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Azelaic Acid 15%/Kojic Acid 6%/Tranexamic Acid 5% Topical Gel

This formulation is a combination of Azelaic Acid 15%, Kojic Acid 6%, and Tranexamic Acid 5% in a topical gel form. It is a semisolid formulation dispensed through a pump mechanism, which allows for easy and precise application on the skin. The gel-like consistency ensures targeted treatment or absorption of the active ingredients.

The Azelaic Acid in the formulation works to reduce inflammation and redness, making it effective for treating rosacea and acne. Kojic Acid is a skin-lightening agent that helps to treat hyperpigmentation and melasma. Tranexamic Acid is known for its ability to reduce bleeding and inflammation, making it beneficial for treating melasma and post-inflammatory hyperpigmentation.

Together, these active ingredients work synergistically to treat various skin conditions, providing relief and promoting healthier skin.

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Topical Gel
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Formula Information

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This formulation combines Azelaic Acid 15%, Kojic Acid 6%, and Tranexamic Acid 5% in a topical gel. The gel is dispensed through a pump mechanism, which allows for easy and precise application on the skin. The gel-like consistency ensures that the active ingredients are absorbed effectively into the skin for targeted treatment.

Azelaic Acid is a naturally occurring acid that helps the skin to renew itself more quickly and therefore reduces pimple and blackhead formation. It also helps to kill the bacteria that cause acne and rosacea. Kojic Acid is a by-product of the fermentation process of malting rice for use in the manufacture of sake, the Japanese rice wine. It is an effective ingredient for brightening skin and reducing the appearance of sun damage, scars, and age spots. Tranexamic Acid is a synthetic derivative of the amino acid lysine and provides a powerful anti-inflammatory and brightening action, making it effective in treating melasma and post-inflammatory hyperpigmentation.

This formulation is particularly effective in treating various skin conditions such as acne, rosacea, melasma, and post-inflammatory hyperpigmentation. It works by reducing inflammation, inhibiting the production of melanin in the skin, and promoting skin renewal. This results in a reduction of skin discoloration, redness, and the appearance of acne and rosacea.

For patients using this formulation, it is important to apply it as directed by your healthcare provider. The gel should be applied to clean, dry skin and massaged gently until it is fully absorbed. Avoid contact with the eyes, mouth, and other mucous membranes. If irritation or sensitivity develops, stop using the product and consult your healthcare provider.

For prescribers, it is important to note that this formulation may not be suitable for all patients. It should not be used by individuals with a known hypersensitivity to any of the ingredients. It should also be used with caution in patients with a history of sensitive skin or skin reactions to topical products. Regular follow-up is recommended to monitor the patient's response to treatment and to adjust the treatment plan as necessary.

If you have any questions about this formulation, please do not hesitate to reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is always here to help.

Drug Interactions

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This formulation combines Azelaic Acid 15%, Kojic Acid 6%, and Tranexamic Acid 5% in a topical gel. These active ingredients work synergistically to treat various skin conditions such as hyperpigmentation, melasma, and acne. However, it's important to be aware of potential drug interactions when using this formulation.

Azelaic Acid is a dicarboxylic acid that helps the skin to renew itself more quickly and therefore reduces pimple and blackhead formation. It also helps to kill the bacteria that cause acne and rosacea. Kojic Acid is a chelation agent produced by several species of fungi which inhibits and prevents the formation of pigment in the skin. Tranexamic Acid is a synthetic derivative of the amino acid lysine and works by reducing the amount of melanin (skin pigment) production.

While these ingredients are generally safe and well-tolerated, they may interact with certain other medications or substances. For instance, using other skin products that can cause irritation such as harsh soaps, shampoos, or skin cleansers, hair coloring or permanent chemicals, hair removers or waxes, or skin products with alcohol, spices, astringents, or lime should be avoided. Also, avoid using other medicated skin products unless your doctor has told you to.

It's also important to note that Tranexamic Acid may interact with hormonal contraceptives. While this interaction is more commonly associated with oral or systemic use of Tranexamic Acid, it's still important to inform your healthcare provider if you're using any form of hormonal contraception.

Furthermore, while using this formulation, exposure to sunlight or tanning beds should be minimized. The treated skin may be more prone to sunburn. If you must be outside, use a sunscreen and wear protective clothing.

As with any medication, it's crucial to inform your healthcare provider of all the medications, supplements, and skincare products you're currently using to avoid any potential interactions. This includes prescription and over-the-counter drugs, as well as any vitamins or herbal products.

Lastly, while this formulation is designed for topical use, it's important to avoid getting it in your eyes, mouth, or nose. If this does happen, rinse with water immediately.

If you have any questions or concerns about this formulation or potential drug interactions, don't hesitate to reach out to us. We're here to help ensure that your treatment is as safe and effective as possible.

How Does it Work

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This formulation combines three active ingredients: Azelaic Acid 15%, Kojic Acid 6%, and Tranexamic Acid 5%. Each of these ingredients plays a unique role in treating various skin conditions.

Azelaic Acid is a dicarboxylic acid that works by inhibiting the growth of skin bacteria that can cause acne, as well as by decreasing the production of keratin, a natural substance that can lead to the development of acne. It also helps to reduce inflammation and redness associated with acne. In addition, Azelaic Acid has been shown to be effective in treating rosacea by decreasing the swelling and redness of the skin.

