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Atomoxetine 25 mg Rectal Suppository

The Atomoxetine 25 mg Rectal Suppository is a solid dosage form designed for insertion into the rectum. Upon insertion, the suppository dissolves or melts, releasing the active ingredient, Atomoxetine, for local or systemic absorption. Atomoxetine is primarily used in the treatment of Attention Deficit Hyperactivity Disorder (ADHD). This formulation provides an alternative route of administration for patients who may have difficulty swallowing oral medications.

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Formula Information

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Atomoxetine 25 mg Rectal Suppository is a specialized formulation designed for rectal administration. This solid dosage form is inserted into the rectum, where it dissolves or melts to release the medication. Atomoxetine is a selective norepinephrine reuptake inhibitor (NRI) that is primarily used to treat Attention Deficit Hyperactivity Disorder (ADHD). It works by increasing the levels of norepinephrine, a substance in the brain that helps control behavior.

The rectal suppository form of Atomoxetine provides an alternative route of administration for patients who may have difficulty swallowing pills or for whom oral administration is not suitable. This can be particularly beneficial for pediatric patients or those with gastrointestinal issues. The rectal route allows for the medication to be absorbed directly into the bloodstream, bypassing the digestive system, which can lead to a faster onset of action.

It's important to note that the use of Atomoxetine requires a prescription from a healthcare provider and should be used under their supervision. The dosage and frequency of use will depend on the individual patient's condition and response to therapy. Common side effects may include nausea, vomiting, fatigue, loss of appetite, and dry mouth. However, most people using this medication do not experience serious side effects.

Patients should be advised to follow their healthcare provider's instructions carefully when using this medication. The suppository should be unwrapped and moistened with water before it is inserted into the rectum. It is recommended to lie on one's side during administration and remain in this position for a few minutes to ensure the suppository stays in place.

As compounding pharmacists, we are able to customize this medication to meet the unique needs of each patient. We can adjust the dosage, change the form of the medication, and even combine multiple medications into a single dosage form. If you have any questions about Atomoxetine 25 mg Rectal Suppository or any other medication, please don't hesitate to reach out to us at Bayview Pharmacy. We are here to help.

Drug Interactions

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Atomoxetine is a selective norepinephrine reuptake inhibitor primarily used for the treatment of attention deficit hyperactivity disorder (ADHD). It works by increasing the levels of norepinephrine in the brain, which can help increase attention span and decrease impulsiveness and hyperactivity in patients with ADHD. This rectal suppository formulation allows for the medication to be absorbed directly into the bloodstream, bypassing the digestive system, which can be beneficial for patients who have difficulty swallowing pills or for those who experience gastrointestinal side effects with oral atomoxetine.

However, atomoxetine can interact with several other medications, which can affect how it works or increase the risk of serious side effects. It is important to inform your healthcare provider about all the medications you are currently taking, including prescription drugs, over-the-counter products, and herbal supplements.

Atomoxetine can interact with monoamine oxidase inhibitors (MAOIs). Using atomoxetine with these drugs can cause serious side effects such as hypertensive crisis (a sudden, severe increase in blood pressure) or serotonin syndrome (a potentially life-threatening drug reaction that causes the body to have too much serotonin, a chemical produced by nerve cells). Therefore, atomoxetine should not be used within 2 weeks of discontinuing an MAOI or vice versa.

Other medications that can interact with atomoxetine include certain blood pressure medications (such as clonidine), certain antidepressants (such as fluoxetine, paroxetine), and certain medications for heart rhythm disorders (such as quinidine). These drugs can affect the removal of atomoxetine from your body, which may affect how atomoxetine works. Your doctor may need to adjust your dose or take other precautions if you are using any of these medications.

Furthermore, atomoxetine can slow down the removal of certain medications from your body, which may affect how they work. Examples of affected drugs include albuterol, aspirin, certain drugs for Parkinson's disease (such as levodopa), certain heart medications (such as digoxin), certain antipsychotic drugs (such as haloperidol, phenothiazines), certain anti-seizure drugs (such as phenytoin), among others.

It is also important to note that atomoxetine can cause a significant increase in heart rate and blood pressure. Therefore, it should be used with caution in patients with cardiovascular or cerebrovascular disease. Regular monitoring of heart rate and blood pressure is recommended for patients taking atomoxetine.

Lastly, atomoxetine has the potential to cause liver injury. Patients should be advised to contact their healthcare provider immediately if they experience symptoms such as dark urine, jaundice (yellowing of the skin or eyes), right upper quadrant tenderness, or unexplained "flu-like" symptoms.

If you have any questions about the potential drug interactions or side effects of atomoxetine, please do not hesitate to reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is always here to help.

How Does it Work

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Atomoxetine 25 mg Rectal Suppository is a unique formulation designed to deliver the active ingredient, Atomoxetine, directly into the bloodstream via the rectal route. This method of administration is particularly useful for patients who may have difficulty swallowing oral medications or for those who require a rapid onset of action.

Atomoxetine is a selective norepinephrine reuptake inhibitor (NRI). It works by increasing the levels of norepinephrine, a neurotransmitter in the brain that helps regulate attention, impulsivity, and activity levels. This increase in norepinephrine can help improve symptoms of certain neurological and mental health conditions.

