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Formulas

Azithromycin 200 mg Rectal Suppository

The Azithromycin 200 mg Rectal Suppository is a solid dosage form designed for insertion into the rectum. Upon insertion, the suppository dissolves or melts, releasing the antibiotic Azithromycin into the body. This method of administration allows for both local and systemic absorption of the medication.

Azithromycin is a broad-spectrum antibiotic used to treat a variety of bacterial infections. This includes respiratory infections, skin infections, ear infections, and sexually transmitted diseases. The rectal suppository form of Azithromycin provides an alternative route of administration for patients who may have difficulty swallowing oral medication or for whom oral administration is not recommended.

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Azithromycin
Suppository
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Formula Information

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Azithromycin 200 mg Rectal Suppository is a specialized formulation designed for rectal administration. This solid dosage form is inserted into the rectum, where it dissolves or melts to release the medication. The active ingredient, Azithromycin, is then absorbed locally or systemically to exert its therapeutic effects.

Azithromycin is a macrolide antibiotic that works by stopping the growth of bacteria. It is used to treat a wide variety of bacterial infections, including respiratory infections, skin infections, ear infections, and sexually transmitted diseases. By delivering the medication rectally, this formulation can provide an alternative route of administration for patients who have difficulty swallowing pills or for whom oral administration is not suitable.

As with any medication, it is important to use Azithromycin Rectal Suppositories as directed by your healthcare provider. The dosage is based on your medical condition and response to treatment. It is crucial to complete the prescribed course of treatment, even if symptoms disappear after a few days. Stopping the medication too early may allow bacteria to continue to grow, which may result in a return of the infection.

Side effects may include stomach upset, diarrhea, nausea, vomiting, or abdominal pain. If any of these effects persist or worsen, notify your doctor or pharmacist promptly. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects.

Before using Azithromycin, tell your doctor or pharmacist your medical history, especially of: liver disease, kidney disease, a certain muscle disease (myasthenia gravis). Azithromycin may cause a condition that affects the heart rhythm (QT prolongation). The risk of QT prolongation may be increased if you have certain medical conditions or are taking other drugs that may cause QT prolongation.

It is important to note that this formulation is compounded in our pharmacy and is not commercially available. Therefore, it requires a prescription from a licensed healthcare provider. If you have any questions about Azithromycin 200 mg Rectal Suppository or would like more information, please reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is here to assist you.

Drug Interactions

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Azithromycin is a macrolide antibiotic that works by stopping the growth of bacteria. This medication is used to treat a variety of bacterial infections, including sexually transmitted infections, respiratory tract infections, skin infections, and ear infections. It is important to note that azithromycin is not effective against viral infections such as the common cold or flu.

When considering drug interactions, it is important to understand that azithromycin can interact with a number of other medications, potentially altering their effectiveness or increasing the risk of side effects. Some of the most common drugs that may interact with azithromycin include antacids containing aluminum or magnesium, such as Maalox or Mylanta, as they can slow down the absorption of azithromycin. Therefore, if you are taking an antacid, it is recommended to take it at least 1 hour before or 2 hours after taking azithromycin.

Other medications that may interact with azithromycin include warfarin, an anticoagulant, and digoxin, a medication used to treat heart conditions. Azithromycin can increase the effects of these drugs, potentially leading to an increased risk of bleeding or cardiac toxicity. If you are taking either of these medications, your doctor may need to monitor you more closely while you are taking azithromycin.

Furthermore, azithromycin can interact with certain medications used to treat seizures, such as carbamazepine, phenytoin, and phenobarbital. These interactions can decrease the effectiveness of the seizure medication, potentially leading to an increased risk of seizures. If you are taking any of these medications, your doctor may need to adjust your dose or monitor you more closely.

It is also important to note that azithromycin can interact with certain types of live vaccines, such as the typhoid vaccine. If you are scheduled to receive a live vaccine, it is recommended to let your doctor know that you are taking azithromycin.

Lastly, azithromycin can interact with certain types of cholesterol-lowering medications, such as statins. This interaction can increase the risk of muscle damage, which can lead to a serious condition called rhabdomyolysis. If you are taking a statin, your doctor may need to adjust your dose or monitor you more closely while you are taking azithromycin.

This is not a complete list of all possible drug interactions. Therefore, it is important to inform your doctor or pharmacist of all the medications you are currently taking, including prescription drugs, over-the-counter medications, and herbal supplements, before starting treatment with azithromycin.

If you have any questions or concerns about the potential drug interactions with azithromycin, please do not hesitate to reach out to us. We are here to help and provide you with the most accurate and up-to-date information.

How Does it Work

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Azithromycin 200 mg Rectal Suppository is a unique formulation designed to deliver the antibiotic azithromycin directly to the body via the rectal route. This solid dosage form is inserted into the rectum, where it dissolves or melts, releasing the medication for local or systemic absorption.

The active ingredient, azithromycin, belongs to a class of drugs known as macrolide antibiotics. It works by inhibiting the growth of bacteria by interfering with their protein synthesis. It binds to the 50S subunit of the bacterial ribosome, thus inhibiting translation of mRNA. This action prevents the bacteria from growing, and its further ability to produce proteins leads to its eventual death.