Kojic Acid is a chelation agent produced by several species of fungi, especially Aspergillus oryzae, which has the Japanese common name koji. It inhibits the production of melanin in the skin. Melanin is the pigment that gives skin its color and can lead to dark spots and hyperpigmentation. By inhibiting melanin production, Kojic Acid can help to lighten the skin and reduce the appearance of dark spots and discoloration.

Tranexamic Acid is a synthetic derivative of the amino acid lysine. It works by inhibiting the activation of plasminogen to plasmin, a molecule responsible for the degradation of fibrin. Fibrin is a protein that forms a mesh-like structure to form a clot to stop bleeding. In the context of skin care, Tranexamic Acid has been found to have a depigmenting effect, helping to reduce the appearance of melasma and post-inflammatory hyperpigmentation.

When combined in a topical gel, these three ingredients work together to treat a variety of skin conditions. The gel formulation allows for easy and precise application, and the pump mechanism ensures that the correct amount of product is dispensed each time. The gel is designed to be absorbed quickly into the skin, allowing the active ingredients to begin working as soon as possible.

This formulation is typically used to treat conditions such as acne, rosacea, hyperpigmentation, and melasma. However, it may also be beneficial for other skin conditions as determined by a healthcare provider. As with any medication, it is important to use this product as directed by a healthcare provider to ensure the best results.

If you have any questions about this formulation or how it works, please don't hesitate to reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is always here to help.

Other Uses

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The azelaic acid, kojic acid and tranexamic acid combination gel is an efficacious preparation most commonly used for the treatment of hyperpigmentation, melasma, and rosacea. However, it offers several other diverse applications as well. The kojic acid component, in particular, acts as a strong antioxidant beneficial for anti-aging treatments. It helps mitigate the effects of free radicals, thus slowing the appearance of fine lines and wrinkles. Azelaic acid, known for its keratolytic characteristics, aids in treating various forms of acne. It can further be used for its anti-inflammatory benefits in mitigating the symptoms of conditions such as psoriasis and eczema.

This potent combination can also be used as a part of pre- and post-operative skincare regimens, as tranexamic acid helps in the prevention and management of post-inflammatory hyperpigmentation, commonly seen after cosmetic procedures. Additionally, tranexamic acid’s anti-fibrinolytic capabilities can contribute to mitigating bleeding and bruising associated with minor skin injuries, making this formulation an asset in any wound care routine. However, this use should always be guided by the consultation of a healthcare professional.

While the formulation is highly effective, skin sensitivity and allergies should always be considered. It’s important to conduct a patch test or initiate use at a lower concentration to assess skin tolerance prior to beginning a full-skincare regimen. Patients should take note that slight tingling, redness, or peeling may occur upon initial use, which is usually a normal reaction. However, if severe irritation persists, discontinue use immediately and get in touch with a healthcare provider. The application of a good sunscreen is also imperative during the day, to shield the skin from UV rays and prevent further hyperpigmentation.

If you have any questions regarding this formulation or its uses, our team of knowledgeable compounding pharmacists at Bayview Pharmacy is available to help. Please feel free to reach out to us at any time.

Frequently Asked Questions

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What is this compounded formulation of Azelaic Acid 15%/Kojic Acid 6%/Tranexamic Acid 5% Topical Gel?

This is a specially formulated skin gel that combines the beneficial properties of Azelaic Acid, Kojic Acid, and Tranexamic Acid. It is delivered in a semisolid dispensable formulation through a pump mechanism for precise application. These ingredients work together to help improve skin conditions.

What form does this medication take?

This medication takes the form of a semisolid gel. It is dispensed through a pump mechanism to ensure easy and accurate application on the skin.

How should I apply this Azelaic Acid/Kojic Acid/Tranexamic Acid Topical Gel?

The gel is applied topically on the skin. Ensure your skin is clean and dry before application. It is recommended to follow the prescribed amount from your healthcare provider.

What should I expect in terms of consistency when using this gel?

The azelaic acid/kojic acid/tranexamic acid topical gel has a gel-like consistency, smooth and easy to spread across the skin for targeted treatment or absorption.

What are the main benefits of using this gel?

This gel aims to improve certain skin conditions. Azelaic Acid can reduce pigmentation and inflammation, Kojic Acid acts as a skin-lightening agent, and Tranexamic Acid can treat melasma and post-inflammatory hyperpigmentation.

Are there any precautions I should take when using this compounded formulation?

Before you start using this gel, make sure to discuss with your healthcare provider if you have any allergies or other medical conditions. Avoid contact with eyes and open wounds. Do not ingest the gel.

Does this formulation require a prescription?

Yes, this compounded formulation of Azelaic Acid 15%/Kojic Acid 6%/Tranexamic Acid 5% Topical Gel is a prescription medication. It should be used under the guidance of a healthcare provider.

How should I store this formula?

Store this formulation in a cool, dry place, away from direct sunlight. Always store it out of reach of children and pets.

What if I miss a dose?

If you miss a dose, apply it as soon as you remember. If it is near the time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to make up for a missed one.

What should I do in case of an overdose?

If you suspect an overdose, contact your healthcare provider or emergency medical aid immediately. Overdosing can cause severe skin irritation.

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Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.