When the suppository is inserted into the rectum, it begins to dissolve due to the body's heat. As it dissolves, the Atomoxetine is released and absorbed through the thin lining of the rectum into the surrounding blood vessels. This allows the medication to bypass the digestive system, providing a faster onset of action and reducing the potential for certain side effects associated with oral administration.

This formulation is often used to treat conditions such as Attention Deficit Hyperactivity Disorder (ADHD). By increasing norepinephrine levels, Atomoxetine can help reduce the core symptoms of ADHD, including inattention, hyperactivity, and impulsivity. It can also be used in the treatment of certain mood disorders, as well as nerve pain.

It's important to note that while this formulation can provide significant benefits, it may not be suitable for all patients. Certain medical conditions, such as glaucoma, pheochromocytoma, and severe heart disorders, may preclude the use of Atomoxetine. Additionally, potential side effects can include dry mouth, loss of appetite, weight loss, and sleep problems. As with any medication, it's crucial to discuss your medical history and any potential risks with your healthcare provider before starting treatment.

If you have any questions about Atomoxetine 25 mg Rectal Suppository, or if you would like more information about how it works, please don't hesitate to reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is always here to help.

Other Uses

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Aside from its primary use for treating Attention Deficit Hyperactivity Disorder (ADHD), Atomoxetine, in the form of a 25 mg rectal suppository, may have other beneficial uses. Atomoxetine is a selective norepinephrine reuptake inhibitor, and it works by increasing the levels of norepinephrine, a substance in the brain that helps control behavior.

In certain cases, Atomoxetine might be utilized off-label in adult patients for the relief of symptoms related to narcolepsy or chronic fatigue syndrome due to its stimulant-like effects. However, this use would only be under the discretion and direct supervision of a healthcare professional. Additionally, because Atomoxetine has the potential to increase norepinephrine in the body, it could theoretically be used in the management of orthostatic hypotension, a condition where low blood pressure occurs on standing up.

It's also important to note that while some patients might find a rectal route more convenient or beneficial, looking at bowel incontinence or difficulties swallowing pills as examples, it is not a commonly preferred route of administration for ADHD medications. The rectal administration of medicine can lead to rapid absorption and, consequently, prompt relief, but it might also cause irritation to the rectal canal or unpredictable variation in drug absorption.

Always consult with a healthcare professional before using Atomoxetine for anything other than its intended use. Off-label use of Atomoxetine should be a decision made collaboratively with your healthcare provider, taking into consideration the potential benefits and risks.

If you have any additional questions about the potential other uses of Atomoxetine 25 mg Rectal Suppository or its administration, do not hesitate to reach out to us at Bayview Pharmacy. Our team of compounding pharmacists believe in actively involving and educating patients and prescribers in their care and decision-making process, and we're always here to provide necessary support and information.

Frequently Asked Questions

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What is the Atomoxetine 25 mg Rectal Suppository?

Atomoxetine 25 mg Rectal Suppository is a type of medicine administered rectally. It is a solid dosage form inserted into the rectum where it dissolves or melts, and the medication is released for local or systemic absorption.

How does the Atomoxetine 25 mg Rectal Suppository work?

Once it is inserted into the rectum, the Atomoxetine suppository melts or dissolves. The medication is then absorbed either locally in the rectum or systemically into the bloodstream depending on the formulation of the suppository.

Why is the Atomoxetine delivered rectally?

Atomoxetine can be administered rectally to provide a more direct and faster absorption of the medication, which can be beneficial for those who cannot take oral medications. This form is also used when a rapid onset of action is required, or when a patient has trouble swallowing drugs.

Is it safe to use Atomoxetine 25 mg Rectal Suppositories?

Yes, Atomoxetine 25 mg Rectal Suppositories are safe to use as directed by a healthcare professional. Always consult your doctor or pharmacist about the appropriate dosing and use for your particular condition or situation.

Can anyone use Atomoxetine 25 mg Rectal Suppositories?

While most people can use rectal suppositories, certain individuals, such as those with specific rectal conditions, may be advised against this form of medication. Always discuss your health conditions and medications with your healthcare provider before starting a new medication.

Are there any side effects with Atomoxetine 25 mg Rectal Suppositories?

As with any medication, side effects may occur. Potential side effects of Atomoxetine can include dry mouth, stomach upset, nausea, vomiting, constipation, tiredness, loss of appetite, weight loss, or dizziness. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.

How do I store Atomoxetine 25 mg Rectal Suppositories?

Rectal suppositories should be stored in a cool, dry place, away from light and moisture. Do not store it in the bathroom. Also, keep all medicines out of reach of children and pets.

What should I do if I forgot to take my Atomoxetine 25 mg Rectal Suppositories?

If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

Will Atomoxetine 25 mg Rectal Suppositories interfere with other medications?

Some drug combinations can interfere with each other. Always share with your healthcare provider the list of all medications you are currently taking to avoid any unwanted interactions.

Can Atomoxetine 25 mg Rectal Suppositories be used for children?

Atomoxetine can be used for children, but only under the supervision of a pediatrician or healthcare professional. Always consult with a healthcare provider before administering any medication to a child.

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Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.