When the suppository is inserted into the rectum, it begins to dissolve due to the body's natural heat. As it dissolves, the azithromycin is released and absorbed through the rectal mucosa into the bloodstream. This allows the drug to circulate throughout the body and reach the site of infection, where it can exert its antibacterial effects.

Rectal administration of azithromycin can be particularly beneficial in certain situations. For instance, it can be useful for patients who have difficulty swallowing oral medication, or for those who are nauseous or vomiting and cannot keep down an oral antibiotic. It may also provide a more direct route of administration for treating certain types of infections, such as those in the lower gastrointestinal tract or the genitourinary system.

Azithromycin is used to treat a wide variety of bacterial infections, including respiratory infections, skin infections, ear infections, and sexually transmitted diseases. It is also used in combination with other medications to treat H. pylori, a bacteria that can lead to ulcers.

As with any medication, it's important to use azithromycin as directed by your healthcare provider. The dosage and length of treatment are based on your medical condition and response to treatment. It's crucial to complete the prescribed course of treatment, even if symptoms disappear after a few days. Stopping the medication too early may allow bacteria to continue to grow, which may result in a return of the infection.

If you have any questions about Azithromycin 200 mg Rectal Suppository, or if you would like more information about this or any other compounding services we offer, please don't hesitate to reach out to us at Bayview Pharmacy. We are here to help.

Other Uses

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Azithromycin 200 mg rectal suppository is primarily used for the treatment of various bacterial infections. This formulation could also be used as an alternative route of administration for patients who have difficulty swallowing tablets or for those who cannot tolerate oral medication due to gastrointestinal issues. Besides, it's also a useful alternative for patients who fail to respond to oral antibiotics or for those requiring continuous drug release and a more predictable absorption than oral administration.

Furthermore, rectal Azithromycin could be beneficial for patients who are unconscious, comatose, or bed-ridden and cannot take oral medication, thus ensuring continued treatment. This form of Azithromycin could also be useful in treating sexually transmitted infections rectally, providing targeted treatment at the site of infection. In addition, this rectal suppository could also be used for the treatment of H. pylori infections, a common cause of peptic ulcers. This is accomplished by reaching the lower parts of the gastrointestinal tract, where H. pylori is often found.

It's also significant to note that the rectal route bypasses the 'first-pass' metabolism, hence increasing the bioavailability of the drug. This can be specifically beneficial for drugs like Azithromycin, which are extensively metabolized by the liver. Therefore, the potential for systemic side effects may be reduced with rectal administration. However, it's crucial to stress that all these uses need to be researched and validated thoroughly.

Please note that any novel usage of Azithromycin 200 mg rectal suppository should take into consideration the patient's overall health condition and needs to be performed under strict healthcare supervision. Always consult with a healthcare provider or pharmacist before starting any new treatment regimen.

If you have any questions about this formulation or any other pharmacy-related queries, don't hesitate to reach out to our knowledgeable team at Bayview Pharmacy. Your health and well-being are our topmost priority, and we are here to provide answers and guidance every step of the way.

Frequently Asked Questions

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What is an Azithromycin 200 mg Rectal Suppository?

An Azithromycin 200 mg Rectal Suppository is a solid dosage form of Azithromycin medication that is inserted into the rectum. It gradually dissolves or melts to release the contained medication, which can then be absorbed either locally or systemically.

How does Azithromycin 200 mg Rectal Suppository work?

Upon insertion into the rectum, the suppository will start to melt due to body heat. It subsequently releases the Azithromycin medication for local or systemic absorption, allowing its therapeutic effects to take place.

Who can use the Azithromycin rectal suppository?

These suppositories must be used under the guidance of a healthcare provider, and they are recommended for patients who are prescribed Azithromycin but cannot take it orally, those who struggle to swallow tablets, or for specific medical conditions as directed by a doctor.

Does the suppository provide instant relief?

While the rate may vary depending on individual body conditions, typically the drug begins to provide relief shortly after the suppository dissolves in the rectum. Please consult your healthcare provider for specific timelines.

Are there any side effects of the Azithromycin 200 mg Rectal Suppository?

All medications can cause side effects. Possible side effects of Azithromycin 200 mg Rectal Suppository may include local irritation or discomfort. If you experience severe discomfort, prolonged side effects, or allergic reactions, please contact your healthcare provider.

How should I store Azithromycin 200 mg Rectal Suppositories?

These suppositories should be stored in a cool and dry place. It is important to keep them out of reach of children to prevent accidental ingestion.

Can I use Azithromycin 200 mg Rectal Suppository if I am pregnant or breastfeeding?

Never use any medication, including the Azithromycin 200 mg Rectal Suppository, without consulting your healthcare provider, especially if you are pregnant, planning to become pregnant or breastfeeding.

How often should I use the Azithromycin 200 mg Rectal Suppository?

The frequency of use should be dictated by your healthcare provider's prescription based on your specific medical condition and response to treatment.

Can I use the suppository while taking other medications?

You should always discuss with your healthcare provider about all the medicines you are currently taking, including over-the-counter drugs, prescribed medications, and herbal products, to avoid potential drug interactions.

What should I do if I miss or forget a dose?

In case you forget to take a dose, take it as soon as you remember. If it’s near the time of your next dose, skip the missed dose and follow your regular schedule. Do not double up on doses to make up for the missed one.

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Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.