic, may interact with other central nervous system depressants, potentially leading to increased sedation or respiratory depression. It may also interact with medications that affect liver function, as it is primarily metabolized in the liver.

Ketoprofen, a nonsteroidal anti-inflammatory drug (NSAID), may interact with anticoagulants, antiplatelet drugs, and other NSAIDs, potentially increasing the risk of bleeding. It may also interact with angiotensin-converting enzyme (ACE) inhibitors, angiotensin II receptor blockers (ARBs), or diuretics, potentially impairing kidney function. Furthermore, it may interact with lithium or methotrexate, potentially increasing their levels in the body.

This formulation is designed to treat various disease states, including neuropathic pain, musculoskeletal pain, and inflammation. Baclofen and Gabapentin work to reduce nerve pain, Ketamine provides local anesthesia, and Ketoprofen reduces inflammation and pain. The topical application allows for targeted treatment, reducing systemic exposure and potential side effects.

It's crucial to use this medication as directed by your healthcare provider and report any side effects or unexpected reactions immediately. Always consult your healthcare provider before starting or stopping any medication.

If you have any questions about this formulation or its potential interactions, please don't hesitate to reach out to us at Bayview Pharmacy. Our knowledgeable team of compounding pharmacists is here to assist you.

How Does it Work

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This formulation is a combination of four active ingredients: Baclofen, Gabapentin, Ketamine, and Ketoprofen, each with a unique mechanism of action to provide relief from various disease states. The formulation is designed to be applied topically, directly to the skin, where it can be absorbed and exert its therapeutic effects.

Baclofen is a muscle relaxant and antispastic agent. It works by inhibiting the transmission of reflexes at the spinal level, which can help to alleviate muscle spasms, pain, and stiffness. This makes it particularly useful in conditions such as multiple sclerosis and spinal cord injuries.

Gabapentin is an anticonvulsant and nerve pain medication. It is believed to work by affecting the way nerves send messages to your brain, reducing the perception of pain. It is commonly used to treat nerve pain conditions such as postherpetic neuralgia and diabetic neuropathy.

Ketamine is a powerful anesthetic that works by blocking the NMDA receptor, a type of glutamate receptor in the brain and spinal cord. This can help to reduce pain and inflammation, making it useful in treating chronic pain conditions.

Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that works by reducing hormones that cause inflammation and pain in the body. It is commonly used to relieve pain, swelling, and joint stiffness caused by arthritis.

The combination of these four active ingredients in a topical gel formulation allows for targeted treatment of pain and inflammation. The gel is designed to be easily applied to the skin and absorbed, providing direct relief to the affected area. This can help to reduce the need for systemic medications and their associated side effects.

As with any medication, it's important to use this formulation as directed by your healthcare provider. If you have any questions about this formulation or how to use it, please don't hesitate to reach out to us at Bayview Pharmacy. We're here to help.

Other Uses

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Other than for the conditions previously mentioned, the Baclofen 2%/Gabapentin 6%/Ketamine 10%/Ketoprofen 10% Topical Gel has several other potential applications. It can be used for the management of other neuropathic pain disorders and symptomatic relief of burning and prickling sensations. In particular, Baclofen, a muscle relaxant and antispasmodic agent, can be utilized in patients with muscle rigidity resulting from conditions like multiple sclerosis or spinal cord injuries. Gabapentin, primarily an anticonvulsant, can be used off-label for conditions like menopausal hot flashes and restless leg syndrome.

Ketamine, a well-known anesthetic, may provide off-label benefits for depression and other mood disorders when applied topically, due to its NMDA receptor antagonism. However, it should be noted that the use of ketamine for this purpose is currently experimental and not FDA-approved. Ketoprofen, a nonsteroidal anti-inflammatory drug (NSAID), may also be used topically for conditions such as arthritis, tendinitis, and other musculoskeletal inflammatory conditions for pain alleviation and reduction of inflammation.

This formulation could also be an effective alternative for patients who may not respond well to or tolerate oral medications, as it bypasses the systemic circulation and targets the required site directly. Despite these other potential uses, it is always crucial to use this medication under medical supervision, as all components can have side effects or cause allergic reactions. Healthcare professionals who are considering to prescribe this topical gel should familiarize themselves with the properties of each component to maximize benefits and minimize side effects for patients.

If you have any questions about this formulation, please feel free to reach out to us at Bayview Pharmacy. We are a team of knowledgeable compounding pharmacists dedicated to providing accurate information and quality care.

Frequently Asked Questions

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What is Baclofen 2%/Gabapentin 6%/Ketamine 10%/Ketoprofen 10% Topical Gel?

This is a specially compounded formulation contained within a semisolid gel, designed to provide targeted pain relief directly through the skin. It comprises four different active ingredients - Baclofen, Gabapentin, Ketamine, and Ketoprofen, each having unique properties for pain management.

How is this topical gel administered?

The formulation is dispensed through a pump mechanism, facilitating easy and precise application on the skin.

What is the consistency of this gel?

The Baclofen/Gabapentin/Ketamine/Ketoprofen topical gel is in a gel-like consistency, which helps in easy application and absorption through the skin.

Does this topical gel provide localized treatment?

Yes, the topical gel is designed for targeted treatment. You apply it directly to the area where you are experiencing pain or discomfort.

Do I need a prescription to use this formulation?

Yes, Baclofen, Gabapentin, Ketamine, and Ketoprofen are all prescription medications, and this combined formulation would also require a prescription from your healthcare provider.

What are the active ingredients in this compounded formulation?

The active ingredients in this topical gel are Baclofen (2%), Gabapentin (6%), Ketamine (10%), and Ketoprofen (10%).

Are there any side effects associated with this formulation?

As with all medications, some side effects may occur. These could include skin irritation at the application site. If you experience any unusual or persistent side effects, consult your healthcare provider immediately.

Can this formulation be used for all types of pain?

This special formulation is commonly prescribed for neuropathic pain and may also be effective in treating musculoskeletal pain. However, your healthcare provider will decide if this medication is right for your specific condition.

How often should I apply this topical gel?

The frequency of application will depend on your specific needs and the directions provided by your healthcare provider. Always follow their instructions carefully.

Will the gel leave a residue on my skin?

The gel is designed to be absorbed through the skin, and therefore should not leave significant residues. However, if you notice a residue or if the gel does not seem to be absorbing correctly, consult your healthcare provider or pharmacist.

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Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.